Hypoxia-inducible factor and the development of stem cells of the cardiovascular system

Stem Cells

Volumn 19, Issue 4, 2001, Pages 279-286

  Ramírez Bergeron, Diana L ^a,b   Celeste Simon, M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Hemangioblast; Hematopoietic development; HIF 1; Hypoxia; Vascular development

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; OXYGEN; PROTEIN SUBUNIT;

ANGIOGENESIS; ANIMAL CELL; CARCINOGENESIS; CARDIOVASCULAR SYSTEM; CELL DIFFERENTIATION; CELL HYPOXIA; CELL MATURATION; CELL PROLIFERATION; EMBRYO; EMBRYO DEVELOPMENT; ERYTHROPOIESIS; GENE INDUCTION; GENE MUTATION; GLUCOSE TRANSPORT; GLYCOLYSIS; HEART DEVELOPMENT; ISCHEMIA; MOUSE; NONHUMAN; OXYGEN TISSUE LEVEL; PROTEIN EXPRESSION; SHORT SURVEY; STEM CELL;

ANIMALIA;

EID: 0034901617     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.19-4-279     Document Type: Short Survey

References (99)

1. 2 homeostasis
2. 2 homeostasis by hypoxia-inducible factor 1
3. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
4. 2 tension
5. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes
6. Oxygen-regulated transferrin expression is mediated by hypoxia- inducible factor-1
7. HIF-1alpha is required for solid tumor formation and embryonic vascularization
8. The role of aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxia induction of gene expression
9. Selection and analysis of a mutant cell line defective in the hypoxia- inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of Hif-1alpha-dependent and -independent hypoxia-inducible gene expression
10. Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene
11. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha
12. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
13. 2 tension
14. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
15. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
16. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
17. Mammalian oxygen sensing, signalling and gene regulation
18. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
19. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
20. VHL takes HIF's breath away
21. Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein
22. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
23. Expression of ARNT, ARNT2, HIF1alpha, HIF2alpha and Ah receptor mRNAs in the developing mouse
24. Endothelial cell responses to hypoxia: Initiation of a cascade of cellular interactions
25. HIF-1 and human disease: One highly involved factor
26. Vascular endothelial growth factor: Molecular and biological aspects
27. Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain
28. Early expression of angiogenesis factors in acute myocardial ischemia and infarction
29. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
30. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis
31. Expression of hypoxia-inducible factor 1alpha in brain tumors: Association with angiogenesis, invasion, and progression
32. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
33. Erythropoietin and platelet production
34. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
35. Hypoxia and human placental development
36. Regulation of human placental development by oxygen tension
37. Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia
38. Studies on the origin of blood vessels and of red corpuscles as seen in the living blastoderm of the chick during the second day of incubation
39. A role for hematopoietic stem cells in promoting angiogenesis
40. The sialomucin CD34 is expressed on hematopoietic cells and blood vessels during murine development
41. PECAM-1: Its expression and function as a cell adhesion molecule on hemopoietic and endothelial cells
42. Flk-1, a flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors
43. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
44. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium
45. Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2
46. Flk-1 expression defines a population of early embryonic hematopoietic precursors
47. Regulation of flt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium
48. The SCL/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis
49. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
50. GATA-binding transcription factors in hematopoietic cells
51. Differentiation of hemangioblasts from embryonic mesothelial cells? A model on the origin of the vertebrate cardiovascular system
52. Formation and early morphogenesis of endocardial endothelial precursor cells and the role of endoderm
53. A common precursor for hematopoietic and endothelial cells
54. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors
55. Vascularization of the mouse embryo: A study of flk-1, tek, tie, and vascular endothelial growth factor expression during development
56. Characterization and strain distribution of four alleles at the hemoglobin-chain structural locus in the mouse
57. A phase and electron microscopic study of vasculogenesis and erythropoiesis in the yolk sac of the mouse
58. TAL1/SCL is expressed in endothelial progenitor cells/angioblasts and defines a dorsal-to-ventral gradient of vasculogenesis
59. Intrauterine oxygen tension during the estrous cycle in the rat: Its relation to uterine respiration and vascular activity
60. Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits
61. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
62. Oxygen, genes, and development: An analysis of the role of hypoxic gene regulation during murine vascular development
63. Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses
64. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
65. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
66. Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor
67. Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis
68. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
69. Erythropoietin and the anaemia of chronic disease
70. Inactivation of erythropoietin leads to defects in cardiac morphogenesis
71. Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression
72. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells
73. Possible participation of autocrine and paracrine vascular endothelial growth factors in hypoxia-induced proliferation of endothelial cells and pericytes
74. A requirement for Flk 1 in primitive and definitive hematopoiesis and vasculogenesis
75. Failure of blood-island formation and vasculogenesis in Flk-1 deficient mice
76. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
77. Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells
78. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
79. 2 homeostasis by hypoxia- inducible factor 1 alpha
80. Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
81. ARNT-deficient mice and placental differentiation
82. HIF-1 is essential for multilineage hematopoiesis in the embryo
83. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
84. Multilineage embryonic hematopoiesis requires hypoxic ARNT activity
85. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
86. The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling
87. Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice
88. Severe hypoxia enhances the formation of erythroid bursts from human cord blood cells and the maintenance of BFU-E in vitro
89. Oxygen tension modulates beta-globin switching in embryoid bodies
90. Effect of hypoxia on the hematopoietic and immune modulator preprotachykinin-I
91. Effect of nitric oxide production and oxygen tension on progenitor preservation in ex vivo culture
92. Dynamic model of ex vivo granulocytic kinetics to examine the effects of oxygen tension, pH, and interleukin-3
93. Oxygen tension influences the differentiation, maturation and apoptosis of human megakaryocytes
94. The expansion of murine bone marrow cells preincubated in hypoxia as an in vitro indicator of their marrow-repopulating ability
95. In vitro differentiation of embryonic stem cells
96. A common precursor for primitive erythropoiesis and definitive haematopoiesis
97. In vitro hematopoietic and endothelial potential of flk-1(-/-) embryonic stem cells and embryos
98. A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1
99. Basic fibroblast growth factor positively regulates hematopoietic development