Flaxseed increased α-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring

Food and Chemical Toxicology

Volumn 41, Issue 6, 2003, Pages 841-855

  Wiesenfeld, P W ^a   Babu, U S ^a   Collins, T F X ^a   Sprando, R ^a   O'Donnell, M W ^a   Flynn, T J ^a   Black, T ^a   Olejnik, N ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Fatty acids; Flaxseed; Pregnant rats; Linolenic acid

Indexed keywords

ARACHIDONIC ACID; CHOLESTEROL; DOCOSAHEXAENOIC ACID; FAT; ICOSAPENTAENOIC ACID; LINOLENIC ACID; NITROGEN ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CALORIE; CHOLESTEROL BLOOD LEVEL; DIET; DIET SUPPLEMENTATION; DIETARY FIBER; FATTY ACID BLOOD LEVEL; FEMALE; LINSEED; LIVER; LIVER LEVEL; MALE; METABOLISM; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PREGNANCY; PROGENY; RAT; SERUM; SUCKLING; TISSUE LEVEL; WEANING;

ANIMALIA;

EID: 0038523748     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(03)00035-8     Document Type: Article

References (93)

1. Abayasekara D.R.E., Wathes D.C. Effects of altering dietary fatty acid composition on prostaglandin synthesis and fertility. Prostaglandins, Leukotrienes, and Essential Fatty Acid. 61(5):1999;275-287.
2. Abedin L., Lien E.L., Vingrys A.J., Sinclair A.J. The effect of dietary alpha-linolenic acid compared with docosahexaenoic acid on brain, retina, liver and heart in the guinea pig. Lipids. 34(5):1999;475-482.
3. Adlercreutz H., Fotsis T., Bannwart C., Wahala K., Makela T., Brunow G., Hase T. Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women of various habitual diets. Journal of Steroid Biochemistry. 25(B):1986;791-797.
4. Allen K.G., Harris M.A. The role of n-3 fatty acids in gestation and parturition. Experimental Biology and Medicine. 226(6):2001;498-506.
5. Allman M.A., Pena M.M., Pang D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet. effects on platelet composition and function European Journal of Clinical Nutrition. 49:1995;169-178.
6. Babu U.S., Bunning V.K., Wiesenfeld P.W., Raybourne R.B., O'Donnell M. Effect of dietary flaxseed on fatty acid composition, superoxide, nitric oxide generation and antilisterial activity of peritoneal macrophages from female Sprague-Dawley rats. Life Science. 60(8):1997;545-554.
7. Babu U.S., Mitchell G.V., Wiesenfeld P., Jenkins M.Y., Gowda H. Nutritional and hematological impact of dietary and defatted flaxseed meal in rats. International Journal of Food Science and Nutrition. 51(2):2000;109-117.
8. Babu, U.S., Wiesenfeld, P.W., Collins, T.F.X., Sprando, R., Flynn, T.J., Black, T., Olejnik, N., Raybourne, R.B., 2003. Impact on high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell subset and fatty acid composition of spleen cells from pregnant and F1 generation Sprague-Dawley rats. Food and Chemical Toxicology (In press) - accepted.
9. Bierenbaum M.L., Reichstein R., Watkins T.R. Reducing atherogenic risk in hyperlipidemic humans with flax seed supplementation. a preliminary report Journal of American College of Nutrition. 12(5):1993;501-504.
10. Bourre J.-M., Dumont O., Pascal G., Durand G. Dietary alpha-linolenic acid at 1. 3 g/kg maintains maximal docosahexaenoic acid concentration in brain, heart and liver in adult rats. Journal of Nutrition. 123(7):1993;1313-1319.
11. Brzezinski A., Debi A. Phytoestrogens. the "natural" selective estrogen receptor modulators? European Journal of Obstetrics & Gynecological and Reproductive Biology. 85(1):1999;47-51.
12. Brunvand L., Henriksen C., Larsson M., Sandberg A.-S. Iron deficiency among pregnant Pakistanis in Norway and the content of phytic acid in their diet. Acta Obstetetrics Gynecology Scandanavia. 74:1995;520-525.
13. Calabrese E.J., Baldwin L.A. The frequency of U-shaped dose responses in the toxicological literature. Toxicological Sciences. 62:2001;330-338.
14. Carter J.F. Potential of flaxseed and flaxseed oil in baked goods and other products in human nutrition. Cereal Foods World. 38(10):1993;753-759.
