-
1
-
-
0022497852
-
Genetic control of programmed cell death in the nematode C. elegans
-
Ellis H.M., Horvitz H.R. Genetic control of programmed cell death in the nematode C. elegans. Cell. 44:1986;817-829.
-
(1986)
Cell
, vol.44
, pp. 817-829
-
-
Ellis, H.M.1
Horvitz, H.R.2
-
2
-
-
0026582702
-
Caenorhabditis elegans gene ced-9 protects cells from programmed cell death
-
Hengartner M.O., Ellis R.E., Horvitz H.R. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature. 356:1992;494-499.
-
(1992)
Nature
, vol.356
, pp. 494-499
-
-
Hengartner, M.O.1
Ellis, R.E.2
Horvitz, H.R.3
-
3
-
-
0027525104
-
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
-
Yuan J., Shaham S., Ledoux S., Ellis H.M., Horvitz H.R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell. 75:1993;641-652.
-
(1993)
Cell
, vol.75
, pp. 641-652
-
-
Yuan, J.1
Shaham, S.2
Ledoux, S.3
Ellis, H.M.4
Horvitz, H.R.5
-
4
-
-
0030821826
-
Role of CED-4 in the activation of CED-3
-
Chinnaiyan A.M., Chaudhary D., O'Rourke K., Koonin E.V., Dixit V.M. Role of CED-4 in the activation of CED-3. Nature. 388:1997;728-729.
-
(1997)
Nature
, vol.388
, pp. 728-729
-
-
Chinnaiyan, A.M.1
Chaudhary, D.2
O'Rourke, K.3
Koonin, E.V.4
Dixit, V.M.5
-
5
-
-
0031194404
-
Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3- induced apoptosis
-
Seshagiri S., Miller L.K. Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3- induced apoptosis. Curr. Biol. 7:1997;455-460.
-
(1997)
Curr. Biol.
, vol.7
, pp. 455-460
-
-
Seshagiri, S.1
Miller, L.K.2
-
6
-
-
0031019739
-
Interaction between the C. elegans cell-death regulators CED-9 and CED-4
-
Spector M.S., Desnoyers S., Hoeppner D.J., Hengartner M.O. Interaction between the C. elegans cell-death regulators CED-9 and CED-4. Nature. 385:1997;653-656.
-
(1997)
Nature
, vol.385
, pp. 653-656
-
-
Spector, M.S.1
Desnoyers, S.2
Hoeppner, D.J.3
Hengartner, M.O.4
-
7
-
-
0031034997
-
Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death
-
Chinnaiyan A.M., O'Rourke K., Lane B.R., Dixit V.M. Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science. 275:1997;1122-1126.
-
(1997)
Science
, vol.275
, pp. 1122-1126
-
-
Chinnaiyan, A.M.1
O'Rourke, K.2
Lane, B.R.3
Dixit, V.M.4
-
8
-
-
0031020227
-
Interaction and regulation of subcellular localization of CED-4 by CED-9
-
Wu D., Wallen H.D., Nunez G. Interaction and regulation of subcellular localization of CED-4 by CED-9. Science. 275:1997;1126-1129.
-
(1997)
Science
, vol.275
, pp. 1126-1129
-
-
Wu, D.1
Wallen, H.D.2
Nunez, G.3
-
9
-
-
0009530192
-
Human ICE/CED-3 protease nomenclature
-
Alnemri E.S., Livingston D.J., Nicholson D.W., Salvesen G., Thornberry N.A., Wong W.W., Yuan J. Human ICE/CED-3 protease nomenclature. Cell. 87:1996;171.
-
(1996)
Cell
, vol.87
, pp. 171
-
-
Alnemri, E.S.1
Livingston, D.J.2
Nicholson, D.W.3
Salvesen, G.4
Thornberry, N.A.5
Wong, W.W.6
Yuan, J.7
-
10
-
-
0030849093
-
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
-
Thornberry N.A., Rano T.A., Peterson E.P., Rasper D.M., Timkey T., Garcia-Calvo M., Houtzager V.M., Nordstrom P.A., Roy S., Vaillancourt J.P., Chapman K.T., Nicholson D.W. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem. 272:1997;17907-17911.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 17907-17911
-
-
Thornberry, N.A.1
Rano, T.A.2
Peterson, E.P.3
Rasper, D.M.4
Timkey, T.5
Garcia-Calvo, M.6
Houtzager, V.M.7
Nordstrom, P.A.8
Roy, S.9
Vaillancourt, J.P.10
Chapman, K.T.11
Nicholson, D.W.12
-
11
-
-
0030745646
-
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
-
Zou H., Henzel W.J., Liu X., Lutschg A., Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 90:1997;405-413.
