Gramicidin channels in phospholipid bilayers with unsaturated acyl chains

Biophysical Journal

Volumn 73, Issue 3, 1997, Pages 1310-1319

  Girshman, Jeffrey ^a   Greathouse, Denise V ^b   Koeppe II, Roger E ^b   Andersen, Olaf S ^a  

^a Medical College ^*  (United States)

^b UNIVERSITY OF ARKANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; DIOLEOYLPHOSPHATIDYLCHOLINE; GRAMICIDIN;

AMINO ACID SEQUENCE; ARTICLE; BILAYER MEMBRANE; CONFORMATION; LIPID BILAYER; MEMBRANE CHANNEL; PHOSPHOLIPID BILAYER; SPECTROSCOPY;

EID: 0030742316     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(97)78164-5     Document Type: Article

References (62)

1. Abdul-Manan, N., and J. F. Hinton. 1994. Conformational states of gramicidin A along the pathway to the formation of channels in model membranes determined by 2D NMR and circular dichroism spectroscopy. Biochemistry. 33:6773-6783.
2. Andersen, O. S. 1983. Ion movement through gramicidin A channels. Single-channel measurements at very high potentials. Biophys. J. 41: 119-133.
3. Andersen, O. S., W. N. Green, and B. W. Urban. 1986. Ion conduction through sodium channels in planar lipid bilayers. In Ion Channel Reconstitution. C. Miller, editor. Plenum Publishing, New York. 385-404.
4. Andersen, O. S., and R. E. Koeppe, II. 1992. Molecular determinants of channel function. Physiol. Rev. 72:S89-S158.
5. Andersen, O. S., D. B. Sawyer, and R. E. Koeppe, II. 1992. Modulation of channel function by the host bilayer. In Biomembrane Structure and Function. B. P. Gaber and K. R. K. Easwaran, editors. Adenine Press, Schenectady, NY. 227-244.
6. Arseniev, A. S., A. L. Lomize, I. L. Barsukov, and V. F. Bystrov. 1986. Gramicidin A transmembrane ion-channel. Three-dimensional structure reconstruction based on NMR spectroscopy and energy refinement. Biol. Membr. 3:1077-1104.
7. Bamberg, E., and P. Läuger. 1973. Channel formation kinetics of gramicidin A in lipid bilayer membranes. J. Membr. Biol. 11:177-194.
8. Baño, M. C., L. Braco, and C. Abad. 1988. New high-performance liquid chromatography-based methodology for monitoring the conformational transitions of self-associating hydrophobic peptides, incorporated into liposomes. J. Chromatogr. 458:105-116.
9. Becker, M. D., D. V. Greathouse, R. E. Koeppe, II, and O. S. Andersen. 1991. Amino acid sequence modulation of gramicidin channel function. Effects of tryptophan-to-phenylalanine substitutions on the single-channel conductance and duration. Biochemistry: 30:8830-8839.
10. Busath, D. D., O. S. Andersen, and R. E. Koeppe, II. 1987. On the conductance heterogeneity in membrane channels formed by gramicidin A. A cooperative study. Biophys. J. 51:79-88.
11. Busath, D. D., and G. Szabo. 1981. Gramicidin forms multi-state rectifying channels. Nature. 294:371-373.
12. Bystrov, V. F., and A. S. Arseniev. 1988. Diversity of the gramicidin A spatial structure: two-dimensional proton NMR study in solution. Tetrahedron. 44:925-940.
13. Cifu, A. S., R. E. Koeppe, II, and O. S. Andersen. 1992. On the supramolecular structure of gramicidin channels. The elementary conducting unit is a dimer. Biophys. J. 61:189-203.
14. Cox, K. J., C. Ho, J. V. Lombardi, and C. D. Stubbs. 1992. Gramicidin conformational studies with mixed-chain unsaturated phospholipid bilayer systems. Biochemistry: 31:1112-1118.
15. Dilger, J. P., S. G. A. McLaughlin, T. J. McIntosh, and S. A. Simon. 1979. The dielectric constant of phospholipid bilayers and the permeability of membrane to ions. Science. 206:1196-1198
16. Doyle, D. A., and B. A. Wallace. 1997. Crystal structure of the gramicidin/ potassium thiocyanate complex. J. Mol. Biol. 266:963-977.
17. Durkin, J. T., R. E. Koeppe, II, and O. S. Andersen. 1990. Energetics of gramicidin hybrid channel formation as a test for structural equivalence. Side-chain substitutions in the native sequence. J. Mol. Biol. 211: 221-234.
