The protective role of NF-κB and AP-1 in arsenite-induced apoptosis in aortic endothelial cells

Toxicology and Applied Pharmacology

Volumn 191, Issue 2, 2003, Pages 177-187

  Tsou, Tsui Chun ^a   Tsai, Feng Yuan ^a   Wu, Meng Chan ^a   Chang, Louis W ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Aortic endothelial cells; AP 1; Apoptosis; Arsenite; NF B

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ARSENIC TRIOXIDE; CAFFEIC ACID PHENETHYL ESTER; CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; SALAZOSULFAPYRIDINE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; AORTA; APOPTOSIS; ARTICLE; BLOOD VESSEL INJURY; CELL PROTECTION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ASSAY; ENZYME DEGRADATION; NONHUMAN; OXIDATION REDUCTION REACTION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SWINE;

SUIDAE;

EID: 0042734959     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00239-4     Document Type: Article

References (66)

1. Barancik M., Htun P., Schaper W. Okadaic acid and anisomycin are protective and stimulate the SAPK/JNK pathway. J. Cardiovasc. Pharmacol. 34:1999;182-190.
2. Barchowsky A., Dudek E.J., Treadwell M.D., Wetterhahn K.E. Arsenic induces oxidant stress and NF-kappa B activation in cultured aortic endothelial cells. Free Radical Biol. Med. 21:1996;783-790.
3. Barchowsky A., Roussel R.R., Klei L.R., James P.E., Ganju N., Smith K.R., Dudek E.J. Low levels of arsenic trioxide stimulate proliferative signals in primary vascular cells without activating stress effector pathways. Toxicol. Appl. Pharmacol. 159:1999;65-75.
4. Bau D.T., Wang T.S., Chung C.H., Wang A.S., Jan K.Y. Oxidative DNA adducts and DNA-protein cross-links are the major DNA lesions induced by arsenite. Environ. Health Perspect. 110:(Suppl. 5):2002;753-756.
5. Beltman J., McCormick F., Cook S.J. The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase. J. Biol. Chem. 271:1996;27018-27024.
6. Bennett B.L., Sasaki D.T., Murray B.W., O'Leary E.C., Sakata S.T., Xu W., Leisten J.C., Motiwala A., Pierce S., Satoh Y., Bhagwat S.S., Manning A.M., Anderson D.W. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA. 98:2001;13681-13686.
7. Carmignani M., Boscolo P., Castellino N. Metabolic fate and cardiovascular effects of arsenic in rats and rabbits chronically exposed to trivalent and pentavalent arsenic. Arch. Toxicol. Suppl. 8:1985;452-455.
8. Cavigelli M., Li W.W., Lin A., Su B., Yoshioka K., Karin M. The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase. EMBO J. 15:1996;6269-6279.
9. Chakravortty D., Kato Y., Sugiyama T., Koide N., Mu M.M., Yoshida T., Yokochi T. The inhibitory action of sodium arsenite on lipopolysaccharide-induced nitric oxide production in RAW 267.4 macrophage cells a role of Raf-1 in lipopolysaccharide signaling . J. Immunol. 166:2001;2011-2017.
10. Chen Y.C., Lin-Shiau S.Y., Lin J.K. Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis. J. Cell. Physiol. 177:1998;324-333.
11. Chiou H.Y., Huang W.I., Su C.L., Chang S.F., Hsu Y.H., Chen C.J. Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. Stroke. 28:1997;1717-1723.
12. Choi Y.J., Park J.W., Suh S.I., Mun K.C., Bae J.H., Song D.K., Kim S.P., Kwon T.K. Arsenic trioxide-induced apoptosis in U937 cells involves generation of reactive oxygen species and inhibition of Akt. Int. J. Oncol. 21:2002;603-610.
13. Chou R.H., Huang H. Sodium arsenite suppresses human papillomavirus-16 E6 gene and enhances apoptosis in E6-transfected human lymphoblastoid cells. J. Cell. Biochem. 84:2002;615-624.
14. Corsini E., Asti L., Viviani B., Marinovich M., Galli C.L. Sodium arsenate induces overproduction of interleukin-1 alpha in murine keratinocytes role of mitochondria . J. Invest. Dermatol. 113:1999;760-765.
15. de Martin R., Schmid J.A., Hofer-Warbinek R. The NF-kappaB/Rel family of transcription factors in oncogenic transformation and apoptosis. Mutat. Res. 437:1999;231-243.
16. De Smaele E., Zazzeroni F., Papa S., Nguyen D.U., Jin R., Jones J., Cong R., Franzoso G. Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling. Nature. 414:2001;308-313.
17. Engel R.R., Hopenhayn-Rich C., Receveur O., Smith A.H. Vascular effects of chronic arsenic exposure a review . Epidemiol. Rev. 16:1994;184-209.
18. Engel R.R., Smith A.H. Arsenic in drinking water and mortality from vascular disease an ecologic analysis in 30 counties in the United States . Arch. Environ. Health. 49:1994;418-427.
