Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids

Pharmacology and Therapeutics

Volumn 98, Issue 3, 2003, Pages 355-377

  Leaf, Alexander ^a   Xiao, Yong Fu ^b   Kang, Jing X ^a   Billman, George E ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Calcium currents; Fatal arrhythmias; Fish oils; Ionic membrane currents; Omega 3 fatty acids; Sodium currents; Ventricular fibrillation

Indexed keywords

ALPHA TOCOPHEROL; ARACHIDONIC ACID; CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; DILTIAZEM; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LYSOPHOSPHATIDYLCHOLINE; MEXILETINE; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; SODIUM CHANNEL; TRITON X 100;

ALLOSTERISM; ANTIARRHYTHMIC ACTIVITY; CALCIUM CURRENT; CLINICAL TRIAL; CONCENTRATION RESPONSE; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; EVOLUTION; GASTROINTESTINAL SYMPTOM; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE POTENTIAL; HEART VENTRICLE ARRHYTHMIA; HIPPOCAMPUS; HUMAN; NONHUMAN; NUTRITION; PREVENTION; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; SARCOLEMMA; SECONDARY PREVENTION; SEIZURE THRESHOLD; SIDE EFFECT; SODIUM CURRENT; SUDDEN DEATH; TREATMENT OUTCOME; VITAMIN SUPPLEMENTATION;

EID: 0038700514     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(03)00039-1     Document Type: Review

References (76)

