Targeting proximal T cell receptor signaling in transplantation

Transplantation

Volumn 75, Issue 12, 2003, Pages 1921-1927

  Hamawy, Majed M ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b CSC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; MITOGEN ACTIVATED PROTEIN KINASE 1; T LYMPHOCYTE RECEPTOR; TACROLIMUS;

CELL NUCLEUS; COMPLEX FORMATION; CROSS LINKING; CYTOPLASM; GENETIC TRANSCRIPTION; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSPLANTATION;

EID: 0037774842     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000070168.42915.47     Document Type: Review

References (61)

1. Irving BA, Chan AC, Weiss A. Functional characterization of a signal transducing motif present in the T cell antigen receptor ζ chain. J Exp Med 1993; 177: 1093-1103.
2. Mustelin T, Abraham RT, Rudd CE, et al. Protein tyrosine phosphorylation in T cell signaling. Front Biosci 2002; 7: d918-d969.
3. Penninger JM, Irie-Sasaki J, Sasaki T, et al. CD45: new jobs for an old acquaintance. Nat Immunol 2001; 2: 389-396.
4. lck by the leukocyte common antigen (CD45). Oncogene 1990; 5: 809-813.
5. lck complex in T lymphocytes: a potential mechanism to regulate T-cell growth. Biochem Cell Biol 1989; 67: 581-589.
6. van Oers NS, Killeen N, Weiss A. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. J Exp Med 1996; 183: 1053-1062.
7. Neumeister EN, Zhu Y, Richard S, et al. Binding of ZAP-70 to phosphorylated T-cell receptor ζ and η enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. Mol Cell Biol 1995; 15: 3171-3178.
8. Chan AC, Irving BA, Fraser JD, et al. The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc Natl Acad Sci USA 1991; 88: 9166-9170.
9. 2+, calcineurin, and NF-AT. Cell 1999; 96: 611-614.
10. Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 1997; 15: 707-747.
11. Isakov N, Altman A. Protein kinase Cθ in T cell activation. Annu Rev Immunol 2002; 20: 761-794.
12. rus upon T-cell activation. Nature 1990; 346: 719-723.
13. Siegel JN, Klausner RD, Rapp UR, et al. T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway. J Biol Chem 1990; 265: 18472-18480.
14. Schaeffer HJ, Weber MJ. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol 1999; 19: 2435-2444.
15. Su B, Jacinto E, Hibi M, et al. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 1994; 77: 727-736.
16. Norman DJ, Kahana L, Stuart FP Jr, et al. A randomized clinical trial of induction therapy with OKT3 in kidney transplantation. Transplantation 1993; 55: 44-50.
17. Alegre ML, Peterson LJ, Xu D, et al. A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo. Transplantation 1994; 57: 1537-1543.
18. Cole MS, Stellrecht KE, Shi JD, et al. HuM291, a humanized anti-CD3 antibody, is immunosuppressive to T cells while exhibiting reduced mitogenicity in vitro. Transplantation 1999; 68: 563-571.
19. Neville DMJ, Scharff J, Hu HZ, et al. A new reagent for the induction of T-cell depletion, anti-CD3-CRM9. J Immunother Emphasis Tumor Immunol 1985; 2: 85-92.
20. Knechtle SJ, Vargo D, Fechner J, et al. FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts. Transplantation 1997; 63: 1-6.
21. Thomas JM, Neville DM, Contreras JL, et al. Preclinical studies of allograft tolerance in rhesus monkeys: a novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts. Transplantation 1997; 64: 124-135.
22. Shaw AS, Gauen LK, Zhu Y. Interactions of TCR tyrosine based activation motifs with tyrosine kinases. Semin Immunol 1995; 7: 13-20.
23. Marengere LE, Pawson T. Structure and function of SH2 domains. J Cell Sci Suppl 1994; 18: 97-104.
24. Marth JD, Peet R, Krebs EG, et al. A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell 1985; 43: 393-404.
25. Samelson LE, Phillips AF, Luong ET, et al. Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc Natl Acad Sci USA 1990; 87: 4358-4362.
26. lck. Cell 1988; 55: 301-308.
27. lck. Nature 1991; 350: 62-66.
28. lck. Nature 1992; 357: 161-164.
29. Waegell W, Babineau M, Hart M, et al. A420983, a novel, small molecule inhibitor of Lck prevents allograft rejection. Transplant Proc 2002; 34: 1411-1417.
30. Huby RD, Weiss A, Ley SC. Nocodazole inhibits signal transduction by the T cell antigen receptor. J Biol Chem 1998; 273: 12024-12031.