-
(1997)
Cell
, vol.90
, pp. 405-413
-
-
Zou, H.1
Henzel, W.J.2
Liu, X.3
Lutschg, A.4
Wang, X.5
-
12
-
-
0032575688
-
The Bcl-2 protein family: Arbiters of cell survival
-
Adams J.M., Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 281:1998;1322-1326.
-
(1998)
Science
, vol.281
, pp. 1322-1326
-
-
Adams, J.M.1
Cory, S.2
-
13
-
-
0030581151
-
Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
-
Liu X., Kim C.N., Yang J., Jemmerson R., Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 86:1996;147-157.
-
(1996)
Cell
, vol.86
, pp. 147-157
-
-
Liu, X.1
Kim, C.N.2
Yang, J.3
Jemmerson, R.4
Wang, X.5
-
14
-
-
0029950290
-
Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
-
Susin S.A., Zamzami N., Castedo M., Hirsch T., Marchetti P., Macho A., Daugas E., Geuskens M., Kroemer G. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J. Exp. Med. 184:1996;1331-1341.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 1331-1341
-
-
Susin, S.A.1
Zamzami, N.2
Castedo, M.3
Hirsch, T.4
Marchetti, P.5
Macho, A.6
Daugas, E.7
Geuskens, M.8
Kroemer, G.9
-
15
-
-
0033521741
-
Molecular characterization of mitochondrial apoptosis-inducing factor
-
Susin S.A., Lorenzo H.K., Zamzami N., Marzo I., Snow B.E., Brothers G.M., Mangion J., Jacotot E., Costantini P., Loeffler M., Larochette N., Goodlett D.R., Aebersold R., Siderovski D.P., Penninger J.M., Kroemer G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 397:1999;441-446.
-
(1999)
Nature
, vol.397
, pp. 441-446
-
-
Susin, S.A.1
Lorenzo, H.K.2
Zamzami, N.3
Marzo, I.4
Snow, B.E.5
Brothers, G.M.6
Mangion, J.7
Jacotot, E.8
Costantini, P.9
Loeffler, M.10
Larochette, N.11
Goodlett, D.R.12
Aebersold, R.13
Siderovski, D.P.14
Penninger, J.M.15
Kroemer, G.16
-
16
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:1997;479-489.
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
Nijhawan, D.2
Budihardjo, I.3
Srinivasula, S.M.4
Ahmad, M.5
Alnemri, E.S.6
Wang, X.7
-
18
-
-
0033596980
-
An APAF-1 · cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
-
Zou H., Li Y., Liu X., Wang X. An APAF-1. · cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9 J. Biol. Chem. 274:1999;11549-11556.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 11549-11556
-
-
Zou, H.1
Li, Y.2
Liu, X.3
Wang, X.4
-
19
-
-
0033529634
-
Caspase activation involves the formation of the aposome, a large (∼700 kDa) caspase-activating complex
-
Cain K., Brown D.G., Langlais C., Cohen G.M. Caspase activation involves the formation of the aposome, a large (∼700. kDa) caspase-activating complex J. Biol. Chem. 274:1999;22686-22692.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 22686-22692
-
-
Cain, K.1
Brown, D.G.2
Langlais, C.3
Cohen, G.M.4
-
20
-
-
0034105784
-
Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes
-
Cain K., Bratton S.B., Langlais C., Walker G., Brown D.G., Sun X.M., Cohen G.M. Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes. J. Biol. Chem. 275:2000;6067-6070.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 6067-6070
-
-
Cain, K.1
Bratton, S.B.2
Langlais, C.3
Walker, G.4
Brown, D.G.5
Sun, X.M.6
Cohen, G.M.7
-
21
-
-
0031036872
-
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
-
Yang J., Liu X., Bhalla K., Kim C.N., Ibrado A.M., Cai J., Peng T.I., Jones D.P., Wang X. Prevention of apoptosis by Bcl-2: release of cytochrome. c from mitochondria blocked Science. 275:1997;1129-1132.
-
(1997)
Science
, vol.275
, pp. 1129-1132
-
-
Yang, J.1
Liu, X.2
Bhalla, K.3
Kim, C.N.4
Ibrado, A.M.5
Cai, J.6
Peng, T.I.7
Jones, D.P.8
Wang, X.9
-
22
-
-
0031037897
-
The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
-
Kluck R.M., Bossy-Wetzel E., Green D.R., Newmeyer D.D. The release of cytochrome. c from mitochondria: a primary site for Bcl-2 regulation of apoptosis Science. 275:1997;1132-1136.
