Human monocyte-derived macrophage phagocytosis of senescent eosinophils undergoing apoptosis: Mediation by α(v)β3/CD36/thrombospondin recognition mechanism and lack of phlogistic response

American Journal of Pathology

Volumn 149, Issue 3, 1996, Pages 911-921

  Stern, Myra ^a   Savill, John ^b   Haslett, Chris ^c  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^c ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; CD36 ANTIGEN; GALACTOSAMINE; GLUCOSAMINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTEGRIN; MANNOSAMINE; MONOCLONAL ANTIBODY; THROMBOSPONDIN; THROMBOXANE A2; VITRONECTIN;

APOPTOSIS; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; EOSINOPHIL; HUMAN; HUMAN CELL; MACROPHAGE; NEUTROPHIL; PHAGOCYTOSIS; PRIORITY JOURNAL;

AMINO SUGARS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD36; APOPTOSIS; CELL ADHESION MOLECULES; CELL AGING; EOSINOPHILS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MONOCYTES; OLIGOPEPTIDES; PHAGOCYTOSIS; RECEPTORS, VITRONECTIN; SIGNAL TRANSDUCTION; THROMBOSPONDINS; THROMBOXANE A2;

EID: 0029765796     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Spry CJF: Eosinophils: A Comprehensive Review and Guide to the Scientific and Medical Literature. Oxford, UK, Oxford Medical Publications, Oxford University Press, 1988
2. Filley WW, Kephart GM, Holly KE, Gleich GJ: Identification by immunofluorescence of eosinophil major basic protein in lung tissue of patients with bronchial asthma. Lancet 1982, ii:11-15
3. Spry CJF, Tai P-C, Barkans J: Tissue localisation of human eosinophilic cationic proteins in allergic disease, Int Arch Allergy Appl Immunol 1986, 77:252-254
4. Olsen RL, Little C: Purification and some properties of rnyeloperoxidase and eosinophil peroxidase from human blood. Biochem J 1983, 209:781-787
5. 4 by human eosinophils. J Immunol 1987, 138: 532-538
6. Gleich GJ, Adolfson CR: The eosinophil leukocyte: structure and function Adv Immunol 1986, 39:177-253
7. Weinstock JV, Blum A, Walder J, Walder R: Eosinophils from granulomas in murine schistosomiasis mansoni produce substance P J Immunol 1988, 141:961-970
8. Stern M, Meagher L, Savill J, Haslett C: Apoptosis in human eosinophils: programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5. J Immunol 1992, 148:3543-3549
9. Savill JS, Wyllie AH, Henson JE, Walport MJ, Henson PM, Haslett C: Macrophage phagocytosis of ageing neutrophils in inflammation: programmed cell death in the neutrophil. J Clin Invest 1989, 83:865-875
10. Kawabori S, Soda K, Perdue MH, Bienenstock J: The dynamics of intestinal eosinophil depletion in rats treated with dexamethasone. Lab Invest 1991, 64:224-233
11. Her E, Frazer J, Austen KF, Owen WF: Eosinophil hematopoietins antagonise the programmed cell death of eosinophils. J Clin Invest 1982, 88:1782-1787
12. Inaba K, Inaba M, Kinashi T, Tashiro K, Witmer-Pack M, Crowley M, Kaplan G, Valinsky J, Romani N, Ikehara S: Macrophages phagocytose thymic lymphocytes with productively rearranged T cell receptor α and β genes. J Exp Med 1988, 168:2279-2288
13. Surh CD, Sprent J: T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 1994, 372:100-103
14. Grigg J, Savill J, Sarraf C, Haslett C, Silverman M: Neutrophil apoptosis and clearance from neonatal lungs. Lancet 1991, 338:720-722
15. Savill JS, Smith J, Ren Y, Sarraf C, Abbott F, Rees AJ: Glomerular mesangial cells and inflammatory macrophages ingest neutrophils undergoing apoptosis. Kidney Int 1992, 42:924-936
16. Meagher LC, Savill JS, Baker A, Fuller RW, Haslett C: Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2. J Leukocyte Biol 1992, 52:269-273
17. Savill JS, Henson PM, Haslett C. Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge sensitive" recognition mechanism. J Clin Invest 1989, 84:1518-1527
18. Savill JS, Dransfield I, Hogg N, Haslett C: Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 1990, 343:170-173
19. Savill JS, Hogg N, Ren Y, Haslett C: Thrombospondin co-operates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J Clin Invest 1992, 90:1513-1522
20. Savill JS, Fadok VA, Henson PM, Haslett C: Phagocyte recognition of cells undergoing apoptosis. Immunol Today 1993, 14:131-136
21. Haslett C, Guthrie LA, Kopaniak MM, Johnston RB, Henson PM: Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide. Am J Pathol 1985, 119:101-110
22. Musson RA: Human serum induces maturation of human monocytes in vitro. Am J Pathol 1983, 111:331-340
23. Newman SL, Henson JE, Henson PM: Phagocytosis of senescent neutrophils by human monocyte-derived macrophages and rabbit inflammatory macrophages. J Exp Med 1982, 156:430-442
24. Davies J, Warwick J, Totty N, Philp R, Helfrich M. Horton M: The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor, J Cell Biol 1989, 109:1817-1826
25. Hogg N, MacDonald S, Slusarenko M, Beverley PCL: Monoclonal antibodies specific for human monocytes, granulocytes, and endothelium. Immunology 1984, 53: 753-767
26. Dixit VM, Haverstick DM. O'Rourke KM, Hennessy SW, Grant GA, Santoro SA, Frazier WA: A monoclonal antibody against human thrombospondin inhibits platelet aggregation. Proc Natl Acad Sci USA 1985, 82:3472-3476
27. Bai Y, Durbin H, Hogg N: Monoclonal antibodies specific for platelet glycoproteins react with human monocytes. Blood 1984, 64:139-164
28. Dixit VM, Galvin NJ, O'Rourke KM, Frazier WA: Monoclonal antibodies that recognize calcium-dependent structures of human thrombospondin: characterisation and mapping of their epitopes. J Biol Chem 1986, 261:1962-1968
29. Fuller RW, Kelsey CR, Cole PJ, Dollery CT, MacDermot J: Dexamethasone inhibits the production of thromboxane B2 and leukotriene B4 by human alveolar and peritoneal macrophages in culture. Clin Sci 1984, 67:653-671
30. Dini L, Autori F, Lentini A, Olivierio S, Piacentini M: The clearance of apoptotic cells in the liver is mediated by the asialoglycoprotein receptor. FEBS Lett 1992, 296: 174-178
31. Hall S, Savill J, Henson P, Haslett C: Apoptotic neutrophils are phagocytosed by fibroblasts with participation of the fibroblast vitronectin receptor and involvement of a mannose/fucose-specific lectin. J Immunol 1994, 153:3218-3227
32. Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM: Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 1992, 148:2207-2216
33. Fadok V, Savill JS, Haslett C, Bratton DL, Doherty DE, Campbell PA, Henson PM: Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognise and remove apoptotic cells. J Immunol 1992, 149:4029-4035
34. Flora PK, Gregory CD: Recognition of apoptotic cells by human macrophages: inhibition by a monocyte/ macrophage-specific monoclonal antibody. Eur J Immunol 1994, 24:2625-2632
35. Platt N Gordon S: Role of murine scavenger receptor in the recognition of apoptotic thymocytes by macrophages. J Cell Biochem Suppl 1995, 19B:300
36. Ellis RE, Yuan J, Horvitz HR: Mechanisms and functions of cell death. Annu Rev Cell Biol 1991, 7:663-698