-
1
-
-
0034628501
-
Directed evolution of new catalytic activity using the alpha/beta-barrel scaffold
-
Altamirano MM, Blackburn JM, Aguayo C, Fersht AR (2000) Directed evolution of new catalytic activity using the alpha/beta-barrel scaffold. Nature 403:617-622
-
(2000)
Nature
, vol.403
, pp. 617-622
-
-
Altamirano, M.M.1
Blackburn, J.M.2
Aguayo, C.3
Fersht, A.R.4
-
2
-
-
0032031614
-
Epoxide hydrolases: New tools for the synthesis of fine organic chemicals
-
Archelas A, Furstoss R (1998) Epoxide hydrolases: new tools for the synthesis of fine organic chemicals. Trends Biotechnol 16:108-116
-
(1998)
Trends Biotechnol
, vol.16
, pp. 108-116
-
-
Archelas, A.1
Furstoss, R.2
-
3
-
-
0001270261
-
Design by directed evolution
-
Arnold FH (1998) Design by directed evolution. Acc Chem Res 31:125-131
-
(1998)
Acc Chem Res
, vol.31
, pp. 125-131
-
-
Arnold, F.H.1
-
5
-
-
0023847706
-
Insights into enzyme function from studies on mutants of dihydrofolate reductase
-
Benkovic SJ, Fierke CA, Naylor AM (1988) Insights into enzyme function from studies on mutants of dihydrofolate reductase. Science 239:1105-1110
-
(1988)
Science
, vol.239
, pp. 1105-1110
-
-
Benkovic, S.J.1
Fierke, C.A.2
Naylor, A.M.3
-
6
-
-
0001132399
-
Infrared thermographic screening of combinatorial libraries of heterogeneous catalysts
-
Bergbreiter DE (1997) Infrared thermographic screening of combinatorial libraries of heterogeneous catalysts. Chemtracts 10:683-686
-
(1997)
Chemtracts
, vol.10
, pp. 683-686
-
-
Bergbreiter, D.E.1
-
8
-
-
0023586254
-
Protein engineering
-
Bryan PN (1987) Protein engineering. Biotechnol Adv 5:221-234
-
(1987)
Biotechnol Adv
, vol.5
, pp. 221-234
-
-
Bryan, P.N.1
-
12
-
-
0033526393
-
A chemosensor-based approach to catalyst discovery in solution and on solid support
-
Copeland GT, Miller SJ (1999) A chemosensor-based approach to catalyst discovery in solution and on solid support. J Am Chem Soc 121:4306-4397
-
(1999)
J Am Chem Soc
, vol.121
, pp. 4306-4397
-
-
Copeland, G.T.1
Miller, S.J.2
-
17
-
-
0000592694
-
Relationships between enzymatic catalysis and active site structure revealed by applications of site-directed mutagenesis
-
Gerlt JA (1987) Relationships between enzymatic catalysis and active site structure revealed by applications of site-directed mutagenesis. Chem Rev 87:1079-1105
-
(1987)
Chem Rev
, vol.87
, pp. 1079-1105
-
-
Gerlt, J.A.1
-
18
-
-
0033553799
-
Measurement of enantiomeric excess by kinetic resolution and mass spectrometry
-
Guo J, Wu J, Siuzdak G, Finn MG (1999) Measurement of enantiomeric excess by kinetic resolution and mass spectrometry. Angew Chem Int Ed 38:1755-1758
-
(1999)
Angew Chem Int Ed
, vol.38
, pp. 1755-1758
-
-
Guo, J.1
Wu, J.2
Siuzdak, G.3
Finn, M.G.4
-
19
-
-
0028859754
-
Inversion of enantioselectivity in hydrolysis of 1,4-dihydropyridines by point mutation of lipase PS
-
Hirose Y, Kariya K, Nakanishi Y, Kurono Y, Achiwa K (1995) Inversion of enantioselectivity in hydrolysis of 1,4-dihydropyridines by point mutation of lipase PS. Tetrahedron Lett 36: 1063-1066
-
(1995)
Tetrahedron Lett
, vol.36
, pp. 1063-1066
-
-
Hirose, Y.1
Kariya, K.2
Nakanishi, Y.3
Kurono, Y.4
Achiwa, K.5
-
20
-
-
0032538479
-
Detection of catalytic activity in combinatorial libraries of heterogeneous catalysts by IR thermography
-
Holzwarth A, Schmidt H-W, Maier WF (1998) Detection of catalytic activity in combinatorial libraries of heterogeneous catalysts by IR thermography. Angew Chem Int Ed 37:2644-2647
-
(1998)
Angew Chem Int Ed
, vol.37
, pp. 2644-2647
-
-
Holzwarth, A.1
Schmidt, H.-W.2
Maier, W.F.3
-
22
-
-
0033520302
-
Combinatorial materials science and catalysis
-
Jandeleit B, Schaefer DJ, Powers TS, Turner HW, Weinberg WH (1999) Combinatorial materials science and catalysis. Angew Chem Int Ed 38:2494-2532
-
(1999)
Angew Chem Int Ed
, vol.38
, pp. 2494-2532
-
-
Jandeleit, B.1
Schaefer, D.J.2
Powers, T.S.3
Turner, H.W.4
Weinberg, W.H.5
-
23
-
-
0031796722
-
Quantitative screening of hydrolase libraries using pH Indicators: Identifying active and enantioselective hydrolases
-
Janes LE, Löwendahl AC, Kazlauskas RJ (1998) Quantitative screening of hydrolase libraries using pH Indicators: identifying active and enantioselective hydrolases. Chem Eur J 4:2324-2331
-
(1998)
Chem Eur J
, vol.4
, pp. 2324-2331
-
-
Janes, L.E.1
Löwendahl, A.C.2
Kazlauskas, R.J.3
-
24
-
-
0033064950
-
Enantioselective fluorogenic assay of acetate hydrolysis for detecting lipase catalytic antibodies
-
Klein G, Reymond J-L (1999) Enantioselective fluorogenic assay of acetate hydrolysis for detecting lipase catalytic antibodies. Helv Chim Acta 82:400-406
-
(1999)
Helv Chim Acta
, vol.82
, pp. 400-406
-
-
Klein, G.1
Reymond, J.-L.2
-
25
-
-
0023645080
-
Tinkering with enzymes: What are we learning?
