Anticonvulsant activity of two metabotropic glutamate Group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893)

Neuropharmacology

Volumn 39, Issue 9, 2000, Pages 1567-1574

  Chapman, Astrid G ^a   Nanan, Karl ^a   Williams, Martin ^a   Meldrum, Brian S ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Anticonvulsant; CHPG; DBA 2 mice; DHPG; Glutamate metabotropic receptor; Lethargic mice (lh lh); mGlu5

Indexed keywords

2 CHLORO 5 PHENYLGLYCINE; 2 METHYL 6 (2 PHENYLVINYL)PYRIDINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3,5 DIHYDROXYPHENYLGLYCINE; 6 METHYL 2 STYRYLPYRIDINE; ANTICONVULSIVE AGENT; GLUTAMATE RECEPTOR AGONIST; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; LETHARGY; MALE; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE; STRAIN DIFFERENCE; TONIC SEIZURE;

ANIMALS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GLYCINE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICE, INBRED DBA; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; RESORCINOLS; SEIZURES; SOUND; TIME FACTORS;

EID: 0034105111     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00242-7     Document Type: Article

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