Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling

Journal of Experimental Medicine

Volumn 195, Issue 6, 2002, Pages 705-717

  Judd, Barbi A ^a,b   Myung, Peggy S ^b,c   Obergfell, Achim ^d   Myers, Erin E ^b   Cheng, Alec M ^e   Watson, Stephen P ^f   Pear, Warren S ^c   Allman, David ^c   Shattil, Sanford J ^d   Koretzky, Gary A ^b,c  

^a UNIVERSITY OF IOWA   (United States)

^b Abramson Family Cancer Research Institute   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

GPVI; Integrin IIb 3; LAT; SLP 76; T cell receptor

Indexed keywords

COLLAGEN; COMPLEMENTARY DNA; CONVULXIN; FIBRINOGEN; GREEN FLUORESCENT PROTEIN; INTEGRIN; LIGAND; PHOSPHOPROTEIN; T LYMPHOCYTE RECEPTOR; THROMBIN;

ANIMAL CELL; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RETROVIRUS; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; HUMANS; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; PHOSPHOPROTEINS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PLATELET MEMBRANE GLYCOPROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0037128640     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011583     Document Type: Article

References (53)

1. Adapter proteins in lymphocyte antigen-receptor signaling
2. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells
3. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
4. SLP-76 expression is restricted to hemopoietic cells of monocyte, granulocyte, and T lymphocyte lineage and is regulated during T cell maturation and activation
5. The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activator of T cells (LAT) in platelets stimulated by collagen and convulxin
6. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function
7. Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity
8. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation
9. P95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells
10. Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase
11. Regulatory and signaling properties of the Vav family
12. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76
13. Interaction of SLP adaptors with the SH2 domain of Tec family kinases
14. Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells
15. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
16. Differential requirement for SLP-76 domains in T cell development and function
17. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases
18. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production
19. SLAP-130/FYB couples the TCR to integrin activation
20. Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap
21. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/Vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton
22. The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton
23. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
24. Grf40, a novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT
25. GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation
26. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
27. Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling
28. Membrane compartmentation is required for efficient T cell activation
29. Active Lyn protein tyrosine kinase is selectively enriched within membrane microdomains of resting platelets
30. Identification of the minimal tyrosine residues required for LAT function
31. Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development
32. Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin
33. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development
34. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76
35. Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice
36. Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets
37. Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors
38. Essential role of LAT in T cell development
39. LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI
40. Requirement for the SLP-76 adaptor GADS in T cell development
41. Expression of the platelet receptor GPVI confers signaling via the Fc receptor gamma-chain in response to the snake venom convulxin but not to collagen
42. Integrin alpha 2 beta 1-independent activation of platelets by simple collagen-like peptides: Collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for alpha 2 beta 1-independent platelet reactivity
43. RhoA and the function of platelet integrin alphaIIbbeta3
44. Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production
45. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
46. Production of high-titer helper-free retroviruses by transient transfection
47. Update on collagen receptor interactions in platelets: Is the two-state model still valid?
48. Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3
49. Lymphocytes with a complex: Adapter proteins in antigen receptor signaling
50. SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells
51. LAT is essential for Fc(epsilon)RI-mediated mast cell activation
52. Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling
53. Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT