A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans

Nature Cell Biology

Volumn 2, Issue 12, 2000, Pages 931-937

  Chung, Sambath ^a   Gumienny, Tina L ^b,c   Hengartner, Michael O ^b,c   Driscoll, Monica ^a  

^a RUTGERS UNIVERSITY   (United States)

^b WM Keck Structural Biology Laboratory   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CELL DAMAGE; CELL DEATH; CELL KINETICS; CELL STIMULATION; CONTROLLED STUDY; CYTOLYSIS; GENE MUTATION; GENETIC ANALYSIS; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL;

CAENORHABDITIS ELEGANS; INVERTEBRATA; MAMMALIA; NEMATODA;

EID: 0033671313     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35046585     Document Type: Article

References (50)

1. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death
2. C. elegans cell survival gene cad-9 encodes a functional homologue of the mammalian proto-oncogene bcl-2
3. Activation of C. elegans cell death protein CED-9 by an aminoacid substitution in a domain conserved in Bcl-2
4. Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2
5. The C. legans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
6. Genetic control of programmed cell death in the nematode C. elegans
7. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleulkn-1β-converting enzyme
8. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 proteaae
9. An alternatively spliced C. elegans cad-4 RNA encodes a novel cell death inhibitor
10. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
11. Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans
12. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans
13. The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration
14. A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans
15. A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans
16. Two functionally dependent acetylcholine subunits are encoded in a single Caenorhabditis elegans operon
17. Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans
18. Neuropathology of degenerative cell death in Caenorhabditis elegans
19. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation
20. Autophagy and related mechanisms of lysosome-mediated protein degradation
21. Expression of bcl-2 inhibits necrotic neural cell death
22. Activation of physiological cell death mechanisms by a necrosis causing agent
23. Retardation of chemical, hypoxia-induced necrotic celt death by Bcl-2 and ICE inhibitors: Possible involvement of common mediators in apoptotic and necrotic signal transductions
24. Bcl-2 prevents caspase-independent cell death
25. Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities
26. Mutational analysis of the C. elegans cell death gene ced-3
27. Morphology of programmed cell death in the ventral cord of Caenorhabditis elegans
28. ABC1, the mammalian homologue of the engulfment gene ced-7, is required during phagocytosis of both necrotic and apoptotic cells
29. The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans
30. An activating mutation in a Caenorhabditis elegans Gs protein induces neural degeneration
31. G-α(s)-induced neurodegeneration in Caenorhabditis elegans
32. The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters
33. CED-2/Crkl1 and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
34. C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
35. Dual signaling of the FAS receptor: Initiation of both apoptotic and necrotic ceil death pathways
36. Caspase-independent cell killing by Fas-associated protein with death domain
37. Interdigital cell death can occur through a necrotic and caspase-independent pathway
38. Constitutive death of platelets heading to scavanger-mediated phagocytosis
39. Phagocyte recognition of cells undergoing apoptosis
40. Recognition of apoptotic cells by phagocytes
41. The role of phosphatidylserine in recognition of apoptotic cells by phagocytes
42. Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans
43. The embryonic cell lineage of the nematode Caenorhabditis elegans
44. The genetics of Caenorhabditis elegans
45. Post embryonic cell lineages of the nematode Caenorhabdltis elegans
46. The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans
47. Methods for the study of cell death in the nematode Caenorhabditis elegans
48. A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant
49. The Caenorhabdiris elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death
50. Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain