Combinatorial de novo synthesis of catalysts: How much of a hit-structure is needed for activity?

Journal of Combinatorial Chemistry

Volumn 2, Issue 3, 2000, Pages 215-219

  Berkessel, Albrecht ^a   Riedl, Rainer ^a,b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001708325     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc990073i     Document Type: Article

References (37)

1. (a) Jandeleit, B.; Schaefer, D. J.; Powers, T. S.; Turner, H. W.; Weinberg, W. H. Angew. Chem. 1999, 111, 2648-2689; Angew. Chem. Int. Ed. 1999, 38, 2494-2532.
2. (a) Jandeleit, B.; Schaefer, D. J.; Powers, T. S.; Turner, H. W.; Weinberg, W. H. Angew. Chem. 1999, 111, 2648-2689; Angew. Chem. Int. Ed. 1999, 38, 2494-2532.
3. (b) Shimizu, K. D.; Snapper, M. L.; Hoveyda, A. H. Chem. Eur. J. 1998, 4, 1885-1889.
4. (c) Gennari, C.; Nestler, H. P.; Piarulli, U.; Salom, B. Liebigs Ann./ Recl. 1997, 637-647.
5. (a) Francis, M. B.; Jacobsen, E. N. Angew. Chem. 1999, 111, 987-991; Angew. Chem. Int. Ed. 1999, 38, 937-941.
6. (a) Francis, M. B.; Jacobsen, E. N. Angew. Chem. 1999, 111, 987-991; Angew. Chem. Int. Ed. 1999, 38, 937-941.
7. (b) Krueger, A. A.; Kuntz, K. W.; Dzierba, C. D.; Wirschun, W. G.; Gleason, J. D.; Snapper, M. L.; Hoveyda, A. H. J. Am. Chem. Soc. 1999, 121, 4284-4285.
8. Taylor, S. J.; Morken, J. P. Science 1998, 280, 267-270.
9. For the combinatorial discovery of peptide-zirconium complexes with phosphatase activity, see: Berkessel, A.; Hérault, D. A. Angew. Chem. 1999, 111, 99-102; Angew. Chem. Int. Ed. 1999, 38, 102-105.
10. For the combinatorial discovery of peptide-zirconium complexes with phosphatase activity, see: Berkessel, A.; Hérault, D. A. Angew. Chem. 1999, 111, 99-102; Angew. Chem. Int. Ed. 1999, 38, 102-105.
11. For a recent issue of Chem. Rev. devoted exclusively to the chemical and biochemical aspects of RNA/DNA cleavage, see: Chem. Rev. 1998, 98, 937-1261.
12. Furka, A.; Sebestyen, F.; Asgedom, M.; Dibo, G.; Int. J. Pept. Protein Res. 1991, 37, 487-493.
13. Lam, K. S.; Salmon, S. E.; Hersh, E. M.; Hruby, V. J.; Kazmiersky, W. M.; Knapp, R. J. Nature 1991, 354, 82-84.
14. Houghten, R. A.; Pinilla, C.; Blondelle, S. E.; Appel, J. R.; Dooley, C. T.; Cuervo, J. H. Nature 1991, 354, 84-86.
15. Sträter, N.; Lipscomb, W. N.; Klabunde, T.; Krebs, B. Angew. Chem. 1996, 108, 2158-2191; Angew. Chem. Int. Ed. Engl. 1996, 35, 2024-2055.
16. Sträter, N.; Lipscomb, W. N.; Klabunde, T.; Krebs, B. Angew. Chem. 1996, 108, 2158-2191; Angew. Chem. Int. Ed. Engl. 1996, 35, 2024-2055.
17. Perreault, D. M.; Anslyn, E. V. Angew. Chem. 1997, 109, 470-490; Angew. Chem., Int. Ed. Engl. 1997, 36, 432-450.
18. Perreault, D. M.; Anslyn, E. V. Angew. Chem. 1997, 109, 470-490; Angew. Chem., Int. Ed. Engl. 1997, 36, 432-450.
19. Kolb, H. C.; VanNieuwenhze, M. S.; Sharpless, K. B. Chem. Rev. 1994, 94, 2483-2547.
20. Riedl, R.; Tappe, R.; Berkessel, A. J. Am. Chem. Soc. 1998, 120, 8994-9000.
21. Coste, J.; Le-Nguyen, D.; Castro, B. Tetrahedron Lett. 1990, 31, 205-208.
22. Kaiser, E. T.; Colescott, R. L.; Bossinger, C. D.; Cook, P. I. Anal. Biochem. 1970, 34, 595-598.
23. Schneider, H.-J.; Rammo, J.; Hettich, R. Angew. Chem. 1993, 105, 1773-1776; Angew. Chem. Int. Ed. Engl. 1993, 32, 1716-1719.
24. Schneider, H.-J.; Rammo, J.; Hettich, R. Angew. Chem. 1993, 105, 1773-1776; Angew. Chem. Int. Ed. Engl. 1993, 32, 1716-1719.
25. For a highly active dinuclear lanthanide complex, see ref 17.
26. Ragunathan, K.; Schneider, H.-J. Angew. Chem. 1996, 108, 1314-1316; Angew. Chem. Int. Ed. Engl. 1996, 35, 1219-1221.
27. Ragunathan, K.; Schneider, H.-J. Angew. Chem. 1996, 108, 1314-1316; Angew. Chem. Int. Ed. Engl. 1996, 35, 1219-1221.
28. See ref 19 for a study in which the activity of polymer bound ligands proved comparable to those in homogeneous solution.
29. (a) Cole, B. M.; Shimizu, K. D.; Krueger, C. A.; Harrity, J. P.; Snapper, M. L.; Hoveyda, A. H. Angew. Chem. 1996, 108, 1776-1779;
30. Angew. Chem. Int. Ed. Engl. 1996, 35, 1668-1671.
31. (b) Shimizu, K. D.; Cole, B. M.; Krueger, C. A.; Kuntz, K. W.; Snapper, M. L.; Hoveyda, A. H. Angew. Chem. 1997, 109, 1782-1785; Angew. Chem. Int. Ed. Engl. 1997, 36, 1704-1707.
32. (b) Shimizu, K. D.; Cole, B. M.; Krueger, C. A.; Kuntz, K. W.; Snapper, M. L.; Hoveyda, A. H. Angew. Chem. 1997, 109, 1782-1785; Angew. Chem. Int. Ed. Engl. 1997, 36, 1704-1707.
33. Polymer bound histidine shows the same activity as the full ligand 8b within ±2%, i.e., within experimental error.
34. (a) Lam, K. S.; Lebl, M.; Krchnák, V. Chem. Rev. 1997, 97, 347-510.
35. (b) Balkenhohl, F.; v. d. Bussche-Hünnefeld, C.; Lansky, A.; Zechel, C. Angew. Chem. 1996, 108, 2436-2488; Angew. Chem., Int. Ed. Engl. 1996, 35, 2288-2337.
36. (b) Balkenhohl, F.; v. d. Bussche-Hünnefeld, C.; Lansky, A.; Zechel, C. Angew. Chem. 1996, 108, 2436-2488; Angew. Chem., Int. Ed. Engl. 1996, 35, 2288-2337.
37. Still, W. C. Acc. Chem. Res. 1996, 29, 155-163.