15. Cater N.B., Denke M.A. Behenic acid is a cholesterol-raising saturated fatty acid in humans. American Journal of Clinical Nutrition. 73(1):2001;41-44.
16. Cheon S.-H., Huh M.-H., Lee Y.-B., Park J.-S., Sohn H.-S., Chung C.-W. Effect of dietary linoleate/alpha-linolenate balance on the brain lipid composition, reproductive outcome and behavior of rats during their prenatal and postnatal development. Bioscience Biotechnology Biochemistry. 64(11):2000;2290-2297.
17. Clandinin M.T., Foxwell A., Goh Y.K., Layne K., Jumpsen J.A. Omega-3 fatty acid intake results in a relationship between the fatty acid composition of LDL cholesterol content in humans. Biochemistry et Biophysica Acta. 1346:1997;247-252.
18. Clark W.F., Muir A.D., Westcott N.D., Parbtani A. A novel treatment for Lupus nephritis. lignan derived precursor from flax Lupus. 9(6):2000;429-436.
19. Clark W.F., Kortas C., Heidenheim A.P., Garland J., Spanner E., Parbtani A. Flaxseed in Lupus nephritis. a two-year nonplacebo-controlled crossover study Journal of the Ameircan College of Nutrition. 20(2):2001;143-148.
20. Classen N., Coetzer H., Steinmann C.M., Kruger M.C. The effect of different n-6/n-3 essential fatty acid ratios on calcium balance and bone in rats. Prostaglandins Leukotrienes Essential Fatty Acids. 53(1):1995;13-19.
21. Collins, T.F.X., Sprando, R.L., Black, T.N., Olejnik, N., Wiesenfeld, P.W., Babu, U.S., Bryant, M., Flynn, T.J., Ruggles, A., 2003. Effects of flaxseed and defatted flaxseed meal on reproduction and development in rats. Food and Chemical Toxicology, in press.
22. Craig W.J. Health-promoting properties of common herbs. American Journal of Clinical Nutrition. 70(suppl.):1999;491. S-499S.
23. Cunnane S.C., Ganguli S., Menard C., Liede A.C., Hamadeh M.J., Chen Z.-Y., Wolever T.M., Jenkins D.J. High alpha-linolenic acid flaxseed (Linum usitatissimum). some nutritional properties in humans British Journal of Nutrition. 69(2):1993;443-453.
24. Cunnane S.C., Hamedeh M.J., Liede A.C., Thompson L.U., Wolever T.M.S., Jenkins D.J.A. Nutritional attributes of traditional flaxseed in healthy young adults. American Journal of Clinical Nutrition. 61:1995;62-68.
25. Cunnane S.C., Menard C.R., Likhodii S.S., Brenna J.T., Crawford M.A. Carbon recycling into de novo lipogenesis is a major pathway in neonatal metabolism of linoleate and alpha-linolenate. Prostaglandins Leukotrienes Essential Fatty Acids. 60(5-6):1999;387-392.
26. Daugherty C.E., Lento H.G. Chloroform-methanol extraction method for determination of fat in foods. collaborative study J. Association of Official Analytical Chemistry. 66(4):1983;927-932.
27. Dell C.A., Likhodii S.S., Musa K., Ryan M.A., Burnham W.M., Cunnane S.C. Lipid and fatty acid profiles in rats consuming different high-fat ketogenic diets. Lipids. 36:2001;373-378.
28. Driskell W.J., Neese J.W., Bryant C.C., Bashor M.M. Measurement of vitamin A and vitamin E in human serum by high-pressure liquid chromatography. Journal of Chromatography. 231:1982;434-444.
29. Fan T.W., Conn E.E. Isolation and characterization of two cyanogenic beta-glucosides from flax seeds. Archives of Biochemistry and Biophysica. 243(2):1985;361-373.
30. Ferrier L.K., Caston L.J., Leeson S., Squires J., Weaver B.J., Holub B.J. α-Linolenic acid and docosahexaenoic acid-enriched eggs from hens fed flaxseed. influence on blood lipids and platelet phospholipid fatty acids in humans American Journal of Clinical Nutrition. 62:1995;81-86.
31. Flynn, T.J., Collins, T.F.X., Sprando, R.L., Black, T.N., Ruggles, D., Wiesenfeld, P.W., Babu, U.S. (2003). Effects of serum from flaxseed-fed rats on cultured rat embryos. Food and Chemical Toxicology, in press.
32. Gonzalez-Esquerra R., Lesson S. Effect of menhaden oil and flaxseed in broiler sensory quality and lipid composition of poultry. British Poultry Science. 41(4):2000;481-488.
