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See, for example: a) M. B. Francis, E. N. Jacobsen, Angew. Chem. 1999, 111, 987-991; Angew. Chem. Int. Ed. 1999, 38, 937-941; b) S. R. Gilbertson, C.-W. T. Chang, Chem. Commun. (Cambridge) 1997, 975-976; c) C. Gennari, S. Ceccarelli, U. Piarulli, C. A. G. N. Montalbetti, R. F. W. Jackson, J. Org. Chem. 1998, 63, 5312-5313; d) K. Burgess, H.-J. Lim, A. M. Porte, G. A. Sulikowski, Angew. Chem. 1996, 108, 192-194; Angew. Chem. Int. Ed. Engl. 1996, 35, 220-222; e) C. A. Krueger, K. W. Kuntz, C. D. Dzierba, W. G. Wirschun, J. D. Gleason, M. L. Snapper, A. H. Hoveyda, J. Am. Chem. Soc. 1999, 121, 4284-4285; f) J. Long, J. Hu, X. Shen, B. Ji, K. Ding, J. Am. Chem. Soc. 2002, 124, 10-11; g) A. Berkessel, R. Riedl, J. Comb. Chem. 2000, 2, 215-219; h) S. Dahmen, S. Bräse, Synthesis 2001, 1431-1449.
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See, for example: a) M. B. Francis, E. N. Jacobsen, Angew. Chem. 1999, 111, 987-991; Angew. Chem. Int. Ed. 1999, 38, 937-941; b) S. R. Gilbertson, C.-W. T. Chang, Chem. Commun. (Cambridge) 1997, 975-976; c) C. Gennari, S. Ceccarelli, U. Piarulli, C. A. G. N. Montalbetti, R. F. W. Jackson, J. Org. Chem. 1998, 63, 5312-5313; d) K. Burgess, H.-J. Lim, A. M. Porte, G. A. Sulikowski, Angew. Chem. 1996, 108, 192-194; Angew. Chem. Int. Ed. Engl. 1996, 35, 220-222; e) C. A. Krueger, K. W. Kuntz, C. D. Dzierba, W. G. Wirschun, J. D. Gleason, M. L. Snapper, A. H. Hoveyda, J. Am. Chem. Soc. 1999, 121, 4284-4285; f) J. Long, J. Hu, X. Shen, B. Ji, K. Ding, J. Am. Chem. Soc. 2002, 124, 10-11; g) A. Berkessel, R. Riedl, J. Comb. Chem. 2000, 2, 215-219; h) S. Dahmen, S. Bräse, Synthesis 2001, 1431-1449.
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See, for example: a) M. B. Francis, E. N. Jacobsen, Angew. Chem. 1999, 111, 987-991; Angew. Chem. Int. Ed. 1999, 38, 937-941; b) S. R. Gilbertson, C.-W. T. Chang, Chem. Commun. (Cambridge) 1997, 975-976; c) C. Gennari, S. Ceccarelli, U. Piarulli, C. A. G. N. Montalbetti, R. F. W. Jackson, J. Org. Chem. 1998, 63, 5312-5313; d) K. Burgess, H.-J. Lim, A. M. Porte, G. A. Sulikowski, Angew. Chem. 1996, 108, 192-194; Angew. Chem. Int. Ed. Engl. 1996, 35, 220-222; e) C. A. Krueger, K. W. Kuntz, C. D. Dzierba, W. G. Wirschun, J. D. Gleason, M. L. Snapper, A. H. Hoveyda, J. Am. Chem. Soc. 1999, 121, 4284-4285; f) J. Long, J. Hu, X. Shen, B. Ji, K. Ding, J. Am. Chem. Soc. 2002, 124, 10-11; g) A. Berkessel, R. Riedl, J. Comb. Chem. 2000, 2, 215-219; h) S. Dahmen, S. Bräse, Synthesis 2001, 1431-1449.
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See, for example: a) M. B. Francis, E. N. Jacobsen, Angew. Chem. 1999, 111, 987-991; Angew. Chem. Int. Ed. 1999, 38, 937-941; b) S. R. Gilbertson, C.-W. T. Chang, Chem. Commun. (Cambridge) 1997, 975-976; c) C. Gennari, S. Ceccarelli, U. Piarulli, C. A. G. N. Montalbetti, R. F. W. Jackson, J. Org. Chem. 1998, 63, 5312-5313; d) K. Burgess, H.-J. Lim, A. M. Porte, G. A. Sulikowski, Angew. Chem. 1996, 108, 192-194; Angew. Chem. Int. Ed. Engl. 1996, 35, 220-222; e) C. A. Krueger, K. W. Kuntz, C. D. Dzierba, W. G. Wirschun, J. D. Gleason, M. L. Snapper, A. H. Hoveyda, J. Am. Chem. Soc. 1999, 121, 4284-4285; f) J. Long, J. Hu, X. Shen, B. Ji, K. Ding, J. Am. Chem. Soc. 2002, 124, 10-11; g) A. Berkessel, R. Riedl, J. Comb. Chem. 2000, 2, 215-219; h) S. Dahmen, S. Bräse, Synthesis 2001, 1431-1449.
