The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat

Nicotine and Tobacco Research

Volumn 3, Issue 4, 2001, Pages 361-373

  Markou, A ^a   Paterson, N E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MECAMYLAMINE; METHYLLYCACONITINE; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; DRUG DEPENDENCE; DRUG EFFECT; DRUG EXPOSURE; MALE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; REINFORCEMENT; WITHDRAWAL SYNDROME;

ACONITINE; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; ELECTRODES, IMPLANTED; MALE; NICOTINE; NICOTINIC ANTAGONISTS; RATS; RATS, WISTAR; REWARD; SELF ADMINISTRATION; SUBSTANCE WITHDRAWAL SYNDROME; TOBACCO USE DISORDER;

EID: 0035180103     PISSN: 14622203     EISSN: None     Source Type: Journal    
DOI: 10.1080/14622200110073380     Document Type: Article

References (78)

1. Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist
2. Potentiation of lateral hypothalamic and midline mesencephalic brain stimulation reinforcement by nicotine: Examination of repeated treatment
3. Nicotine cue: Lack of effect of the α7 receptor antagonist methyllycaconitine
4. The pharmacology of (-)-nicotine and novel cholinergic channel modulators
5. Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat
6. Nicotine reinstatement of nicotine self-administration after long-term extinction
7. Nicotine binding in rat brain: Autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin
8. Mesolimbic dopamine activation - The key to nicotine reinforcement?
9. The fall and rise of neuronal α-bungarotoxin binding proteins
10. Nicotine does not improve discrimination of brain stimulation reward by rats
11. Nicotine maintains robust self-administration in rats on a limited access schedule
12. Selective dopamine antagonists reduce nicotine self-administration
13. The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
14. Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area
15. Nicotinic receptors at the amino acid level
16. In vivo pharmacological effects of dihydro-β-erythroidine, a nicotinic antagonist, in mice
17. Nicotine self-administration in rats
18. Acquisition of nicotine self-administration in rats: The effects of dose, feeding schedule, and drug contingency
19. Methyllycaconitine: A novel nicotinic antagonist
20. Dramatic decreases in brain reward function during nicotine withdrawal
21. A subtype of nicotinic cholinergic receptors in rat brain is composed of α4 and β2 sub-units and is up-regulated by chronic nicotine treatment
22. Lateralization of reward in rats: Differences in reinforcing thresholds
23. An oral self-administration model of nicotine preference in rats: Effects of mecamylamine
24. Maintenance and suppression of behavior by intravenous nicotine injections in squirrel monkeys
25. Persistent behavior at high rates maintained by intravenous self-administration of nicotine
26. Uptake and distribution of some quaternary ammonium compounds in the central nervous system of the rat
27. Evidence that nicotinic alpha 7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine
28. Behavioral manifestations of the nicotine abstinence syndrome in the rat: Peripheral versus central mechanisms
29. Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying the mecamylamine-precipitated nicotine withdrawal syndrome
30. Behavioral and biochemical manifestations of mecamylamine-precipitated nicotine withdrawal in the rat: Role of nicotinic receptors in the ventral tegmental area
31. Symptoms of tobacco withdrawal: A replication and extension
32. Effects of nicotine on the threshold for rewarding brain stimulation in rats
33. Opponent process and drug dependence: Neurobiological mechanisms
34. Euphorigenic drugs: Effects on reward pathways of the brain
35. Methyllycaconitine and (+)-anatoxin-a differentiate between nicotinic receptors in vertebrate and invertebrate nervous systems
36. Rodent model of nicotine abstinence syndrome
37. The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat
38. The effect of operant and electrode placement on self-stimulation train duration response functions
39. Construct validity of a self-stimulation threshold paradigm: Effects of reward and performance manipulations
40. Intracranial self-stimulation thresholds as a measure of reward
41. Neurobiological similarities in depression and drug dependence: A self-medication hypothesis
42. Nicotinic binding sites in rat and mouse brain: Comparison of acetylcholine, nicotine, and alpha-bungarotoxin
43. Isradipine inhibits nicotine intravenous self-administration in drug-naive mice
44. Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine
45. Nicotine administration to rats: Methodological considerations
46. Nicotine withdrawal in the rat: Role of α7 nicotinic receptors in the ventral tegmental area
47. Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents
48. Effects of methyllycaconitine (MLA), an α7 nicotinic receptor antagonist, on nicotine- and cocaine-induced potentiation of brain stimulation reward
49. Neuroanatomical bases of ICSS - Untying the Gordian knot
50. Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine
51. A comparison of nicotine and cocaine self-administration in the dog: Fixed-ratio and progressive-ratio schedules of intravenous drug infusion
52. Nicotine self-administration in animals and humans: Similarities and differences
53. The effect of sertraline on nicotine self-administration and food-maintained responding in squirrel monkeys
54. The diversity of neuronal nicotinic acetylcholine receptors
55. Molecular cloning. Functional properties, and distribution of rat brain α7: A nicotinic cation channel highly permeable to calcium
56. Reinstatement and spontaneous recovery of nicotine seeking in rats
57. Smoking withdrawal symptoms within two weeks of abstinence
58. Nicotine self-administration in rats: Strain and nicotine pre-exposure effects on acquisition
59. Maintenance of schedule-controlled behavior by intravenous injections of nicotine in squirrel monkeys
60. Pharmacological basis of ICSS reward
61. Smoking relapse: The role of pharmacological and behavioral factors
62. The scientific case that nicotine is addictive
63. Selective antagonism of behavioural effects of nicotine by dihydro-beta-erythroidine in rats
64. A sensitive technique for the detection of the α7 neuronal nicotinic acetylcholine receptor antagonist, methyllycaconitine, in rat plasma and brain
65. Methyllycaconitine: A selective probe for neuronal α-bungarotoxin binding sites
66. Blockade of nicotine self-administration with nicotinic antagonists in rats
67. Neural mechanisms underlying nicotine addiction: Acute positive reinforcement and withdrawal
68. Reward and somatic changes during precipitated nicotine withdrawal in rats: Centrally and peripherally mediated effects
69. Blockade of the reward potentiating effect of nicotine on lateral hypothalamic brain stimulation by chlorisondamine
70. Presynaptic nicotinic ACh receptors
71. Methyllycaconitine: A new probe that discriminates between nicotinic acetylcholine receptor subclasses
72. Nicotinic acetylcholine receptors in separate brain regions exhibit different affinities for methyllycaconitine
73. Identification of four classes of brain nicotinic receptors using β2 mutant mice