Metabotropic glutamate receptor activation and blockade: Their role in long-term potentiation, learning and neurotoxicity

Neuroscience and Biobehavioral Reviews

Volumn 23, Issue 3, 1999, Pages 399-410

  Hölscher, Christian ^a   Gigg, John ^b   O'Mara, Shane M ^b  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Development; Learning; Long term potentiation; Synaptic transmission

Indexed keywords

GLUTAMATE RECEPTOR; ION CHANNEL; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR; PROTEIN G;

BRAIN ISCHEMIA; LEARNING; LONG TERM POTENTIATION; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RECEPTOR BLOCKING; RECEPTOR INTRINSIC ACTIVITY; REVIEW; SYNAPTIC TRANSMISSION;

EID: 0345059225     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0149-7634(98)00045-1     Document Type: Article

References (125)

1. Aiba A.et al. Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell. 79:1994;377-388.
2. Akiyama K.et al. Long-lasting enhancement of metabotropic excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/pyriform cortex of deep prepiriform cortical kindled rats. Brain Res. 509:1992;71-77.
3. Attwell P.J.E.et al. Blockade of both epileptogenesis and glutamate release by (1S,3S)-ACPD, a presynaptic glutamate receptor agonist. Brain Res. 698:1995;155-162.
4. Bannerman D.M., Good M.A., Butcher S.P., Ramsay M., Morris R.G.M. Distinct components of spatial learning revealed by prior training and NMDA receptor blockade. Nature. 378:1995;182-186.
5. Bashir Z.I.et al. Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors. Nature. 363:1993;347-350.
6. Baskys A. Metabotropic receptors and the 'slow' excitatory actions of glutamate agonists in the hippocampus. Trends Neurosci. 15:1992;92-96.
7. Baskys A., Malenka R.C. Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocamus. J Physiol. 444:1991;687-701.
8. Bliss T.V.P., Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 361:1993;31-39.
9. Bliss TVP, Lynch MA. Long-term potentiation of synaptic transmission in the hippocampus: properties and mechanisms. In: Long-term potentiation: from biophysics to behavior. New York: Alan R. Liss, 19??:3-72.
10. Bockaert J., Pin J., Fagni L. Metabotropic glutamate receptors: an original family of G protein-coupled receptors. Fundam Clin Pharmacol. 7:1993;473-485.
11. Bonhoeffer T., Staiger V., Aertsen A. Synaptic plasticity in rat hippocampal slice cultures: Local 'Hebbian' conjunction of pre- and postsynaptic stimulation leads to distributed synaptic enhancement. Proc Natl Acad Sci USA. 86:1989;8113-8117.
12. Bordi F., Ugolini A. Antagonists of the metabotropic glutamate receptor do not prevent induction of long-term potentiation in the dentate gyrus of rats. Eur J Pharmacol. 273:1995;291-294.
13. Bortolotto Z.A., Bashir Z.I., Davies C.H., Collingridge G.L. A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation. Nature. 368:1994;740-743.
14. Bortolotto Z.A., Collingridge G.L. Activation of glutamate metabotropic receptors induces long-term potentiation. Eur J Pharmacol. 214:1992;297-298.
15. Boss V., Conn P.J. Metabotropic excitatory amino-acid receptor activation stimulates phospholipase-D in hippocampal slices. J Neurochem. 59:1992;2340-2342.
16. Bradford H.F., Peterson D.W. Current views of the pathobiochemistry of epilepsy. Mol Aspects Med. 9:1987;119-172.
17. Brucato F.H.et al. Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade. Neuroscience. 74:1996;331-339.
18. Bruno V.et al. Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death. Eur J Pharmacol. 256:1994;109-112.
19. Buisson A., Choi D.W. The inhibitory mGluR agonist S-4-carboxy-3-hydroxy phenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death. Neuropharmacology. 34:1995;1081-1087.
20. Cavanni P.et al. Pharmacological analysis of carboxyphenylglycines at metabotropic glutamate receptors. Eur J Pharmacol. 269:1994;9-15.
21. Chiamulera C., Albertini P., Valerio E., Reggiani A. Activation of metabotropic receptors has a neuroprotective effect in a rodent model of focal ischaemia. Eur J Pharmacol. 216:1992;335-336.
22. Collingridge G.L., Lester R.A.J. Excitatory amino acid receptors in the vertebrate nervous system. Physiol Rev. 40:1989;143-210.
