The bHLH/PAS factor MOP3 does not participate in hypoxia responses

Biochemical and Biophysical Research Communications

Volumn 290, Issue 4, 2002, Pages 1228-1236

  Cowden, Karen D ^a,b   Simon, M Celeste ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

BHLH PAS proteins; Hypoxia

Indexed keywords

DIMER; HELIX LOOP HELIX PROTEIN; OXYGEN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ARNT; TRANSCRIPTION FACTOR ARNT2; TRANSCRIPTION FACTOR PAS; TRANSCRIPTION FACTRO MOP3; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN 3T3; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; HYPOXIA; HYPOXIC CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0036298008     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6309     Document Type: Article

References (49)

1. The PAS superfamily: Sensors of environmental and developmental signals
2. Remembrance of things PAS: Regulation of development by bHLH-PAS proteins
3. Control of cell lineage-specific development and transcription by bHLH-PAS proteins
4. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
5. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
6. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
7. Hypoxia-inducible factor 1: Master regulator of O2 homeostasis
8. Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology
9. Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
10. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
11. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
12. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer
13. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
14. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
15. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3′ enhancer
16. The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia
17. Role of the PAS domain in regulation of dimerization and DNA binding specificity of the dioxin receptor
18. Protein-protein interaction via PAS domains: Role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex
19. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
20. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
21. Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock
22. Role of the CLOCK protein in the mammalian circadian mechanism
23. Mop3 is an essential component of the master circadian pacemaker in mammals
24. Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt
25. Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses
26. ARNT-deficient mice and placental differentiation
27. The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling
28. HIF-1 alpha is required for solid tumor formation and embryonic vascularization
29. Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis
30. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
31. Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway
32. Loss of PTEN facilitates HIF-1-mediated gene expression
33. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway
34. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
35. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
36. Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse
37. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
38. Positional cloning of the mouse circadian clock gene
39. Clock mutants of Drosophila melanogaster
40. CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless
41. Molecular analysis of mammalian circadian rhythms
42. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior
43. Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock
44. The mPer2 gene encodes a functional component of the mammalian circadian clock
45. Targeted disruption of the mPer3 gene: Subtle effects on circadian clock function
46. A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock
47. Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
48. Hypoxia-induced transcriptional activation of vascular endothelial growth factor is inhibited by serum
49. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development