Dexamethasone prevents apoptosis in a neonatal rat model of hypoxic-ischemic encephalopathy (HIE) by a reactive oxygen species-independent mechanism

Brain Research

Volumn 747, Issue 1, 1997, Pages 9-17

  Ekert, Paul ^a   MacLusky, Neil ^b   Luo, Xiao Ping ^a   Lehotay, Denis C ^a   Smith, Barry ^a,b   Post, Martin ^a,b   Tanswell, A Keith ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

brain; cell death; lipid peroxidation; peroxynitrite; reactive oxygen species

Indexed keywords

DEXAMETHASONE; DNA FRAGMENT; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; HYPOXIA; INTRAPERITONEAL DRUG ADMINISTRATION; LIPID PEROXIDATION; NEWBORN; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT;

ALDEHYDES; ANIMALS; ANIMALS, NEWBORN; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BLOTTING, NORTHERN; BRAIN CHEMISTRY; BRAIN ISCHEMIA; DEXAMETHASONE; DNA; HYPOXIA, BRAIN; LIPID PEROXIDATION; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 0031052072     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01201-2     Document Type: Article

References (39)

1. Barks, J.D.E., Post, M. and Tuor, U.I. Dexamethasone prevents hypoxic-ischemic brain damage in the neonatal rat. Pediatr. Res. 29 (1991) 558-563.
2. Brück, Y., Brück W, Kretzschmar, H.A. and Lassmann, H. Evidence for neuronal apoptosis in pontosubicular neuron necrosis. Neuropathol. Appl. Neurobiol. 22 (1996) 23-29.
3. Buttyan, R., Zakeri, Z., Lockshin, R. and Wolgemuth, D. Cascade induction of c-fos, c-myc and heat shock 70K transcripts during regression of the rat ventral prostate gland. Mol. Endocrinol. 2 (1988) 650-657.
4. Cheng, J., Zhou, T., Liu, C., Shapiro, J.P., Brauer, M.J., Kiefer, M.C., Barr, P.J. and Mountz, J.D. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 263 (1994) 1759-1762.
5. Chomczymski, P. and Sacchi, N. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162 (1987) 156-159.
6. Clerch, L.B., Iqbal, J. and Massaro, D. Perinatal rat lung catalase gene expression: influence of corticosteroid and hyperoxia. Am. J. Physiol. 260 (1991) L428-L433.
7. Fridovich, I. Measurement of superoxide anion. 1985. In R.A. Greenwald (Ed.), Handbook of Methods for Oxygen Radical Research, CRC Press, Boca Raton, 1985, pp. 121-122.
8. Goldaber, K.G., Gilstrap, L.C., Leveno, K.J., Dax, J.S. and McIntire, D.O. Pathological fetal acidemia. Obstet. Gynecol. 78 (1991) 1103-1107.
9. Gubits, R.M., Burke, R.E., Casey-McIntosh, G., Bandele, A. and Munell, F. Immediate early gene induction after neonatal hypoxiaischemia. Molec. Brain Res. 18 (1993) 228-238.
10. +)-ATPase activity. J. Neurosurg. 57 (1982) 247-253.
11. Hill, I.E., McManus, J.P., Rasquinha, I. and Tuor, U.I. DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat. Brain Res. 676 (1995) 398-403.
12. Hockenbery, D.M., Oltval, Z.N., Yin, X.-M., Milliman, C.L. and Korsmeyer, S.J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75 (1993) 241-251.
13. Kane, D.J., Ord, T., Anton, R. and Bredesen, D.E. Expression of bcl-2 inhibits necrotic cell death. J. Neurosci. Res. 40 (1995) 269-275.
14. Kerr, J.F.R., Wyllie, A.H. and Currie, A.R. Apoptosis: basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26 (1972) 239-257.
15. Kooy, N.W., Royall, J.A., Ye, Y.Z., Kelly, D.R. and Beckman, J.S. Evidence for in vivo peroxynitrite production in human acute lung injury. Am. J. Respir. Crit. Care Med. 151 (1995) 1250-1254.
16. Lin, K.-T., Xue, J.-Y., Nomen, M., Spur, B. and Wong, P.Y.-K. Peroxynitrite-induced apoptosis in HL-60 cells. J. Biol. Chem. 270 (1995) 16487-16490.