1. Albert C.M., Campos H., Stampfer M.J., Ridker P.M., Manson J.A., Willett W.C., Ma J. Blood levels of long chain n-3 fatty acids and the risk of sudden cardiac death. N Engl J Med. 346:2002;1113-1118.
2. Heart and Stroke Facts. Statistical Supplement. 1998;American Heart Association.
3. Andersen O.S., Nielsen C., Maer A.M., Lundbaek J.A., Goulian M., Koeppe R.E. II Ion channels as tools to monitor lipid bilayer-membrane protein interactions: gramicidin channels as molecular transducers. Methods Enzymol. 294:1999;208-224.
4. 3 release in rat heart: possible antiarrhythmic mechanism. Am J Physiol Heart Circ Physiol. 271(40):1996;H1490-H1843.
5. Billman G.E., Schwartz P.J., Stone H.L. Baroreceptor reflex control of heart rate: a predictor of sudden cardiac death. Circulation. 66:1989;874-880.
6. Billman G.E., Hallaq H., Leaf A. Prevention of ischemia: induced fatal ventricular arrhythmias by ω6 fatty acids. Proc Natl Acad Sci U S A. 91:1994;4427-4430.
7. Billman G.E., Kang J.X., Leaf A. Prevention of ischemia-induced cardiac sudden death by n-3 polyunsaturated fatty acids. Lipids. 32:1997;1161-1168.
8. Billman G.E., Kang J.X., Leaf A. Prevention of ischemia-induced cardiac sudden death by pure n-3 polyunsaturated fatty acids. Circulation. 99:1999;2452-2457.
9. Boden W.E., Krone R.J., Kleiger R.E., Oakes D., Greenberg H., Dwyer E.J. Jr., Miller J.P., Abrams J., Coromilas J., Goldstein R., Moss A.J. Electrocardiographic subset analysis of diltiazem administration on the long-term outcome after acute myocardial infarction. Am J Cardiol. 67:1991;335-342.
10. + current. Biophys J. 68:1995;A108.
11. Burr M., Gilbert J.F., Holliday R.M., Elwood P.C., Fehily A.M., Rogers S., Sweetnam P.M., Deadman N.M. Effect of changes in fat, fish and fibre intakes on death and myocardial infarction: diet and reinfarction trial (DART). Lancet. 334:1989;757-761.
12. + channel activity. Am J Physiol. 261:1991;C882-C888.
13. Corr P.B., Gross R.W., Sobel B.E. Amphipathic metabolites and membrane dysfunction in ischemic myocardium. Circ Res. 55:1984;135-154.
14. Corr P.B., Yamada K.A., Creer M.H., Sharma A.D., Sobel B.F. Lysophosphatidylcholine and fibrillation early after onset of ischemia. Mol Cell Cardiol. 19(Suppl V):1987;45-53.
15. Duff H.J., Offord J., West J., Catterall W.A. Class I and IV antiarrhythmic drugs and cytosolic calcium regulate mRNA encoding the sodium alpha subunit in rat cardiac muscle. Mol Pharmacol. 42:1992;570-574.
16. Ford A.D., Hazen S.L., Saffitz J.E., Gross R.W. The rapid and reversible activation of a calcium-independent plasmalogen-selective phospholipase A2 during myocardial ischemia. J Clin Invest. 88:1991;331-335.
17. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet. 354:1999;447-455.
18. Girshman J., Greathouse D.V., Koeppe R.E. II, Andersen O.S. Gramicidin channels in phospholipid bilayers with unsaturated acyl chains. Biophys J. 73:1997;1310-1319.
19. Goldman L. Sodium channel inactivation from closed states: evidence for an intrinsic voltage dependency. Biophys J. 69:1995;2369-2377.
20. Gudbjarnason S., Hallgrimsson J. The role of myocardial membrane lipids in the development of cardiac necrosis. Acta Med Scand Suppl. 587:1975;17-26.
21. Hallaq H., Smith T.W., Leaf A. Modulation of the dihydropine-sensitive calcium channels in heart cells by fish oil fatty acids. Proc Natl Acad Sci U S A. 89:1992;1760-1764.
22. Hamilton J.A. Binding of fatty acids to albumin: a case study of lipid-protein interactions. News Physiol Sci. 7:1992;264-270.
23. Hibbeln J.R. Fish consumption and major depression. Lancet. 351:1998;1210-1213.
24. Hille B. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol. 69:1977;497-515.
25. Hock C.E., Beck L.D., Bodine L.C., Reibel D.K. Influence of dietary n-3 fatty acids on myocardial ischemia and reperfusion. Am J Physiol. 259:1990;H1518-H1561.
26. + (Kv1.5) by polyunsaturated fatty acids. Proc Natl Acad Sci U S A. 91:1994;1937-1941.
27. Kang J.X., Leaf A. Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes. Proc Natl Acad Sci U S A. 91:1994;9886-9890.
28. Kang J.X., Leaf A. Prevention and termination of the β-adrenergic agonist-induced arrhythmias by free polyunsaturated fatty acids in neonatal rat cardiac myocytes. Biochem Biophys Res Commun. 208:1995;629-636.
29. Kang J.X., Leaf A. Prevention and termination of arrhythmias induced by lysophosphatidyl choline and acylcarnitine in neonatal rat cardiac myocytes by free omega-3 polyunsaturated fatty acids. Eur J Pharmacol. 297:1996;96-97.
30. Kang J.X., Leaf A. Protective effect of all-trans-retinoic acid against cardiac arrhythmias induced by isoproterenol, lysophosphatidylcholine or ischemia and reperfusion. J Cardiovasc Pharmacol. 297:1996;87-106.
31. + channels by directly binding to the channel proteins. Proc Natl Acad Sci U S A. 93:1996;3542-3546.
32. Kang J.X., Xiao Y.F., Leaf A. Free long-chain polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. Proc Natl Acad Sci U S A. 92:1995;3997-4001.
33. Kang J.X., Li Y., Leaf A. Regulation of sodium channel gene expression by class I antiarrhythmic drugs and n-3 polyunsaturated fatty acids in cultured neonatal rat cardiomyocytes. Proc Natl Acad Sci U S A. 94:1997;2724-2728.
34. 2+-ATPase activity. Jpn Circ J. 58:1994;903-912.
35. Klausner R.D., Kleinfeld A.M., Hoover R.I., Karnovsky M.J. Lipid domains in membranes. J Biol Chem. 255:1980;1286-1295.
36. Koeppe R.E. II, Andersen O.S. Engineering the gramicidin channel. Annu Rev Biophys Biomed Struct. 25:1995;231-258.
37. Leaf A., Weber P.C. A new era for science in nutrition. Am J Clin Nutr. 45:1987;1048-1053.
38. Leaf A., Xiao Y.-F. The modulation of ionic currents in excitable tissues by n-3 polyunsaturated fatty acids. J Membr Biol. 184:2001;263-271.
