Therapy and prophylaxis of inhaled biological toxins

Journal of Applied Toxicology

Volumn 23, Issue 3, 2003, Pages 139-170

  Paddle, Brian M ^a  

^a DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

Author keywords

Aptamers; Biological warfare; Dendrimers; Inhalation; Lung; Monoclonal antibodies; Prophylaxis; Therapy; Toxicity; Toxins

Indexed keywords

ABRIN; AFLATOXIN; ALPHA TOXIN; AMILORIDE DERIVATIVE; AMIODARONE; APTAMER; ATROPINE; BACTERIAL TOXIN; BAFILOMYCIN A1; BOTULINUM TOXIN; CALCIUM CHANNEL BLOCKING AGENT; CAPTOPRIL; CERULENIN; DENDRIMER; DIPHTHERIA TOXIN; IMIDAZOLE DERIVATIVE; IMMUNOMODULATING AGENT; MAITOTOXIN; MANNITOL; MONOCLONAL ANTIBODY; OUABAIN; PALYTOXIN; PHOSPHORAMIDON; RICIN; SAXITOXIN; SHIGA TOXIN; STAPHYLOCOCCUS ENTEROTOXIN B; TETANUS TOXIN; TRIFLUOPERAZINE; UNINDEXED DRUG;

AEROSOL; BINDING SITE; BIOLOGICAL WARFARE; CYTOTOXICITY; HUMAN; IMMUNITY; INFLAMMATION; LUNG ALVEOLUS CELL; LUNG TOXICITY; MEMBRANE BINDING; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PUBLIC HEALTH; REVIEW; SKIN ABSORPTION;

ADMINISTRATION, INHALATION; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; BACTERIAL TOXINS; BACTERIAL VACCINES; BIOLOGICAL WARFARE; HUMANS; INHALATION EXPOSURE; LUNG; PNEUMONIA, BACTERIAL; PUBLIC HEALTH;

EID: 0037503914     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.903     Document Type: Review

References (312)

1. Adler KB, Fischer BM, Wright DT, Cohn LA, Becker S. 1994. Interactions between respiratory epithelial cells and cytokines: relationships to lung inflammation. Ann. NY Acad. Sci. 725: 128-145.
2. Adler M, Nicholson JD, Starks DF, Kane CT, Cornille F, Hackley BEJ. 1999. Evaluation of phosphoramidon and three synthetic phosphonates for inhibition of botulinum neurotoxin B catalytic activity. J. Appl. Toxicol. 19: S5-11.
3. Adler M, Capacio B, Deshpande SS. 2000. Antagonism of botulinum toxin A-mediated muscle paralysis by 3,4-diaminopyridine delivered via osmotic minipumps. Toxicon 38: 1381-1388.
4. Ahnert-Hilger G, Bigalke H. 1995. Molecular aspects of tetanus and botulinum neurotoxin poisoning. Prog. Neurobiol. 46: 83-96.
5. Allenby AC, Brown JF, Clarke JL, Dewey J, Griffiths GD, Mode NK, Rubidge T, Scawin JW, Titball RW, Upshall DG. 1994. The production, purification and toxicity of Clostridium perfringens alpha-toxin cloned into Escherichia coli. In Minutes of The Technical Cooperation Program, Subgroup E - Technical Panel 1 Meeting of 3-5 May 1994, Annex C (U). Chemical and Biological Defence Establishment: Porton Down, Salisbury, UK.
6. Andersson J, Nagy S, Bjork L, Abrams J, Holm S, Andersson U. 1992. Bacterial toxin-induced cytokine production studied at the single-cell level. Immunol. Rev. 127: 69-96.
7. Arad G, Levy R, Hillman D, Kaempfer R. 2000. Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation. Nat. Med. 6: 414-421.
8. Arbibe L, Koumanov K, Vial D, Rougeot C, Faure G, Havet N, Longacre S, Vargaftig BB, Bereziat G, Voelker DR, Wolf C, Touqui L. 1998. Generation of lysophospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction. J. Clin. Invest. 102: 1152-1160.
9. Arias HR, Blanton MP. 2000. Alpha conotoxins. Int. J. Biochem. Cell Biol. 32: 1017-1028.
10. Ashcom JD, Stiles BG. 1997. Characterization of alpha-conotoxin interactions with the nicotinic acetylcholine receptor and monoclonal antibodies. Biochem. J. 328: 245-250.