-
(1997)
Science
, vol.275
, pp. 1132-1136
-
-
Kluck, R.M.1
Bossy-Wetzel, E.2
Green, D.R.3
Newmeyer, D.D.4
-
23
-
-
0032575752
-
Mitochondria and apoptosis
-
Green D.R., Reed J.C. Mitochondria and apoptosis. Science. 281:1998;1309-1312.
-
(1998)
Science
, vol.281
, pp. 1309-1312
-
-
Green, D.R.1
Reed, J.C.2
-
26
-
-
0033578303
-
Bcl-2 family members do not inhibit apoptosis by binding the caspase activator apaf-1
-
Moriishi K., Huang D.C.S., Cory S., Adams J.M. Bcl-2 family members do not inhibit apoptosis by binding the caspase activator apaf-1. Proc. Natl. Acad. Sci. USA. 96:1999;9683-9688.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 9683-9688
-
-
Moriishi, K.1
Huang, D.C.S.2
Cory, S.3
Adams, J.M.4
-
27
-
-
0028017880
-
Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system
-
Sato T., Hanada M., Bodrug S., Irie S., Iwama N., Boise L.H., Thompson C.B., Golemis E., Fong L., Wang H.G., Reed J.C. Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl. Acad. Sci. USA. 91:1994;9238-9242.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9238-9242
-
-
Sato, T.1
Hanada, M.2
Bodrug, S.3
Irie, S.4
Iwama, N.5
Boise, L.H.6
Thompson, C.B.7
Golemis, E.8
Fong, L.9
Wang, H.G.10
Reed, J.C.11
-
28
-
-
0033546722
-
Three new types of Apaf-1 in mammalian cells
-
Hahn C., Hirsch B., Jahnke D., Durkop H., Stein H. Three new types of Apaf-1 in mammalian cells. Biochem. Biophys. Res. Commun. 261:1999;746-749.
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.261
, pp. 746-749
-
-
Hahn, C.1
Hirsch, B.2
Jahnke, D.3
Durkop, H.4
Stein, H.5
-
29
-
-
0001607723
-
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
-
Walker J.E., Saraste M., Runswick M.J., Gay N.J. Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1:1982;945-951.
-
(1982)
EMBO J.
, vol.1
, pp. 945-951
-
-
Walker, J.E.1
Saraste, M.2
Runswick, M.J.3
Gay, N.J.4
-
30
-
-
0033179760
-
BCL-2 family members and the mitochondria in apoptosis
-
Gross A., McDonnell J.M., Korsmeyer S.J. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 13:1999;1899-1911.
-
(1999)
Genes Dev.
, vol.13
, pp. 1899-1911
-
-
Gross, A.1
McDonnell, J.M.2
Korsmeyer, S.J.3
-
31
-
-
0031442184
-
Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy
-
Iwahashi H., Eguchi Y., Yasuhara N., Hanafusa T., Matsuzawa Y., Tsujimoto Y. Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy. Nature. 390:1997;413-417.
-
(1997)
Nature
, vol.390
, pp. 413-417
-
-
Iwahashi, H.1
Eguchi, Y.2
Yasuhara, N.3
Hanafusa, T.4
Matsuzawa, Y.5
Tsujimoto, Y.6
-
32
-
-
0001003612
-
Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members
-
Hsu S.Y., Kaipia A., McGee E., Lomeli M., Hsueh A.J. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. USA. 94:1997;12401-12406.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 12401-12406
-
-
Hsu, S.Y.1
Kaipia, A.2
McGee, E.3
Lomeli, M.4
Hsueh, A.J.5
-
33
-
-
0344348821
-
Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis
-
Hu Y., Benedict M.A., Ding L., Nunez G. Role of cytochrome. c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis EMBO J. 18:1999;3586-3595.
-
(1999)
EMBO J.
, vol.18
, pp. 3586-3595
-
-
Hu, Y.1
Benedict, M.A.2
Ding, L.3
Nunez, G.4
-
34
-
-
0034708504
-
Expression and functional analysis of Apaf-1 isoforms. Extra WD-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9
-
Benedict M.A., Hu Y., Inohara N., Nunez G. Expression and functional analysis of Apaf-1 isoforms. Extra WD-40 repeat is required for cytochrome. c binding and regulated activation of procaspase-9 J. Biol. Chem. 275:2000;8461-8468.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8461-8468
-
-
Benedict, M.A.1
Hu, Y.2
Inohara, N.3
Nunez, G.4
-
36
-
-
0033193863
-
Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
-
Rodriguez A., Oliver H., Zou H., Chen P., Wang X., Abrams J.M. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat. Cell Biol. 1:1999;272-279.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 272-279
-
-
Rodriguez, A.1
Oliver, H.2
Zou, H.3
Chen, P.4
Wang, X.5
Abrams, J.M.6
-
37
-
-
0033231548
-
HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis
-
Zhou L., Song Z., Tittel J., Steller H. HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis. Mol. Cell. 4:1999;745-755.
