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Volumn 286, Issue 2, 2003, Pages 241-251

Upregulation and antiapoptotic role of endogenous Alzheimer amyloid precursor protein in dorsal root ganglion neurons

Author keywords

Alzheimer amyloid precursor protein; Alzheimer's disease; Apoptosis; Caspase 3; Dorsal root ganglion; Nerve growth factor; Proteolytic processing; Sensory neurons

Indexed keywords

ADENOVIRUS VECTOR; AMYLOID PRECURSOR PROTEIN; ANTIBODY; CASPASE 3; MEMBRANE PROTEIN; NERVE GROWTH FACTOR; OLIGODEOXYNUCLEOTIDE;

EID: 0037960223     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4827(03)00066-1     Document Type: Article
Times cited : (24)

References (55)
  • 2
    • 0028267440 scopus 로고
    • Normal and abnormal biology of the beta-amyloid precursor protein
    • Selkoe D.J. Normal and abnormal biology of the beta-amyloid precursor protein. Annu. Rev. Neurosci. 17:1994;489-517.
    • (1994) Annu. Rev. Neurosci. , vol.17 , pp. 489-517
    • Selkoe, D.J.1
  • 3
    • 0029896354 scopus 로고    scopus 로고
    • Mechanisms of neuronal degeneration in Alzheimer's disease
    • Yankner B.A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 16:1996;921-932.
    • (1996) Neuron , vol.16 , pp. 921-932
    • Yankner, B.A.1
  • 4
    • 0030779677 scopus 로고    scopus 로고
    • Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
    • Mattson M.P. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol. Rev. 77:1997;1081-1132.
    • (1997) Physiol. Rev. , vol.77 , pp. 1081-1132
    • Mattson, M.P.1
  • 5
    • 0024997546 scopus 로고
    • Neural differentiation increases expression of Alzheimer amyloid protein precursor gene in murine embryonal carcinoma cells
    • Yoshikawa K., Aizawa T., Maruyama K. Neural differentiation increases expression of Alzheimer amyloid protein precursor gene in murine embryonal carcinoma cells. Biochem. Biophys. Res. Commun. 171:1990;204-209.
    • (1990) Biochem. Biophys. Res. Commun. , vol.171 , pp. 204-209
    • Yoshikawa, K.1    Aizawa, T.2    Maruyama, K.3
  • 6
    • 0026767361 scopus 로고
    • Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage
    • Hung A.Y., Koo E.H., Haass C., Selkoe D.J. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proc. Natl. Acad. Sci. USA. 89:1992;9439-9443.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9439-9443
    • Hung, A.Y.1    Koo, E.H.2    Haass, C.3    Selkoe, D.J.4
  • 7
    • 0026779680 scopus 로고
    • Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor
    • Yoshikawa K., Aizawa T., Hayashi Y. Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature. 359:1992;64-67.
    • (1992) Nature , vol.359 , pp. 64-67
    • Yoshikawa, K.1    Aizawa, T.2    Hayashi, Y.3
  • 9
    • 0026646280 scopus 로고
    • Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat
    • Stephenson D.T., Rash K., Clemens J.A. Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat. Brain Res. 593:1992;128-135.
    • (1992) Brain Res. , vol.593 , pp. 128-135
    • Stephenson, D.T.1    Rash, K.2    Clemens, J.A.3
  • 11
    • 0025778325 scopus 로고
    • Beta-amyloid precursor protein gene is differentially expressed in axotomized sensory and motor systems
    • Scott J.N., Parhad I.M., Clark A.W. Beta-amyloid precursor protein gene is differentially expressed in axotomized sensory and motor systems. Brain Res. Mol. Brain Res. 10:1991;315-325.
    • (1991) Brain Res. Mol. Brain Res. , vol.10 , pp. 315-325
    • Scott, J.N.1    Parhad, I.M.2    Clark, A.W.3
  • 12
    • 0026671821 scopus 로고
    • Beta-amyloid precursor protein localization in the Golgi apparatus in neurons and oligodendrocytes. An immunocytochemical structural and ultrastructural study in normal and axotomized neurons
    • Palacios G., Palacios J.M., Mengod G., Frey P. Beta-amyloid precursor protein localization in the Golgi apparatus in neurons and oligodendrocytes. An immunocytochemical structural and ultrastructural study in normal and axotomized neurons. Brain Res. Mol. Brain Res. 15:1992;195-206.