11. Baden DG. 1983. Marine food-borne dinoflagellate toxins. Int. Rev. Cytol. 82: 99-150.
12. 1: the ultimate carcinogenic species. J. Am. Chem. Soc. 110: 7929-7931.
13. Ball RW, Huie JM, Coulombe RAJ. 1995. Comparative activation of aflatoxin B1 by mammalian pulmonary tissues. Toxicol. Lett. 75: 119-125.
14. Ballantyne B, Marrs TC, Turner P. 1995. Fundamentals of toxicology. In General and Applied Toxicology, Ballantyne B, Marrs T, Turner P (eds), abreviated edition. Macmillan Press: New York; 3-38.
15. Barnes PJ, Adcock IM. 1997. Glucocorticoid receptors. In The Lung: Scientific Foundations (2nd edn), Crystal RG, West JB, Weibel ER, Barnes PJ (eds). Lippincott-Raven: Philadelphia; 37-55.
16. Becerril B, Marangoni S, Possani LD. 1997. Toxins and genes isolated from scorpions of the genus tityus [Review]. Toxicon 35: 821-835.
17. Benton BJ, Keller SA, Spriggs DL, Capacio BR, Chang FC. 1998. Recovery from the lethal effects of saxitoxin: a therapeutic window for 4-aminopyridine (4-AP). Toxicon 36: 571-588.
18. Bezdicek P, Crystal RG. 1997. Pulmonary macrophages. In The Lung: Scientific Foundations (2nd edn), Crystal RG, West JB, Weibel ER, Barnes PJ (eds). Lippincott-Raven: Philadelphia; 859-875.
19. + channel toxin. J. Biol. Chem. 259: 8353-8357.
20. Bide RW, Armour SJ, Lee E. 1997. Estimation of Human Toxicity from Animal Inhalation Toxicity Data: 1. Minute Volume-Body Weight Relationships between Animals and Man, Report No. DRES-SR 673 (U). Defence Research Establishment: Suffield, Canada.
21. Blythe DG, De Sylva DP, Fleming LE, Ayyar RA, Baden DG, Shrank K. 1992. Clinical experience with i.v. mannitol in the treatment of ciguatera. Bull. Soc. Pathol. Exot. 85: 425-426.
22. Bodnar Z, Steger MM, Saurwein-Teissl M, Maczek C, Grubeck-Loebenstein B. 1997. Cytokine production in response to stimulation with tetanus toxoid, Mycobacterium tuberculosis and influenza antigens in peripheral blood mononuclear cells and T cell lines from healthy elderlies. Int. Arch. Allergy Immunol. 112: 323-330.
23. Bonnard C, Lechner JF, Gerwin BI, Fujiki H, Harris CC. 1988. Effects of palytoxin or ouabain on growth and squamous differentiation of human bronchial epithelial cells in vitro. Carcinogenesis 9: 2245-2249.
24. Bouhafs RK, Jarstrand C. 1999. Lipid peroxidation of lung surfactant by bacteria. Lung 177: 101-110.
25. Breinholt V, Hendricks J, Pereira C, Arbogast D, Bailey G. 1995. Dietry chlorophyllin is a potent inhibitor of aflatoxin B1 hepatocarcinogenesis in rainbow trout. Cancer Res. 55: 57-62.
26. Brigotti M, Carnicelli D, Accorsi P, Rizzi S, Montanaro L, Sperti S. 2000. 4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1. Nucleic Acids Res. 28: 2383-2388.
27. Brigotti M, Alfieri R, Sestili P, Bonelli M, Petronini PG, Guidarelli A, Barbieri L, Stirpe F, Sperti S. 2002. Damage to nuclear DNA induced by Shiga toxin 1 and ricin in human endothelial cells. FASEB J. 16: 365-372.
28. Brooke JS, Cha JH, Eidels L. 1998. Diphtheria toxin: receptor interaction: association, dissociation, and effect of pH. Biochem. Biophys. Res. Commun. 248: 297-302.
29. Brooke JS, Cha JH. 2000. Molecular characterization of key diphtheria toxin: receptor interactions. Biochem. Biophys. Res. Commun. 275: 374-381.
30. Brown RF, White DE. 1997. Ultrastructure of rat lung following inhalation of ricin aerosol. Int. J. Exp. Pathol. 78: 267-276.
