The YRD Motif is a Major Determinant of Substrate and Inhibitor Specificity in T-cell Protein-tyrosine Phosphatase

Journal of Biological Chemistry

Volumn 276, Issue 28, 2001, Pages 26036-26043

  Asante Appiah, Ernest ^a   Ball, Kristen ^a   Bateman, Kevin ^a   Skorey, Kathryn ^a   Friesen, Rick ^a   Desponts, Caroline ^a   Payette, Paul ^a   Bayly, Christopher ^a   Zamboni, Robert ^a   Scapin, Giovanna ^b   Ramachandran, Chidambaram ^a   Kennedy, Brian P ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; ENZYME INHIBITION; ENZYME KINETICS; HYDROLYSIS; MASS SPECTROMETRY; PROTEINS;

PHOSPHORYLATION;

BIOCHEMISTRY;

ALANINE; AMIDE; AMINO ACID; ARGININE; ASPARTIC ACID; GLUTAMIC ACID; LYSINE; METHIONINE; N BENZOYLGLUTAMYL [4 PHOSPHONO(DIFLUOROMETHYL)]PHENYLALANYL [4 PHOSPHONO(DIFLUOROMETHYL)]PHENYLALANINAMIDE; PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; T CELL PROTEIN TYROSINE PHOSPHATASE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; STEADY STATE; T LYMPHOCYTE; YRD MOTIF; BINDING SITE; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM;

AMINO ACID SUBSTITUTION; BINDING SITES; HUMANS; PROTEIN-TYROSINE-PHOSPHATASE; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES;

EID: 0035854750     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011697200     Document Type: Article

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