Functional evidence of CFTR gene transfer in nasal epithelium of cystic fibrosis mice in vivo following luminal application of DNA complexes targeted to the serpin-enzyme complex receptor

Molecular Therapy

Volumn 5, Issue 4, 2002, Pages 413-419

  Ziady, Assem Galal ^a   Kelley, Thomas J ^a   Milliken, Erin ^a   Ferkol, Thomas ^b   Davis, Pamela B ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Airway epithelia; Apical gene delivery; CF mutant mice; Poly L lysine; Receptor mediated gene transfer

Indexed keywords

BETA GALACTOSIDASE; CELL RECEPTOR; COMPLEMENTARY DNA; CYCLIC AMP; DNA; INDUCIBLE NITRIC OXIDE SYNTHASE; LIGAND; NITRIC OXIDE SYNTHASE; PLASMID DNA; SERPIN ENZYME COMPLEX RECEPTOR; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHLORIDE TRANSPORT; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONJUGATION; CONTROLLED STUDY; CYSTIC FIBROSIS; DOWN REGULATION; DRUG TARGETING; ELECTROPHYSIOLOGY; EPITHELIUM CELL; GENE EXPRESSION; GENETIC CODE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; NOSE MUCOSA; SUBMUCOSA;

ANIMALIA;

EID: 0036222250     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2002.0556     Document Type: Article

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