Bcl-x(L) is phosphorylated in malignant cells following microtubule disruption

Cancer Research

Volumn 58, Issue 15, 1998, Pages 3331-3338

  Poruchynsky, Marianne S ^a   Wang, Emily E ^a   Rudin, Charles M ^b   Blagosklonny, Mikhail V ^a   Fojo, Tito ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PACLITAXEL; PROTEIN BCL 2; RAF PROTEIN; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; BCL2L1 PROTEIN, HUMAN; BENZOQUINONE DERIVATIVE; DODECYL SULFATE SODIUM; GELDANAMYCIN; MACROCYCLIC LACTAM; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORUS; PROTEIN BCL X; QUINONE DERIVATIVE; TUBULIN; TUMOR PROTEIN;

BREAST CARCINOGENESIS; CELL STRAIN MCF 7; CONTROLLED STUDY; HUMAN; HUMAN CELL; MICROTUBULE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTO ONCOGENE; SHORT SURVEY; SIGNAL TRANSDUCTION; ARTICLE; BIOSYNTHESIS; CELL COUNT; CELL CULTURE; DRUG EFFECT; DRUG RESISTANCE; METABOLISM; NEOPLASM; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; ULTRASTRUCTURE;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BCL-X PROTEIN; BENZOQUINONES; CELL COUNT; DRUG RESISTANCE, NEOPLASM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; LACTAMS, MACROCYCLIC; MICROTUBULES; NEOPLASM PROTEINS; NEOPLASMS; PACLITAXEL; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORUS RADIOISOTOPES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-RAF; QUINONES; SODIUM DODECYL SULFATE; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0032129272     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (38)