33. German J.B., Dillard C.J., Whelan J. Symposium: Biological Effects of Dietary Arachidonic Acid, Introduction. Journal of Nutrition. 12:1995;1076S-1080S.
34. Gerster H. Can adults adequately convert α-linolenic acid (18:3, n-3) to eicosapentaenoic acid (20:5, n-3) and docosahexaenoic acid (22:6, n-3)? International Journal of Vitamins and Nutrition Research. 68:1998;159-173.
35. Green P., Yavin E. Mechanism of docosahexaenoic acid accretion in the fetal brain. Journal of Neuroscience Research. 52(2):1998;129-136.
36. Greiner R.C.S., Winter J., Nathanielsz P.W., Brenna J.T. Brain docosahexaenoate accretion in fetal baboons. bioequivalence of dietary alpha-linolenic and docosahexaenoic acids Pediatric Research. 42(6):1997;86-134.
37. Hallberg L., Rossander L., Skanberg A.-B. Phytates and inhibitory effect of bran on iron absorption in man. American Journal of Clinical Nutrition. 45:1987;988-996.
38. Harris W.S. n-3 Fatty acids and serum lipoproteins. human studies American Journal of Clinical Nutrition. 65(suppl.):1997;1645. S-1654S.
39. Hasler C.M., Kundrat S., Wool D. Functional foods and cardiovascular disease. Current Atherosclerosis Reports. 2:2000;467-475.
40. Hwang D.H., Bourdreau M., Chanmugan P. Dietary linolenic acid and longer-chain n-3 fatty acids. comparison of effects on arachidonic acid metabolism in rats Journal of Nutrition. 118:1988;427-437.
41. Ingram A.J., Parbtani A., Clark W.F., Spanner E., Huff M.W., Philbrick D.J., Holub B.J. Effects of flaxseed and flax oil diets in a rat 5/6 renal ablation model. American Journal of Kidney Disease. 25(2):1995;320-329.
42. Innis S.M. The role of dietary n-6 and n-3 fatty acids in developing brain. Developmental Neuroscience. 22(5-6):2000;474-480.
43. James M.J., Gibson R.A., Cleland L.G. Dietary polyunsaturated fatty acids and inflammatory mediator production. American Journal of Clinical Nutrition. 71(suppl):2000;343. S-348S.
44. Javouhey-Donzel A., Guenot L., Maupoll V., Rochette L., Rocquelin G. Rat vitamin E status and heart lipid peroxidation. effect of dietary α-linolenic acid and marine n-3 fatty acids Lipids. 28:1993;651-655.
45. Jeffery N.M., Sanderson P., Sherrington E.J., Newsholme E.A., Calder P.C. The ratio of n-6 to n-3 polyunsaturated fatty acids in the rat diet alters serum lipid levels and lymphocyte functions. Lipids. 31(7):1996;737-745.
46. Jenab M., Thompson L.U. The influence of flaxseed and lignans on colon carcinogenesis and α-glucoronidase activity. Carcinogenesis. 17(6):1996;1343-1348.
47. Jenkins D.J.A., Kendall C.W.W., Vidgen E., Agarwal S., Rao A.V., Rosenberg R.S., Diamandis E.P., Novokmet R., Mehling C.C., Perera T., Griffin L.C., Cunnane S.C. Health aspects of partially defatted flaxseed, including effects on serum lipids, oxidative measures, and ex vivo androgen and progestin activity: a controlled crossover trial. American Journal of Clinical Nutrition. 69(3):1999;395-402.
48. Jones J.W., Capar S.G. Critical evaluation of a multi-element scheme using plasma emission and hydride evolution of atomic- absorption spectrometry for the analysis of plan and animal tissues. The Analyst. 107(No1273):1982;353-373.
49. Kelley D.S., Nelson G.J., Love J.E., Branch L.B., Taylor P.C., Schmidt P.C., Mackey B.E., Iacono J.M. Dietary α-linolenic acid alters tissue fatty acid composition, but not blood lipids, lipoproteins or coagulation status in humans. Lipids. 28:1993;533-537.
50. Kitts D.D., Yuan Y.U., Wijewickreme A.N., Thompson L.U. Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. Molecular and Cellular Biochemistry. 202(1-2):1999;91-100.
51. Kritchevsky D., Tepper S.A., Klurfeld D.M. Influence of flaxseed on serum and liver lipids in rats. Journal of Nutritional Biochemistry. 2:1991;133-134.
52. Kurzer M.S., Xu X. Dietary phytoestrogens. Annual Reviews of Nutrition. 17:1997;353-381.