39. Leaf A., Jorgensen M.B., Jacobs A.K., Cote G., Schoenfeld D.A., Scheer J., Weiner B.H., Slack J.D., Kellett M.A., Raizner A.E., Weber P.C., Mahrer P.R., Rossouw J.E. Do fish oils prevent restenosis after coronary angioplasty? Circulation. 90:1994;2248-2257.
40. Leaf A., Kang J.X., Xiao Y.-F., Billman G.E., Voskuyl R.A. Topical review: the antiarrhythmic and anticonvulsant effects of dietary n-3 fatty acids. J Membrane Biol. 172:1999;1-11.
41. Li Y., Kang J.X., Leaf A. Differential effects of various eicosanoids on the production or prevention of arrhythmias in cultured neonatal rat cardiac myocytes. Prostaglandins. 54:1997;511-530.
42. Lundbaek J.A., Andersen O.S. Membrane stiffness and channel function. Biochemistry. 35:1996;3825-3830.
43. Lundbaek J.A., Andersen O.S. Spring constants for channel-induced bilayer deformations - estimates using gramicidin channels. Biophys J. 76:1999;889-895.
44. Lundbaek J.A., Maer A.M., Andersen O.S. Lipid bilayer energy, curvature stress and assembly of gramicidin channels. Biochemistry. 36:1997;5695-5701.
45. MacLeod J.C., Macknight A.D.C., Rodrigo G.C. The electrical and mechanical response of adult guinea pig and rat ventricular myocytes to ω-3 polyunsaturated fatty acids. Eur J Pharmacol. 356:1998;261-270.
46. McLennan P.L. Relative effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on cardiac arrhythmias in rats. Am J Clin Nutr. 57:1993;207-212.
47. McLennan P.L., Abeywardena M.Y., Charnock J.S. Influence of dietary lipids on arrhythmias and infarction after coronary artery ligation in rats. Can J Physiol Pharmacol. 63:1985;1411-1417.
48. McLennan P.L., Bridle T.M., Abeywardena M.Y., Charnock J.S. Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey. Am Heart J. 123:1992;1555-1561.
49. Marchioli R., Barzi F., Bomba E., Chieffo C., Di Gregorio D., Di Mascio R., Franzoni M.G., Geraci E., Levantisi G., Maggioni A.P., Mantini L., Marfisi R.M., Mastrogiuseppe M., Mininni N., Nicolosi G.L., Santini M., Schweiger C., Tavazzi L., Tognoni G., Tucci C., Valaguss F. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time course analysis of the results of the Gruppo Italiano per lo Studio della sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation. 105:2002;1897-1903.
50. Murnaghan M.F. Effects of fatty acids on the ventricular arrhythmia threshold in the isolated heart of the rabbit. Br J Pharmacol. 73:1985;909-915.
51. Negretti N., Perez M.R., Walker D., O'Neill S.C. Inhibition of sarcoplasmic reticulum function by polyunsaturated fatty acids on intact, isolated myocytes from rat ventricular muscle. J Physiol. 523:2000;367-375.
52. Nielsen C., Goulian M., Andersen O.S. Energetics of inclusion-induced bilayer deformation. Biophys J. 74:1998;1966-1983.
53. 2+ regulation and the tuna fish sandwich. News Physiol Sci. 17:2002;162-165.
54. 3H]-batrachotoxin A 20-α-benzoate to sodium channels by local anesthetics. Mol Pharmacol. 25:1984;219-227.
55. Pound E.M., Kang J.X., Leaf A. Partition of polyunsaturated fatty acids, which prevent arrhythmias, into phospholipids of cell membranes. J Lipid Res. 42:2001;346-351.
56. + channels by local anesthetics. Science. 265:1994;1724-1728.
57. + channels. Proc Natl Acad Sci U S A. 93:1996;9275-9279.
58. Robinson P.J., Noronha J., DeGeorge J.J., Freed L.M., Nariai T., Rapaport S.I. A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis. Brain Res Rev. 17:1992;187-214.
59. Srinivasan Y., Elmer L., Davis J., Bennett V., Angelides K. Ankyrin and spectrin associate with voltage-dependent sodium channels in brain. Nature. 333:1988;177-180.
60. Stoll A.L., Severus E., Freeman M.P., Rueter S., Zboyan H.A., Diamond E., Cress K.K., Marangell L.B. Arch Gen Psychiatry. 56:1999;407-412.
61. 2+-ATPase of mouse cardiac sarcoplasmic reticulum is affected by membrane n-6 and n-3 polyunsaturated fatty acid content. J Nutr. 119:1989;364-372.
62. The Cardiac Arrhythmia Suppression Trial Investigators Preliminary report effect of encainide and flecainide on mortality. N Engl J Med. 321:1989;406-412.
63. Trainer V., Brown G.B., Catteral W.A. Sites of covalent labeling of photoreactive batrachotoxin derivative near transmembrane segment IS6 of the sodium channel α-subunit. J Biochem. 271:1996;11261-11267.
64. Voskuyl R.A., Vreugdenhil M., Kang J.X., Leaf A. Anticonvulsant effects of polyunsaturated fatty acids in rats using the cortical stimulation model. Eur J Pharmacol. 31:1998;145-152.
65. Vreugdenhil M., Breuhl C., Voskuyl R.A., Kang J.X., Leaf A., Wadman W.J. Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. Proc Natl Acad Sci U S A. 93:1996;12559-12563.
66. Wang S.-Y., Wang G.K. A mutation in segment I-S6 alters slow inactivation of sodium channels. Biophys J. 72:1997;1633-1640.
67. + channels. Eur J Physiol. 435:1998;293-302.
68. Weylandt K., Kang J.X., Leaf A. Polyunsaturated fatty acids exert antiarrhythmic actions as free fatty acids rather than in phospholipids. Lipids. 31:1996;977-982.
69. + channel D4-pS6 reduce inactivated channel block by local anesthetics. Mol Pharmacol. 54:1998;733-739.
70. + channels of neonatal rat ventricular myocytes. Proc Natl Acad Sci U S A. 92:1995;1000-11004.
71. 2+ currents by polyunsaturated fatty acids in adult and neonatal rat cardiac myocytes. Proc Natl Acad Sci U S A. 94:1997;4182-4187.
72. + channel. Proc Natl Acad Sci U S A. 95:1998;2680-2685.
73. + channels. Am J Physiol Heart Circ Physiol. 279:2000;H35-H46.
74. + channels. Proc Natl Acad Sci U S A. 98:2001;3606-3611.
75. + currents in adult ferret cardiomyocytes. Acta Physiol Sinica. 54:2002;271-281.
76. Yang B.C., Saldeen G.P., Bryant L.J., Nichols W.W., Mehta J.L. Dietary fish oil supplementation attenuates myocardial dysfunction and injury in isolated rat hearts. J Nutr. 123:1993;2067-2074.