23. Conn P.J., Desai M.A. Pharmacology and physiology of metabotropic glutamate receptors in mammalian central nervous system. Drug Dev Res. 24:1991;207-229.
24. Conquet F.et al. Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature. 372:1994;237-243.
25. Coutinho-Netto J., Abdul-Ghani A.S., Collins J.F., Bradford H.F. Is glutamate a trigger factor in epileptic hyperactivity? Epilepsia. 22:1981;289-296.
26. Crepel F., Daniel H., Hemart N., Jaillard D. Effects of ACPD and AP3 on parallel-fibre-mediated EPSPs of Purkinje cells in cerebellar slices in vitro. Exp Brain Res. 86:1991;402-406.
27. Duvoisin R.M., Zhang C., Ramonell K. A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. J Neurosci. 15:1995;3075-3083.
28. Faden A.I., Demediuk P., Panter Vink R. The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science. 244:1989;98-100.
29. Faden A.I., Simon R.P. A potential role for neurotoxins in the pathophysiology of spinal cord injuries. Ann Neurol. 23:1988;623-626.
30. 2+ influx: how many mechanisms for how many channels? Trends Pharmacol Sci. 15:1994;77-83.
31. Fiala J.C., Grossberg S., Bullock D. Metabotropic glutamate receptor activation in cerebellar Purkinje cells as a substrate for adaptive timing of the classically conditioned eye-blink response. J Neurosci. 16:1996;3760-3774.
32. Genazzani A.A.et al. Characterization of metabotropic glutamate receptors negatively linked to adenylyl cyclase in brain slices. Brain Res. 622:1993;132-138.
33. Goddard G.H. Development of epileptic seizures through brain stimulation at low intensity. Nature. 214:1967;1020-1021.
34. Gong Q.Z., Delahunty T.M., Hamm R.J., Lyeth B.G. Metabotropic glutamate antagonist (MCPG) treatment of traumatic brain injury in rats. Brain Res. 700:1995;299-302.
35. Gozlan H., Khazipov R., Diabira D., Ben A.Y. In CA1 hippocampal neurons, the redox state of NMDA receptors determines LTP expressed by NMDA but not by AMPA receptors. J Neurophysiol. 73:1995;2612-2617.
36. Hayes R.L.et al. Preteatment with phencyclidine, an N-methyl-D-aspartate antagonist, attenuates long-term behavioural defecits in the rat produced by traumatic brain injury. J Neurotrauma. 5:1988;259-274.
37. Hebb DO. The organization of behavior. Chichester: Wiley, 1949.
38. Herrero I., Miras-Portugal M.T., Sánchez-Prieto J. Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation. Nature. 360:1992;163-166.
39. Herrero I., Miras-Portugal M.T., Sánchez-Prieto J. Rapid desensitization of the metabotropic glutamate receptor that facilitates glutamate release in rat cerebrocortical nerve terminals. Eur J Neurosci. 6:1994;115-120.
40. Hölscher C. Inhibitors of metabotropic glutamate receptors produce amnestic effects in chicks. NeuroReport. 5:1994;1037-1040.
41. Hölscher C., Anwyl R., Rowan M. Block of HFS-induced LTP in the dentate gyrus by 1S,3S-ACPD: Further evidence against LTP as a model for learning. NeuroReport. 8:1997;451-454.
42. Hölscher C., Anwyl R., Rowan M.J. Block of theta-burst induced LTP by 1S,3S-ACPD: Further evidence against LTP as a model for learning. Neuroscience. 81:1997;17-22.
43. Hölscher C., McGlinchey L., Anwyl R., Rowan M.J. HFS-induced long-term potentiation and depotentiation in area CA1 of the hippocampus are not good models for learning. Psychopharmacology. 130:1997;174-182.
44. Hölscher C., McGlinchey L., Rowan M.J. L-AP4 (L-(+)-2-amino-4-phosphonobutyric acid) induced impairment of spatial learning in the rat is antagonized by MAP4 ((S)-2-amino-2-methyl-4-phosphonobutanoic acid). Behav Brain Res. 81:1996;69-79.
45. Hölscher C, O'Mara S. Model learning and memory systems in neurobiological research: conditioning and associative learning procedures and spatial learning paradigms. In: Neuroscience labfax manual, chapter 20. New York: Academic Press, 1997.
46. Itano Y., Murayama T., Kitamura Y., Nomura Y. Glutamate inhibits adenylate cyclase activity in dispersed rat hippocampal cells directly via an N-methyl-D-aspartate-like metabotropic receptor. J Neurochem. 59:1992;822-828.
47. Jane D.E., Jones P.L.S.J., Pook P.C.-K., Tse H.-W., Watkins J.C. Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord. Br J Pharmacol. 112:1994;809-816.
48. Jane D.E., Pittaway K., Sunter D.C., Thomas N.K., Watkins J.C. New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology. 34:1995;851-856.
