Hydrophobicity of residue351 of the G protein G(il)α determines the extent of activation by the α(2A)-adrenoceptor

Biochemistry

Volumn 37, Issue 33, 1998, Pages 11555-11562

  Bahia, Daljit S ^a   Wise, Alan ^c   Fanelli, Francesca ^b   Lee, Melanie ^c   Rees, Stephen ^c   Milligan, Graeme ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; BRIMONIDINE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); PERTUSSIS TOXIN; SULFUR 35; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BORDETELLA VIRULENCE FACTOR; CYSTEINE; GLYCINE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; QUINOXALINE DERIVATIVE; RECEPTOR, ADRENERGIC, ALPHA 2A; RECEPTOR, ADRENERGIC, ALPHA-2A;

ADENOSINE DIPHOSPHATE RIBOSYLATION; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; GENE MUTATION; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; ANIMAL; CELL LINE; DRUG EFFECT; DRUG POTENTIATION; GENETIC TRANSFECTION; GENETICS; HUMAN; KIDNEY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN BINDING; RAT; SITE DIRECTED MUTAGENESIS;

ADRENERGIC ALPHA-AGONISTS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CYSTEINE; GLYCINE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; KIDNEY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PERTUSSIS TOXIN; PROTEIN BINDING; QUINOXALINES; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; TRANSFECTION; VIRULENCE FACTORS, BORDETELLA;

EID: 0032543961     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980284o     Document Type: Article

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