18. Durkin, J. T., L. L. Providence, R. E. Koeppe, II, and O. S. Andersen. 1992. Formation of non-β-helical gramicidin channels between sequence-substituted gramicidin analogues. Biophys. J. 62:145-159.
19. Eisenberg, D., and W. Kauzmann. 1969. The Structure and Properties of Water. Clarendon Press, Oxford.
20. Elliott, J. R., D. Needham, J. P. Dilger, and D. A. Haydon. 1983. The effects of bilayer thickness and tension on gramicidin single-channel lifetime. Biochim. Biophys. Acta. 735:95-103.
21. Fonseca, V., P. Daumas, L. Ranjalahy-Rasoloarijao, F. Heitz, R. Lazaro, Y. Trudelle, and O. S. Andersen. 1992. Gramicidin channels that have no tryptophan residues. Biochemistry. 31:5340-5350.
22. Girshman, J., O. S. Andersen, D. V. Greathouse, and R. E. Koeppe, II. 1996. Gramicidin channels in phospholipid bilayers having unsaturated acyl chains. Biophys. J. 70:A79 (Abstr.).
23. Glickson, J. D., D. F. Mayers, J. M. Settine, and D. W. Urry. 1972. Spectroscopic studies on the conformation of gramicidin A′. Proton magnetic resonance assignments, coupling constants, and hydrogendeuterium exchange. Biochemistry. 11:477-486.
24. Greathouse, D. V., J. F. Hinton, K. S. Kim, and R. E. Koeppe, II. 1994. Gramicidin A/short-chain phospholipid dispersions: chain length dependence of gramicidin conformation and lipid organization. Biochemistry. 33:4291-4299.
25. Hawkes, G. E., L. Y. Lian, E. W. Randall, K. D. Sales, and E. H. Curzon. 1987. The conformation of gramicidin A in dimethyl sulfoxide solution. A full analysis of the one-and two-dimensional proton, carbon-13, and nitrogen-15 nuclear magnetic resonance spectra. Eur. J. Biochem. 166: 437-445.
26. Heitz, F., G. Spach, and Y. Trudelle. 1982. Single channel of 9,11,13,15-destryptophyl-phenylalanyl-gramicidin A. Biophys. J. 40:87-89.
27. Helfrich, P., and E. Jakobsson. 1990. Calculation of deformation energies and conformations in lipid membranes containing gramicidin channels. Biophys. J. 57:1075-1084.
28. Hille, B. 1992. Ionic Channels of Excitable Membranes, 2nd Ed. Sinauer Associates, Sunderland, MA.
29. Hladky, S. B., and D. A. Haydon. 1972. Ion transfer across lipid membranes in the presence of gramicidin A. I. Unit conductance channel. Biochim. Biophys. Acta. 274:294-312.
30. Huang, H. W. 1986. Deformation free energy of bilayer membrane and its effect on gramicidin channel lifetime. Biophys. J. 50:1061-1070.
31. Jordan, P. C. 1981. Energy barriers for passage of ions through channels. Exact solutions of two electrostatic problems. Biophys. Chem. 13: 203-212.
32. Killian, J. A. 1992. Gramicidin and gramicidin-lipid interactions. Biochim. Biophys. Acta. 1113:391-425.
33. Killian, J. A., K. N. J. Burger, and B. De Kruijff. 1987. Phase separation and hexagonal HII phase formation by gramicidins A, B and C in dioleoylphosphatidylcholine model membranes. A study on the role of the tryptophan residues. Biochim. Biophys. Acta. 897:269-284.
34. Killian, J. A., K. U. Prasad, D. W. Urry, and B. De Kruijff. 1989. A mismatch between the length of gramicidin and the lipid acyl chains is a prerequisite for HII phase formation in phosphatidylcholine model membranes. Biochim. Biophys. Acta. 978:341-345.
35. Killian, J. A., J. W. Timmermans, S. Keur, and B. De Kruijff. 1985. The tryptophans of gramicidin are essential for the lipid structure modulating effect of the peptide. Biochim. Biophys. Acta. 820:154-158.
36. Koeppe, R. E., II, and O. S. Andersen. 1996. Engineering the gramicidin channel. Annu. Rev. Biophys. Biomol. Struct. 25:231-258.
37. Koeppe, R. E., II, D. V. Greathouse, L. L. Providence, and O. S. Andersen. 1991. [L-Leu9-D-Trp10-L-Leu11-D-Trp12-L-Leu13-D-Trp14-L-Leu15]gramicidin forms both single-and double-helical channels. Biophys. J. 59:319a (Abstr.).
38. Koeppe, R. E., II, L. L. Providence, D. V. Greathouse, F. Heitz, Y. Trudelle, N. Purdie, and O. S. Andersen. 1992. On the helix sense of gramicidin A single channels. Proteins. 12:49-62.
39. Koeppe, R. E., II, and L. B. Weiss. 1981. Resolution of linear gramicidins by preparative reversed-phase high-performance liquid chromatography. J. Chromatogr. 208:414-418.