31. Bruno JG, Kiel JL. 2002. Use of magnetic beads in selection and detection of biotoxin aptamers by electrochemiluminescence and enzymatic methods. Biotechniques 32: 178-183.
32. Buchi G, Spitzner D, Paglialunga S, Wogan GN. 1973. Synthesis and toxicity evaluation of aflatoxin P. Life Sci. 13: 1143-1149.
33. Bunner DL, Morris ER. 1988. Alteration of multiple cell membrane functions in L-6 myoblasts by T-2 toxin: an important mechanism of action. Toxicol. Appl. Pharmacol. 92: 113-121.
34. Bunting M, Lorant DE, Bryant AE, Zimmerman GA, McIntyre TM, Stevens DL, Prescott SM. 1997. Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells. J. Clin. Invest. 100: 565-574.
35. Capra MF, Cameron J. 1992. Ciguatera poisoning. In Toxins and Targets, Watters D, Lavin M, Maguire D, Pearn J (eds). Harwood Academic Publishers: Melbourne; 87-96.
36. Carmichael WW. 1994. The toxins of cyanobacteria. Sci. Am. 270: 64-72.
37. Catterall WA. 1988. Structure and function of voltage-sensitive ion channels. Science 242: 50-61.
38. Center DM, Kornfeld H, Cruikshank WW. 1997. Interleukin-16. Int. J. Biochem. Cell Biol. 29: 1231-1234.
39. Chang FC, Benton BJ, Lenz RA, Capacio BR. 1993. Central and peripheral cardiorespiratory effects of saxitoxin (STX) in urethane-anesthetized guinea-pigs. Toxicon 31: 645-664.
40. Chang FC, Spriggs DL, Benton BJ, Keller SA, Capacio BR. 1997. 4-Aminopyridine reverses saxitoxin (STX)- and tetrodotoxin (TTX)-induced cardiorespiratory depression in chronically instrumented guinea pigs. Fundam. Appl. Toxicol. 38: 75-88.
41. Choy WN. 1993. A review of the dose-response induction of DNA adducts by aflatoxin B1 and its implications to quantitative cancer-risk assessment. Mutat. Res. 296: 181-198.
42. Cook WO, Beasley VR, Dahlem AM, Dellinger JA, Harlin KS, Carmichael WW. 1988. Comparison of effects of anatoxina(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity. Toxicon 26: 750-753.
43. Cook WO, Iwamoto GA, Schaeffer DJ, Beasley VR. 1989. Effect of anatoxin-a(s) from Anabaena flos-aquae NRC-525-17 on blood pressure, heart rate, respiratory rate, tidal volume, minute volume, and phrenic nerve activity in rats. J. Environ Pathol. Toxicol. Oncol. 9: 393-400.
44. Creasia DA, Thurman JD, Jones LJ, Nealley ML, York CG, Wannemacher RW, Bunner DL. 1987. Acute inhalation toxicity of T-2 mycotoxin in mice. Fundam. Appl. Toxicol. 8: 230-235.
45. Creasia DA, Thurman JD, Wannemacher RW, Bunner DL. 1990. Acute inhalation toxicity of T-2 mycotoxin in the rat and guinea pig. Fundam. Appl. Toxicol. 14: 54-59.
46. Creveling CR, McNeal ET, Daly JW, Brown GB. 1983. Batrachotoxin-induced depolarization and [3H]batrachotoxinin-a 20 alpha-benzoate binding in a vesicular preparation from guinea pig cerebral cortex. Mol. Pharmacol. 23: 350-358.
47. Crosland RD. 1991. Effect of drugs on the lethality in mice of the venoms and neurotoxins from sundry snakes. Toxicon 29: 613-631.
48. Cross CE, Eiserich JP, Halliwell B. 1997. General biological consequences of inhaled environmental toxicants. In The Lung: Scientific Foundations (2nd edn), Crystal RG, West JB, Weibel ER, Barnes PJ (eds). Lippincott-Raven: Philadelphia; 2421-2437.
49. Cruz LJ, Gray WR, Olivera BM. 1978. Purification and properties of a myotoxin from Conus geographus venom. Arch. Biochem. Biophys. 190: 539-548.
50. Crystal RG, West JB, Weibel ER, Barnes JB (eds). 1997. The Lung: Scientific Foundations (2nd edn). Lippincott-Raven: Philadelphia.