    • (1992) Brain Res. Mol. Brain Res. , vol.15 , pp. 195-206
    • Palacios, G.1    Palacios, J.M.2    Mengod, G.3    Frey, P.4
  • 14
    • 0024815331 scopus 로고
    • The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects
    • Benowitz L.I., Rodriguez W., Paskevich P., Mufson E.J., Schenk D., Neve R.L. The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects. Exp. Neurol. 106:1989;237-250.
    • (1989) Exp. Neurol. , vol.106 , pp. 237-250
    • Benowitz, L.I.1    Rodriguez, W.2    Paskevich, P.3    Mufson, E.J.4    Schenk, D.5    Neve, R.L.6
  • 16
    • 0026718402 scopus 로고
    • Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease
    • Cummings B.J., Su J.H., Geddes J.W., Van Nostrand W.E., Wagner S.L., Cunningham D.D., Cotman C.W. Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience. 48:1992;763-777.
    • (1992) Neuroscience , vol.48 , pp. 763-777
    • Cummings, B.J.1    Su, J.H.2    Geddes, J.W.3    Van Nostrand, W.E.4    Wagner, S.L.5    Cunningham, D.D.6    Cotman, C.W.7
  • 17
    • 0026058318 scopus 로고
    • Cell death during development of the nervous system
    • Oppenheim R.W. Cell death during development of the nervous system. Annu. Rev. Neurosci. 14:1991;453-501.
    • (1991) Annu. Rev. Neurosci. , vol.14 , pp. 453-501
    • Oppenheim, R.W.1
  • 18
    • 0027186004 scopus 로고
    • Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons
    • Buchman V.L., Davies A.M. Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons. Development. 118:1993;989-1001.
    • (1993) Development , vol.118 , pp. 989-1001
    • Buchman, V.L.1    Davies, A.M.2
  • 19
    • 0032736358 scopus 로고    scopus 로고
    • Developmental changes in the response of trigeminal neurons to neurotrophins: Influence of birthdate and the ganglion environment
    • Enokido Y., Wyatt S., Davies A.M. Developmental changes in the response of trigeminal neurons to neurotrophins influence of birthdate and the ganglion environment . Development. 126:1999;4365-4373.
    • (1999) Development , vol.126 , pp. 4365-4373
    • Enokido, Y.1    Wyatt, S.2    Davies, A.M.3
  • 20
  • 22
    • 0036318022 scopus 로고    scopus 로고
    • Necdin is required for terminal differentiation and survival of primary dorsal root ganglion neurons
    • Takazaki R., Nishimura I., Yoshikawa K. Necdin is required for terminal differentiation and survival of primary dorsal root ganglion neurons. Exp. Cell Res. 277:2002;220-232.
    • (2002) Exp. Cell Res. , vol.277 , pp. 220-232
    • Takazaki, R.1    Nishimura, I.2    Yoshikawa, K.3
  • 24
    • 0030070724 scopus 로고    scopus 로고
    • Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome
    • Miyake S., Makimura M., Kanegae Y., Harada S., Sato Y., Takamori K., Tokuda C., Saito I. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc. Natl. Acad. Sci. USA. 93:1996;1320-1324.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 1320-1324
    • Miyake, S.1    Makimura, M.2    Kanegae, Y.3    Harada, S.4    Sato, Y.5    Takamori, K.6    Tokuda, C.7    Saito, I.8
  • 25
    • 0032053984 scopus 로고    scopus 로고
    • Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer
    • Nishimura I., Uetsuki T., Dani S.U., Ohsawa Y., Saito I., Okamura H., Uchiyama Y., Yoshikawa K. Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer. J. Neurosci. 18:1998;2387-2398.
    • (1998) J. Neurosci. , vol.18 , pp. 2387-2398
    • Nishimura, I.1    Uetsuki, T.2    Dani, S.U.3    Ohsawa, Y.4    Saito, I.5    Okamura, H.6    Uchiyama, Y.7    Yoshikawa, K.8
  • 26
    • 0033566644 scopus 로고    scopus 로고
    • Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein
    • Uetsuki T., Takemoto K., Nishimura I., Okamoto M., Niinobe M., Momoi T., Miura M., Yoshikawa K. Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein. J. Neurosci. 19:1999;6955-6964.