49. Jane D.E., Thomas N.K., Tse H.W., Watkins J.C. Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord. Neuropharmacology. 35:1996;1029-1035.
50. Johansen P.A.et al. Type 4a metabotropic glutamate receptor: identification of new potent agonists and differentiation from the L-(+)-2-amino-4-phosphonobutanoic acid-sensitive receptor in the lateral perforant pathway in rats. Mol Pharmacol. 48:1995;140-149.
51. Joly C.et al. Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: Comparison with mGluR1. J Neurosci. 15:1995;3970-3981.
52. Kaba H., Hayashi Y., Higuchi H., Nakanishi S. Induction of an olfactory memory by the activation of a metabotropic glutamate receptor. Science. 265:1994;262-264.
53. Laurie D.J., Danzeisen M., Boddeke H.W.G.M., Sommer B. Ligand binding profile of the rat metabotropic glutamate receptor mGluR3 expressed in a transfected cell line. Naunyn Schmiedebergs Arch Pharmacol. 351:1995;565.
54. Lisman J. A mechanism for the Hebb and the anti-Hebb process underlying learning and memory. Proc Natl Acad Sci USA. 86:1989;9574-9578.
55. Littman L., Munir M., Flagg S.D., Robinson M.B. Multiple mechanisms for inhibition of excitatory amino acid receptors coupled to phosphoinositide hydrolysis. J Neurochem. 59:1992;1893-1904.
56. Liu Y.-B., Disterhoft J.F., Slater N.T. Activation of metabotropic glutamate receptors induces long-term depression of GABAergic inhibition of hippocampus. J Neurophysiol. 69:1993;1000-1004.
57. Lu Y.et al. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci. 17:1997;5196-5205.
58. Maiese K., Swiriduk M., TenBroeke M. Cellular mechanisms of protection by metabotropic glutamate receptors during anoxia and nitric oxide toxicicty. J Neurochem. 66:1996;2419-2428.
59. Malinow R. Transmission between pairs of hippocampal slice neurons: Quantal levels, oscillations and LTP. Science. 252:1991;722-724.
60. Manahan-Vaughan D., Reymann K.G. 1S,3R-ACPD dose dependently induces a slow onset potentiation in the dentate gyrus in vivo. Neuropharmacology. 34:1995;1103-1105.
61. Manahan-Vaughan D., Reymann K.G. Regional and developmental profile of modulation of hippocampal synaptic transmission and LTP by AP4-sensitive mGluRs in vivo. Neuropharmacology. 34:1995;995-1005.
62. Martin S., Morris R. (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivo. Neuropharmacology. 36:1997;1339-1354.
63. McDonald J.W., Fix A.S., Tizzano J.P., Schoepp D.D. Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotrobic glutamate receptor agonist. J Neurosci. 13:1993;4445-4455.
64. McDonald J.W., Schoepp D.D. The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury. Eur J Pharmacol. 215:1992;353-354.
65. McGahon B., Lynch M.A. A study of the synergism between metabotropic glutamate receptor activation and arachidonic acid in the rat hippocampus. NeuroReport. 5:1994;2353-2357.
66. McIntosh T.K. Novel pharmacological therapies in the treatment of experimental traumatic brain injury: a review. J Neurotrauma. 10:1993;215-261.
67. Meldrum B.S. Excitatory amino acid receptors and their role in epilepsy and cerebral ischemia. Ann NY Acad Sci. 757:1995;492-505.
68. Mody I., Heinemann U. NMDA receptors of dentate granule cells participate in synaptic transmission following kindling. Nature. 326:1987;701-704.
69. Morris R.G.M., Anderson E., Lynch G.S., Baudry M. Selective impairment of learning and blockade of LTP by a NMDA receptor antagonist, AP5. Nature. 319:1986;774-776.
70. Mukhin A., Fan L., Faden A.I. Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury. J Neurosci. 16:1996;6012-6020.
71. Nakanishi S. Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity. Neuron. 13:1994;1031-1037.
72. Nicoletti F., Bruno V., Copani A., Casabona G., Knöpfel T. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci. 19:1996;267-271.
73. O'Mara S., Rowan M.J., Anwyl R. Metabotropic glutamate receptor-induced homosynaptic long-term depression and depotentiation in the dentate gyrus of the rat hippocampus in vitro. Neuropharmacology. 34:1995;983-989.
74. Okamoto N.et al. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. J Biol Chem. 269:1994;1231-1236.