51. Cunningham AC, Zhang JG, Moy JV, Ali S, Kirby JA. 1997. A comparison of the antigen-presenting capabilities of class II MHC-expressing human lung epithelial and endothelial cells. Immunology 91: 458-463.
52. Daly JW, Lueders J, Padgett WL, Shin Y, Gusovsky F. 1995. Maitotoxin-elicited calcium influx in cultured cells. Biochem. Pharmacol. 50: 1187-1197.
53. Dawson RM. 1998. The toxicology of microcystins. Toxicon 36: 953-962.
54. Dawson RM, Paddle BM, Alderton MR. 1999. Characterization of the asialofetuin microtitre plate-binding assay for evaluating inhibitors of ricin lectin activity. J. Appl. Toxicol. 19: 307-312.
55. Delmas A, Gruaz G, Pedoussaut S, Pierre P, Rivaille P, Vaerman JP. 1989. Neutralization of cholera toxin by rat IgA secretory antibodies induced by a free synthetic peptide. Biochem. Biophys. Res. Commun. 159: 707-712.
56. Denyer J, Worley J, Cox B, Allenby G, Banks M. 1998. HTS approaches to voltage-gated ion channel drug discovery. Drug Discov. Today 3: 323-332.
57. Dodds DC, Omeis IA, Cushman SJ, Helms JA, Perin MS. 1997. Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. J. Biol. Chem. 272: 21488-21494.
58. 125I] ricin in mice following aerosol inhalation exposure. Toxicology 98: 137-149.
59. Dumbacher JP, Spande TF, Daly JW. 2000. Batrachotoxin alkaloids from passerine birds: a second toxic bird genus (Ifrita kowaldi) from New Guinea. Proc. Natl. Acad. Sci. USA 97: 12970-12975.
60. Dutton JL, Craik DJ. 2001. Alpha-conotoxins: nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads. Curr. Med. Chem. 8: 327-344.
61. Eiklid K, Olsnes S. 1983. Animal toxicity of Shigella dysenteriae cytotoxin: evidence that the neurotoxic, enterotoxic, and cytotoxic activities are due to one toxin. J. Immunol. 130: 380-384.
62. Ellington AD, Szostak JW. 1990. In vitro selection of RNA molecules that bind specific ligands. Nature 346: 818-822.
63. Ellison DH. 1999. Handbook of Chemical and Biological Warfare Agents. CRC Press: New York; 184-191.
64. Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW. 2000. The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding. J. Biol. Chem. 275: 8889-8894.
65. Endo Y, Mitsui K, Motizuki M, Tsurugi K. 1987. The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins. J. Biol. Chem. 262: 5908-5912.
66. Endo Y, Tsurugi K, Yutsudo T, Takeda Y, Ogasawara T, Igarashi K. 1988. Site of action of a Vero toxin (VT2) from Escherichia coli O157: H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins. Eur. J. Biochem. 171: 45-50.
67. Ermert L, Bruckner H, Walmrath D, Grimminger F, Aktories K, Suttorp N, Duncker HR, Seeger W. 1995. Role of endothelial cytoskeleton in high-permeability edema due to botulinum C2 toxin in perfused rabbit lungs. Am. J. Physiol. 268: L753-L761.
68. Ermert L, Rossig R, Hansen T, Schutte H, Aktories K, Seeger W. 1996. Differential role of actin in lung endothelial and epithelial barrier properties in perfused rabbit lungs. Eur. Respir. J. 9: 93-99.
69. Ermert L, Duncker HR, Bruckner H, Grimminger F, Hansen T, Rossig R, Aktories K, Seeger W. 1997. Ultrastructural changes of lung capillary endothelium in response to botulinum C2 toxin. J. Appl. Physiol. 82: 382-388.
70. Escobar LI, Salvador C, Martinez M, Vaca L. 1998. Maitotoxin, a cationic channel activator. Neurobiology (Bp) 6: 59-74.
71. Famulok M. 1999. Oligonucleotide aptamers that recognize small molecules. Curr. Opin. Struct. Biol. 9: 324-329.
72. Famulok M, Mayer G, Blind M. 2000. Nucleic acid aptamers from selection in vitro to applications in vivo. Acc. Chem. Res. 33: 591-599.