    • (1999) J. Neurosci. , vol.19 , pp. 6955-6964
    • Uetsuki, T.1    Takemoto, K.2    Nishimura, I.3    Okamoto, M.4    Niinobe, M.5    Momoi, T.6    Miura, M.7    Yoshikawa, K.8
  • 27
    • 0001585073 scopus 로고
    • Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain
    • Mobley W.C., Neve R.L., Prusiner S.B., McKinley M.P. Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain. Proc. Natl. Acad. Sci. USA. 85:1988;9811-9815.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9811-9815
    • Mobley, W.C.1    Neve, R.L.2    Prusiner, S.B.3    McKinley, M.P.4
  • 28
    • 0027459976 scopus 로고
    • Nerve growth factor-induced neuronal differentiation is accompanied by differential induction and localization of the amyloid precursor protein (APP) in PC12 cells and variant PC12S cells
    • Fukuyama R., Chandrasekaran K., Rapoport S.I. Nerve growth factor-induced neuronal differentiation is accompanied by differential induction and localization of the amyloid precursor protein (APP) in PC12 cells and variant PC12S cells. Brain Res. Mol. Brain Res. 17:1993;17-22.
    • (1993) Brain Res. Mol. Brain Res. , vol.17 , pp. 17-22
    • Fukuyama, R.1    Chandrasekaran, K.2    Rapoport, S.I.3
  • 29
    • 0027481495 scopus 로고
    • Effect of growth factors and cytokines on expression of amyloid beta protein precursor mRNAs in cultured neural cells
    • Ohyagi Y., Tabira T. Effect of growth factors and cytokines on expression of amyloid beta protein precursor mRNAs in cultured neural cells. Brain Res. Mol. Brain Res. 18:1993;127-132.
    • (1993) Brain Res. Mol. Brain Res. , vol.18 , pp. 127-132
    • Ohyagi, Y.1    Tabira, T.2
  • 30
    • 0029888642 scopus 로고    scopus 로고
    • Nerve growth factor and ras regulate beta-amyloid precursor protein gene expression in PC12 cells
    • Cosgaya J.M., Latasa M.J., Pascual A. Nerve growth factor and ras regulate beta-amyloid precursor protein gene expression in PC12 cells. J. Neurochem. 67:1996;98-104.
    • (1996) J. Neurochem. , vol.67 , pp. 98-104
    • Cosgaya, J.M.1    Latasa, M.J.2    Pascual, A.3
  • 31
    • 0026663993 scopus 로고
    • The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth
    • Milward E.A., Papadopoulos R., Fuller S.J., Moir R.D., Small D., Beyreuther K., Masters C.L. The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron. 9:1992;129-137.
    • (1992) Neuron , vol.9 , pp. 129-137
    • Milward, E.A.1    Papadopoulos, R.2    Fuller, S.J.3    Moir, R.D.4    Small, D.5    Beyreuther, K.6    Masters, C.L.7
  • 32
    • 0027212769 scopus 로고
    • Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system
    • Sisodia S.S., Koo E.H., Hoffman P.N., Perry G., Price D.L. Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J. Neurosci. 13:1993;3136-3142.
    • (1993) J. Neurosci. , vol.13 , pp. 3136-3142
    • Sisodia, S.S.1    Koo, E.H.2    Hoffman, P.N.3    Perry, G.4    Price, D.L.5
  • 33
    • 0028913471 scopus 로고
    • Trafficking of cell surface beta-amyloid precursor protein: Retrograde and transcytotic transport in cultured neurons
    • Yamazaki T., Selkoe D.J., Koo E.H. Trafficking of cell surface beta-amyloid precursor protein retrograde and transcytotic transport in cultured neurons . J. Cell Biol. 129:1995;431-442.
