Dexamethasone suppresses tumor necrosis factor-α-induced apoptosis in osteoblasts: Possible role for ceramide

Endocrinology

Volumn 141, Issue 8, 2000, Pages 2904-2913

  Chae, Han Jung ^a,b   Chae, Soo Wan ^b   Kang, Jang Sook ^a   Bang, Byung Gwan ^a   Cho, Seoung Bum ^a   Park, Rae Kil ^c   So, Hong Seob ^c   Kim, Yong Kwang ^c   Kim, Hyung Min ^c   Kim, Hyung Ryong ^a,c  

^a Wonkwang University School of Medicine   (South Korea)

^b Chonbuk National University   (South Korea)

^c Wonkwang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CERAMIDE; CYSTEINE PROTEINASE; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; IMMUNE RESPONSE; INFLAMMATION; MOUSE; NONHUMAN; OSTEOBLAST; PERIODONTITIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

EID: 17744394279     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.141.8.7604     Document Type: Article

References (51)

1. Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53
2. Apoptosis: Cell death in tissue regulation
3. NF-κB inactivation converts a hepatocyte cell line TNF-α response from proliferation to apoptosis
4. Osteoblast programmed cell death (apoptosis): Modulation by growth factors and cytokines
5. Effect of tumor necrosis factor-alpha on the expression of insulin-like growth factor I and insulin-like growth factor binding protein 4 in mouse osteoblasts
6. IκB α overexpression in human breast carcinoma MCF7 cells inhibits nuclear factor-κB activation but not tumor necrosis factor-α-induced apoptosis
7. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway
8. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon. Specific role in cell differentiation
9. Glucocorticoids potently block tumor necrosis factor-α- and lipopolysaccharide-induced apoptotic cell death in bovine glomerular endothelial cells upstream of caspase-3 activation
10. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticolds
11. A dual mechanism mediates repression of NF-κB activity by glucocorticoids
12. Cross-talk between steroids and NF-κB: What language?
13. An APRF-1, cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
14. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
15. Rapid colorimetric assay for cell viability; application to the quantitation of cytotoxic and growth inhibitory lymphokines
16. Nitric oxide-mediated apoptosis in murine peritoneal macrophages
17. Modulation of radiation-induced apoptosis and G2/M block in murine T-lymphoma cells
18. Koningic acid (a potent glyceraldehyde-3-phosphate dehydrogenase inhibitor)-induced fragmentation and condensation of DNA in NG108-15 cells
19. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
20. Rapid method of total lipid extraction and purification
21. Separation of gangliosides on a new type of anion-exchange resin
22. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
23. Involvement of nuclear factor-κB in platelet-activating factor-mediated tumor necrosis factor-α expression
24. Suppression of arachidonic acid cascade-mediated apoptosis in aflatoxin B1-induced rat hepatoma cells by glucocorticoids
25. WAFI/CIPI protein accumulation
26. Ceramide-induced nuclear translocation of NF-κB is a potential mediator of the apoptotic response to TNF-α in murine clonal osteoblasts
27. Activation of SAPK and increases in Bak levels during ceramide and indomethacin-induced apoptosis in HT29 cells
28. Signal transduction of thapsigargin-induced apoptosis in osteoblast
29. Estrogen prevents glucocorticoid-induced apoptosis in osteoblasts in vivo and in vitro
30. Inhibitory effect of glucocorticoid for osteoblast apoptosis induced by activated peripheral blood mononuclear cells
31. Dexamethasone suppress apoptosis in a human gastric cancer cell line through modulation of bcl-x gene expression
32. Dexamethasone-induced suppression of apoptosis in human neutrophils requires continuous stimulation of new protein synthesis
33. Effects of prednisolone and deflazacort on osteocalcin metabolism in sheep
34. Users of low-dose glucocorticoids have increased bone loss rates: A longitudinal study
35. Inhibition of osteoblastogenesis and promotion of apoptosis by osteoblasts and osteocytes by glucocorticoids
36. Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity
37. Molecular characterization of mitochondrial apoptosis-inducing factor
38. Induction of cytokine receptors by glucocorticoids; functional and pathological significance
39. Inducible nuclear expression of NF-κB in primary B cells stimulated through the surface Ig receptor
40. Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms
41. Role of protein kinases on NF-κB activation and cell death in bovine cerebral endothelial cells
42. Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production
43. 2+-ATPase inhibitor thapsigargin
44. 2+ fluxes
45. Internalization and sorting of plasma membrane sphingolipid analogues in differentiating oligodendrocytes
46. N-Acetyl serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells
47. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
48. Investigation of glucocorticoid-induced apoptotic pathway; processing of caspase-6 but not caspase-3
49. Inhibition of TNF-induced apoptosis by NF-κB
50. Nuclear factor (NF)-κB-regulated X-chromosome-linked lap gene expression protects endothelial cells from tumor necrosis factor α-induced apoptosis
51. Cellular protection mechanisms against extracellular heme. Heme-hemopexin, but not free heme, activates the N-terminal c-jun kinase