31. Burchat AF, Calderwood DJ, Friedman MM, et al. Pyrazolo[3, 4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck: a selectivity insight. Bioorg Med Chem Lett 2002; 12: 1687-1690.
32. van Oers NS, Weiss A. The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes. Semin Immunol 1995; 7: 227-236.
33. Chan AC, van Oers NS, Tran A, et al. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol 1994; 152: 4758-4766.
34. Elder ME, Lin D, Clever J, et al. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 1994; 264: 1596-1599.
35. Fernandez LA, Torrealba J, Yagci G, et al. Piceatannol in combination with low doses of cyclosporin A prolongs kidney allograft survival in a stringent rat transplant model. Transplantation 2002; 74: 1609-1617.
36. Siliciano JD, Morrow TA, Desiderio SV. Itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2. Proc Natl Acad Sci USA 1992; 89: 11194-11198.
37. Gibson S, August A, Kawakami Y, et al. The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT. J Immunol 1996; 156: 2716-2722.
38. Ching KA, Grasis JA, Tailor P, et al. TCR/CD3-induced activation and binding of Emt/Itk to linker of activated T cell complexes: requirement for the Src homology 2 domain. J Immunol 2000; 165: 256-262.
39. Schaeffer EM, Debnath J, Yap G, et al. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 1999; 284: 638-641.
40. Liao XC, Littman DR. Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity 1995; 3: 757-769.
41. Zhang W, Sloan-Lancaster J, Kitchen J, et al. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 1998; 92: 83-92.
42. Tsuchida M, Manthei ER, Knechtle SJ, et al. CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and Zap-70 tyrosine phosphorylation. Eur J Immunol 1999; 29: 2354-2359.
43. Sommers CL, Park CS, Lee J, et al. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 2002; 296: 2040-2043.
44. Aguado E, Richelme S, Nunez-Cruz S, et al. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 2002; 296: 2036-2040.
45. Zhang W, Sommers CL, Burshtyn DN, et al. Essential role of LAT in T cell development. Immunity 1999; 10: 323-332.
46. Bosselut R, Zhang W, Ashe JM, et al. Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in t cell receptor signal transduction. J Exp Med 1999; 190: 1517-1526.
47. Peters D, Tsuchida M, Manthei ER, et al. Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506. Blood 2000; 95: 2733-2741.
48. Cho CS, Elkahwaji J, Chang Z, et al. Modulation of the electrophoretic mobility of the linker for activation of T cells (LAT) by the calcineurin inhibitors CsA and FK506: LAT is a potential substrate for PKC and calcineurin signaling pathways. Cell Signal 2003; 15: 85-93.
49. Jackman JK, Motto DG, Sun Q, et al. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J Biol Chem 1995; 270: 7029-7032.
50. Wardenburg JB, Fu C, Jackman JK, et al. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. J Biol Chem 1996; 271: 19641-19644.
51. Liu SK, Fang N, Koretzky GA, et al. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr Biol 1999; 9: 67-75.
52. Yablonski D, Kuhne MR, Kadlecek T, et al. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell. Science 1998; 281: 413-416.
53. Pivniouk V, Tsitsikov E, Swinton P, et al. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell 1998; 94: 229-238.
54. Clements JL, Yang B, Ross-Barta SE, et al. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 1998; 281: 416-419.
55. Lazarovits AI, Poppema S, Zhang Z, et al. Prevention and reversal of renal allograft rejection by antibody against CD45RB. Nature 1996; 380: 717-720.
56. Fecteau S, Basadonna GP, Freitas A, et al. CTLA-4 up-regulation plays a role in tolerance mediated by CD45. Nat Immunol 2001; 2: 58-63.
57. Brunner MC, Chambers CA, Chan FK, et al. CTLA-4-mediated inhibition of early events of T cell proliferation. J Immunol 1999; 162: 5813-5820.
58. Lee KM, Chuang E, Griffin M, et al. Molecular basis of T cell inactivation by CTLA-4. Science 1998; 282: 2263-2266.
59. Marengere LE, Waterhouse P, Duncan GS, et al. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 1996; 272: 1170-1173.
60. Guntermann C, Alexander DR. CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases. J Immunol 2002; 168: 4420-4429.
61. Hwang KW, Sweatt WB, Brown IE, et al. Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells. J Immunol 2002; 169: 633-637.