Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation

Biochemical Pharmacology

Volumn 66, Issue 5, 2003, Pages 711-724

  Chow, Kai Uwe ^a   Nowak, Daniel ^a   Boehrer, Simone ^a   Ruthardt, Martin ^a   Knau, Andrea ^a   Hoelzer, Dieter ^a   Mitrou, Paris S ^a   Weidmann, Eckhart ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Bendamustine; Caspases; Cladribine; Daxx; IAPs; Par 4

Indexed keywords

BENDAMUSTINE; CASPASE; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; CLADRIBINE; DEATH ASSOCIATED PROTEIN; DOXORUBICIN; INHIBITOR OF APOPTOSIS PROTEIN; MITOXANTRONE; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOWN REGULATION; DRUG ANTAGONISM; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; IMMUNE RESPONSE GENE; LYMPHOMA CELL; MITOCHONDRIAL MEMBRANE; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROSTATE APOPTOSIS RESPONSE GENE; PROTEIN EXPRESSION;

EID: 0041930595     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00410-6     Document Type: Article

References (46)

1. Debatin K.M. Activation of apoptosis pathways by anticancer drugs. Adv. Exp. Med. Biol. 457:1999;237-244.
2. Green D.R., Reed J.C. Mitochondria and apoptosis. Science. 281:1998;1309-1312.
3. Green D., Kroemer G. The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol. 8:1998;267-271.
4. Reed J.C., Jurgensmeier J.M., Matsuyama S. Bcl-2 family proteins and mitochondria. Biochim. Biophys. Acta. 1366:1998;127-137.
5. Bellosillo B., Villamor N., Colomer D., Pons G., Montserrat E., Gil J. In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia. Blood. 94:1999;2836-2843.
6. Begleiter A., Wang H., Verburg L., Lee K., Israels L.G., Mowat M.R., Johnston J.B. In vitro cytotoxicity of 2-chlorodeoxyadenosine and chlorambucil in chronic lymphocytic leukemia. Leukemia. 10:1996;1959-1965.
7. Chow K.U., Rummel M.J., Weidmann E., Ries J., Jantschke P., Boehrer S., Pourebrahim F., Napieralski S., Stein J., Martin H., Hoelzer D., Mitrou P.S. Induction of apoptosis by 2-chloro-2′-deoxyadenosine (2-CdA) alone and in combination with other cytotoxic drugs: synergistic effects on normal and neoplastic lymphocytes by addition of doxorubicin and mitoxantrone. Leuk. Lymphoma. 36:2000;559-567.
8. Kano Y., Akutsu M., Tsunoda S., Suzuki K., Ichikawa A., Furukawa Y., Bai L., Kon K. In vitro cytotoxic effects of fludarabine (2-F-ara-A) in combination with commonly used antileukemic agents by isobologram analysis. Leukemia. 14:2000;379-388.
9. Chow K.U., Sommerlad W.D., Boehrer S., Schneider B., Seipelt G., Rummel M.J., Hoelzer D., Mitrou P.S., Weidmann E. Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases. Haematologica. 87:2002;33-43.
10. Friesen C., Herr I., Krammer P.H., Debatin K.M. Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat. Med. 2:1996;574-577.
11. Fulda S., Strauss G., Meyer E., Debatin K.M. Functional CD95 ligand and CD95 deathinducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells. Blood. 95:2000;301-308.
12. Lacour S., Hammann A., Wotawa A., Corcos L., Solary E., Dimanche-Boitrel M.-T. Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis. Cancer Res. 61:2001;1645-1651.
13. Seol D.-W., Li J., Seol M.-H., Park S.-Y., Talanian R.V., Billiar T.R. Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): caspase-8 is required for TRAIL-induced apoptosis. Cancer Res. 61:2001;1138-1143.
14. Kroemer G., Reed J.C. Mitochondrial control of cell death. Nat. Med. 6:2000;513-519.
15. Lorenzo H.K., Susin S.A., Penninger J., Kroemer G. Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death. Cell Death Differ. 6:1999;516-524.
16. Srinivasula S.M., Datta P., Fan X.J., Fernandes-Alnemri T., Huang Z., Alnemri E.S. Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway. J. Biol. Chem. 275:2000;36152-36157.
17. Boehrer S., Chow K.U., Beske F., Kukoc-Zivojnov N., Puccetti E., Ruthardt M., Baum C., Rangnekar V.M., Hoelzer D., Mitrou P.S., Weidmann E. In lymphatic cells Par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation. Cancer Res. 62:2002;1768-1775.
18. Slee E.A., Adrain C., Martin S.J. Executioner caspases-3, -6 and -7 perform distinct, non-redundant, roles during the demolition phase of apoptosis. J. Biol. Chem. 276:2000;7320-7326.
19. Deveraux Q.L., Stennicke H.R., Salvesen G.S., Reed J.C. Endogenous inhibitors of caspases. J. Clin. Immunol. 19:1999;388-398.
20. Reed J.C. Caspases and cytokines: roles in inflammation and autoimmunity. Adv. Immunol. 73:1999;265-299.
