Hypoxia, HIFs, and cardiovascular development

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 67, Issue , 2002, Pages 127-132

  Simon, M C ^a,b   Ramirez Bergeron, D ^a,b   Mack, F ^a,b   Hu, C J ^b   Pan, Y ^a,b   Mansfield, K ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; PROTEIN SUBUNIT; UNCLASSIFIED DRUG; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR ALPHA SUBUNIT; HYPOXIA INDUCIBLE FACTOR BETA SUBUNIT; OXYGEN;

CONFERENCE PAPER; ENDOTHELIUM CELL; GENE EXPRESSION; HEART DEVELOPMENT; HEMATOPOIESIS; HUMAN; HYPOXIA; PLACENTA DEVELOPMENT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VON HIPPEL LINDAU DISEASE; ARTICLE; EMBRYO; HOMEOSTASIS; NEOPLASM; NONHUMAN;

EID: 0038463621     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2002.67.127     Document Type: Conference Paper

References (47)

1. Adelman D.M., Maltepe E., and Simon M.C. 1999. Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. Genes Dev. 13: 2478.
2. Adelman D.M., Gertsenstein M., Nagy A., Simon M.C., and Maltepe E. 2000. Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses. Genes Dev. 14: 3191.
3. An W.G., Kanekal M., Simon M.C., Maltepe E., Blagosklonny M.V., and Neckers L.M. 1998. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 392: 405.
4. Bunger M.K., Wilsbacher L.D., Moran S.M., Clendenin C., Radcliffe L.A., Hogenesch J.B., Simon M.C., Takahashi J.S., and Bradfield C.A. 2000. Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 103: 1009.
5. Chandel N.S., Maltepe E., Goldwasser E., Mathieu C.E., Simon M.C., and Schumacker P.T. 1998. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc. Natl. Acad. Sci. 95: 11715.
6. 2 sensing. J. Biol. Chem. 275: 25130.
7. Cockman M.E., Masson N., Mole D.R., Jaakkola P., Chang G.W., Clifford S.C., Maher E.R., Pugh C.W., Ratcliffe P.J., and Maxwell P.H. 2000. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 275: 25733.
8. Cowden K.D. and Simon M.C. 2002. The bHLH/PAS factor MOP3 does not participate in hypoxia responses. Biochem. Biophys. Res. Commun. 290: 1228.
9. Ema M., Taya S., Yokotani N., Sogawa K, Matsuda Y., and Fujii-Kuriyama Y. 1997. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl. Acad. Sci. 94: 4273.
10. Ferrara N., Carver-Moore K., Chen H., Dowd M., Lu L., O'Shea K.S., Powell-Braxton L., Hillan K.J., and Moore M.W. 1996. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380: 439.
11. Flamme I., Frohlich T., von Reutem M., Kappel A., Damert A., and Risau W. 1997. HRF, a putative basic helix-loop-helixPAS-domain transcription factor is closely related to hypoxia-inducible factor-1alpha and developmentally expressed in blood vessels. Mech. Dev. 63: 51.
12. Fong G.H., Rossant J., Gertsenstein M., and Breitman M.L. 1995. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376: 66.
13. Gardner L.B., Li Q., Park M.S., Flanagan W.M., Semenza G.L., and Dang C.V. 2001. Hypoxia inhibits G1/S transition through regulation of p27 expression. J. Biol. Chem. 276: 7919.
14. Genbacev O., Zhou Y., Ludlow J.W., and Fisher S.J. 1997. Regulation of human placental development by oxygen tension. Science 277: 1669.
15. Graeber T.G., Peterson J.F., Tsai M., Monica K., Fomace A.J., Jr., and Giaccia A.J. 1994. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell. Biol. 14: 6264.
16. Graeber T.G., Osmanian C., Jacks T., Housman D.E., Koch C.J., Lowe S.W., and Giaccia A.J. 1996. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours (comments). Nature 379: 88.
17. Gu Y.Z., Moran S.M., Hogenesch J.B., Wartman L., and Bradield C.A. 1998. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr. 7: 205.
18. 2 sensing. Science 292: 464.
19. 2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 12: 149.
20. 2-regulated prolyl hydroxylation. Science 292: 468.
21. 2 tension. Am. J. Physiol. 271: C1172.
