Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells

British Journal of Cancer

Volumn 85, Issue 2, 2001, Pages 303-311

  Liu, B ^a   Fang, M ^a   Lu, Y ^a,a   Mills, G B ^a   Fan, Z ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Apoptosis; EGF; JNK; MAPK; Paclitaxel; PI 3K

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROTECTION; CONCENTRATION RESPONSE; ENZYME ACTIVATION; ENZYME INACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UTERINE CERVIX CANCER;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; FEMALE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PACLITAXEL; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 0034935815     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.1910     Document Type: Article

References (62)

1. Constitutive activation of c-Jun N-terminal kinase by a mutant epidermal growth factor receptor
2. Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
3. DNA end-joining catalyzed by human cell-free extracts
4. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
5. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription facton
6. Interferon-alpha induces apoptosis in human KB cells through a stress-dependent mitogen activated protein kinase pathway that is antagonized by epidermal growth factor
7. Regulation of cell death protease caspase-9 by phosphorylation
8. Essential role of mitogen-activated protein kinase pathway and c-Jun induction in epidermal growth factor-induced gene expression of human 12-lipoxygenase
9. Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway
10. Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and transactivation
11. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
12. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
13. Mechanisms and consequences of activation of protein kinase B/Akt
14. A synthetic inhibitor of the mitogen-activated protein kinase cascade
15. Cip1/WAF1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition
16. Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway
17. Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation
18. The SH2 domain of Shc suppresses EGF-induced mitogenesis in a dominant negative manner
19. Shc regulates epidermal growth factor-induced activation of the JNK signaling pathway
20. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
21. From receptors to stress-activated MAP kinases
22. Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells
23. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
24. Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2
25. Phosphatidylinositol 3-kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor
26. Negative feedback regulation and desensitization of ins
27. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
28. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
29. Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway
30. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
31. Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity
32. Dissection of TNF receptor I effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
33. Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway
34. CD28-dependent killing by human YT cells requires phosphatidylinositol 3-kinase activation
35. Regulation of proliferation and apoptosis by epidermal growth factor and protein kinase C in human ovarian surface epithelial cells
36. c-jun N-terminal kinase is involved in AUUUA-mediated interleukin-3 mRNA turnover in mast cells
37. Accumulation of human papillomavirus type 16 E7 protein bypasses G1 arrest induced by serum deprivation and by the cell cycle inhibitor p21
38. Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor
39. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
40. Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts
41. Epidermal growth factor induction of human papillomavirus type 16 E6/E7 MRNA in tumor cells involves two AP-1 binding sites in the viral enhancer
42. A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
43. Phosphatidylinositol-3-OH kinase as a direct target of Ras
44. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
45. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
46. Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase
47. A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells
48. Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells
49. Mitogen-activated protein kinase cascades and regulation of gene expression
50. Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 and p38 mitogen-activated protein kinase pathways
51. Molecular characterization of mitochondrial apoptosis-inducing factor
52. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
53. Regulation of transcription by MAP kinase cascades
54. Signal transduction by receptors with tyrosine kinase activity
55. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
56. Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase
57. Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells
58. Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex
59. Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
60. Biochemical and pharmacological studies with KT7692 and LY294002 on the role of phosphatidylinositol 3-kinase in Fc epsilon RI-mediated signal transduction
61. The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat
62. L