n-3 polyunsaturated fatty acids and human cytokine synthesis

Current Opinion in Lipidology

Volumn 7, Issue 1, 1996, Pages 48-52

  Endres, Stefan ^a   Von Schacky, Clemens ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 1; OMEGA 3 FATTY ACID; POLYUNSATURATED FATTY ACID; TUMOR NECROSIS FACTOR;

ATHEROGENESIS; CLINICAL TRIAL; DIET SUPPLEMENTATION; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; INFLAMMATORY DISEASE; KIDNEY GRAFT REJECTION; ORAL DRUG ADMINISTRATION; PATHOGENESIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SHORT SURVEY;

ANIMALS; ARTHRITIS, RHEUMATOID; CLINICAL TRIALS; CYTOKINES; FATTY ACIDS, OMEGA-3; GRAFT REJECTION; HUMANS; INTERLEUKIN-1; MULTIPLE SCLEROSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029875557     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-199602000-00011     Document Type: Short Survey

References (33)

1. Endres S, Ghorbani R, Kelley VE, Georgilis K, Lonnemann G, van der Meer J, Cannon JG, Rogers TS, Klempner MS, Weber PC, et al.: The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989, 320:262-271.
2. Kremer J, Lawrence D, Jubiz W, Di Giacomo R, Rynes R, Bartholomew LE, Sherman M: Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunological effects. Arthritis Rheum 1990, 33:810-820.
3. Gallai V, Sarchielli P, Trequattrini A, Franceschini M, Floridi A, Firenze C, Alberti A, Dibenedetto D, Stragliotto E: Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids. J Neuroimmunol 1995, 56:143-153. Patients with muliple sclerosis received n-3 polyunsaturated fatty acids for a period of 6 months. Production of IL-1β and of TNF was decreased at 3 and 6 months. This shows that peripheral blood mononuclear cells, not only of healthy individuals, but also of patients with an inflammatory disease, can be inhibited in their capacity to release cytokines. This paper does not comment on clinical effects of the supplementation.
4. Meydani SN, Lichtenstein AH, Cornwall S, Meydani M, Goldin BR, Rasmussen H, Dinarello CA, Schaefer EJ: Immunological effects of national cholesterol education panel (NCEP) step-2 diets with and without fish-derived n-3 fatty acid enrichment J Clin Invest 1993, 92:101-113.
5. Urakaze M, Sugiyama E, Xu L, Auron P, Yeh E, Robinson D: Dietary marine lipids suppress IL-1β mRNA levels in lipopolysaccharide stimulated monocytes [Abstract]. Clin Res 1991, 23:111.
6. Dinarello CA: The interleukin-1 family: 10 years of discovery. FASEB J 1994, 8:1314-1325. A comprehensive review of this inflammatory cytokine 10 years after its cloning, by the author who first isolated IL-1 and described its complementary DNA sequence.
7. Meydani SN, Endres S, Woods MM, Goldin BR, Soo C, Morrill LA, Dinarello CA, Gorbach SL: Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. J Nutr 1991, 121:547-555.
8. Molvig J, Pociot F, Worsaae H, Wogensen LD, Baek L, Christensen P, Mandrup PT, Andersen K, Madsen P, Dyerberg J, Nerup J: Dietary supplementation with omega-3-polyunsaturated fatty acids decreases mononuclear cell proliferation and interleukin-1β content but not monokine secretion in healthy and insulin-dependent diabetic individuals. Scand J Immunol 1991, 34:394-410.
9. Cooper AL, Gibbons L, Horan MA, Little RA, Rothwell NJ: Effect of dietary fish oil supplementation on fever and cytokine production in human volunteers. Clin Nutr 1993, 12:321-328.
10. De Caterina R, Cybulsky MI, Clinton SK, Gimbrone MAJ, Libby P: The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. Arterioscler Thromb 1994, 14:1829-1836. The first study to show that docosahexaenoic acid decreases expression of an adhesion protein. This mechanism may contribute to the beneficial effect of n-3 fatty acids in several inflammatory and atherogenic diseases.
11. Kaminski WE, Jendraschak E, Kiefl R, von Schacky C: Dietary ω-3 fatty acids lower levels of platelet-derived growth factor mRNA in human mononuclear cells. Blood 1993, 81:1871-1879.
12. Robinson DR, Knoell CT, Urakaze M, Huang R, Taki H, Sugiyama E, Xu LL, Yeh ETH, Olesiak W, Guo M, Colvin RB, Auron PE: Suppression of autoimmune disease by omega-3 fatty acids. Biochem Soc Trans 1995, 23:287-291.
13. Calder PC: Fatty acids, dietary lipids and lymphocyte functions. Biochem Soc Trans 1995, 23:302-309.
14. Endres S, Meydani SN, Ghorbani R, Schindler R, Dinarello CA: Dietary supplementation with n-3 fatty acids suppresses interleukin-2 production and mononuclear cell proliferation. J Leukocyte Biol 1993, 599-603.
15. Yaqoob P, Newsholme EA, Calder PC: The effect of dietary lipid manipulation on rat lymphocyte subsets and proliferation. Immunology 1994, 82:603-610.
