Gene dose-dependent maturation and receptor editing of B cells expressing immunoglobulin (Ig)G1 or IgM/IgG1 tail antigen receptors

Journal of Experimental Medicine

Volumn 191, Issue 6, 2000, Pages 1031-1043

  Pogue, Sarah L ^a   Goodnow, Christopher C ^b  

^a STANFORD UNIVERSITY   (United States)

^b Biology and Environment   (Australia)

Author keywords

Allelic exclusion; B lymphocyte; Development; Isotype switch; Transgene

Indexed keywords

IMMUNOGLOBULIN G1; IMMUNOGLOBULIN M; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; GENE DOSAGE; GENE NUMBER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; B-LYMPHOCYTE SUBSETS; CELL DIFFERENTIATION; CHICKENS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; GENE DOSAGE; GENETIC VECTORS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN M; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; MURAMIDASE; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, FC; RECEPTORS, IGG; RECOMBINANT FUSION PROTEINS; RNA EDITING; SPLEEN; STEM CELLS; TRANSPOSASES;

EID: 0034689025     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.6.1031     Document Type: Article

References (80)

1. Antigen-induced co-capping of IgM and IgD-like receptors on murine B cells
2. The class of surface immunoglobulin on virgin and memory B lymphocytes
3. Ontogeny of Ia and IgD on IgM-bearing B lymphocytes in mice
4. IgD and B cell differentiation
5. Germinal centre B cells: Antigen specificity and changes in heavy chain class expression
6. Somatic mutations in antibodies expressed by germinal centre B cells early after primary immunization
7. Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM
8. Two distinct immunoglobulin heavy Chain isotypes in a primitive, cartilaginous fish, Raja erinacea
9. The immunoglobulin M heavy chain constant region gene of the channel catfish, Ictalurus punctatus: An unusual form of the molecule
10. Complete structure and organization of immunoglobulin heavy chain constant region genes in a phylogenetically primitive vertebrate
11. Two unusual forms of human immunoglobulin E encoded by alternate RNA splicing of epsilon heavy chain membrane exons
12. The membrane exons of the pseudo-gamma-chain gene of the human immunoglobulin are apparently functional and highly homologous to those of the gamma 1 gene
13. Characterization of four novel epsilon chain mRNA and a comparative analysis of genes for immunoglobulin E in rodents and man
14. Gene segments encoding membrane domains for the human immunoglobulin gamma 3 and alpha chains
15. Nucleotide sequence of all the gamma gene loci of murine immunoglobulin heavy chains
16. Complete nucleotide sequence of immunoglobulin γ2b chain gene cloned from newborn mouse DNA
17. Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains
18. mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 23-residue intracellular domain
19. The murine immunoglobulin alpha gene expresses multiple transcripts from a unique membrane exon
20. Endosomal targeting by the cytoplasmic tail of membrane immunoglobulin
21. The roles of gamma1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses
22. Effect of transmembrane and cytoplasmic domains of IgE on the IgE response
23. Cell-type-specific and regulated expression of a human γ1 heavy-chain immunoglobulin gene in transgenic mice
24. Failed self-tolerance and autoimmunity in IgG anti-DNA transgenic mice
25. Induction of tolerance to an IgG autoantibody
26. High-level expression of a human immunoglobulin γ1 transgene depends on switch region sequences
27. Immunoglobulin γ2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development
28. Igγ2b transgenes promote B cell development but alternate developmental pathways appear to function in different transgenic lines
29. γ5, but not μ, is required for B cell maturation in a unique γ2b transgenic mouse line
30. Non-tolerant B cells cause autoimmunity in anti-CD8 IgG2a-transgenic mice
31. Lack of allelic exclusion permits autoreactive B cells to escape deletion
32. Antigenic regions defined by monoclonal antibodies correspond to structural domains of avian lysozyme
33. Structure of an antibody-antigen complex: Crystal structure of the HyHEL-10 Fab-lysozyme complex
34. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
35. Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen
36. Cloned embryonic DNA sequences flanking the mouse immunoglobulin Cγ3 and Cγ1 genes
37. 'Sticky feet'-directed mutagenesis and its application to swapping antibody domains
38. A simple screening method for transgenic mice using the polymerase chain reaction
39. Monoclonal anti-allotype antibody towards BALB/c IgM. Analysis of specificity and site of a V-C crossover in recombinant strain BALB-Igh-Cb
40. Allotypic specificities of murine IgD and IgM recognized by monoclonal antibodies
41. Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development
42. Mapping the antigenic epitope for a monoclonal antibody against avian lysozyme
43. Characterization of murine complement receptor type 2 and its immunological cross-reactivity with type 1 receptor
44. Censoring of selfreactive B cells with a range of receptor affinities in transgenic mice expressing heavy chains for a lysozyme-specific antbody
45. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
46. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
47. Clonal selection and learning in the antibody system
48. Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation
49. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice
50. CD45 sets thresholds for negative and positive selection orb lymphocytes
51. Aberrant B cell development and immune response in mice with a compromised BCR complex
52. Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death
53. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection
54. RAG-1-deficient mice have no mature B and T lymphocytes
55. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
56. A critical role of λ5 protein in B cell development
57. Syk tyrosine kinase required for mouse viability and B-cell development
58. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
59. Cloning of a γ2b gene encoding anti-Pseudomonas aeruginosa H chains and its introduction into the germ line of mice
60. Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator gene
61. Deletion and editing of B cells that express antibodies to DNA
62. Evidence for a preformed transducer complex by the B cell antigen receptor
63. The role of Bruton's tyrosine kinase in B cell development and function in mice and man
64. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
65. Reduced life span of anergic self-reactive B cells in a double-transgenic model
66. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling
67. Receptor editing in self-reactive bone marrow B cells
68. Receptor editing: An approach by autoreactive B cells to escape tolerance
69. Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing
70. - bone marrow B cells in vitro
71. Hyperresponsive B cells in CD22-deficient mice
72. CD22 regulates thymus-independent responses and the lifespan of B cells
73. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: Altered signaling in CD22-deficient mice
74. CD22 is a negative regulator of B-cell receptor signalling
75. CD19 expression levels regulate B lymphocyte development: Human CD19 restores normal function in mice lacking endogenous CD19
76. Isolation of high-affinity memory B cells: Phycoerythrin as a probe for antigen-binding cells
77. Memory B cells in T cell-dependent antibody responses colonize the splenic marginal zones
78. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-B1 and B7-2
79. The human gut contains a novel population of B lymphocytes which resemble marginal zone cells