Suramin analogues as subtype-selective G protein inhibitors

Molecular Pharmacology

Volumn 49, Issue 4, 1996, Pages 602-611

  Freissmuth, Michael ^a   Boehm, Stefan ^b   Beindl, Wolfgang ^a   Nickel, Peter ^c   Ijzerman, Adriaan P ^d   Hohenegger, Martin ^a   Nanoff, Christian ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF BONN   (Germany)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

8 (3 NITROBENZAMIDO) 1,3,5 NAPHTHALENETRISULFONIC ACID; 8 [3 (3 NITROBENZAMIDO)BENZAMIDO] 1,3,5 NAPHTHALENETRISULFONIC ACID; 8,8 [CARBONYLBIS(IMINO 3,1 PHENYLENE)CARBONYLIMINO(3,1 PHENYLENE)]BIS(1,3,5 NAPHTHALENETRISULFONIC ACID); 8,8' [CARBONYLBIS(IMINO 3,1 PHENYLENE)]BIS(1,3,5 NAPHTHALENETRISULFONIC ACID); ADENYLATE CYCLASE; ALPHA 2 ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC RECEPTOR; NF 007; NF 018; NF 023; NF 037; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE;

ARTICLE; BINDING SITE; CALCIUM CURRENT; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; THROMBOCYTE MEMBRANE;

ANIMALS; BINDING SITES; CALCIUM CHANNELS; ENZYME INHIBITORS; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; RATS; RATS, SPRAGUE-DAWLEY; SURAMIN;