73. Fleming LE, Stephan W. 2001. Blue-green Algae, their Toxins and Public Health Issues. Report to the Florida Harmful Algal Bloom Taskforce. NIEHS Marine and Freshwater Biomedical Sciences Center: University of Miami, Miami.
74. Fodstad O, Olsnes S, Pihl A. 1976. Toxicity, distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice. Br. J. Cancer 34: 418-425.
75. Fohlman J, Eaker D, Karlsoon E, Thesleff S. 1976. Taipoxin, an extremely potent presynaptic neurotoxin from the venom of the Australian snake taipan (Oxyuranus s. scutellatus). Isolation, characterization, quaternary structure and pharmacological properties. Eur. J. Biochem. 68: 457-469.
76. Fotinou C, Emsley P, Black I, Ando H, Ishida H, Kiso M, Sinha KA, Fairweather NF, Isaacs NW. 2001. The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin. J. Biol. Chem. 276: 32274-32281.
77. Franz DR. 1997. Defense against toxin weapons. In Textbook of Military Medicine. Part 1: Medical Aspects of Chemical and, Biological Warfare, Zajtchuk R, Bellamy RF (eds). Office of the Surgeon General, Department of the Army: USA; 603-619.
78. Franz DR, LeClaire RD. 1989. Respiratory effects of brevetoxin and saxitoxin in awake guinea pigs. Toxicon 27: 647-654.
79. Frelin C, Van Renterghem C. 1995. Palytoxin. Recent electrophysiological and pharmacological evidence for several mechanisms of action. Gen. Pharmacol. 26: 33-37.
80. Fricke RF, Jorge J. 1991. Methylthiazolidine-4-carboxylate for treatment of acute T-2 toxin exposure. J. Appl. Toxicol. 11: 135-140.
81. + channels [Letter]. Planta Med. 64: 458-459.
82. Fujii N, Kimura K, Yokosawa N, Tsuzuki K, Oguma K. 1992. The zinc-protease specific domain in botulinum and tetanus neurotoxins. Toxicon 30: 1486-1488.
83. Gabrielson EW, Kuppusamy P, Povey AC, Zweier JL, Harris CC. 1992. Measurement of neutrophil activation and epidermal cell toxicity by palytoxin and 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis 13: 1671-1674.
84. Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D. 1998. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Mol. Biol. Cell 9: 1437-1448.
85. Garcia GE, Moorad DR, Gordon RK. 1999. Buforin 1, a natural peptide, inhibits botulinum neurotoxin B activity in vitro. J. Appl. Toxicol. 19: S19-S22.
86. Garred O, van Deurs B, Sandvig K. 1995a. Furin-induced cleavage and activation of Shiga toxin. J. Biol. Chem. 270: 10817-10821.
87. Garred O, Dubinina E, Holm PK, Olsnes S, van Deurs B, Kozlov JV, Sandvig K. 1995b. Role of processing and intracellular transport for optimal toxicity of Shiga toxin and toxin mutants. Exp. Cell Res. 218: 39-49.
88. Gehrmann J, Alewood PF, Craik DJ. 1998. Structure determination of the three disulfide bond isomers of alpha-conotoxin GI: a model for the role of disulfide bonds in structural stability. J. Mol. Biol. 278: 401-415.
89. Gill DM. 1982. Bacterial toxins: a table of lethal amounts. Microbiol. Rev. 46: 86-94.
90. Glasgow HBJ, Burkholder JM, Schmechel DE, Tester PA, Rublee PA. 1995. Insidious effects of a toxic estuarine dinoflagellate on fish survival and human health. J. Toxicol. Environ. Health 46: 501-522.
91. + currents in a cultured endothelial cell line derived from rat interlobar artery and human umbilical vein. Pflugers Arch. 428: 91-93.
92. Gordon T, Amdur MO. 1991. Responses of the respiratory system to toxic agents. In Casarett and Doull's Toxicology: The Basic Science of Poisons (4th edn), Klaassen CD, Amdur MO, Doull J (eds). McGraw-Hill: New York; 383-406.
93. Gosling M, Harley SL, Turner RJ, Carey N, Powell JT. 1998. Human saphenous vein endothelial cells express a tetrodotoxin-resistant, voltage-gated sodium current. J. Biol. Chem. 273: 21084-21090.
94. Grangette C, Muller A, Goudercourt D, Geoffroy MC, Turneer M, Mercenier A. 2001. Mucosal immune responses and protection against tetanus toxin after intranasal immunization with recombinant Lactobacillus plantarum. Infect. Immun. 69: 1547-1553.