75. Opitz T., Reymann K.G. (1S,3R)-ACPD protects synaptic transmission from hypoxia in hippocampal slices. Neuropharmacology. 32:1993;103-104.
76. Pekhletski R.et al. Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor. J Neurosci. 16:1996;6364-6373.
77. Pellicciari R.et al. 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. J Med Chem. 38:1995;3717-3719.
78. Peterson N.L., Kroona H.B., Johnson R.L., Koerner J.F. Activity of the conformationally rigid 2-amino-4-phosphonobutanoic acid (AP4) analogue (RS)-1-amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid (cyclobutylene AP5) on evoked responses in the perforant pathway of rat hippocampus. Brain Res. 571:1992;162-164.
79. Pin J.-P., Bockaert J. Get receptive to metabotropic glutamate receptors. Curr Opin Neurobiol. 5:1995;342-349.
80. Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology. 34:1995;1-26.
81. Pizzi M., Consolandi O., Memo M., Spano P. Activation of multiple metabotropic glutamate receptor subtypes prevents NMDA-induced excitotoxicity in rat hippocampal slices. Eur J Neurosci. 8:1996;1516-1521.
82. Reid S.N.M., Daw N.W. Activation of metabotropic glutamate receptors has different effects in different layers of cat visual cortex. Visual Neurosci. 14:1997;83-88.
83. Reid S.N.M., Romano C., Hughes T., Daw N.W. Immunohistochemical study of two phosphoinositide-linked metabotropic glutamate receptors (mGluR1a and mGluR5) in the cat visual cortex before, during and after the peak of the critical period for eye-specific connection. J Comp Neurol. 355:1995;470-478.
84. Richter-Levin G., Errington M.L., Maegawa H., Bliss T.V.P. Activation of metabotropic glutamate receptors is necessary for long-term potentiation in the dentate gyrus and for spatial learning. Neuropharmacology. 33:1994;853-857.
85. Rickard N.S., Ng K.T. Blockade of metabotropic glutamate receptors prevents long-term memory consolidation. Brain Res Bull. 36:1995;355-359.
86. Riedel G., Casabona G., Reymann K.G. Inhibition of long-term potentiation in the dentate gyrus of freely moving rats by the metabotropic glutamate receptor antagonist MCPG. J Neurosci. 15:1995;87-98.
87. Riedel G., Manahan-Vaughan D., Kozikowski A., Reymann K. Metabotropic glutamate receptor agonist trans-azetidine-2,4-dicarboxylic acid facilitates maintenance of LTP in the dentate gyrus in vivo. Neuropharmacology. 34:1995;1107-1109.
88. Riedel G., Reymann K.G. An antagonist of the metabotropic glutamate receptor prevents LTP in the dentate gyrus of freely moving rats. Neuropharmacology. 32:1993;929-931.
89. Riedel G., Reymann K.G. Metabotropic glutamate receptors in hippocampal long-term potentiation and learning and memory. Acta Physiol Scand. 157:1996;1-19.
90. Riedel G., Wetzel W., Kozikowski A.P., Reymann K.G. Block of spatial learning by mGluR agonist tADA in rats. Neuropharmacology. 34:1995;559-561.
91. Riedel G., Wetzel W., Reymann K.G. (R,S)-α-methyl-4-carboxyphenylglycine (MCPG) blocks spatial learning in rats and long-term potentiation in the dentate gyrus in vivo. Neurosci Lett. 167:1994;141-144.
92. Rosdahl D., Seitzberg D.A., Christensen T., Balchen T., Diemer N.H. Changes in mRNA for metabotropic receptors after transient cerebral ischaemia. NeuroReport. 5:1994;593-596.
93. Rose SPR. On chicks and Rosetta stones. In: Butters S, editor. Neuropsychology of memory. New York: Guildford Press, 547-556.
94. Sacaan A.I., Schoepp D.D. Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage. Neurosci Lett. 139:1992;77-82.
95. Sacaan A.L., Monn J.A., Schoepp D.D. Intrastriatal injection of a selective metabotropic excitatory amino acid receptor agonist induces contralateral turning in the rat. J Pharmacol Exp Therap. 259:1991;1366-1370.
96. Sánchez-Prietro J., Budd D.C., Herrero I., Vázquez E., Nicholls D.G. Presynaptic receptors and the control of glutamate exocytosis. Trends Neurosci. 19:1996;235-240.
97. Saugstad J.A., Kinzie J.M., Mulvihill E.R., Segerson T.P., Westbrook G.L. Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors. Mol Pharmacol. 45:1994;367-372.
98. Saugstad J.A., Kinzie J.M., Segerson T.P., Westbrook G.L. Agonist profile of recombinant rat mGluR8. Neuropharmacology. 35:1996;A27.
99. Saugstad J.A., Kinzie J.M., Shinohara M.M., Segerson T.P., Westbrook G.L. Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile. Mol Pharmacol. 51:1997;119-125.