53. Lamartiniere C.A., Moore J.B., Brown N.M., Thompson R., Hardin M.J., Barnes S. Genistein suppresses mammary cancer in rats. Carcinogenesis. 16(11):1995;2833-2840.
54. Leat W.M.F., Northrop C.A., Harrison F.A., Cox R.W. Effect of dietary linoleic and α-linolenic acids on testicular development in the rat. QJ Experimental Physiology. 68:1983;221-231.
55. Lindner A., Bankson D.D., Stehman-Breen C., Mahuren J.D., Coburn S.P. Vitamin B6 metabolism and homocysteine in end-stage renal disease and chronic renal insufficiency. American Journal of Kidney Disease. 39(1):2002;134-145.
56. Mantzioris E., James M.J., Gibson R.A., Cleland L.G. Dietary substitution with an linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. American Journal of Clinical Nutrition. 59:1994;1304-1309.
57. Mantzioris E., Cleland L.G., Gibson R.A., Neumann M.A., Demasi M., James M.J. Biochemical effects of a diet containing foods enriched with n-3 fatty acids. American Journal of Clinical Nutrition. 72:2000;42-48.
58. Matthews K.R., Homer D.B., Thies F., Calder P.C. Effect of whole linseed (Linum usitatissimum) in the diet of finishing pigs on growth performance and on quality and fatty acid composition of various tissues. British Journal of Nutrition. 83(6):2000;637-643.
59. Mitchell G.V., Grundel E., Jenkins M.Y., Blakely S.R. Effects of graded dietary levels of Spirulina maxima on vitamin A and E in male rats. Journal of Nutrition. 120:1990;1235-1309.
60. Mitchell G.V., Grundel E., Jenkins M.Y. Bioavailability for rats of vitamin E from fortified breakfast cereals. Journal of Food Science. 61(6):1996;1257-1260.
61. Nesbitt P.D., Thompson L.U. Lignans in homemade and commercial products containing flaxseed. Nutrition and Cancer. 29(3):1997;222-227.
62. Nestel P.J., Pomeroy S.E., Sasahara T., Yamashita T., Liang Y.L., Dart A.M., Jenning G.L., Abbey M., Cameron J.D. Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increase LDL oxidation. Arteriosclerosis Thrombosis and Vascular Biology. 17:1997;1163-1170.
63. Ogborn M.R., Nitschmann E., Weiler H., Leswick D., Bankovic-Calic N. Flaxseed ameliorates interstital nephritis in rat polycystic kidney disease. Kidney International. 55(2):1999;417-423.
64. Oomah B.D., Mazza G., Kenaschuk E.O. Cyanogenic compounds in flaxseed. Journal of Agriculture and Food Chemistry. 40:1992;1346-1348.
65. Orcheson L.J., Rickard S.E., Seidl M.M., Thompson L.U. Flaxseed and its mammalian lignan precursor cause a lengthing or cessation of estrous cycling in rats. Cancer Letters. 125:1998;69-76.
66. Prasad K. Dietary flax seed in prevention of hypercholesterolemic atherosclerosis. Atherosclerosis. 132:1997;69-76.
67. Prasad K., Mantha S.V., Muir A.D., Westcott N.D. Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low alpha-linolenic acid. Atherosclerosis. 136:1998;367-375.
68. Rammell C.G., Cunliffe B., Kieboom A.J. Determination of alpha-tocopherol in biological specimens by high-performance liquid chromatography. Journal of Liquid Chromatography. 6(6):1983;1123-1130.
69. Ranich T., Bhathena S.J., Velasques M.T. Protective effects of dietary phytoestrogens in chronic renal disease. Journal of Renal Nutrition. 11(4):2001;183-193.
70. Ratnayake W.M.N., Behrens W.A., Fischer P.W.F., L'Abbe M.R.L., Mongeau R., Beare-Rogers J.L. Chemical and nutritional studies of flaxseed (variety Linott) in rats. Journal of Nutritional Biochemistry. 3:1992;232-240.
71. Reeves P.G., Nielsen F.H., Fahey G.C. AIN-93 purified diets for laboratory rodents. final report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76-A Rodent Diet Journal of Nutrition. 123:1993;1939-1951.
72. SAS/STAT, 1994. User's Guide, Fisher's Protected LSD, Version 6, 4th ed. SAS Inst. Inc., Cary NC (Chapter 24).
73. Serraino M., Thompson L.U. The effect of flaxseed supplementation and early risk markers of mammary carcinogenesis. Cancer Letters. 60:1991;135-142.
