A double-blind, placebo controlled, dose ranging study to evaluate the safety and biological efficacy of the lipid-DNA complex GR213487B in the nasal epithelium of adult patients with cystic fibrosis

Human Gene Therapy

Volumn 9, Issue 2, 1998, Pages

  Knowles, Michael R ^a   Noone, Peadar G ^a   Hohneker, Kathy ^a   Johnson, Larry G ^a   Boucher, Richard C ^a   Efthimiou, John ^b   Crawford, Catriona ^b   Brown, Ronan ^b   Schwartzbach, Caryl ^c   Pearlman, Rodney ^d  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c GLAXOSMITHKLINE   (United States)

^d Megabios Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; DNA; DORNASE ALFA; LIPID; LIPOSOME; NONSTEROID ANTIINFLAMMATORY AGENT; TETRACYCLINE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CYSTIC FIBROSIS; DOSE CALCULATION; GENE TRANSFER; HUMAN; NOSE MUCOSA; PATIENT SELECTION;

EID: 17344365059     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.2-249     Document Type: Article

References (5)

1. Boat TF, Welsh MJ, Beaudet AL. Cystic fibrosis. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The Metabolic Basis of Inherited Disease. McGraw-Hill, New York 1989;2649-80.
2. Hodson ME. Cystic fibrosis:respiratory disease in adults In: Hodson ME, Geddes DM, editors. Cystic Fibrosis. Chapman & Hall Medical 1994;237-259.
3. Welsh MJ. Abnormal regulation of ion channels in cystic fibrosis epithelia. FASEB J 1990; 4:2718-25.
4. Cheng SH, Gregory RJ, Marshall J et al. Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis. Cell 1990;63:827-34.
5. Knowles MR, Gatzy JT, Boucher RC. Increased bioelectric potential difference across respiratory epithelia in cystic fibrosis. N Engl J Med 1981; 305:1489-95.