Arginines 97 and 108 in CYP2C9 are important determinants of the catalytic function

Biochemical and Biophysical Research Communications

Volumn 270, Issue 3, 2000, Pages 983-987

  Ridderström, Marianne ^a   Masimirembwa, Collen ^a   Trump Kallmeyer, Susanne ^a   Ahlefelt, Maria ^a   Otter, Charlotta ^a   Andersson, Tommy B ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Active site; CYP2C9; Cytochrome P459; Diclofenac; Function; Mutagenesis

Indexed keywords

ALANINE; ARGININE; CYTOCHROME P450 2C9; DICLOFENAC;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; DRUG METABOLISM; ENZYME SPECIFICITY; GENETIC CONSERVATION; MICHAELIS CONSTANT; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

EID: 0034696808     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2538     Document Type: Article

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