-
Knowles JR (1987) Tinkering with enzymes: what are we learning? Science 236:1252-1258
-
(1987)
Science
, vol.236
, pp. 1252-1258
-
-
Knowles, J.R.1
-
27
-
-
0002694056
-
A method for random mutagenesis of a defined DNA segment using a modified polymerase chain reaction
-
Leung DW, Chen E, Goeddel DV (1989) A method for random mutagenesis of a defined DNA segment using a modified polymerase chain reaction. Technique 1:11-15
-
(1989)
Technique
, vol.1
, pp. 11-15
-
-
Leung, D.W.1
Chen, E.2
Goeddel, D.V.3
-
28
-
-
0033834791
-
Directed evolution of an enantioselective lipase
-
Liebeton K, Zonta A, Schimossek K, Nardini M, Lang D, Dijkstra BW, Reetz MT, Jaeger K-E (2000) Directed evolution of an enantioselective lipase. Chem Biol 7:709-718
-
(2000)
Chem Biol
, vol.7
, pp. 709-718
-
-
Liebeton, K.1
Zonta, A.2
Schimossek, K.3
Nardini, M.4
Lang, D.5
Dijkstra, B.W.6
Reetz, M.T.7
Jaeger, K.-E.8
-
29
-
-
0030399120
-
Infrared thermographic screening of combinatorial libraries of heterogeneous catalysts
-
Moates FC, Somani M, Annamalai J, Richardson JT, Luss D, Willson RC (1996) Infrared thermographic screening of combinatorial libraries of heterogeneous catalysts. Ind Eng Chem Res 35:4801-4803
-
(1996)
Ind Eng Chem Res
, vol.35
, pp. 4801-4803
-
-
Moates, F.C.1
Somani, M.2
Annamalai, J.3
Richardson, J.T.4
Luss, D.5
Willson, R.C.6
-
32
-
-
0023289078
-
Spatial effects on supported catalysts: Thermal infrared imaging is a useful tool for studying local rate variations on catalytic surfaces in situ
-
Pawlicki PC, Schmitz RA (1987) Spatial effects on supported catalysts: thermal infrared imaging is a useful tool for studying local rate variations on catalytic surfaces in situ. Chem Eng Prog 83: 40-45
-
(1987)
Chem Eng Prog
, vol.83
, pp. 40-45
-
-
Pawlicki, P.C.1
Schmitz, R.A.2
-
33
-
-
0035910597
-
Combinatorial and evolution-based methods in the creation of enantioselective catalysts
-
Reetz MT (2001) Combinatorial and evolution-based methods in the creation of enantioselective catalysts. Angew Chem Int Ed 40:284-310
-
(2001)
Angew Chem Int Ed
, vol.40
, pp. 284-310
-
-
Reetz, M.T.1
-
34
-
-
0034603040
-
Enantioselective enzymes for organic synthesis created by directed evolution
-
Reetz MT, Jaeger K-E (2000) Enantioselective enzymes for organic synthesis created by directed evolution. Chem Eur J 6:407-412
-
(2000)
Chem Eur J
, vol.6
, pp. 407-412
-
-
Reetz, M.T.1
Jaeger, K.-E.2
-
35
-
-
0032491867
-
Creation of enantioselective biocatalysts for organic chemistry by in vitro evolution
-
Reetz MT, Zonta A, Schimossek K, Liebeton K, Jaeger K-E (1997) Creation of enantioselective biocatalysts for organic chemistry by in vitro evolution. Angew Chem Int Ed Engl 36:2830-2832
-
(1997)
Angew Chem Int Ed Engl
, vol.36
, pp. 2830-2832
-
-
Reetz, M.T.1
Zonta, A.2
Schimossek, K.3
Liebeton, K.4
Jaeger, K.-E.5
-
36
-
-
0032538361
-
Time-resolved IR-thermographic detection and screening of enantioselectivity in catalytic reactions
-
Reetz MT, Becker MH, Kühling KM, Holzwarth A (1998) Time-resolved IR-thermographic detection and screening of enantioselectivity in catalytic reactions. Angew Chem Int Ed 37: 2647-2650
-
(1998)
Angew Chem Int Ed
, vol.37
, pp. 2647-2650
-
-
Reetz, M.T.1
Becker, M.H.2
Kühling, K.M.3
Holzwarth, A.4
-
38