EID: 0029917666     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Hepler, J., and A. G. Gilman. G proteins. Trends Biochem. Sci. 17:383-387 (1992).
2. Neubig, R. R. Membrane organization in G protein mechanisms. FASEB J. 8:939-946 (1994).
3. Hohenegger, M , C. Nanoff, H. Ahorn, and M. Freissmuth Structural and functional characterization of the interaction between 2′:3′-dialdehyde guanine nucleotide analogues and the stimulatory G protein α subunit J Biol. Chem 269:32008-32015 (1994).
4. Nanoff, C., S. Boehm, M. Hohenegger, W. Schutz, and M. Freissmuth. 2′:3′-Dialdehyde GTP as an irreversible G protein antagonist: disruption and reconstitution of G protein-mediated signal transduction in cells and cell membranes. J. Biol. Chem. 269:31999-32007 (1994).
5. Bourne, H. R., D. A. Sanders, and F. McCormick. The GTPase superfamily: a conserved switch for diverse cell functions. Nature (Lond.) 348:125-132 (1990).
6. Bourne, H. R., D. A. Sanders, and F. McCormick. The GTPase superfamily: conserved structure and molecular mechanisms. Nature (Lond.) 349:117-127 (1991).
7. Higashijima, T., S. Uzu, T. Nakajima, and E. M. Ross. Mastoparan, a peptide toxin from wasp venom, mimics receptor by activating GTP-binding proteins (G proteins). J. Biol Chem. 263:6491-6494 (1988)
8. Palm, D., G. Munch, C Dees, and M. Hekman. Mapping of the β-adrenoceptor coupling domains to Gs-protein by site-specific synthetic peptides. FEBS Lett. 254:89-93 (1989).
9. Higashijima, T., J. Burnier, and E. M. Ross. Regulation of Gi and Go by mastoparan related amphiphilic peptides and hydrophobic amines: mechanism and structural determinants. J. Biol. Chem. 265:14176-14186 (1990)
10. Munch, G., C. Dees, M, Hekman, and D. Palm. Multisite contacts involved in coupling of the β-adrenergic receptor with the stimulatory guanine nucleotide binding regulatory protein: structural and functional studies by β-receptor site-specific peptides. Eur. J. Biochem. 198:357-364 (1991).
11. Oppi, C., T. Wagner, A. Crisari, B. Camerini, and G. P. Tocchini Valentini. Attenuation of GTPase activity of recombinant G(o) alpha by peptides representing sequence permutations of mastoparan. Proc. Natl. Acad. Sci. USA 89:8268-8273 (1992).
12. Voss, T., E. Wallner, A. P. Csernilofsky, and M. Freissmuth. An amphipathic α-helical structure does not predict the ability of receptor-derived peptides to interact with G proteins. J. Biol. Chem. 268:4637-4642 (1993).
13. Varrault, A., D. LeNguyen, S. McClue, B. Harris, P. Jouin, and J. Bockaert. 5-Hydroxytryptamine-1A receptor synthetic peptides: mechanisms of adenylyl cyclase inhibition. J. Biol. Chem. 269:16720-16725 (1994).
14. Mukai, H., E. Munekata, and T. Higashijima. G protein antagonists: a novel hydrophobic peptide competes with receptor for G protein binding. J. Biol. Chem. 267:16237-16243 (1992).
15. 1 proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes. Mol. Pharmacol. 45:578-586 (1994).
16. Trieb, K., K. Dorfinger, E. Selzer, N. Neuhold, A. Wilfing, S. Czernin, A. Gessl, M. Herrmann, B. Niederle, H. Vierhapper, M. Freissmuth, and B. Grubeck-Loebenstein. Suramin affects differentiated and undifferentiated thyroid epithelial cells in vitro. J. Endocrinol. 134:505-511 (1992).
17. Butler, S., E. C. H. Kelly, F. McKenzie, S. Guild, M O. Wakelam, and G. Milligan. Differential effects of suramin on the coupling of receptors to individual species of pertussis toxin-sensitive guanine nucleotide binding proteins. Biochem. J. 251:201-205 (1988).
18. Huang, R.-R. C., R. N. Dehaven, A. H. Cheung, R. E. Diehl, R. A. F. Dixon, and C. D. Strader. Identification of allosteric antagonists of receptor-guanine nucleotide binding protein interactions. Mol. Pharmacol. 37:304-310 (1990).
19. van Rhee, A. M., M. P A. van der Heijden, M. W. Beukers, A. P. Ijzerman, W. Soudjin, and P. Nickel. Novel competitive antagonists for P2 purinoceptors. Eur. J. Pharmacol 268:1-7 (1994).
20. sα in Escherichia coli: purification and characterization of two forms of the protein. J. Biol. Chem. 264:409-418 (1989).
21. Mumby, S. M., and M. E. Linder. Myristoylation of G protein α subunits. Methods Eraymol. 237:254-268 (1994).
22. sα. Biochemistry 28: 611-616 (1989).
23. Pfeuffer, E., S. Mollner, and T. Pfeuffer. Adenylate cyclase from bovine brain cortex, purification and characterization of the catalytic unit. EMBO J. 4:3675-3679 (1985).
24. Johnson, R. A., and Y Salomon. Assay of adenylyl cyclase catalytic activity. Methods Enzymol. 195:32-41 (1991).
25. 187 result in loss of GTPase activity. J. Biol. Chem. 264:21907-21914 (1989).
26. Mumby, S. M, and A. G. Gilman. Synthetic peptide antisera with determined specificity for G protein α or β subunits. Methods Enzymol. 195: 215-233 (1991).
27. s). Biochem. J. 262:643-649 (1989).
28. Boehm, S. Noradrenaline release from rat sympathetic neurons evoked by P2-purinoceptor activation. Naunyn-Schmiedeberg's Arch. Pharmacol. 350:454-458 (1994).
29. Hamill, O. P., A. Marty, E. Neher, E., B. Sakman, and F. J. Sigworth. Improved patch-clamp technique for high resolution current recording from cells and cell-free membrane patches Pfluegers Arch. 391:85-100 (1981).
30. 2+ and the βγ subunit complex on the interactions of guanine nucleotides with G proteins. J. Biol. Chem. 262:762-766 (1987).
31. Tolkovsky, A. M., S. Braun, and A. Levitzki. Kinetics of interaction between β-receptor, GTP-binding protein, and catalytic unit of turkey erythrocyte adenylate cyclase. Proc. Natl. Acad. Sci. USA 79:213-217 (1982).
32. Wong, S. K.-F., and B. R. Martin. The interactions between the activatory guanine nucleotide binding protein and the catalytic subunit of adenylate cyclase in rat liver plasma membranes. Biochem. J. 231:39-46 (1985).
33. s and the catalytic unit of adenylate cyclase are tightly associated: mechanistic consequences. Proc. Natl. Acad. Sci. USA 81:6579-6583 (1984).
34. Conklin, B R., and H. R. Bourne. Structural elements of G α subunits that interact with G βγ subunits, receptors and effectors. Cell 73:631-641 (1993).
35. Noel, J. P., H. E, Hamm, and P. B. Sigler. The 2.2 A crystal structure of transducin-α complexed with GTPγS. Nature (Lond.) 366:654-663 (1993).
36. 2+ current in rat sympathetic neurons. Proc. Natl. Acad. Sci. USA 84:4313-4317 (1987).
37. o in rat sympathetic neurons. J. Physiol. 477:415-422 (1994).
38. Boehm, S., C. Nanoff, M. Hohenegger, M. Freissmuth, and S. Huck. The GTP-analogue 2′:3′-dialdehyde GTP abolishes the modulation of neuronal calcium currents by various neurotransmitters. Soc. Neurosci. Abstr. 19: 1263 (1993).
39. 2- channels of sympathetic neurons via a pertussis toxin-insensitive but cholera toxin-sensitive pathway. Neuron 13:657-669 (1994).
40. Inuiguez-Lluhi, J. A., M I. Simon, J. D. Robishaw, and A G. Gilman. G protein βγ subunits synthesized in SF9-cells: functional characterization and the significance of prenylation of γ. J. Biol. Chem. 267:23409-23417 (1992).
41. o subunit: mutation of conserved cysteines identifies a subunit contact surface and alters GDP affinity. Proc. Natl. Acad. Sci. USA 90:10295-10298 (1993).
42. Faurobert, E., A. Otto-Bruc, P. Chardin, and M. Chabre. Tryptophane W207 in transducin Tα is the fluorescence sensor of the G protein activation switch and is involved in effector binding. EMBO J. 12:4191-4198 (1993).
43. Lambright, D. G., J P. Noel, H. E. Hamm, and P. B. Sigler. Structural determinants for activation of the α subunit of a heterotrimeric G protein. Nature (Lond.) 369:621-628 (1994).
44. 1α-1 and the mechanism of GTP hydrolysis. Science (Washington D. C.) 265:1405-1412 (1994).
45. Birnbaumer, L., J. Abramowitz, and A. M. Brown. Receptor-effector coupling by G proteins. Biochim. Biophys. Acta 1031:163-224 (1990).