95. Griffiths GD, Lindsay D, Rice P, Upshall DG. 1992. The toxicology of ricin and abrin toxins. In vivo and in vitro studies. In Minutes of The Technical Cooperation Program, Subgroup E - AG37 Meeting of 21-22 September 1992, Annex C (U). Defence Research Establishment Suffield: Alberta, Canada.
96. Griffiths GD, Rice P, Allenby AC, Bailey SC, Upshall DG. 1995. Inhalation toxicology and histopathology of ricin and abrin toxins. Inhal. Toxicol. 7: 269-288.
97. Gusovsky F, Yasumoto T, Daly JW. 1989. Maitotoxin, a potent, general activator of phosphoinositide breakdown. FEBS Lett. 243: 307-312.
98. Gutierrez B, Vilumara A, Farre AJ. 1987. Inhibition of aconitine-induced mortality in the conscious rat: a screening test for antiarrhythmic drugs. Methods Find. Exp. Clin. Pharmacol. 9: 307-310.
99. Gutierrez D, Diaz de L, Vaca L. 1997. Characterization of the maitotoxin-induced calcium influx pathway from human skin fibroblasts. Cell Calcium 22: 31-38.
100. Guyonnet D, Belloir C, Suschetet M, Siess MH, Le B. 2002. Mechanisms of protection against aflatoxin B(1) genotoxicity in rats treated by organosulfur compounds from garlic. Carcinogenesis 23: 1335-1341.
101. +-ATPase. Toxicon 27: 1171-1187.
102. +-ATPase. Toxicon 27: 419-430.
103. Hains PG, Broady KW. 2000. Purification and inhibitory profile of phospholipase A2 inhibitors from Australian elapid sera. Biochem. J. 346: 139-146.
104. Hamilton MG. 1996. Toxins. The Emerging Threat, Special Publication, SSP 184 (U). Defence Research Establishment Suffield: Canada.
105. Hance AJ. 1997. Accessory-cell-lymphocyte interactions. In The Lung: Scientific Foundations (2nd edn), Crystal RG, West JB, Weibel ER, Barnes PJ (eds). Lippincott-Raven: Philadelphia; 821-839.
106. Hanna P. 1999. Lethal toxin actions and their consequences. J. Appl. Microbiol. 87: 285-287.
107. Harris JB, Maltin CA. 1982. Myotoxic activity of the crude venom and the principal neurotoxin, taipoxin, of the Australian taipan, Oxyuranus scutellatus. Br. J. Pharmacol. 76: 61-75.
108. Hassoun EA, Stohs SJ. 1996. Potential chemoprotectant activity of 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxycytidine (DDC) against ricin toxicity in Chinese hamster ovary and macrophage J774A.1 cell cultures. J. Appl. Toxicol. 16: 43-48.
109. Hassoun EA, Wang X. 1999. Time- and concentration-dependent production of superoxide anion, nitric oxide, DNA damage and cellular death by ricin in the J774A.1 macrophage cells. J. Biochem. Mol. Toxicol. 13: 179-185.
110. Hassoun EA, Bagchi D, Roche VF, Stohs SJ. 1996. Potential chemoprotectant activity of mechanism-based glycosidase inhibitors against ricin toxicity in Chinese hamster ovary and macrophage J774A.1 cell cultures. J. Appl. Toxicol. 16: 49-54.
111. Haugland RP. 1999a. Assays for cell viability, proliferation and function. In Handbook of Fluorescent Probes and Research Chemicals (7th edn). Molecular Probes: Eugene, Oregon; Chapt. 15.
112. - and other anions. In Handbook of Fluorescent Probes and Research Chemicals (7th edn). Molecular Probes: Eugene, Oregon; Chapt. 22.
113. Haugland RP. 1999c. Probes for membrane potential. In Handbook of Fluorescent Probes and Research Chemicals (7th edn). Molecular Probes: Eugene, Oregon; Chapt. 23.
114. Herman A, Kappler JW, Marrack P, Pullen AM. 1991. Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu. Rev. Immunol. 9: 745-772.
115. Hermansky SJ, Casey PJ, Stohs SJ. 1990. Cyclosporin A - a chemoprotectant against microcystin-LR toxicity. Toxicol. Lett. 54: 279-285.
