Plasmid-encoded metallo-β-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 5, 2001, Pages 1343-1348

  Yano, H ^a   Kuga, A ^a   Okamoto, R ^a   Kitasato, H ^a   Kobayashi, T ^a   Inoue, M ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AZTREONAM; BETA LACTAMASE; CARBAPENEM DERIVATIVE; CEFALOTIN; CEFEPIME; CEFMETAZOLE; CEFOTAXIME; CEFOTIAM; CHLORAMPHENICOL; CLAVULANIC ACID; IMIPENEM; MEROPENEM; NALIDIXIC ACID; PANIPENEM; PENICILLIN G; PIPERACILLIN; STREPTOMYCIN; TETRACYCLINE;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE AMPLIFICATION; GENE SEQUENCE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; RECOMBINANT PLASMID; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; BETA-LACTAMASES; DNA, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PLASMIDS; SERRATIA INFECTIONS; SERRATIA MARCESCENS; SUBSTRATE SPECIFICITY; THIENAMYCINS;

EID: 0035042388     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.5.1343-1348.2001     Document Type: Article

References (41)

1. The structure of β-lactamases
2. Metallo-β-lactamases: A class apart
3. A functional classification scheme for β-lactamases and its correlation with molecular structure
4. Methodology, for the study of β-lactamases
5. Appearance of IMP-1 metallo-β-lactamase in Europe
6. Relative importances of outer membrane permeability and group 1 β-lactamase as determinants of meropenem and imipenem activities against Enterobacter cloacae
7. IMP
8. Cephalosporinase interactions and antimicrobial activity of BMY-28142, ceftazidime and cefotaxime
9. A simple and efficient method for direct cloning of PCR products using ddT-tailed vectors
10. pMS76, a plasmid capable of amplification by treatment with chloramphenicol
11. Why do antimicrobial agents become ineffectual?
12. Comparative in vitro activity of RP59500 against clinical bacterial isolates
13. Cloning and sequence of the gene encoding a cefotaxime-hydrolyzing class A β-lactamase isolated from Escherichia coli
14. IMP among clinically isolated strains of Serratia marcescens
15. Amino acid substitutions in a variant of IMP-1 metallo-β-lactamase
16. Cloning and expression in Enterobacteriaceae of the extended-spectrum β-lactamase gene from a Pseudomonas aeruginosa plasmid
17. Insertion of a carbapenemase gene cassette into an integron of a Pseudomonas aeruginosa plasmid
18. Transposition of the carbenicillin-hydrolyzing β-lactamase gene
19. Antibacterial activity of meropenem against gram-negative bacteria with a permeability defect and against staphylococci
20. Characterization of a new plasmid-mediated extended-spectrum β-lactamase from Serratia marcescens
21. Worldwide proliferation of carbapenem-resistant gram-negative bacteria
22. Biochemical characterization of the Pseudomonas aeruginosa 101/1477 metallo-β-lactamase IMP-1 produced by Escherichia coli
23. IMP-containing Pseudomonas aeruginosa integron phyletically related to In5, which carries an unusual array of gene cassettes
24. Transduction of linked genetic characters of the host by bacteriophage P1
25. Antibiotic resistance and production of extended-spectrum β-lactamases amongst Klebsiella spp. from intensive care units in Europe
26. Purification and characterization of metallo-β-lactamase from Serratia marcescens
27. Imipenem and cephem resistant Pseudomonas aeruginosa carrying plasmids coding for class B β-lactamase
28. The crisis in antibiotic resistance
29. Detection of genes regulating β-lactamase production in Enterococcus faecalis and Staphylococcus aureus
30. Molecular characterization of an enterobacterial metallo β-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance
31. Carbapenem-hydrolyzing β-lactamases
32. IMP allelic variants carried by gene cassettes of different phylogeny
33. DNA sequencing with chain-terminating inhibitors
34. Multifocal outbreaks of metallo-β-lactamase-producing Pseudomonas aeruginosa resistant to broad-spectrum β-lactams, including carbapenems
35. Lambda ZAP: A bacteriophage lambda expression vector with in vivo excision properties
36. High-copy-number and low-copy-number plasmid vectors for lacZα-complementation and chloramphenicol- or kanamycin-resistance selection
37. Detection and reporting of organisms producing extended-spectrum β-lactamases: Survey of laboratories in Connecticut
38. Transferable imipenem resistance in Pseudomonas aeruginosa
39. Panipenem-betamipron and decreases in serum valproic acid concentration
40. Presence of genes for β-lactamases of two different classes on a single plasmid from a clinical isolate of Serratia marcescens