CTLA-4 up-regulation plays a role in tolerance mediated by CD45

Nature Immunology

Volumn 2, Issue 1, 2001, Pages 58-63

  Fecteau, Scott ^a   Basadonna, Giacomo P ^a   Freitas, Alexander ^a   Ariyan, Charlotte ^a   Sayegh, Mohamed H ^b   Rothstein, David M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ANTIBODY CONJUGATE; CALCINEURIN; CD45 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN;

ALLOTRANSPLANTATION; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; GRAFT SURVIVAL; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MOUSE; PANCREAS ISLET TRANSPLANTATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UPREGULATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION; CALCINEURIN; GRAFT SURVIVAL; IMMUNE TOLERANCE; IMMUNOCONJUGATES; ISLETS OF LANGERHANS TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS; UP-REGULATION;

EID: 0035236195     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/83175     Document Type: Article

References (44)

1. Tivol, E. et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547 (1995).
2. Waterhouse P. et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270, 985-988 (1995).
3. Perez, V. L. et al. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6, 411-417 (1997).
4. Leach, D. R., Krummel, M. F. & Allison, J. P. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271, 1734-1736 (1996).
5. Luhder, F., Hoglund, P., Allison, J. P., Benoist, C. & Mathis, D. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. 187, 427-432 (1998).
6. Karandikar, N. J., Vanderlugt, C. L., Walunas, T. L., Miller, S. D. & Bluestone, J. A. CTLA-4: a negative regulator of autoimmune disease. J. Exp. Med. 184, 783-788 (1996).
7. Takahashi, T. et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192, 303-310 (2000).
8. Judge, T. A. et al. The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival. J. Immunol. 162, 1947-1951 (1999).
9. Linsley, P. S. et al. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 4, 535-543 (1996).
10. Alegre, M. L. et al. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J. Immunol. 157, 4762-4770 (1996).
11. Finn, P.W. et al. Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonudeic acid stability. J. Immunol. 158, 4074-4081 (1997).
12. Krummel, M. F. & Allison, J. P. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182, 459-465 (1995).
13. Walunas, T. L. et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1, 405-413 (1994).
14. Trowbridge, I. S. & Thomas, M. L. CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Ann. Rev. Immunol. 12, 85-116 (1994).
15. Kashio, N., Matsumoto, W., Parker, S. & Rothstein, D. M. The second domain of the CD45 transmembrane protein tyrosine phosphatase is critical for IL-2 secretion and for recruitment of substrates in vivo. J. Biol. Chem. 273, 33856-33863 (1998).
16. Bottomly, K. et al. A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines. Eur. J. Immunol. 19, 617-623 (1989).
17. +T cells. J. Immunol. 144, 3288-3295 (1990).
18. +T cells. Immunity 1, 553-562 (1994).
19. Morimoto, C., Letvin, N. L., Distaso, J. A., Aldrich, W. R. & Schlossman, S. F. The isolation and characterization of the human suppressor inducer T cell subset. J. Immunol. 134, 1508-1515 (1985).
20. +T cell line. J. Immunol. 146, 1175-1183 (1991).
21. Sparshott, S. & Bell, E. Membrane CD45R isoform exchange on CD4 T cells is rapid, frequent and dynamic in vivo. Eur. J. Immunol. 24, 2573-2578 (1994).
22. Michie, C.A., McLean, A., Alcock, C. & Beverley, P. C. L. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 360, 264-265 (1992).
23. McKenney, D.W., Onodera, H., Gorman, L., Mimura, T. & Rothstein, D. M. Individual isoforms of the CD45 protein tyrosine phosphatase differentially regulate IL-2 secretion and activation signal pathways involving Vav in T cells. J. Biol. Chem. 270, 24949-24954 (1995).
24. Onodera, H., Motto, D. G., Koretzky, G. A. & Rothstein, D. M. Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein tyrosine phosphatase. J. Biol. Chem. 271, 2225-2230 (1996).
25. Novak, T. et al. Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T cell recognition. Immunity 1, 109-119 (1994).
26. Basadonna, G. et al. Antibody mediated targeting of CD45 isoforms: A novel immunotherapeutic strategy. Proc. Natl Acad Sci USA 95, 3821-3826 (1998).
27. Lazarovits, A. et al. Prevention and reversal of renal allograft rejection by antibody against CD45RB. Nature 380, 717-720 (1996).
28. Metz, D. P., Farber, D. L., Taylor, T. & Bottomly, K. Differential role of CTLA-4 in regulation of resting memory versus naïve CD4 T cell activation. J. Immunol. 161, 5855-5861 (1998).
29. Chuang, E. et al. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J. Immunol. 159, 144-151 (1997).
30. +T cells in vitro: characteristics and antigen-presenting cell requirements. J. Exp. Med. 176, 1431-1437 (1992).
31. Liu, J. et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66, 807-815 (1991).
32. Walunas, T. L. & Bluestone, J. A. CTLA-4 regulates tolerance induction and T cell differentiation in vivo. J. Immunol. 160, 3855-3860 (1998).
33. Read, S., Malmstrom, V. & Powrie, F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J. Exp. Med. 192, 295-302 (2000).
34. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12, 431-440 (2000).
35. Perkins, D. et al. Regulation of CTLA-4 expression during T cell activation. J. Immunol. 156, 4154-4159 (1996).
36. Shiratori, T. et al. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 6, 583-589 (1997).
37. Schneider, H. et al. Cytolytic T lymphocyte-associated antigen-4 and the TCR ζ/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J. Immunol. 163, 1868-1879 (1999).
38. Rothstein, D. M., Saito, H., Streuli, M., Schlossman, S. F. & Morimoto, C. The alternative splicing of the CD45 tyrosine phosphatase is controlled by negative regulatory trans-acting splicing factors. J. Biol. Chem. 267, 7139-7147 (1992).
39. Tedder, T. F., Clement, L. T. & Cooper, M. D. Human lymphocyte differentiation antigens HB-10 and HB-11 1. Ontogeny of antigen expression. J. Immunol. 134, 2983-2988 (1985).
40. Bell, E. B. & Sparshott, S. M. Interconversion of CD45R subsets of CD4 T cell in vivo. Nature 348, 163-166 (1990).
41. Leitenberg, D., Novak, T., Farber, D. L., Smith, B. R. & Bottomly, K. The extracellular domain of CD45 controls association with the CD4/T cell receptor complex and the response to antigen specific stimulation. J. Exp. Med. 183, 249-259 (1996).
42. +T cells. Eur. J. Immunol. 25, 2445-2451 (1995).
43. Desai, D., Sap, J., Schlessinger, J. & Weiss, A. Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase. Cell 73, 541-554 (1993).
44. Li, Y. et al. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nature Med. 5, 1298-1302 (1999).