Coexpression with β1-subunit modifies the kinetics and fatty acid block of hHlα Na+ channels

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 279, Issue 1 48-1, 2000, Pages

  Xiao, Yong Fu ^a,b,d   Wright, Sterling N ^e   Wang, Ging Kuo ^c,d   Morgan, James P ^a,d   Leaf, Alexander ^b,d  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e MURRAY STATE UNIVERSITY   (United States)

Author keywords

Cardiac sodium ion channel; Polyunsaturated fatty acids; Subunit

Indexed keywords

FATTY ACID; ICOSAPENTAENOIC ACID; SODIUM CHANNEL;

ALPHA CHAIN; ARTICLE; BETA CHAIN; CHANNEL GATING; CONTROLLED STUDY; HEART DEPOLARIZATION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; MEMBRANE STEADY POTENTIAL; PRIORITY JOURNAL; SODIUM CURRENT;

EID: 0033859504     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.279.1.h35     Document Type: Article

References (43)

1. Fish consumption and risk of sudden cardiac death
2. + Channel activity through interactions between alpha- and beta1-subunits
3. Lidocaine block of cardiac sodium channels
4. Mechanism of modulation of the voltage-gated skeletal and cardiac muscle sodium channels by fatty acids
5. A molecular basis for gating mode transitions in human skeletal muscle sodium chain nels
6. Single sodium channels from canine ventricular myocytes: Voltage dependence and relative rates of activation and inactivation
7. Prevention of ischemic-induced ventricular fibrillation by omega-3 fatty acids
8. Prevention of ischemic-induced cardiac sudden death by n-3 polyunsaturated fatty acids in dogs
9. Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids
10. + current conducted by the rat skeletal muscle α subunit by coexpression with a human brain β subunit
11. Functional expression of sodium channel mutations identified in families with periodic paralysis
12. Cellular and molecular biology of voltage-gated sodium channels
13. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease
14. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico
15. Sodium channel inactivation from closed states: Evidence for an intrinsic voltage dependency
16. Local anesthetics: Hydrophilic and hydrophobic pathway for the drug-receptor reaction
17. Influence of dietary n-3 fatty acids on myocardial ischemia and reperfusion
18. Sodium channels need not open before they inactivate
19. 1 subunit of the rat brain sodium channel
20. Prevention and termination of arrhythmias induced by lysophosphatidyl choline and acyl carnitine in neonatal rat cardiac myocytes by free omega-3 polyunasaturated fatty acids
21. Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes
22. Sodium channel inactivation from resting states in guinea-pig ventricular myocytes
23. Reversal of lidocaine effects on sodium currents by isoproterenol in rabbit hearts and heart cells
24. Coexpression of β1 with cardiac sodium channel α subunits in oocytes decreases lidocaine block
25. + channel beta1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene
26. Relative effects of dietary saturated, monounsaturated and polyunsaturated fatty acids on cardiac arrhythmias in rats
27. Influence of dietary lipids on arrhythmias and infarction after coronary artery ligation in rats
28. Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey
29. 1 subunit with human cardiac (hH1) and rat skeletal muscle (μ1) sodium channel α subunits expressed in Xenopus oocytes
30. 1 subunit modifies activation and inactivation gating of multiple sodium channel α subunits
31. 1 subunit
32. + channels
33. Kinetic analysis of single sodium channels from canine cardiac Purkinje cells
34. Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: The India experiment of infarct survival
35. Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest
36. Beta-1 subunits of sodium channels: Studies with subunit-specific antibodies
37. Comparison of heterologously expressed human cardiac and skeletal muscle sodium channels
38. A mutation in segment I-S6 alters slow inactivation of sodium channel
39. 1 subunit
40. 2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes
41. + channels of neonatal rat ventricular myocytes
42. Elevated density and altered pharmacologic properties of myocardial calcium current of the spontaneously hypertensive rat
43. + channel