    • (1995) J. Cell Biol. , vol.129 , pp. 431-442
    • Yamazaki, T.1    Selkoe, D.J.2    Koo, E.H.3
  • 34
    • 0033636136 scopus 로고    scopus 로고
    • Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I
    • Kamal A., Stokin G.B., Yang Z., Xia C.H., Goldstein L.S. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron. 28:2000;449-459.
    • (2000) Neuron , vol.28 , pp. 449-459
    • Kamal, A.1    Stokin, G.B.2    Yang, Z.3    Xia, C.H.4    Goldstein, L.S.5
  • 35
    • 0034029430 scopus 로고    scopus 로고
    • Monoclonal antibody to amyloid precursor protein induces neuronal apoptosis
    • Rohn T.T., Ivins K.J., Bahr B.A., Cotman C.W., Cribbs D.H.A. monoclonal antibody to amyloid precursor protein induces neuronal apoptosis. J. Neurochem. 74:2000;2331-2342.
    • (2000) J. Neurochem. , vol.74 , pp. 2331-2342
    • Rohn, T.T.1    Ivins, K.J.2    Bahr, B.A.3    Cotman, C.W.4    Cribbs, D.H.A.5
  • 37
    • 0032146775 scopus 로고    scopus 로고
    • Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons
    • Barnes N.Y., Li L., Yoshikawa K., Schwartz L.M., Oppenheim R.W., Milligan C.E. Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons. J. Neurosci. 18:1998;5869-5880.
    • (1998) J. Neurosci. , vol.18 , pp. 5869-5880
    • Barnes, N.Y.1    Li, L.2    Yoshikawa, K.3    Schwartz, L.M.4    Oppenheim, R.W.5    Milligan, C.E.6
  • 38
    • 0032077640 scopus 로고    scopus 로고
    • Increased expression of amyloid precursor protein and amyloid precursor-like protein 2 during trophic factor withdrawal- induced death of neuronal PC12 cells
    • Araki W., Wurtman R.J. Increased expression of amyloid precursor protein and amyloid precursor-like protein 2 during trophic factor withdrawal- induced death of neuronal PC12 cells. Brain Res. Mol. Brain Res. 56:1998;169-177.
    • (1998) Brain Res. Mol. Brain Res. , vol.56 , pp. 169-177
    • Araki, W.1    Wurtman, R.J.2
  • 39
    • 0027421474 scopus 로고
    • The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix
    • Schubert D., Behl C. The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix. Brain Res. 629:1993;275-282.
    • (1993) Brain Res. , vol.629 , pp. 275-282
    • Schubert, D.1    Behl, C.2
  • 40
    • 0029924264 scopus 로고    scopus 로고
    • Neurotrophic and neuroprotective effects of hAPP in transgenic mice
    • Mucke L., Abraham C.R., Masliah E. Neurotrophic and neuroprotective effects of hAPP in transgenic mice. Ann. N.Y. Acad. Sci. 777:1996;82-88.
    • (1996) Ann. N.Y. Acad. Sci. , vol.777 , pp. 82-88
    • Mucke, L.1    Abraham, C.R.2    Masliah, E.3
  • 41
    • 0031453752 scopus 로고    scopus 로고
    • The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity
    • Perez R.G., Zheng H., Van der Ploeg L.H., Koo E.H. The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J. Neurosci. 17:1997;9407-9414.
    • (1997) J. Neurosci. , vol.17 , pp. 9407-9414
    • Perez, R.G.1    Zheng, H.2    Van der Ploeg, L.H.3    Koo, E.H.4
  • 42
    • 0033595020 scopus 로고    scopus 로고
    • Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis
    • Xu X., Yang D., Wyss-Coray T., Yan J., Gan L., Sun Y., Mucke L. Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA. 96:1999;7547-7552.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7547-7552
    • Xu, X.1    Yang, D.2    Wyss-Coray, T.3    Yan, J.4    Gan, L.5    Sun, Y.6    Mucke, L.7
  • 44
    • 0029910628 scopus 로고    scopus 로고
    • Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
    • Macleod K.F., Hu Y., Jacks T. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 15:1996;6178-6188.
    • (1996) EMBO J. , vol.15 , pp. 6178-6188
    • Macleod, K.F.1    Hu, Y.2    Jacks, T.3
  • 45
    • 0032400818 scopus 로고    scopus 로고
    • Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis
    • Bursztajn S., DeSouza R., McPhie D.L., Berman S.A., Shioi J., Robakis N.K., Neve R.L. Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis. J. Neurosci. 18:1998;9790-9799.