100. Saugstad J.A., Segerson T.P., Westbrook G.L. L-2-amino-3-phosphonopropionic acid competitively antagonizes metabotropic glutamate receptors 1a and 5 in Xenopus oocytes. Eur J Pharmacol Mol Pharmacol. 289:1995;395-397.
101. Saugstad JA, Segerson TP, Westbrook GL. Modulation of ion channels and synaptic transmission by metabotropic glutamate receptors. In: Thomson W, editor. Excitatory amino acids and synaptic transmission. New York: Academic Press, 1995.
102. Saugstad J.A., Segerson T.P., Westbrook G.L. Metabotropic glutamate receptors activate G-protein-coupled inwardly rectifying potassium channels in Xenopus oocytes. J Neurosci. 16:1996;5979-5985.
103. Schoepp D. 3,5-Dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus. J Neurochem. 63:1994;769-775.
104. Schoepp D.D., Conn P.J. Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol. 14:1993;13-20.
105. Schoepp D.D., Johnson B.G. Pharmacology of metabotropic glutamate receptor inhibition of cyclic AMP formation in the adult rat hippocampus. Neurochem Int. 22:1993;277-283.
106. Schoepp D.D., Johnson B.G., Monn J.A. Inhibition of cyclic AMP formation by a selective metabotropic glutamate receptor agonist. J Neurochem. 58:1992;1184-1186.
107. Schoepp D.D. Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, R,4R-4-aminopyrrolidine-2,4-dicarboxylate. Neuropharmacology. 34:1995;843-850.
108. Selden N.R.W., Cole B.J., Everitt B.J., Robbins T.W. Damage to ceruleo-cortical noradrenergic projections impairs locally cued but enhances spatially cued water maze acquisition. Behav Brain Res. 39:1990;29-51.
109. Selig D.K., Lee H.K., Bear M.F., Malenka R.C. Re-examination of the effects of MCPG on hippocampal LTP, LTD and depotentiation. J Neurophysiol. 74:1995;1075-1082.
110. Shapira Y., Yadid C., Cotev A., Niska A., Shohami E. Protective effect of MK-801 in experimental brain trauma. J Neurotrauma. 1:1990;131-139.
111. Shaw P.J. Excitatory amino acid receptors, excitotoxicity, and the human nervous system. Curr Opin Neurol Neurosurg. 6:1993;414-422.
112. Shigemoto R.et al. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J Neurosci. 17:1997;7503-7522.
113. Shigemoto R.et al. Target-cell-specific concentration of a metabotropic glutamater receptor in the presynaptic active zone. Nature. 381:1996;523-525.
114. Sladeczeck F., Momiyama A., Takahashi T. Presynaptic inhibitory action of a metabotropic glutamate receptor agonist on excitatory neurotransmission in visual cortical neurons. Proc R Soc Lond B. 253:1993;297-303.
115. Swartz K.J., Bean B.P. Inhibition of calcium channels in rat CA3 pyramidal neurons by a metabotropic glutamate receptor. J Neurosci. 12:1992;4358-4371.
116. Tanabe Y., Masu M., Ishii T., Shigemoto R., Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 8:1992;169-179.
117. Tanabe Y.et al. Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. J Neurosci. 13:1993;1372-1378.
118. Thomas M.J., O'Dell T.J. The molecular switch hypothesis fails to explain the inconsistent effects of the metabotropic glutamate receptor antagonist MCPG on LTP. Brain Res. 695:1995;45-52.
119. Thomsen C., Bruno V., Nicoetti F., Marinozzi M., Pellicciari R. (2S, 1′S, 2′S, 3′R)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors. Mol Pharmacol. 50:1996;6-9.
120. Thomsen C., Suzdak D. Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor. Neuroreport. 4:1993;1099-1101.
121. Toulmond S., Serrano A., Benavides J., Scatton B. Prevention by eliprodil (SL 82,0715) of traumatic brain damage in the rat: existence of a large (18 h) therapeutic window. Brain Res. 620:1993;32-41.
122. Watkins J., Collingridge G. Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. Trends Pharmac Sci. 15:1994;333-342.
123. Winder D.G., Conn P.J. Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine. J Neurosci. 13:1993;38-44.
124. Yokoi M.et al. Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science. 273:1996;645-650.
125. Zheng F., Lonart G., Johnson K. M., Gallagher J. P. (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) induces burst firing via an inositol-1,4,5-triphosphate-independent pathway at rat dorsolateral septal nucleus. Neuropharmacology. 33:1994;97-102.