74. Serraino M., Thompson L.U. The effect of flaxseed supplementation on the initiation and promotional stages of mammary tumorigenesis. Nutrition and Cancer. 17:1992;153-159.
75. Serraino M., Thompson L.U. Flaxseed supplementation and early markers of colon carcinogenesis. Cancer Letters. 63:1992;159-165.
76. Scollan N.D., Choi N.-J., Kurt E., Fisher A.V., Enser M., Wood J.D. Manipulating the fatty acid composition of muscle and adipose tissue in beef cattle. British Journal of Nutrition. 85:2001;115-124.
77. Shantha N.C., Decker E.A. Rapid, sensitive, iron-based spectrophotometric methods for determination of peroxide values of food lipids. Journal of the Association of Official Analytical Chemist, International. 77(2):1994;421-428.
78. Simopoulos A.P. Symposium: role of poultry products in enriching the human diet with n-3 PUFA. Human requirement for n-3 polyunsaturated fatty acids. Poultry Science. 79:2000;961-970.
79. Sprando R.L., Collins T.F.X., Black T.N., Olejnik N., Rorie J.I., Wiesenfeld P., Babu U.S., O'Donnell M. The effect of maternal exposure to flaxseed on spermatogenesis in F(1) generation rats. Food and Chemical Toxicology. 38(4):2000;325-334.
80. Su H.-M., Bernardo L., Mirmiran M., Ma X.-H., Nathanielsz P.W., Brenna J.T. Dietary 18:3n-3 and 22:6n-3 as sources of 22:6n-3 accretion in neonatal baboon brain and associated organs. Lipids. 34(suppl.):1999;S347-S350.
81. Thompson J.N. Problems of official methods and new techniques for analysis of foods and feeds for vitamin A. Journal of the Association of Official Analytical Chemists. 69:1986;727-738.
82. Thompson L.U. Potential health benefits and problems associated with antinutrients in foods. Food Research International. 26:1993;131-149.
83. Thompson L.U., Rickard S.E., Orcheson L.J., Seidl M.M. Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis. Carcinogenesis. 17(6):1996;1373-1376.
84. Thompson L.U. Experimental studies on lignans and cancer. Baillieres Clinical Endocrinology and Metabolism. 12(4):1998;691-705.
85. Tou J.C.L., Chen J., Thompson L.U. Flaxseed and its lignan precursor, secoisolariciresinol diglycoside, affect pregnancy outcome and reproductive development in rats. Journal of Nutrition. 128(11):1998;1861-1868.
86. Tou J.C.L., Chen J., Thompson L.U. Dose, timing and duration of flaxseed exposure alter reproductive indices and sex hormones in rats. Journal of Toxicology and Environmental Health, Part A. 56(8):1999;555-570.
87. Trujillo E.P., Broughton K.S. Ingestion of n-3 polyunsaturated fatty acids and ovulation in rats. Journal of Reproductive Fertility. 105:1995;197-203.
88. Wander R.C., Hall J.A., Gradin J.L., Du S.-H., Jewell D.E. The ratio of dietary n-6 to (n-3) fatty acids influence immune system function, eicosanoid metabolism, lipid peroxidation and vitamin E status in aged dogs. Journal of Nutrition. 127:1997;1198-1205.
89. Ward W.E., Yuan Y.V., Cheung A.M., Thompson L.U. Exposure to flaxseed and its purified lignan reduces bone strength in young but not older male rats. Journal of Toxicology and Environmental Health, Part A. 63(1):2001;53-65.
90. Watkins B.A., Li Y., Allen K.G., Hoffmann W.E., Seifert M.F. Dietary ratio of (n-6)/(n-3) polyunsaturated fatty acids alters the fatty acid composition of bone compartments and biomarkers of bone formation in rats. Journal of Nutrition. 130(9):2000;2274-2284.
91. Wiesenfeld P.W., Babu U.S., O'Donnell M.W. Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A. 1 cells. Comparative Biochemistry and Physiology, Part B. 128(1):2001;123-134.
92. Yang J., Chen Z.Y., Cunnane S.C. Application of the balance method to determine accumulation, metabolism and apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. Metabolism. 43(8):1994;940-944.
93. Yaqoob P., Calder P.C. The effects of fatty acids on lymphocyte functions. International Journal of Biochemistry. 25(12):1993;1705-1714.