22. Kallio P.J., Wilson W.J., O'Brien S., Makino Y., and Poellinger L. 1999. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway. J. Biol. Chem. 274: 6519.
23. Keith B., Adelman D.M., and Simon M.C. 2001. Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc. Natl. Acad. Sci. 98: 6692.
24. Kojima H., Gu H., Nomura S., Caldwell C.C., Kobata T., Carmeliet P., Semenza G.L., and Sitkovsky M.V. 2002. Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha-deficient chimeric mice. Proc. Natl. Acad. Sci. 99: 2170.
25. Kondo K. and Kaelin W.G., Jr. 2001. The von Hippel-Lindau tumor suppressor gene. Exp. Cell Res. 264: 117-25.
26. Krek W. 2000. VHL takes HIF's breath away. Nat. Cell. Biol. 2: E1.3.
27. Maltepe E., Keith B., Arsham A., Brorson J., and Simon M.C. 2000. The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia. Biochem. Biophys. Res. Commun. 273: 231.
28. Maltepe E., Schmidt J.V., Baunoch D., Bradfield C.A., and Simon M.C. 1997. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386: 403.
29. Maxwell P.H., Wiesener M.S., Chang G.W., Clifford S.C., Vaux E.C., Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., and Ratcliffe P.J. 1999. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271.
30. Michaud J.L., DeRossi C., May N.R., Holdener B.C., and Fan C. 2000. ARNT2 acts as the dimerization partner of SIM 1 for the development of the hypothalamus. Mech. Dev. 90: 253.
31. Ohh M., Park C.W., Ivan M., Hoffman M.A., Kim T.Y., Huang L.E., Pavletich N., Chau V., and Kaelin W.G. 2000. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell Biol. 2: 423.
32. Peng J., Zhang L., Drysdale L., and Fong G.H. 2000. The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc. Natl. Acad. Sci. 97: 8386.
33. Pugh C.W., Tan C.C., Jones R.W., and Ratcliffe P.J. 1991. Functional analysis of an oxygen-regulated transcriptional enhancer lying 3′ to the mouse erythropoietin gene. Proc. Natl. Acad. Sci. USA 88: 10553-7.
34. Ramirez-Bergeron D.L. and Simon M.C. 2001. Hypoxia-inducible factor and the development of stem cells of the cardiovascular system. Stem Cells 19: 279.
35. Ravi R., Mookerjee B., Bhujwalla Z.M., Sutter C.H., Artemov D., Zeng Q., Dillehay L.E., Madan A., Semenza G.L., and Bedi A. 2000. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 14: 34.
36. Risau W. 1997. Mechanisms of angiogenesis. Nature 386: 671.
37. Ryan H.E., Lo J., and Johnson R.S. 1998. HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J. 17: 3005.
38. Sato T.N., Tozawa Y., Deutsch U., Wolburg-Buchholz K., Fujiwara Y., Gendron-Maguire M., Gridley T., Wolburg H., Risau W., and Qin Y. 1995. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376: 70.
39. Semenza G.L. 2000. HIF-1 and human disease: One highly involved factor. Genes Dev. 14: 1983.
40. Semenza G.L., Nejfelt M.K., Chi S.M., and Antonarakis S.E. 1991. Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene. Proc. Natl. Acad. Sci. 88: 5680.
41. 2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15: 551.
42. Shalaby F., Rossant J., Yamaguchi T.P., Gertsenstein M., Wu X.F., Breitman M.L., and Schuh A. 1995. Failure of blood-island formation and vasculogenesis in Flk-1 deficient mice. Nature 376: 62.
43. Tian H., McKnight S.L., and Russell D.W. 1997. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11: 72.
44. 2 tension. Proc. Natl. Acad. Sci. 92: 5510.
45. Yu F., White S.B., Zhao Q., and Lee F.S. 2001. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl. Acad. Sci. 98: 9630.
46. Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M.M., Simons J.W., and Semenza G.L. 2000. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics. Cancer Res. 60: 1541.
47. Zundel W., Schindler C., Haas-Kogan D., Koong A., Kaper F., Chen E., Gottschalk A.R., Ryan H.E., Johnson R.S., Jefferson A.B., Stokoe D., and Giaccia A.J. 2000. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 14: 391.