-
-
0034599407
-
IR-thermographic screening of thermoneutral or endothermic transformations: The ring-closing olefin metathesis reaction
-
Reetz MT, Becker MH, Liebl M, Fürstner A (2000a) IR-thermographic screening of thermoneutral or endothermic transformations: the ring-closing olefin metathesis reaction. Angew Chem Int Ed 39:1236-1239
-
(2000)
Angew Chem Int Ed
, vol.39
, pp. 1236-1239
-
-
Reetz, M.T.1
Becker, M.H.2
Liebl, M.3
Fürstner, A.4
-
39
-
-
0034602059
-
Super-high-throughput screening of enantioselective catalysts by using capillary array electrophoresis
-
Reetz MT, Kühling KM, Deege A, Hinrichs H, Belder D (2000b) Super-high-throughput screening of enantioselective catalysts by using capillary array electrophoresis. Angew Chem Int Ed 39:3891-3893
-
(2000)
Angew Chem Int Ed
, vol.39
, pp. 3891-3893
-
-
Reetz, M.T.1
Kühling, K.M.2
Deege, A.3
Hinrichs, H.4
Belder, D.5
-
40
-
-
0032558964
-
Kinetic mechanism of the enantioselective conversion of styrene oxide by epoxide hydrolase from Agrobacterium radiobacter AD1
-
Rink R, Janssen DB (1998) Kinetic mechanism of the enantioselective conversion of styrene oxide by epoxide hydrolase from Agrobacterium radiobacter AD1. Biochemistry 37:1811918127
-
(1998)
Biochemistry
, vol.37
, pp. 18119-18127
-
-
Rink, R.1
Janssen, D.B.2
-
41
-
-
0030220851
-
Engineering new functions and altering existing functions
-
Shao Z, Arnold FH (1996) Engineering new functions and altering existing functions. Curr Opin Struct Biol 6:513-518
-
(1996)
Curr Opin Struct Biol
, vol.6
, pp. 513-518
-
-
Shao, Z.1
Arnold, F.H.2
-
43
-
-
0028050350
-
Rapid evolution of a protein in vitro by DNA shuffling
-
Stemmer WPC (1994) Rapid evolution of a protein in vitro by DNA shuffling. Nature 370:389-391
-
(1994)
Nature
, vol.370
, pp. 389-391
-
-
Stemmer, W.P.C.1
-
44
-
-
0032502884
-
Thermographic selection of effective catalysts from an encoded polymer-bound library
-
Taylor SJ, Morken JP (1998) Thermographic selection of effective catalysts from an encoded polymer-bound library. Science 280:267-270
-
(1998)
Science
, vol.280
, pp. 267-270
-
-
Taylor, S.J.1
Morken, J.P.2
-
45
-
-
0030860279
-
Asymmetric catalysis with water: Efficient kinetic resolution of terminal epoxides by means of catalytic hydrolysis
-
Tokunaga M, Larrow JF, Kakiuchi F, Jacobsen EN (1997) Asymmetric catalysis with water: efficient kinetic resolution of terminal epoxides by means of catalytic hydrolysis. Science 277:936-938
-
(1997)
Science
, vol.277
, pp. 936-938
-
-
Tokunaga, M.1
Larrow, J.F.2
Kakiuchi, F.3
Jacobsen, E.N.4
-
46
-
-
0023783073
-
Subtilisin - An enzyme designed to be engineered
-
Wells JA, Estell DA (1988) Subtilisin - an enzyme designed to be engineered. Trends Biochem Sci 13:291-297
-
(1988)
Trends Biochem Sci
, vol.13
, pp. 291-297
-
-
Wells, J.A.1
Estell, D.A.2
-
48
-
-
0033522895
-
A colorimetric assay suitable for screening epoxide hydrolase activity
-
Zocher F, Enzelberger MM, Bornscheuer UT, Hauer B, Schmid RD (1999) A colorimetric assay suitable for screening epoxide hydrolase activity. Anal Chim Acta 391:345-351
-
(1999)
Anal Chim Acta
, vol.391
, pp. 345-351
-
-
Zocher, F.1
Enzelberger, M.M.2
Bornscheuer, U.T.3
Hauer, B.4
Schmid, R.D.5
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