19. Germolec D.R., Spalding J., Yu H.S., Chen G.S., Simeonova P.P., Humble M.C., Bruccoleri A., Boorman G.A., Foley J.F., Yoshida T., Luster M.I. Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors. Am. J. Pathol. 153:1998;1775-1785.
20. Ghosh S., May M.J., Kopp E.B. NF-kappa B and Rel proteins evolutionarily conserved mediators of immune responses . Annu. Rev. Immunol. 16:1998;225-260.
21. Hei T.K., Liu S.X., Waldren C. Mutagenicity of arsenic in mammalian cells role of reactive oxygen species . Proc. Natl. Acad. Sci. USA. 95:1998;8103-8107.
22. Hershko D.D., Robb B.W., Hungness E.S., Luo G., Hasselgren P.O. Arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1 beta-stimulated Caco-2 cells independent of the heat shock response. J. Cell. Biochem. 84:2002;687-698.
23. Hoyer L.W., De los Santos R.P., Hoyer J.R. Antihemophilic factor antigen Localization in endothelial cells by immunofluorescent microscopy . J. Clin. Invest. 52:1973;2737-2744.
24. Hu Y., Jin X., Snow E.T. Effect of arsenic on transcription factor AP-1 and NF-kappaB DNA binding activity and related gene expression. Toxicol. Lett. 133:2002;33-45.
25. Huang C., Bode A.M., Chen N.Y., Ma W.Y., Li J., Nomura M., Dong Z. Transactivation of AP-1 in AP-1-luciferase reporter transgenic mice by arsenite and arsenate. Anticancer Res. 21:2001;261-267.
26. Huang C., Li J., Ding M., Wang L., Shi X., Castranova V., Vallyathan V., Ju G., Costa M. Arsenic-induced NFkappaB transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells. Mol. Cell. Biochem. 222:2001;29-34.
27. Jha A.N., Noditi M., Nilsson R., Natarajan A.T. Genotoxic effects of sodium arsenite on human cells. Mutat. Res. 284:1992;215-221.
28. Kapahi P., Takahashi T., Natoli G., Adams S.R., Chen Y., Tsien R.Y., Karin M. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J. Biol. Chem. 275:2000;36062-36066.
29. Karin M., Takahashi T., Kapahi P., Delhase M., Chen Y., Makris C., Rothwarf D., Baud V., Natoli G., Guido F., Li N. Oxidative stress and gene expression the AP-1 and NF-kappaB connections . Biofactors. 15:2001;87-89.
30. Kyriakis J.M., Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81:2001;807-869.
31. Liu B., Fang M., Lu Y., Mills G.B., Fan Z. Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells. Br. J. Cancer. 85:2001;303-311.
32. Liu Y., Guyton K.Z., Gorospe M., Xu Q., Lee J.C., Holbrook N.J. Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite. Free Radical Biol. Med. 21:1996;771-781.
33. Liu Z.G., Hsu H., Goeddel D.V., Karin M. Dissection of TNF receptor 1 effector functions JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death . Cell. 87:1996;565-576.
34. Lynn S., Gurr J.R., Lai H.T., Jan K.Y. NADH oxidase activation is involved in arsenite-induced oxidative DNA damage in human vascular smooth muscle cells. Circ. Res. 86:2000;514-519.
35. Lynn S., Shiung J.N., Gurr J.R., Jan K.Y. Arsenite stimulates poly(ADP-ribosylation) by generation of nitric oxide. Free Radical Biol. Med. 24:1998;442-449.
36. Mann K.K., Doerre S., Schlezinger J.J., Sherr D.H., Quadri S. The role of NF-kappaB as a survival factor in environmental chemical-induced pre-B cell apoptosis. Mol. Pharmacol. 59:2001;302-309.
37. Morgan D.M., Clover J., Pearson J.D. Effects of synthetic polycations on leucine incorporation, lactate dehydrogenase release, and morphology of human umbilical vein endothelial cells. J. Cell Sci. 91:(Pt. 2):1988;231-238.
38. Muscarella D.E., Bloom S.E. Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines. Toxicol. Sci. 68:2002;82-92.
39. Natarajan K., Singh S., Burke T.R. Jr., Grunberger D., Aggarwal B.B. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc. Natl. Acad. Sci. USA. 93:1996;9090-9095.
40. Qu W., Bortner C.D., Sakurai T., Hobson M.J., Waalkes M.P. Acquisition of apoptotic resistance in arsenic-induced malignant transformation role of the JNK signal transduction pathway . Carcinogenesis. 23:2002;151-159.
41. Roussel R.R., Barchowsky A. Arsenic inhibits NF-kappaB-mediated gene transcription by blocking IkappaB kinase activity and IkappaBalpha phosphorylation and degradation. Arch. Biochem. Biophys. 377:2000;204-212.
42. Sadoshima J., Montagne O., Wang Q., Yang G., Warden J., Liu J., Takagi G., Karoor V., Hong C., Johnson G.L., Vatner D.E., Vatner S.F. The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. J. Clin. Invest. 110:2002;271-279.