40. Kolb, H. A., and E. Bamberg. 1977. Influence of membrane thickness and ion concentration on the properties of the gramicidin A channel. Auto-correlation, spectral power density, relaxation and single-channel studies. Biochim. Biophys. Acta. 464:127-141.
41. Langs, D. A. 1988. Three-dimensional structure at 0.86 Å of the uncomplexed form of the transmembrane ion channel peptide gramicidin A. Science. 241:188-191.
42. Lewis, B. A., and D. M. Engelman. 1983. Lipid bilayer thickness varies linearly with acyl chain length in fluid phosphatidylcholine vesicles. J. Mol. Biol. 166:211-217.
43. Lundbæk, J. A., and O. S. Andersen. 1994. Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayers. J. Gen. Physiol. 104:645-673.
44. Masotti, L., A. Spisni, and D. W. Urry. 1980. Conformational studies on the gramicidin A transmembrane channel in lipid micelles and liposomes. Cell Biophys. 2:241-251.
45. Nicholson, L. K., and T. A. Cross. 1989. Gramicidin cation channel: an experimental determination of the right-handed helix sense and verification of β-type hydrogen bonding. Biochemistry. 28:9379-9385.
46. Nielsen, C., N. Mobashery, and O. S. Andersen. 1997. Membrane dependent changes in conformational preference of gramicidin A channels. Biophys. J. 72:A191.
47. O'Connell, A. M., R. E. Koeppe, II, and O. S. Andersen. 1990. Kinetics of gramicidin channel formation in lipid bilayers: transmembrane monomer association. Science. 250:1256-1259.
48. Pascal, S. M., and T. A. Cross. 1992. Structure of an isolated gramicidin A double helical species by high-resolution nuclear magnetic resonance. J. Mol. Biol. 226:1101-1109.
49. Providence, L. L., O. S. Andersen, D. V. Greathouse, R. E. Koeppe, II, and R. Bittman. 1995. Gramicidin channel function does not depend on phospholipid chirality. Biochemistry. 34:16404-16411.
50. Ranjalahy-Rasoloarijao, L., R. Lazoro, P. Daumas, and F. Heitz. 1989. Synthesis and ionic channels of a linear gramicidin containing naphtylalanine instead of tryptophan. Int. J. Pept. Protein Res. 33:273-280.
51. Roux, B., R. Brüschweiler, and R. R. Ernst. 1990. The structure of gramicidin A in dimethylsulfoxide/acetone. Eur. J. Biochem. 194: 57-60.
52. Russell, E. W. B., L. B. Weiss, F. I. Navetta, R. E. Koeppe, II, and O. S. Andersen. 1986. Single-channel studies on linear gramicidins with altered amino acid side chains. Effects of altering the polarity of the side chain at position 1 in gramicidin A. Biophys. J. 49:673-686.
53. Sackmann, E., R. Kotulla, and F.-J. Heiszler. 1984. On the role of lipid-bilayer elasticity for the lipid-protein interactions and the indirect protein-protein coupling. Can. J. Biachem. Cell. Biol. 62:778-788.
54. Sarges, R., and B. Witkop. 1965. Gramicidin A. V. The structure of valine-and isoleucine-gramicidin A. J. Am. Chem. Soc. 87:2011-2019.
55. Sawyer, D. B., R. E. Koeppe, II, and O. S. Andersen. 1989. Induction of conductance heterogeneity in gramicidin channels. Biochemistry. 28: 6571-6583.
56. 5.6 helix of gramicidin A predominates in unsaturated lipid membranes. Eur. Biophys. J. 22:279-288.
57. II phase formation in dioleoylphosphatidylcholine model membranes. Biochim. Biophys. Acta. 905:222-226.
58. Trudelle, Y., and F. Heitz. 1987. Synthesis and characterization of Tyr-(Bzl)9,11,13,15 and Tyr9,11,13,15 gramicidin A. Int. J. Pept. Protein Res. 30:163-169.
59. Veatch, W. R., E. T. Fossel, and E. R. Blout. 1974. Conformation of gramicidin A. Biochemistry. 13:5249-5256.
60. Wallace, B. A., and K. Ravikumar. 1988. The gramicidin pore: crystal structure of a cesium complex. Science. 241:182-187.
61. Weast, R. C., editor. 1972. Handbook of Chemistry and Physics. CRC Press, Boca Raton, FL.
62. Zhang, Z., S. M. Pascal, and T. A. Cross. 1992. A conformational rear-rangement in gramicidin A: from a double-stranded left-handed to a single-stranded right-handed helix. Biochemistry. 31:8822-8828.