1. Kroemer, G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat. Med., 3: 614-620, 1997.
2. Reed, J. C. Double identity for proteins of the Bcl-2 family. Nature (Lond.), 387: 773-776, 1997.
3. Kroemer, G., Zamzami, N., and Susin, S. A. Mitochondnal control of apoptosis. Immunol. Today, 18: 44-51, 1997.
4. Werner, M. H. Stopping death cold. Structure, 4: 879-883, 1996.
5. Diaz, J-L., Oltersdorf, T., Horne, W., McConnell, M., Wilson, G., Weeks, S., Garcia, T., and Fritz, L. C. A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members. J. Biol. Chem., 272: 11350-11355, 1997.
6. Wang, H-G. Rapp, U. R., and Reed, J. C. Bcl-2 targets the protein kinase raf-1 to mitochondria. Cell, 87: 629-638, 1996.
7. Wang, H-G., Miyashita, T., Takyama, S., Sato, T., Torigoe, S., Krajewski, S., Tanaka, S., Hovey, L., III, Troppmair, J., Rapp, U. R., and Reed, J. C. Apoptosis regulation by interaction of bcl-2 protein and Raf-1 kinase. Oncogene, 9: 2751-2756, 1994.
8. Waf1 and p53 requires c-raf-1. Cancer Res., 55: 4623-4626, 1995.
9. Blagosklonny, M. V., Schulte, T. W., Nguyen, P., Trepel, J., and Neckers, L. Taxol-induced apoptosis and phosphorylation of bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway. Cancer Res., 56: 1851-1854, 1996.
10. Blagosklonny, M. V., Giannakakou, P., El-Deiry, W. S., Kingston, D. G. I, Higgs, P. I., Neckers, L., and Fojo, T. Raf-1/Bcl-2 phosphorylation: A step from microtubule damage to cell death. Cancer Res., 57: 130-135, 1997.
11. Haldar, S., Chintapalli, J., and Croce, C. M. Taxol induces bcl-2 phosphorylation and death of prostate cancer cells. Cancer Res., 56: 1253-1255, 1996.
12. Haldar, S., Basu, A., and Croce, C. M. Bcl-2 is the guardian of microtubule integrity. Cancer Res., 57: 229-233, 1997.
13. L and Bcl-2. EMBO J., 16: 968-977, 1997.
14. Uhlman, E. J. et al. Deletion of a nonconserved region of bcl-2 confers a novel gain of function: suppression of apoptosis with concomitant cell proliferation. Cancer Res., 56: 2506-2509, 1996.
15. L. Cell, 87: 619-628, 1996.
16. Giannakakou, P., Sackett, D. L., Kang, Y-K., Zhan, Z., Buters, J. T. M., Fojo, T., and Poruchynsky, M. S. Paclitaxel-resistant human ovarian cancer cells have mutant β-tubulins that exhibit impaired paclitaxel-driven polymerization. J. Biol. Chem., 272: 17118-17125, 1997.
17. Minn, A. J., Rudin, C. M., Boise, L. H., and Thompson, C. B. Expression of Bcl-xL can confer a multidrug resistance phenotype. Blood, 86: 1903-1910, 1995.
18. L. Mol. Cell Biol., 17: 7040-7046, 1997.
19. L. J. Biol. Chem., 271: 6306-6312, 1996.
20. Sackett, D. L., Giannakakou, P., Poruchynsky, M., and Fojo, T. Tubulin from paclitaxel-resistant cells as a probe for novel antimicrotubule agents. Cancer Chemother. Pharmacol., 40: 228-232, 1997.
21. 2-M arrest and apoptosis in human ovarian cancer cells grown as multicellular tumor spheroids. Cancer Res., 57: 2388-2393, 1997.
22. Zhuo, S., Clemens, J. C., Hakes, D. J., Barford, D., and Dixon, J. E. Expression, purification, crystallization, and biochemical characterization of a recombinant protein phosphatase. J. Biol. Chem., 268: 17754-17761, 1993.
23. Stebbins, C. E., Russo, A. A., Schneider, C., Rosen, N., Hartl, F. U., and Pavletich, N. P. Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell, 89: 239-250, 1997.
24. Horwitz, S. B. Mechanism of action of Taxol. Trends Pharmocol. Sci., 13: 134-136, 1992.
25. Kumar, N. Taxol induced polymerization of purified tubulin: mechanism of action. J. Biol. Chem., 256: 10435-10441, 1981.
26. Donaldson, K. L., Goolsby, G., Kiener, P. A., and Wahl, A. F. Activation of p34 cdc coincident with Taxol-induced apoptosis. Cell Growth Differ., 5: 1041-1050, 1994.
27. Jacobson, M. D., Weil, M., and Raff, M. C. Programmed cell death in animal development. Cell, 88: 347-354, 1997.
28. Petit, P. X., Susin, S-A., Zamzami, N., Mignotte, B., and Kroemer, G. Mitochondria and programmed cell death: back to the future. FEBS Lett., 396: 7-13, 1996.
29. Yang, J., Liu X., Bhalla, K., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T-I., Jones, D. P., and Wang, X. Prevention of apoptosis by bcl-2: Release of cytochrome c from mitochondria blocked. Science (Washington DC), 275: 1129-1132, 1997.
30. Kluck, R. M., Bossy-Wetzel, E., Green, D. R., and Newmeyer, D. D. The release of cytochrome c from mitochondria: a primary site for bcl-2 regulation of apoptosis. Science (Washington DC), 275: 1132-1136, 1997.
31. L inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res., 57: 3115-3120, 1997.
32. L forms an ion channel in synthetic lipid membranes. Nature (Lond.), 385: 353-357, 1997.
33. Schendel, S. L., Xie, I., Montal, M. O., Matsuyama S., Montal, M., and Reed, J. C. Channel formation by antiapoptotic protein Bcl-2. Proc. Natl. Acad. Sci. USA, 94: 5113-5118, 1997.
34. Antonsson, B., Conti, F., Ciavata, A., Montessuit, S., Lewis, S., Martinou, I., Bermascom, L., Bernard, A., Mermod, J-J., Mazzei, G., Maundrell, K., Gambale, F., Sadoul, R., and Martinou, J-C. Inhibition of bax channel-forming activity by bcl-2. Science (Washington DC), 277: 370-372, 1997.
35. L during apoptosis. Proc. Natl. Acad. Sci. USA, 94: 3668-3672, 1997.
36. Ito, T., Deng, X., Carr, B., and May, W. S. Bcl-2 phosphorylation required for antiapoptosis function. J. Biol. Chem., 272: 11671-11673, 1997.
37. Aime Sempe, C., Kitada, S., and Reed, J. C. Investigations of Taxol-mediated phosphorylation of Bcl-2. Proc. Am Assoc. Cancer Res., 38: 171, 1997.
38. L overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells. Cancer Res., 57: 1109-1115, 1997.