Sodium arsenite-induced dysregulation of proteins involved in proliferative signaling

Toxicology and Applied Pharmacology

Volumn 164, Issue 2, 2000, Pages 161-170

  Trouba, Kevin J ^a   Wauson, Eric M ^a   Vorce, Roseann L ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Arsenic; Cancer; Cell cycle; E2F; MAP kinase; Mitogenesis; MKP 1; myc; p27; Signal transduction

Indexed keywords

ARSENITE SODIUM; CARCINOGEN; DNA; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR E2F;

ARTICLE; CELL CYCLE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; FIBROBLAST CULTURE; GROWTH REGULATION; MITOGENESIS; NONHUMAN; ONCOGENE C MYC; SIGNAL TRANSDUCTION;

MURINAE;

EID: 0034655707     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1999.8873     Document Type: Article

References (59)

1. Amati B., Alevizopoulos K., Vlach J. Myc and the cell cycle. Front. Biosci. 3:1998;D250-D268.
2. Andrews G. K., Harding M. A., Calvet J. P., Adamson E. D. The heat shock response in HeLa cells is accompanied by elevated expression of the c-fos proto-oncogene. Mol. Cell. Biol. 7:1987;3452-3458.
3. Bagla P., Kaiser J. India's spreading health crisis draws global arsenic experts. Science. 274:1996;174-175.
4. Balasubramanian S., Ahmad N., Mukhtar H. Upregulation of E2F transcription factors in chemically induced mouse skin tumors. Int. J. Oncol. 15:1999;387-390.
5. Barrett J. C., Lamb P. W., Wang T. C., Lee T. C. Mechanisms of arsenic-induced cell transformation. Biol. Trace Elem. Res. 21:1989;421-429.
6. Bennett B. G. Exposure of man to environmental arsenic - an exposure commitment assessment. Sci. Total Environ. 20:1981;99-107.
7. Brown J. L., Kitchin K. T. Arsenite, but not cadmium, induces ornithine decarboxylase and heme oxygenase activity in rat liver: Relevance to arsenic carcinogenesis. Cancer Lett. 98:1996;227-231.
8. Chen C. J., Chen C. W., Wu M. M., Kuo T. L. Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Br. J. Cancer. 66:1992;888-892.
9. Chen W., Martindale J. L., Holbrook N. J., Liu Y. Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc. Mol. Cell. Biol. 18:1998;5178-5188.
10. Chowdhury A. M., Jakariya M. Testing of water for arsenic in Bangladesh. Science. 284:1999;1622.
11. Doza Y. N., Hall-Jackson C. A., Cohen P. Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos. Oncogene. 17:1998;19-24.
12. Facchini L. M., Penn L. Z. The molecular role of Myc in growth and transformation: Recent discoveries lead to new insights. FASEB J. 12:1998;633-651.
13. Germolec D. R., Spalding J., Boorman G. A., Wilmer J. L., Yoshida T., Simeonova P. P., Bruccoleri A., Kayama F., Gaido K., Tennant R., Burleson F., Dong W., Lang R. W., Luster M. I. Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors. Mutat. Res. 386:1997;209-218.
14. Germolec D. R., Yoshida T., Gaido K., Wilmer J. L., Simeonova P. P., Kayama F., Burleson F., Dong W., Lange R. W., Luster M. I. Arsenic induces overexpression of growth factors in human keratinocytes. Toxicol. Appl. Pharmacol. 141:1996;308-318.
15. Goering P. L., Aposhian H. V., Mass M. J., Cebrian M., Beck B. D., Waalkes M. P. The enigma of arsenic carcinogenesis: Role of metabolism. Toxicol. Sci. 49:1999;5-14.
16. Greenwood D., Srinivasan A., McGoogan S., Pipas J. M. Effects of oncogene expression on cellular growth factor requirements: Defined media for the culture of C3H 10T1/2 and NIH3T3 cells. Baserga R. Cell Growth and Division. A Practical Approach. 1989;37-60 Oxford University Press, New York.
