Okadaic acid and anisomycin are protective and stimulate the SAPK/JNK pathway

Journal of Cardiovascular Pharmacology

Volumn 34, Issue 2, 1999, Pages 182-190

  Barancik, Miroslav ^a,b   Htun, Patrik ^a   Schaper, Wolfgang ^a  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

Ischemia reperfusion; MAPKs; Okadaic acid; Pig; Protein phosphatases

Indexed keywords

ANISOMYCIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SIMULATION; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INDUCTION; HEART INFARCTION SIZE; HEART MUSCLE BIOPSY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IMMUNOBLOTTING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SWINE;

ANIMALS; ANISOMYCIN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; HEMODYNAMIC PROCESSES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; OKADAIC ACID; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASES; SWINE;

EID: 0032792161     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199908000-00002     Document Type: Article

References (23)

1. Schott RJ, Rohmann S, Braun ER, Schaper W. Ischemic preconditioning reduces infarct size in swine myocardium. Circ Res 1990; 66:1133-42.
2. 1 adenosine receptors in rabbit heart. Circulation 1991;84:350-6.
3. Bogoyevitch MA, Gillespie-Brown J, Ketterman AJ, et al. Stimulation of the stress-activated mitogen-activated protein kinases and c-jun N-terminal kinases are activated by ischemia/reperfusion. Circ Res 1996;79:162-73.
4. Knight RJ, Buxton DB. Stimulation of c-jun kinase and mitogenactivated protein kinase by ischemia and reperfusion in the perfused rat hearts. Biochem Biophys Res Commun 1996;218:83-8.
5. Laderoute KR, Webster KA. Hypoxia/reoxygenation stimulates jun kinase activity through redox signaling in cardiac myocytes. Circ Res 1997;80:336-44.
6. Seko Y, Tobe K, Ueki K, Kadowaki T, Yazaki Y. Hypoxia and hypoxia/reoxygenation activate Raf-1, mitogen-activated protein kinase kinase, mitogen-activated protein kinases, and S6 kinase in cultured rat cardiac myocytes. Circ Res 1996;78:82-90.
7. Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 1997;9:180-6.
8. Weinbrenner C, Liu GS, Cohen MV, Downey JM. Phosphorylation of tyrosine 182 of p38 mitogen-activated protein kinase correlates with the protection of preconditioning in rabbit heart. J Mol Cell Cardiol 1997;29:2383-91.
9. Maulik N, Watanabe M, Zu YL, et al. Ischemic preconditioning triggers the activation of MAP kinases and MAPKAP kinase 2 in rat heart. FEBS Lett 1996;396:233-7.
10. Armstrong SC, Ganote CC. Effect of the protein phosphatase inhibitors okadaic acid and calyculin A on metabolically inhibited and ischemic isolated myocytes. J Mol Cell Cardiol 1992;24:869-84.
11. Armstrong SC, Gao W, Lane JR, Ganote CE. Protein phosphatase inhibitors calyculin A and fostriecin protect cardiomyocytes in late ischemia. J Mol Cell Cardiol 1998;30:61-73.
12. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Analyt Biochem 1976;72:248-54.
13. Hafen E. Kinases and phosphatases: a marriage is consummated. Science 1998;280:1212-3.
14. 2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A. Science 1998;280:1258-61.
15. Muda M, Boschert U, Dickinson R, et al. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. J Biol Chem 1996;271: 4319-26.
16. Weinbrenner C, Baines CP, Liu GS, et al. Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia. Circulation 1998;98: 899-905.
17. Cumming DVE, Heads RJ, Coffin RS, Yellon DM, Latchman DS. Pharmacological preconditioning of primary rat cardiac myocytes by FK506. Basic Res Cardiol 1996;91:367-73.
18. Barancik M, Htun P, Maeno Y, Zimmermann R, Schaper W. Differential regulation of distinct protein kinase cascades by ischemia and ischemia/reperfusion in porcine myocardium [Abstract]. Circulation 1997;96(suppl I):1397.
19. Hardie DG, Haystead AJ, Sim ATR. Use of okadaic acid to inhibit protein phosphatases in intact cells. Methods Enzymol 1991;201: 469-76.
20. Cano E, Hazzalin C, Kardalinou E, Buckle R, Mahadevan L. Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction. J Cell Sci 1995;108:3599-3609.
21. Yue TL, Ma XL, Wang X, et al. Possible involvement of SAPK-signaling pathway and fas receptor expression in ischemia/ reperfusion-induced cardiomyocyte apoptosis by carvedilol. Circ Res 1998;82:166-74.
22. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR. Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7: a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J Biol Chem 1998;273:5423-6.
23. Htun P, Barancik M, Maeno Y, Kilian S, Schaper W. Inhibition of the p38 kinase by SB 203585 delays ischemic cell death in pig myocardium [Abstract]. J Mol Cell Cardiol 1998;30:A16.