    • (1998) J. Neurosci. , vol.18 , pp. 9790-9799
    • Bursztajn, S.1    DeSouza, R.2    McPhie, D.L.3    Berman, S.A.4    Shioi, J.5    Robakis, N.K.6    Neve, R.L.7
  • 46
    • 0035829720 scopus 로고    scopus 로고
    • Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila
    • Gunawardena S., Goldstein L.S. Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. Neuron. 32:2001;389-401.
    • (2001) Neuron , vol.32 , pp. 389-401
    • Gunawardena, S.1    Goldstein, L.S.2
  • 47
    • 0037013327 scopus 로고    scopus 로고
    • Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis
    • Kienlen-Campard P., Miolet S., Tasiaux B., Octave J.N. Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis. J. Biol. Chem. 277:2002;15666-15670.
    • (2002) J. Biol. Chem. , vol.277 , pp. 15666-15670
    • Kienlen-Campard, P.1    Miolet, S.2    Tasiaux, B.3    Octave, J.N.4
  • 48
    • 0035834340 scopus 로고    scopus 로고
    • Neurotoxic and neuroprotective effects of glutamate are enhanced by introduction of amyloid precursor protein cDNA
    • Tominaga-Yoshino K., Uetsuki T., Yoshikawa K., Ogura A. Neurotoxic and neuroprotective effects of glutamate are enhanced by introduction of amyloid precursor protein cDNA. Brain Res. 918:2001;121-130.
    • (2001) Brain Res. , vol.918 , pp. 121-130
    • Tominaga-Yoshino, K.1    Uetsuki, T.2    Yoshikawa, K.3    Ogura, A.4
  • 49
    • 0037112117 scopus 로고    scopus 로고
    • Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein
    • Kuwako K., Nishimura I., Uetsuki T., Saido T.C., Yoshikawa K. Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein. Brain Res. Mol. Brain Res. 107:2002;166-175.
    • (2002) Brain Res. Mol. Brain Res. , vol.107 , pp. 166-175
    • Kuwako, K.1    Nishimura, I.2    Uetsuki, T.3    Saido, T.C.4    Yoshikawa, K.5
  • 51
    • 0033551738 scopus 로고    scopus 로고
    • Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease
    • LeBlanc A., Liu H., Goodyer C., Bergeron C., Hammond J. Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease. J. Biol. Chem. 274:1999;23426-23436.
    • (1999) J. Biol. Chem. , vol.274 , pp. 23426-23436
    • LeBlanc, A.1    Liu, H.2    Goodyer, C.3    Bergeron, C.4    Hammond, J.5
  • 52
    • 0033597884 scopus 로고    scopus 로고
    • Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8
    • Pellegrini L., Passer B.J., Tabaton M., Ganjei J.K., D'Adamio L. Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8. J. Biol. Chem. 274:1999;21011-21016.
    • (1999) J. Biol. Chem. , vol.274 , pp. 21011-21016
    • Pellegrini, L.1    Passer, B.J.2    Tabaton, M.3    Ganjei, J.K.4    D'Adamio, L.5
  • 53
    • 0033605252 scopus 로고    scopus 로고
    • Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases
    • Weidemann A., Paliga K., Drrwang U., Reinhard F.B., Schuckert O., Evin G., Masters C.L. Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases. J. Biol. Chem. 274:1999;5823-5829.
    • (1999) J. Biol. Chem. , vol.274 , pp. 5823-5829
    • Weidemann, A.1    Paliga, K.2    Drrwang, U.3    Reinhard, F.B.4    Schuckert, O.5    Evin, G.6    Masters, C.L.7
  • 55
    • 0032102110 scopus 로고    scopus 로고
    • The role of neuronal growth factors in neurodegenerative disorders of the human brain
    • Connor B., Dragunow M. The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Res. Brain Res. Rev. 27:1998;1-39.
    • (1998) Brain Res. Brain Res. Rev. , vol.27 , pp. 1-39
    • Connor, B.1    Dragunow, M.2


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