116. Herreros J, Lalli G, Schiavo G. 2000. C-terminal half of tetanus toxin C is sufficient for neuronal binding and interaction with a putative protein receptor. Biochem. J. 347: 199-204.
117. Herreros J, Ng T, Schiavo G. 2001. Lipid rafts as specialized domains for tetanus toxin binding and internalization into neurons. Mol. Biol. Cell 12: 2947-2960.
118. Hesselberth JR, Miller D, Robertus J, Ellington AD. 2000. In vitro selection of RNA molecules that inhibit the activity of ricin A-chain. J. Biol. Chem. 275: 4937-4942.
119. Hewetson JF, Rivera VR, Creasia DA, Lemley PV, Rippy MK, Poli MA. 1993. Protection of mice from inhaled ricin by vaccination with ricin or by passive treatment with heterologous antibody. Vaccine 11: 743-746.
120. Hirao I, Madin K, Endo Y, Yokoyama S, Ellington AD. 2000. RNA aptamers that bind to and inhibit the ribosome-inactivating protein, pepocin. J. Biol. Chem. 275: 4943-4948.
121. Holmes MJ, Lewis RJ. 1994. Purification and characterisation of large and small maitotoxins from cultured Gambierdiscus toxicus. Nat. Toxins 2: 64-72.
122. Holt PG, Haining S, Nelson DJ, Sedgwick JD. 1994. Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways. J. Immunol. 153: 256-261.
123. Holtzman MJ. 1992. Arachidonic acid metabolism in airway epithelial cells. Annu. Rev. Physiol. 54: 303-329.
124. Hooser SB, Beasley VR, Basgall EJ, Carmichael WW, Haschek WM. 1990. Microcystin-LR-induced ultrastructural changes in rats. Vet. Pathol. 27: 9-15.
125. Huang IY, Bergdoll MS. 1970. The primary structure of staphylococcal enterotoxin B. 3. The cyanogen bromide peptides of reduced and aminoethylated enterotoxin B, and the complete amino acid sequence. J. Biol. Chem. 245: 3518-3525.
126. Hughes JN, Lindsay CD, Griffiths GD. 1996. Morphology of ricin and abrin exposed endothelial cells is consistent with apoptotic cell death. Hum. Exp. Toxicol. 15: 443-451.
127. Hyde EG, Carmichael WW. 1991. Anatoxin-a(s), a naturally occurring organophosphate, is an irreversible active site-directed inhibitor of acetylcholinesterase (EC 3.1.1.7). J. Biochem. Toxicol. 6: 195-201.
128. + mimics ribotoxic stress. Inhibition of protein synthesis and activation of the stress kinases SEK1/MKK4, stress-activated protein kinase/c-Jun NH2-terminal kinase 1, and p38/HOG1 by palytoxin. J. Biol. Chem. 273: 3528-3534.
129. Iqball S, Bhatt R, Bedford P, Borriello P, Knight S. 1993. Dendritic cells are potent antigen-presenting cells for microbial superantigen. Adv. Exp. Med. Biol. 329: 41-46.
130. ++ mobilization in porcine coronary artery. J. Pharmacol. Exp. Ther. 281: 1077-1084.
131. Ito E, Kondo F, Harada K. 2000. First report on the distribution of orally administered microcystin-LR in mouse tissue using an immunostaining method. Toxicon 38: 37-48.
132. Ito E, Kondo F, Harada K. 2001. Intratracheal administration of microcystin-LR, and its distribution. Toxicon 39: 265-271.
133. Jacewicz M, Clausen H, Nudelman E, Donohue R, Keusch GT. 1986. Pathogenesis of shigella diarrhea. XI. Isolation of a shigella toxin-binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide. J. Exp. Med. 163: 1391-1404.
134. Jacewicz MS, Acheson DW, Mobassaleh M, Donohue-Rolfe A, Balasubramanian KA, Keusch GT. 1995. Maturational regulation of globotriaosylceramide, the Shiga-like toxin 1 receptor, in cultured human gut epithelial cells. J. Chin. Invest. 96: 1328-1335.
135. Janeway Jr. CA, Travers P. 1994. Immunobiology. The Immune System in Health and Disease. Blackwell Scientific Publications: Oxford; 8.20-8.26.
