Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of Parkinsonism

Journal of Neuroscience

Volumn 22, Issue 13, 2002, Pages 5669-5678

  Breysse, Nathalie ^a   Baunez, Christelle ^a   Spooren, Will ^b,c   Gasparini, Fabrizio ^b   Amalric, Marianne ^a  

^a CNRS   (France)

^b NOVARTIS PHARMA AG   (Switzerland)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

6 OHDA lesions; Basal ganglia; Glutamate; Metabotropic receptor antagonist; Metabotropic receptors (mGluR5 subtype); MPEP; Parkinson's disease; Rat; Reaction time task

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; GLUTAMATE 5 RECEPTOR ANTAGONIST; GLUTAMATE RECEPTOR ANTAGONIST; HALOPERIDOL; METABOTROPIC RECEPTOR ANTAGONIST; OXIDOPAMINE; UNCLASSIFIED DRUG;

AKINESIA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; CATALEPSY; CONTROLLED STUDY; CORPUS STRIATUM; DEGENERATIVE DISEASE; EXTRAPYRAMIDAL SYSTEM; LONG TERM CARE; MALE; MOTOR PERFORMANCE; NERVE ENDING; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; RAT; REACTION TIME; RECEPTOR BLOCKING;

EID: 0036662945     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-13-05669.2002     Document Type: Article

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