17. Gubits R. M., Fairhurst J. L. c-fos mRNA levels are increased by the cellular stressors, heat shock and sodium arsenite. Oncogene. 3:1988;163-168.
18. Hamel P. A., Hanley-Hyde J. G1 cyclins and control of the cell division cycle in normal and transformed cells. Cancer Invest. 15:1997;143-152.
19. Hartwig A., Groblinghoff U. D., Beyersmann D., Natarajan A. T., Filon R., Mullenders L. H. Interaction of arsenic(III) with nucleotide excision repair in UV-irradiated human fibroblasts. Carcinogenesis. 18:1997;399-405.
20. Hiebert S. W., Lipp M., Nevins J. R. E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor. Proc. Natl. Acad. Sci. USA. 86:1989;3594-3598.
21. Holt J. Fos and Jun: Inducible transcription factors regulating growth of normal and transformed cells. Cancer Treat. Res. 63:1992;301-311.
22. Hsiao K. M., McMahon S. L., Farnham P. J. Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev. 8:1994;1526-1537.
23. Hunter T., Pines J. Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell. 79:1994;573-582.
24. Ishinishi N., Kodama Y., Nobutomo K., Hisanaga A. Preliminary experimental study on carcinogenicity of arsenic trioxide in rat lung. Environ. Health Perspect. 19:1977;191-196.
25. Johnson D. G., Cress W. D., Jakoi L., Nevins J. R. Oncogenic capacity of the E2F1 gene. Proc. Natl. Acad. Sci. USA. 91:1994a;12823-12827.
26. Johnson D. G., Ohtani K., Nevins J. R. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev. 8:1994b;1514-1525.
27. Johnson D. G., Schneider-Broussard R. Role of E2F in cell cycle control and cancer. Front. Biosci. 3:1998;D447-D448.
28. Landolph J. R. Molecular mechanisms of transformation of C3H 10T1/2 C1 8 mouse embryo cells and diploid human fibroblasts by carcinogenic metal compounds. Environ. Health Perspect. 102:1994;119-125.
29. Liu Y., Guyton K. Z., Gorospe M., Xu Q., Lee J. C., Holbrook N. J. Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite. Free Radical Biol. Med. 21:1996;771-781.
30. Marhin W. W., Chen S., Facchini L. M., Fornace A. J. Jr., Penn L. Z. Myc represses the growth arrest gene gadd45. Oncogene. 14:1997;2825-2834.
31. Mass M. J., Wang L. Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: A model for a mechanism of carcinogenesis. Mutat. Res. 1997;263-277.
32. Mazumder D. N., Das Gupta J., Santra A., Pal A., Ghose A., Sarkar S. Chronic arsenic toxicity in west Bengal - The worst calamity in the world. J. Indian Med. Assoc. 96:1998;4-7.
33. Mudryj M., Hiebert S. W., Nevins J. R. A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J. 9:1990;2179-2184.
34. Muller S., Miller W. H. Jr., Dejean A. Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells. Blood. 92:1998;4308-4316.
35. Nelson K. W. Industrial contributions of arsenic to the environment. Environ. Health Perspect. 19:1977;31-34.
36. Nickson R., McArthur J., Burgess W., Ahmed K. M., Ravenscroft P., Rahman M. Arsenic poisoning of Bangladesh groundwater. Nature. 395:1998;338.
37. Pagano M., Tam S. W., Theodoras A. M., Beer-Romero P., Del Sal G., Chau V., Yew P. R., Draetta G. F., Rolfe M. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science. 269:1995;682-685.
38. Parrish A. R., Zheng X. H., Turney K. D., Younis H. S., Gandolfi A. J. Enhanced transcription factor DNA binding and gene expression induced by arsenite or arsenate in renal slices. Toxicol. Sci. 50:1999;98-105.
