Suppression of T cell signaling by polyunsaturated fatty acids: Selectivity in inhibition of mitogen-activated protein kinase and nuclear factor activation

Journal of Immunology

Volumn 170, Issue 12, 2003, Pages 6033-6039

  Zeyda, Maximilian ^a   Szekeres, Andreas B ^a   Säemann, Marcus D ^a   Geyeregger, René ^a   Stockinger, Hannes ^a   Zlabinger, Gerhard J ^a   Waldhäusl, Werner ^a,b   Stulnig, Thomas M ^a,b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CD28 ANTIGEN; CD3 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR FACTOR; PHOSPHOLIPASE C; POLYUNSATURATED FATTY ACID; T LYMPHOCYTE RECEPTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOIMMUNITY; CALCIUM SIGNALING; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; FATTY ACID METABOLISM; HUMAN; HUMAN CELL; INFLAMMATION; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0038281190     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.12.6033     Document Type: Article

References (45)

1. Calder, P. C. 1998. Fat chance of immunomodulation. Immunol. Today 19:244.
2. Field, C. J., I. R. Johnson, and P. D. Schley. 2002. Nutrients and their role in host resistance to infection. J. Leukocyte Biol. 71:16.
3. Calder, P. C., and R. B. Zurier. 2001. Polyunsaturated fatty acids and rheumatoid arthritis. Curr. Opin. Clin. Nutr. Metab. Care 4:115.
4. van der Heide, J. J., H. J. Bilo, J. M. Donker, J. M. Wilmink, and A. M. Tegzess. 1993. Effect of dietary fish oil on renal function and rejection in cyclosporine-treated recipients of renal transplants. N. Engl. J. Med. 329:769.
5. Leiba, A., H. Amital, M. E. Gershwin, and Y. Shoenfeld. 2001. Diet and lupus. Lupus 10:246.
6. Meydani, S. N., S. Endres, M. M. Woods, B. R. Goldin, C. Soo, A. Morrill Labrode, C. A. Dinarello, and S. L. Gorbach. 1991. Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. J. Nutr. 121:547.
7. Blok, W. L., M. B. Katan, and J. W. van der Meer. 1996. Modulation of inflammation and cytokine production by dietary (n-3) fatty acids. J. Nutr. 126:1515.
8. Endres, S., and C. von Schacky. 1996. n-3 polyunsaturated fatty acids and human cytokine synthesis. Curr. Opin. Lipidol. 7:48.
9. James, M. J., R. A. Gibson, and L. G. Cleland. 2000. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am. J. Clin. Nutr. 71:343S.
10. Jump, D. B. 2002. The biochemistry of n-3 polyunsaturated fatty acids. J. Biol. Chem. 277:8755.
11. Kane, L. P., J. Lin, and A. Weiss. 2000. Signal transduction by the TCR for antigen. Curr. Opin. Immunol. 12:242.
12. Berridge, M. J., P. Lipp, and M. D. Bootman. 2000. The versatility and universality of calcium signalling. Nat. Rev. Mol. Cell Biol. 1:11.
13. Schwartz, R. H. 1992. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71:1065.
14. Deckert, M., J. Kubar, and A. Bernard. 1992. CD58 and CD59 molecules exhibit potentializing effects in T-cell adhesion and activation. J. Immunol. 148:672.
15. Garrington, T. P., and G. L. Johnson. 1999. Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr. Opin. Cell Biol. 11:211.
16. Masuda, E. S., R. Imamura, Y. Amasaki, K. Arai, and N. Arai. 1998. Signalling into the T-cell nucleus: NFAT regulation. Cell Signal. 10:599.
17. Karin, M., Z. Liu, and E. Zandi. 1997. AP-1 function and regulation. Curr. Opin. Cell Biol. 9:240.
18. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141.
19. Cantrell, D. 1996. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14:259.
20. Stulnig, T. M., M. Berger, T. Sigmund, H. Stockinger, and W. Waldhäusl. 1998. Polyunsaturated fatty acids inhibit T cell signal transduction by modification of detergent-insoluble membrane domains. J. Cell Biol. 143:637.
21. Zeyda, M., G. Staffler, V. Hořjší, W. Waldhäusl, and T. M. Stulnig. 2002. LAT displacement from lipid rafts as molecular mechanism for inhibition of T cell signaling by polyunsaturated fatty acids. J Biol. Chem. 277:28418.
22. Zurier, R. B., R. G. Rossetti, C. M. Seiler, and M. Laposata. 1999. Human peripheral blood T lymphocyte proliferation after activation of the T cell receptor: effects of unsaturated fatty acids. Prostaglandins Leukotrienes Essent. Fatty Acids 60:371.