21. Slee E.A., Harte M.T., Kluck R.M., Wolf B.B., Casiano C.A., Newmeyer D.D., Wang H.G., Reed J.C., Nicholson D.W., Alnemri E.S., Green D.R., Martin S.J. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J. Cell Biol. 144:1999;281-292.
22. Deveraux Q.L., Reed J.C. IAP family proteins - suppressors of apoptosis. Genes Dev. 13:1999;239-252.
23. Suzuki Y., Nakabayashi Y., Nakata K., Reed J.C., Takahashi R. XIAP inhibits caspases-3 and -7 in distinct modes. J. Biol. Chem. 18:2001;18.
24. Silke J., Ekert P.G., Day C.L., Hawkins C.J., Baca M., Chew J., Pakusch M., Verhagen A.M., Vaux D.L. Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP. EMBO J. 20:2001;3114-3123.
25. Datta R., Oki E., Endo K., Biedermann V., Ren J., Kufe D. XIAP regulates DNA damage-induced apoptosis downstream of caspase-9 cleavage. J. Biol. Chem. 275:2000;31733-31738.
26. Tamm I., Wang Y., Sausville E., Scudiero D.A., Vigna N., Oltersdorf T., Reed J.C. IAP family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 58:1998;5315-5320.
27. Charette S.J., Lambert H., Landry J. A kinase-independent function of Ask1 in caspase-independent cell death. J. Biol. Chem. 276:2001;36071-36074.
28. Amin H.M., Saeed S., Alkan S. Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of Daxx in acute promyelocytic leukaemia with t(15;17). Br. J. Haematol. 115:2001;287-297.
29. Chow K.U., Boehrer S., Geduldig K., Krapohl A., Hoelzer D., Mitrou P.S., Weidmann E. In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine. Haematologica. 86:2001;485-493.
30. Schwaenen C., Karakas T., Bergmann L. Bendamustine in the treatment of low-grade non-Hodgkin's lymphomas. Onkologie. 23:2000;318-324.
31. Weidmann E., Kim S.Z., Rost A., Schuppert H., Seipelt G., Hoelzer D., Mitrou P.S. Bendamustine is effective in relapsed or refractory aggressive non-Hodgkin's lymphoma. Ann. Oncol. 13:2002;1285-1289.
32. Chou T.C., Talaly P. A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems. J. Biol. Chem. 252:1977;6438-6442.
33. Chou T.C. Assessment of synergistic and antagonistic effects of chemotherapeutic agents in vitro. Contrib. Gynecol. Obstet. 19:1994;91-107.
34. Chou T.C., Motzer R.J., Tong Y., Bosl G.J. Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design. J. Natl. Cancer Inst. 86:1994;1517-1524.
35. Kluin-Nelemans H.C., Limpens J., Meerabux J., Beverstock G.C., Jansen J.H., de Jong D., Kluin P.M. A new non-Hodgkin's B-cell line (DoHH2) with a chromosomal translocation t(14;18)(q32;q21). Leukemia. 5:1991;221-224.
36. Zhong S., Salomoni P., Ronchetti S., Guo A., Ruggero D., Pandolfi P.P. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J. Exp. Med. 191:2000;631-640.
37. Friesen C., Fulda S., Debatin K.M. Cytotoxic drugs and the CD95 pathway. Leukemia. 13:1999;1854-1858.
38. Budihardjo I., Oliver H., Lutter M., Luo X., Wang X. Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell Dev. Biol. 15:1999;269-290.
39. Alas S., Ng C.P., Bonavida B. Rituximab modifies the cisplatin-mitochondrial signaling pathway, resulting in apoptosis in cisplatin-resistant non-Hodgkin's lymphoma. Clin. Cancer Res. 8:2002;836-845.
40. Genini D., Adachi S., Chao Q., Rose D.W., Carrera C.J., Cottam H.B., Carson D.A., Leoni L.M. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood. 96:2000;3537-3543.
41. Arnoult D., Parone P., Martinou J.C., Antonsson B., Estaquier J., Ameisen J.C. Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J. Cell Biol. 159:2002;923-929.
42. Du C., Fang M., Li Y., Li L., Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 102:2000;33-42.
43. Schwanen C., Hecker T., Hubinger G., Wolfle M., Rittgen W., Bergmann L., Karakas T. In vitro evaluation of bendamustine induced apoptosis in B-chronic lymphocytic leukemia. Leukemia. 16:2002;2096-2105.
44. Engels I.H., Stepczynska A., Stroh C., Lauber K., Berg C., Schwenzer R., Wajant H., Janicke R.U., Porter A.G., Belka C., Gregor M., Schulze-Osthoff K., Wesselborg S. Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis. Oncogene. 19:2000;4563-4573.
45. Wieder T., Essmann F., Prokop A., Schmelz K., Schulze-Osthoff K., Beyaert R., Dorken B., Daniel P.T. Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3. Blood. 97:2001;1378-1387.
46. Deveraux Q.L., Roy N., Stennicke H.R., Van Arsdale T., Zhou Q., Srinivasula S.M., Alnemri E.S., Salvesen G.S., Reed J.C. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 17:1998;2215-2223.