Glucocorticoids reduce ischemia-reperfusion-induced myocardial apoptosis in immature hearts

Annals of Thoracic Surgery

Volumn 74, Issue 3, 2002, Pages 830-837

  Pearl, Jeffrey M ^a   Nelson, David P ^a   Schwartz, Steven M ^a   Wagner, Connie J ^a   Bauer, Steven M ^a   Setser, Elizabeth A ^a   Duffy, Jodie Y ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA NUCLEOTIDYLEXOTRANSFERASE; GLUTATHIONE PEROXIDASE; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; METHYLPREDNISOLONE; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIOPULMONARY BYPASS; CELL ADHESION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HEART ARREST; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; NEUTROPHIL; NEWBORN; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CARDIOPULMONARY BYPASS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; GLUCOCORTICOIDS; METHYLPREDNISOLONE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PREMEDICATION; SWINE; VENTRICULAR FUNCTION, LEFT;

EID: 0036713718     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(02)03843-2     Document Type: Article

References (26)

1. Studies of myocardial protection in the immature heart: IV. Models of ischemic and hypoxic/ischemic injury in the immature puppy heart
2. Studies of myocardial protection in the immature heart. V. Safety of prolonged aortic clamping with hypocalcemic glutamate/aspartate blood cardioplegia
3. Cytokine-mediated apoptosis in cardiac myocytes. The role of inducible nitric oxide synthase induction and peroxynitrite generation
4. Reperfusion injury induces apoptosis in rabbit cardiomyocytes
5. Molecular mechanisms of apoptosis in the cardiac myocyte
6. The inflammatory response in myocardial infarction
7. Neutrophil induced oxidative injury of cardiac myocytes. A compartmented system requiring CD11b/CD18-ICAM-1 adherence
8. Oxidative stress developed during the reperfusion of ischemic myocardium induces apoptosis
9. Emigrated neutrophils regulate ventricular contractility via α4 integrin
10. Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1
11. Roles and relationship of macrophages and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in the ischemic and reperfused rat heart
12. Expression of intercellular adhesion molecule-1 on rat cardiac myocytes by monocyte chemoattractant protein-1
13. Chronic therapy with metoprolol attenuates cardiomyocyte apoptosis in dogs with heart failure
14. Heart-targeted overexpression of caspase3 in mice increases infarct size, and depresses cardiac function
15. Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo
16. The role of apoptosis in myocardial ischemia: A critical appraisal
17. Direct measurement of free radical generation following reperfusion of ischemic myocardium
18. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
19. Status of myocardial antioxidants in ischemia-reperfusion injury
20. Regulation of intercellular adhesion molecule-1 (ICAM-1) in ischemic and reperfused canine myocardium
21. α4-Integrin mediates neutrophil-induced free radical injury to cardiac myocytes
22. Hydrogen peroxide induces LFA-1-dependent neutrophil adherence to cardiac myocytes
23. Monoclonal antibody to ICAM-1 preserves post-ischemic blood flow and reduces infarct size after ischemia-reperfusion in rabbit
24. Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury
25. Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury
26. Monocyte chemoattractant protein I (MCP-1) gene expression in dilated cardiomyopathy