23. Rossetti, R. G., C. M. Seiler, P. DeLuca, M. Laposata, and R. B. Zurier. 1997. Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation. J. Leukocyte Biol. 62:438.
24. Arrington, J. L., D. N. McMurray, K. C. Switzer, Y. Y. Fan, and R. S. Chapkin. 2001. Docosahexaenoic acid suppresses function of the CD28 costimulatory membrane receptor in primary murine and Jurkat T cells. J. Nutr. 131:1147.
25. Brombacher, F., T. Schafer, U. Weissenstein, C. Tschopp, E. Andersen, K. Burki, and G. Baumann. 1994. IL-2 promoter-driven lacZ expression as a monitoring tool for IL-2 expression in primary T cells of transgenic mice. Int. Immunol. 6:189.
26. Taniguchi. T., and Y. Minami. 1993. The IL-2/IL-2 receptor system: a current overview. Cell 73:5.
27. Schuh, K., T. Twardzik, B. Kneitz, J. Heyer, A. Schimpl, and E. Serfling. 1998. The interleukin 2 receptor α chain/CD25 promoter is a target for nuclear factor of activated T cells. J. Exp. Med. 188:1369.
28. Liang, X., A. Nazarian, H. Erdjument-Bromage, W. Bommann, P. Tempst, and M. D. Resh. 2001. Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction. J. Biol. Chem. 276:30987.
29. ras activation in T cell CD69 expression. Eur. J. Immunol. 24:616.
30. Kempiak, S. J., T. S. Hiura, and A. E. Nel. 1999. The Jun kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter: proof of cross-talk with the IκB kinase cascade. J. Immunol. 162:3176.
31. 2-terminal kinase (JNK)1 and JNK2 have similar and stage- dependent roles in regulating T cell apoptosis and proliferation. J. Exp. Med. 193:317.
32. Behrens, A., K. Sabapathy, I. Graef, M. Cleary, G. R. Crabtree, and E. F. Wagner. 2001. Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT). Proc. Natl. Acad. Sci. USA 98:1769.
33. Werlen, G., E. Jacinto, Y. Xia, and M. Karin. 1998. Calcineurin preferentially synergizes with PKC-θ to activate JNK and IL-2 promoter in T lymphocytes. EMBO J. 17:3101.
34. Wallace, F. A., E. A. Miles, C. Evans, T. E. Stock, P. Yaqoob, and P. C. Calder. 2001. Dietary fatty acids influence the production of Th1- but not Th2-type cytokines. J. Leukocyte Biol. 69:449.
35. + T cells to Th1 cells requires MAP kinase JNK2. Immunity 9:575.
36. + T cells. J. Immunol. 168:4936.
37. Van der Pouw Kraan, T. C., J. S. Van der Zee, L. C. Boeije, E. R. De Groot, S. O. Stapel, and L. A. Aarden. 1998. The role of IL-13 in IgE synthesis by allergic asthma patients. Clin. Exp. Immunol. 111:129.
38. Nagakura, T., S. Matsuda, K. Shichijyo, H. Sugimoto, and K. Hata. 2000. Dietary supplementation with fish oil rich in ω-3 polyunsaturated fatty acids in children with bronchial asthma. Eur. Respir. J 16:861.
39. Villani, F., R. Comazzi, P. De Maria, and M. Galimberti. 1998. Effect of dietary supplementation with polyunsaturated fatty acids on bronchial hyperreactivity in subjects with seasonal asthma. Respiration 65:265.
40. Fallon, P. G., H. E. Jolin, P. Smith, C. L. Emson, M. J. Townsend, R. Fallon, and A. N. McKenzie. 2002. IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity 17:7.
41. Kim, H. P., and W. J. Leonard. 2002. The basis for TCR-mediated regulation of the IL-2 receptor α chain gene: role of widely separated regulatory elements. EMBO J. 21:3051.
42. Xu, H. E., M. H. Lambert, V. G. Montana, D. J. Parks, S. G. Blanchard, P. J. Brown, D. D. Sternbach, J. M. Lehmann, G. B. Wisely, T. M. Willson, et al. 1999. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol. Cell 3:397.
43. Jones, D. C., X. Ding. and R. A. Daynes. 2002. Nuclear receptor peroxisome proliferator-activated receptor a (PPARα) is expressed in resting murine lymphocytes: the PPARα in T and B lymphocytes is both transactivation and transrepression competent. J. Biol. Chem. 277:6838.
44. Clark, R. B., D. Bishop-Bailey, T. Estrada-Hernandez, T. Hla, L. Puddington, and S. J. Padula. 2000. The nuclear receptor PPARγ and immunoregulation: PPARγ mediates inhibition of helper T cell responses. J. Immunol. 164:1364.
45. Stulnig, T. M., J. Huber, N. Leitinger, E.-M. Imre, P. Angelisová, P. Nowotny, and W. Waldäusl. 2001. Polyunsaturated eicosapentaenoic acid displaces proteins from membrane rafts by altering raft lipid composition. J. Biol. Chem. 276:37335.