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See, for example: a) M. B. Francis, E. N. Jacobsen, Angew. Chem. 1999, 111, 987-991; Angew. Chem. Int. Ed. 1999, 38, 937-941; b) S. R. Gilbertson, C.-W. T. Chang, Chem. Commun. (Cambridge) 1997, 975-976; c) C. Gennari, S. Ceccarelli, U. Piarulli, C. A. G. N. Montalbetti, R. F. W. Jackson, J. Org. Chem. 1998, 63, 5312-5313; d) K. Burgess, H.-J. Lim, A. M. Porte, G. A. Sulikowski, Angew. Chem. 1996, 108, 192-194; Angew. Chem. Int. Ed. Engl. 1996, 35, 220-222; e) C. A. Krueger, K. W. Kuntz, C. D. Dzierba, W. G. Wirschun, J. D. Gleason, M. L. Snapper, A. H. Hoveyda, J. Am. Chem. Soc. 1999, 121, 4284-4285; f) J. Long, J. Hu, X. Shen, B. Ji, K. Ding, J. Am. Chem. Soc. 2002, 124, 10-11; g) A. Berkessel, R. Riedl, J. Comb. Chem. 2000, 2, 215-219; h) S. Dahmen, S. Bräse, Synthesis 2001, 1431-1449.
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See, for example: a) M. B. Francis, E. N. Jacobsen, Angew. Chem. 1999, 111, 987-991; Angew. Chem. Int. Ed. 1999, 38, 937-941; b) S. R. Gilbertson, C.-W. T. Chang, Chem. Commun. (Cambridge) 1997, 975-976; c) C. Gennari, S. Ceccarelli, U. Piarulli, C. A. G. N. Montalbetti, R. F. W. Jackson, J. Org. Chem. 1998, 63, 5312-5313; d) K. Burgess, H.-J. Lim, A. M. Porte, G. A. Sulikowski, Angew. Chem. 1996, 108, 192-194; Angew. Chem. Int. Ed. Engl. 1996, 35, 220-222; e) C. A. Krueger, K. W. Kuntz, C. D. Dzierba, W. G. Wirschun, J. D. Gleason, M. L. Snapper, A. H. Hoveyda, J. Am. Chem. Soc. 1999, 121, 4284-4285; f) J. Long, J. Hu, X. Shen, B. Ji, K. Ding, J. Am. Chem. Soc. 2002, 124, 10-11; g) A. Berkessel, R. Riedl, J. Comb. Chem. 2000, 2, 215-219; h) S. Dahmen, S. Bräse, Synthesis 2001, 1431-1449.
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See, for example: a) M. B. Francis, E. N. Jacobsen, Angew. Chem. 1999, 111, 987-991; Angew. Chem. Int. Ed. 1999, 38, 937-941; b) S. R. Gilbertson, C.-W. T. Chang, Chem. Commun. (Cambridge) 1997, 975-976; c) C. Gennari, S. Ceccarelli, U. Piarulli, C. A. G. N. Montalbetti, R. F. W. Jackson, J. Org. Chem. 1998, 63, 5312-5313; d) K. Burgess, H.-J. Lim, A. M. Porte, G. A. Sulikowski, Angew. Chem. 1996, 108, 192-194; Angew. Chem. Int. Ed. Engl. 1996, 35, 220-222; e) C. A. Krueger, K. W. Kuntz, C. D. Dzierba, W. G. Wirschun, J. D. Gleason, M. L. Snapper, A. H. Hoveyda, J. Am. Chem. Soc. 1999, 121, 4284-4285; f) J. Long, J. Hu, X. Shen, B. Ji, K. Ding, J. Am. Chem. Soc. 2002, 124, 10-11; g) A. Berkessel, R. Riedl, J. Comb. Chem. 2000, 2, 215-219; h) S. Dahmen, S. Bräse, Synthesis 2001, 1431-1449.
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See, for example: a) M. B. Francis, E. N. Jacobsen, Angew. Chem. 1999, 111, 987-991; Angew. Chem. Int. Ed. 1999, 38, 937-941; b) S. R. Gilbertson, C.-W. T. Chang, Chem. Commun. (Cambridge) 1997, 975-976; c) C. Gennari, S. Ceccarelli, U. Piarulli, C. A. G. N. Montalbetti, R. F. W. Jackson, J. Org. Chem. 1998, 63, 5312-5313; d) K. Burgess, H.-J. Lim, A. M. Porte, G. A. Sulikowski, Angew. Chem. 1996, 108, 192-194; Angew. Chem. Int. Ed. Engl. 1996, 35, 220-222; e) C. A. Krueger, K. W. Kuntz, C. D. Dzierba, W. G. Wirschun, J. D. Gleason, M. L. Snapper, A. H. Hoveyda, J. Am. Chem. Soc. 1999, 121, 4284-4285; f) J. Long, J. Hu, X. Shen, B. Ji, K. Ding, J. Am. Chem. Soc. 2002, 124, 10-11; g) A. Berkessel, R. Riedl, J. Comb. Chem. 2000, 2, 215-219; h) S. Dahmen, S. Bräse, Synthesis 2001, 1431-1449.