17. Luo, X.P., Yazdanpanah, M., Bhooi, N. and Lehotay, D.C. Determination of aldehydes and other lipid peroxidation products in biological samples by gas chromatography-mass spectrometry. Anal. Biochem. 228 (1995) 294-298.
18. Martinou, J.-C., Dubois-Daphin, M., Staple, J.K., Rodriguez, I., Frankowski, H., Missotten, M., Albertini, P., Talabot, D., Catsicas, S., Pietra, C. and Huarte, J. Over expression of bcl-2 in transgenic mice protects neurones from naturally occurring cell death and experimental ischemia. Neuron 13 (1994) 1017-1030.
19. Mito, T., Kamei, A., Takashima, S. and Becker, L.E. Clinicopathological study of pontosubicular necrosis. Neuropediatry 24 (1993) 204-207.
20. Nicolaou, K.C., Stabila, P., Esmaeli-Azad, B., Wrasidlo, W. and Hiatt, A. Cell-specific regulation of apoptosis by designed enediynes. Proc. Natl. Acad. Sci. USA 90 (1993) 3142-3146.
21. Oppenheim, R.W. Naturally occurring cell death during neural development. Trends Neurosci. 8 (1985) 487-493.
22. Palmer, C., Towfighi, J., Roberts, R.L. and Heitjan, D.F. Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7 day old rats. Pediatr. Res. 33 (1993) 405-411.
23. Palmer, C. and Vannucci, R.C. Potential new therapies for perinatal cerebral hypoxia-ischemia. Clin. Perinatol. 20 (1993) 411-432.
24. Palmer, C., Roberts, R.L. and Bero, C. Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats. Stroke 25 (1994) 1039-1045.
25. Pulsinelli, W.A., Brierley, J.B. and Plum, F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11 (1982) 491-498.
26. Rice, J.E., Vannucci, R.C. and Brierley, J.B.. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann. Neurol. 9 (1981) 131-141.
27. Robertson, C.M.T., Finer, N.N. and Grace, M.G.A. School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term. J. Pediatr. 114 (1989) 753-760.
28. Roffler-Tarlov, S., Gibson Brown, J.J., Tarlov, E., Stolarov, J., Chapman, D.L., Alexiou, M. and Papaioannou, V.E. Programmed cell death in the absence of c-fos and c-jun. Development 122 (1996) 1-9.
29. Rosenberg, A.A., Murdaugh, E. and White, C.W. The role of oxygen free radicals in post asphyxia cerebral hypoperfusion in newborn lambs. Pediatr. Res. 26 (1989) 215-219.
30. Rosi, F. A simple and rapid method for detection of apoptosis in human cells. Nucleic Acid Res. 20 (1992) 5243.
31. Schwartzman, R.A. and Cidlowski, J.A. Apoptosis: the biochemistry and molecular biology of programmed cell death. Endocrine Rev. 14 (1993) 133-151.
32. Smeyne, R.J., Vendrell, M., Hayward, M.M., Baker, S.J., Miao, G.G., Schilling, K., Robertson, L.M., Curran, T. and Morgan, J.I. Continuous c-fos expression precedes programmed cell death in vivo. Nature 363 (1993) 166-169.
33. Snedecor, G.W. and Cochran, W.G. Statistical Methods. Iowa State University Press, Ames, 1982, 236 pp.
34. Thompson, C.B. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267 (1995) 1456-1462.
35. Traystman, R.J., Kirsch, J.R. and Koehler, R.C. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J. Appl. Physiol. 71 (1991) 1185-1195.
36. Tuor, U.I., Simone, C.S., Arellano, R., Tanswell, K. and Post, M. Glucocorticoid prevention of neonatal hypoxic-ischemic damage: role of hyperglycaemia and antioxidant enzymes. Brain Res. 604 (1993) 165-172.
37. Tuor, U.I., Simone, C.S., Barks, J.D.E. and Post, M. Dexamethasone prevents cerebral infarction without affecting cerebral blood flow in the neonatal rat. Stroke 24 (1993) 452-457.
38. Tuor, U.I., Chumas, P.D. and Del Bigio, M.R.. Prevention of hypoxic-ischemic damage with dexamethasone is dependent on age and not influenced by fasting. Exp. Neurol. 132 (1995) 116-122.
39. Wyllie, A.H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284 (1980) 555-556.