16. Rotondo D: Fatty acid modulation of cell responsiveness. Biochem Soc Trans 1995, 23:292-296.
17. Chang HR, Arsenijevic D, Vladoianu IR, Girardier L, Dulloo AG: Fish oil enhances macrophage tumor necrosis factor-alpha mRNA expression at the transcriptional level. Metabolism 1995, 44:800-805.
18. Yaqoob P, Calder P: Effects of dietary lipid manipulation upon inflammatory mediator production by murine macrophages. Cell Immunol 1995, 163:120-128.
19. Endres S, De Caterina R, Schmidt EB, Kristensen SD: n-3 Polyunsaturated fatty acids: Update 1995. Europ J Clin Invest 1995, 25:629-638.
20. Kristensen SD, De Caterina R, Schmidt EB, Endres S: Fish oil and ischaemic heart disease. Br Heart J 1993, 70:212-214.
21. Leaf A, Jorgensen MB, Jacobs AK, Cote G, Schoenfeldt DA, Scheer J, Weiner B, Slack JD, Kellett MA, Raizner AE, et al.: Do fish oils prevent restenosis after coronary angioplasty? Circulation 1994, 90:2248-2257. A thoroughly performed study with negative outcome. In a large patient group with long-term intervention the beneficial effect of n-3 fatty acids observed in earlier, smaller studies could not be confirmed.
22. Caims JA, Gill JB, Morton B, Roberts R, Gent M, Hirsh J, and the EMPAR Collaborators: Enoxaprine and Maxepa for the prevention of angioplasty restenosis [Abstract]. Circulation 1994, 90(Suppl):I-651.
23. Eritsland J, Arnesen H, Gronseth K, Fjeld NB, Abdelnoor M: Effect of supplementation with n-3 fatty acids on graft patency in patients undergoing coronary artery bypass operation. Results from the SHOT study [Abstract]. Eur Heart J 1994, 15:29.
24. Eritsland J, Seljeflot I, Arnesen H, Westvik AB, Kierulf P: Effect of long-term, moderate-dose supplementation with omega-3 fatty acids on monocyte procoagulant activity and release of interleukin-6 in patients with coronary artery disease. Thromb Res 1995, 77: 337-346.
25. de Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, Guidollet J, Touboul P, Delaye J: Mediterranean α-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994, 343: 1454-1459. Six hundred and three patients less than 70 years of age were assigned to an experimental diet or to a control group. The experimental diet, tailored after a typical mediterranean food intake, contained less total lipids, saturated fats and cholesterol, but more oleic and alpha-linolenic acid (an n-3 polyunsaturated fatty acid). After a mean follow-up of 27 months there were 16 cardiac deaths in the control group but only three in the experimental group.
26. De Caterina R, Endres S, Kristensen SD, Schmidt EB: n-3 Fatty acids and renal diseases. Am J Kidn Dis 1994, 24:394-415.
27. Homan van der Heide JJ, Bilo HJG, Donker JM, Wilmik JM, Tegzess AM: Effect of dietary fish oil on renal function and rejection in cyclosporine-treated recipients of renal transplants. N Engl J Med 1993, 329: 769-773.
28. Maachi K, Berthoux P, Burgard G, Alamartine E, Berthoux F: Results of a 1-year randomized controlled trial with omega-3 fatty acid fish oil in renal transplantation under triple immunosuppressive therapy. Transplant Proc 1995, 27:846-849.
29. Bennett WM, Carpenter CB, Shapiro ME, Strom TB, Hefty D, Tillman M, Abrams J, Ryan D, Kelley VR: Delayed omega-3 fatty acid supplements in renal transplantation. A double-blind, placebo-controlled study. Transplantation 1995, 59:353-356.
30. Donadio JVJ, Bergstralh EJ, Offord KR Spencer DC, Holley KE, for the Mayo Nephrology Collaborative Group: A controlled trial of fish oil in IgA nephropathy. N Engl J Med 1994, 331:1194-1199. One hundred and two patients with immunoglobulin A nephropathy were assigned to receive fish oil or placebo. The cumulative percentage of patients who died or had end-stage renal disease was 40% in the placebo group after 4 years and 10% in the fish oil group. Suppression of cytokine production is discussed as a possible mechanism for the beneficial effect of this inflammatory disease for which no other established therapy exists.
31. Geusens P, Wouters C, Nijs J, Jiang YB, Dequeker J: Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis - a 12-month, double-blind, controlled study. Arthritis Rheum 1994, 37:824-829.
32. Endres S, Loeschke K, Lorenz R: n-3 fatty acids in inflammatory bowel disease. In Preventive strategies in vascular disease: focus on n-3 fatty acids. Edited by Kristensen SD, Endres S, Schmidt EB, De Caterina R. Heidelberg: Springer-Verlag; 1996 (In press).
33. Shahar E, Folsom AR, Melnick SL, Tockman MS, Comstock GW, Gennaro V, Higgins MW, Sorlie PD, Ko WJ, Szklo M: Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. N Engl J Med 1994, 331:228-233.