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See, for example: a) M. B. Francis, E. N. Jacobsen, Angew. Chem. 1999, 111, 987-991; Angew. Chem. Int. Ed. 1999, 38, 937-941; b) S. R. Gilbertson, C.-W. T. Chang, Chem. Commun. (Cambridge) 1997, 975-976; c) C. Gennari, S. Ceccarelli, U. Piarulli, C. A. G. N. Montalbetti, R. F. W. Jackson, J. Org. Chem. 1998, 63, 5312-5313; d) K. Burgess, H.-J. Lim, A. M. Porte, G. A. Sulikowski, Angew. Chem. 1996, 108, 192-194; Angew. Chem. Int. Ed. Engl. 1996, 35, 220-222; e) C. A. Krueger, K. W. Kuntz, C. D. Dzierba, W. G. Wirschun, J. D. Gleason, M. L. Snapper, A. H. Hoveyda, J. Am. Chem. Soc. 1999, 121, 4284-4285; f) J. Long, J. Hu, X. Shen, B. Ji, K. Ding, J. Am. Chem. Soc. 2002, 124, 10-11; g) A. Berkessel, R. Riedl, J. Comb. Chem. 2000, 2, 215-219; h) S. Dahmen, S. Bräse, Synthesis 2001, 1431-1449.
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Synthesis
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Reviews of high-throughput ee assays: a) M. T. Reetz, Angew. Chem. 2001, 113, 292-320; Angew. Chem. Int. Ed. 2001, 40, 284-310; b) M.T. Reetz, Angew. Chem. 2002, 114, 1391-1394; Angew. Chem. Int. Ed. 2002, 41, 1335-1338; c) D. Wahler, J.-L. Reymond, Curr. Opin. Biotechnol. 2001, 12, 535-544; d) M. Tsukamoto, H. B. Kagan, Adv. Synth. Catal. 2002, 344, 453-463; e) A. M. Rouhi, Chem. Eng. News, 2002, 80(23), 51-57.
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Reviews of high-throughput ee assays: a) M. T. Reetz, Angew. Chem. 2001, 113, 292-320; Angew. Chem. Int. Ed. 2001, 40, 284-310; b) M.T. Reetz, Angew. Chem. 2002, 114, 1391-1394; Angew. Chem. Int. Ed. 2002, 41, 1335-1338; c) D. Wahler, J.-L. Reymond, Curr. Opin. Biotechnol. 2001, 12, 535-544; d) M. Tsukamoto, H. B. Kagan, Adv. Synth. Catal. 2002, 344, 453-463; e) A. M. Rouhi, Chem. Eng. News, 2002, 80(23), 51-57.
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Reviews of high-throughput ee assays: a) M. T. Reetz, Angew. Chem. 2001, 113, 292-320; Angew. Chem. Int. Ed. 2001, 40, 284-310; b) M.T. Reetz, Angew. Chem. 2002, 114, 1391-1394; Angew. Chem. Int. Ed. 2002, 41, 1335-1338; c) D. Wahler, J.-L. Reymond, Curr. Opin. Biotechnol. 2001, 12, 535-544; d) M. Tsukamoto, H. B. Kagan, Adv. Synth. Catal. 2002, 344, 453-463; e) A. M. Rouhi, Chem. Eng. News, 2002, 80(23), 51-57.
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Reviews of high-throughput ee assays: a) M. T. Reetz, Angew. Chem. 2001, 113, 292-320; Angew. Chem. Int. Ed. 2001, 40, 284-310; b) M.T. Reetz, Angew. Chem. 2002, 114, 1391-1394; Angew. Chem. Int. Ed. 2002, 41, 1335-1338; c) D. Wahler, J.-L. Reymond, Curr. Opin. Biotechnol. 2001, 12, 535-544; d) M. Tsukamoto, H. B. Kagan, Adv. Synth. Catal. 2002, 344, 453-463; e) A. M. Rouhi, Chem. Eng. News, 2002, 80(23), 51-57.
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AMIX™ is available from Bruker Biospin GmbH, Rheinstetten, Germany.
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note
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The Gilson 215 autosampler is commercially available from Gilson Inc., Middlton, USA.
-
-
-
-
83
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-
0347574464
-
-
The BEST™ cell system is available from Bruker Biospin GmbH (76287 Rheinstetten, Germany). For a detailed description see www.bruker.de/analytic/nmr-dep/best.html.
-
-
-
-
84
-
-
0346943612
-
-
note
-
Other manufactures also supply flow-through systems, e.g., the VAST™ system from Varian.
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