43. Sambrook J., Russell D.W. Assay for β-galactosidase in extracts of mammalian cells. Irwin N. Molecular Cloning. 2001;17.48-17.51 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
44. Sambrook J., Russell D.W. Assay for luciferase in extracts of mammalian cells. Irwin N. Molecular Cloning. 2001;17.42-17.47 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
45. Sandau K.B., Callsen D., Brune B. Protection against nitric oxide-induced apoptosis in rat mesangial cells demands mitogen-activated protein kinases and reduced glutathione. Mol. Pharmacol. 56:1999;744-751.
46. Sotoudeh M., Li Y.S., Yajima N., Chang C.C., Tsou T.C., Wang Y., Usami S., Ratcliffe A., Chien S., Shyy J.Y. Induction of apoptosis in vascular smooth muscle cells by mechanical stretch. Am. J. Physiol. Heart Circ. Physiol. 282:2002;H1709-H1716.
47. States J.C., Reiners J.J. Jr., Pounds J.G., Kaplan D.J., Beauerle B.D., McNeely S.C., Mathieu P., McCabe M.J. Jr. Arsenite disrupts mitosis and induces apoptosis in SV40-transformed human skin fibroblasts. Toxicol. Appl. Pharmacol. 180:2002;83-91.
48. Stehlik C., deMartin R., Kumabashiri I., Schmid J.A., Binder B.R., Lipp J. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J. Exp. Med. 188:1998;211-216.
49. Tang G., Minemoto Y., Dibling B., Purcell N.H., Li Z., Karin M., Lin A. Inhibition of JNK activation through NF-kappaB target genes. Nature. 414:2001;313-317.
50. Tobiume K., Matsuzawa A., Takahashi T., Nishitoh H., Morita K., Takeda K., Minowa O., Miyazono K., Noda T., Ichijo H. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2:2001;222-228.
51. Tong X., Liu B., Dong Y., Sun Z. Cleavage of ATM during radiation-induced apoptosis caspase-3-like apoptotic protease as a candidate . Int. J. Radiat. Biol. 76:2000;1387-1395.
52. Tournier C., Hess P., Yang D.D., Xu J., Turner T.K., Nimnual A., Bar-Sagi D., Jones S.N., Flavell R.A., Davis R.J. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science. 288:2000;870-874.
53. Trouba K.J., Wauson E.M., Vorce R.L. Sodium arsenite-induced dysregulation of proteins involved in proliferative signaling. Toxicol. Appl. Pharmacol. 164:2000;161-170.
54. Tseng C.H. An overview on peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan. Angiology. 53:2002;529-537.
55. Tseng C.H., Chong C.K., Chen C.J., Tai T.Y. Lipid profile and peripheral vascular disease in arseniasis-hyperendemic villages in Taiwan. Angiology. 48:1997;321-335.
56. Vermes I., Haanen C., Steffens-Nakken H., Reutelingsperger C. A novel assay for apoptosis flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V . J. Immunol. Methods. 184:1995;39-51.
57. Voyta J.C., Via D.P., Butterfield C.E., Zetter B.R. Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein. J. Cell Biol. 99:1984;2034-2040.
58. Wahl C., Liptay S., Adler G., Schmid R.M. Sulfasalazine a potent and specific inhibitor of nuclear factor kappa B . J. Clin. Invest. 101:1998;1163-1174.
59. Wang C.Y., Mayo M.W., Korneluk R.G., Goeddel D.V., Baldwin A.S. Jr. NF-kappaB antiapoptosis induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation . Science. 281:1998;1680-1683.
60. Wang T.S., Kuo C.F., Jan K.Y., Huang H. Arsenite induces apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species. J. Cell. Physiol. 169:1996;256-268.
61. Wang Y.M., Seibenhener M.L., Vandenplas M.L., Wooten M.W. Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival. J. Neurosci. Res. 55:1999;293-302.
62. Wijeweera J.B., Gandolfi A.J., Parrish A., Lantz R.C. Sodium arsenite enhances AP-1 and NFkappaB DNA binding and induces stress protein expression in precision-cut rat lung slices. Toxicol. Sci. 61:2001;283-294.
63. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
64. Yi J., Gao F., Shi G., Li H., Shi X., Tang X. Apoptosis susceptibility of tumor cells to arsenic trioxide and the inherent cellular level of reactive oxygen species. Chin. Med. J. (Engl.). 115:2002;603-606.
65. Yu H.S., Lee C.H., Chen G.S. Peripheral vascular diseases resulting from chronic arsenical poisoning. J. Dermatol. 29:2002;123-130.
66. Zen K., Karsan A., Stempien-Otero A., Yee E., Tupper J., Li X., Eunson T., Kay M.A., Wilson C.B., Winn R.K., Harlan J.M. NF-kappaB activation is required for human endothelial survival during exposure to tumor necrosis factor-alpha but not to interleukin-1beta or lipopolysaccharide. J. Biol. Chem. 274:1999;28808-28815.