Mitochondrially localized active caspase-9 and caspase-3 result mostly from translocation from the cytosol and partly from caspase-mediated activation in the organelle. Lack of evidence for Apaf-1-mediated procaspase-9 activation in the mitochondria

Journal of Biological Chemistry

Volumn 278, Issue 19, 2003, Pages 17408-17420

  Chandra, Dhyan ^b   Tang, Dean G ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; CHEMICAL ACTIVATION; PROTEINS;

MITOCHONDRIA;

BIOCHEMISTRY;

ACTIN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE; CASPASE 3; CASPASE 9; CYCLOOXYGENASE 2; CYTOCHROME C; HEAT SHOCK PROTEIN 60; MONOCLONAL ANTIBODY; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLYCLONAL ANTIBODY; PROTEIN PRECURSOR; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG; VOLTAGE GATED CHANNEL FORMING PROTEIN; APAF1 PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; ENZYME PRECURSOR; PROTEIN;

ARTICLE; CELL FRACTIONATION; CELL ORGANELLE; ENZYME ACTIVATION; ENZYME KINETICS; MITOCHONDRION; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; APOPTOSIS; CELL LINE; CYTOSOL; ENZYMOLOGY; HUMAN; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALIA;

APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BIOLOGICAL TRANSPORT; CASPASE 3; CASPASE 9; CASPASES; CELL LINE; CYTOSOL; ENZYME ACTIVATION; ENZYME PRECURSORS; HUMANS; MITOCHONDRIA; PROTEINS;

EID: 0037593851     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300750200     Document Type: Article

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