-
(1999)
Mol. Cell
, vol.4
, pp. 745-755
-
-
Zhou, L.1
Song, Z.2
Tittel, J.3
Steller, H.4
-
38
-
-
0033231614
-
Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator
-
Kanuka H., Sawamoto K., Inohara N., Matsuno K., Okano H., Miura M. Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator. Mol. Cell. 4:1999;757-769.
-
(1999)
Mol. Cell
, vol.4
, pp. 757-769
-
-
Kanuka, H.1
Sawamoto, K.2
Inohara, N.3
Matsuno, K.4
Okano, H.5
Miura, M.6
-
39
-
-
0033532091
-
Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB
-
Bertin J., Nir W.J., Fischer C.M., Tayber O.V., Errada P.R., Grant J.R., Keilty J.J., Gosselin M.L., Robison K.E., Wong G.H., Glucksmann M.A., DiStefano P.S. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB. J. Biol. Chem. 274:1999;12955-12958.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12955-12958
-
-
Bertin, J.1
Nir, W.J.2
Fischer, C.M.3
Tayber, O.V.4
Errada, P.R.5
Grant, J.R.6
Keilty, J.J.7
Gosselin, M.L.8
Robison, K.E.9
Wong, G.H.10
Glucksmann, M.A.11
DiStefano, P.S.12
-
40
-
-
0033591330
-
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB
-
Inohara N., Koseki T., del-Peso L., Hu Y., Yee C., Chen S., Carrio R., Merino J., Liu D., Ni J., Nunez G. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB. J. Biol. Chem. 274:1999;14560-14567.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 14560-14567
-
-
Inohara, N.1
Koseki, T.2
Del-Peso, L.3
Hu, Y.4
Yee, C.5
Chen, S.6
Carrio, R.7
Merino, J.8
Liu, D.9
Ni, J.10
Nunez, G.11
-
41
-
-
0035895992
-
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB
-
Ogura Y., Inohara N., Benito A., Chen F.F., Yamaoka S., Nunez G. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J. Biol. Chem. 276:2000;4812-4818.
-
(2000)
J. Biol. Chem.
, vol.276
, pp. 4812-4818
-
-
Ogura, Y.1
Inohara, N.2
Benito, A.3
Chen, F.F.4
Yamaoka, S.5
Nunez, G.6
-
42
-
-
0035937775
-
Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins
-
Hlaing T., Guo R.F., Dilley K.A., Loussia J.M., Morrish T.A., Shi M.M., Vincenz C., Ward P.A. Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. J. Biol. Chem. 276:2001;9230-9238.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9230-9238
-
-
Hlaing, T.1
Guo, R.F.2
Dilley, K.A.3
Loussia, J.M.4
Morrish, T.A.5
Shi, M.M.6
Vincenz, C.7
Ward, P.A.8
-
43
-
-
0035854790
-
L blocks transforming growth factor-β1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells
-
L blocks transforming growth factor-β1-induced apoptosis by inhibiting cytochrome. c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells J. Biol. Chem. 276:2001;26614-26621.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 26614-26621
-
-
Chipuk, J.E.1
Bhat, M.2
Hsing, A.Y.3
Ma, J.4
Danielpour, D.5
-
46
-
-
18644376568
-
L deamidation is a critical switch in the regulation of the response to DNA damage
-
L deamidation is a critical switch in the regulation of the response to DNA damage. Cell. 111:2002;51-62.
-
(2002)
Cell
, vol.111
, pp. 51-62
-
-
Deverman, B.E.1
Cook, B.L.2
Manson, S.R.3
Niederhoff, R.A.4
Langer, E.M.5
Rosova, I.6
Kulans, L.A.7
Fu, X.8
Weinberg, J.S.9
Heinecke, J.W.10
Roth, K.A.11
Weintraub, S.J.12
-
47
-
-
0036187036
-
Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
-
Acehan D., Jiang X., Morgan D.G., Heuser J.E., Wang X., Akey C.W. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol. Cell. 9:2002;423-432.
-
(2002)
Mol. Cell
, vol.9
, pp. 423-432
-
-
Acehan, D.1
Jiang, X.2
Morgan, D.G.3
Heuser, J.E.4
Wang, X.5
Akey, C.W.6
|