39. Peters G. The D-type cyclins and their role in tumorigenesis. J. Cell Sci. Suppl. 18:1994;89-96.
40. Pines J. Cyclins, CDKs and cancer. Semin. Cancer Biol. 6:1995;63-72.
41. Qian X., Jin L., Kulig E., Lloyd R. V. DNA methylation regulates p27kip1 expression in rodent pituitary cell lines. Am. J. Pathol. 153:1998;1475-1482.
42. Rahman M., Tondel M., Chowdhury I. A., Axelson O. Relations between exposure to arsenic, skin lesions, and glucosuria. Occup. Environ. Med. 56:1999;277-281.
43. Rossman T., Goncharova E., Rajah T., Wang Z. Human cells lack the inducible tolerance to arsenite seen in hamster cells. Mutat. Res. 386:1997;307-314.
44. Rossman T. G., Wang Z. Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: Possible involvement of the ubiquitin system in arsenic carcinogenesis. Carcinogenesis. 20:1999;311-316.
45. Rudel R., Slayton T. M., Beck B. D. Implications of arsenic genotoxicity for dose response of carcinogenic effects. Regul. Toxicol. Pharmacol. 23:1996;87-105.
46. Saha D. P. Arsenic poisoning in West Bengal. Science. 274:1996;1287.
47. Samet J. M., Graves L. M., Quay J., Dailey L. A., Devlin R. B., Ghio A. J., Wu W., Bromberg P. A., Reed W. Activation of MAPKs in human bronchial epithelial cells exposed to metals. Am. J. Physiol. 275:1998;L551-L558.
48. Sherr C. J. Cancer cell cycles. Science. 274:1996;1672-1677.
49. Shimizu M., Hochadel J. F., Fulmer B. A., Waalkes M. P. Effect of glutathione depletion and metallothionein gene expression on arsenic-induced cytotoxicity and c-myc expression in vitro. Toxicol. Sci. 45:1998;204-211.
50. Smith A. H., Hopenhayn-Rich C., Bates M. N., Goeden H. M., Hertz-Picciotto I., Duggan H. M., Wood R., Kosnett M. J., Smith M. T. Cancer risks from arsenic in drinking water. Environ. Health Perspect. 97:1992;259-267.
51. Soos T. J., Kiyokawa H., Yan J. S., Rubin M. S., Giordano A., DeBlasio A., Bottega S., Wong B., Mendelsohn J., Koff A. Formation of p27-CDK complexes during the human mitotic cell cycle. Cell Growth Differ. 7:1996;135-146.
52. Thalmeier K., Synovzik H., Mertz R., Winnacker E. L., Lipp M. Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter. Genes Dev. 3:1989;527-536.
53. Trouba K. J., Glanzer J. G., Vorce R. L. Wild-type and Ras-transformed fibroblasts display differential mitogenic responses to transient sodium arsenite exposure. Toxicol. Sci. 50:1999;72-81.
54. Vahter M. Methylation of inorganic arsenic in different mammalian species and population groups. Sci. Prog. 82:1999;69-88.
55. Vahter M., Couch R., Nermell B., Nilsson R. Lack of methylation of inorganic arsenic in the chimpanzee. Toxicol. Appl. Pharmacol. 133:1995;262-268.
56. Vindelov L. L. Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. A new method for rapid isolation and straining of nuclei. Virchows Arch. B Cell Pathol. 24:1977;227-242.
57. Wu J., Shen Z. Z., Lu J. S., Jiang M., Han Q. X., Fontana J. A., Barsky S. H., Shao Z. M. Prognostic role of p27Kip1 and apoptosis in human breast cancer. Br. J. Cancer. 79:1999;1572-1578.
58. Yen H. T., Chiang L. C., Wen K. H., Chang S. F., Tsai C. C., Yu C. L., Yu H. S. Arsenic induces interleukin-8 expression in cultured keratinocytes. Arch. Dermatol. Res. 288:1996;716-717.
59. Zhao C. Q., Young M. R., Diwan B. A., Coogan T. P., Waalkes M. P. Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proc. Natl. Acad. Sci. USA. 94:1997;10907-10912.