136. Jennings GS, Heck R, Oesch F, Steinberg P. 1994. Metabolism and cytotoxicity of aflatoxin B1 in cultured rat hepatocytes and nonparenchymal cells: implications for tumorigenesis. Toxicol. Appl. Pharmacol. 129: 86-94.
137. Kaul PN, Farmer MR, Ciereszko LS. 1974. Pharmacology of palytoxin. Most potent marine toxin. Proc. West Pharmacol. Soc. 17: 294-301.
138. Kelly JD, Eaton DL, Guengerich FP, Coulombe RA. 1997. Aflatoxin b-1 activation in human lung. Toxicol. Appl. Pharmacol. 144: 88-95.
139. Keren DF, Brown JE, McDonald RA, Wassef JS. 1989. Secretory immunoglobulin A response to Shiga toxin in rabbits: kinetics of the initial mucosal immune response and inhibition of toxicity in vitro and in vivo. Infect. Immun. 57: 1885-1889.
140. Khachatourians GG. 1990. Metabolic effects of trichothecene T-2 toxin. Can. J. Physiol. Pharmacol. 68: 1004-1008.
141. Kimura I, Takada M, Nojima H, Kimura M. 1996. Aconitine, a main component of aconite, increases spontaneous acetylcholine release from the frontal cerebral cortex of freely moving rats. Biol. Pharm. Bull. 19: 1440-1442.
142. Kimura I, Takada M, Nojima H. 1997. Aconitine induces bradycardia through a transmission pathway including the anterior hypothalamus in conscious mice. Biol. Pharm. Bull. 20: 856-860.
143. Kitov PI, Sadowska JM, Mulvey G, Armstrong GD, Ling H, Pannu NS, Read RJ, Bundle DR. 2000. Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands. Nature 403: 669-672.
144. Kiyokawa N, Taguchi T, Mori T, Uchida H, Sato N, Takeda T, Fujimoto J. 1998. Induction of apoptosis in normal human renal tubular epithelial cells by Escherichia coli Shiga toxins 1 and 2. J. Infect. Dis. 178: 178-184.
145. Knight PA, Queminet J, Blanchard JH, Tilleray JH. 1990. In vitro tests for the measurement of clostridial toxins, toxoids and antisera. II. Titration of Clostridium perfringens toxins and antitoxins in cell culture. Biologicals 18: 263-270.
146. Kodama M, Sato S, Sakamoto S, Ogata T. 1996. Occurrence of tetrodotoxin in Alexandrium tamarense, a causative dinoflagellate of paralytic shellfish poisoning. Toxicon 34: 1101-1105.
147. Kohli E, Raj H, Kumari R, Rohil V, Kaushik N, Prasad A, Parmar V. 2002. Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate. Bioorg. Med. Chem. Lett. 12: 2579.
148. Kozaki S, Kamata Y, Watarai S, Nishiki T, Mochida S. 1998. Ganglioside GT1b as a complementary receptor component for Clostridium botulinum neurotoxins. Microb. Pathogen. 25: 91-99.
149. Krakauer T. 1995. Differential inhibitory effects of interleukin-10, interleukin-4, and dexamethasone on staphylococcal enterotoxin-induced cytokine production and T cell activation. J. Leuk. Biol. 57: 450-454.
150. Krieglstein KG, DasGupta BR, Henschen AH. 1994. Covalent structure of botulinum neurotoxin type A: location of sulfhydryl groups, and disulfide bridges and identification of C-termini of light and heavy chains. J. Protein Chem. 13: 49-57.
151. Kwon OJ, Au BT, Collins PD, Baraniuk JN, Adcock IM, Chung KF, Barnes PJ. 1994. Inhibition of interleukin-8 expression by dexamethasone in human cultured airway epithelial cells. Immunology 81: 389-394.
152. Lanzrein M, Falnes PO, Sand O, Olsnes S. 1997. Structure-function relationship of the ion channel formed by diphtheria toxin in Vero cell membranes. J. Membr. Biol. 156: 141-148.
153. LeClaire RD, Kell W, Bavari S, Smith TJ, Hunt RE. 1996. Protective effects of niacinamide in staphylococcal enterotoxin-B-induced toxicity. Toxicology 107: 69-81.
154. Lecomte C, Ferrat G, Fajloun Z, Van Rietschoten J, Rochat H, Martin E, Darbon H, Sabatier JM. 1999. Chemical synthesis and structure-activity relationships of Ts kappa, a novel scorpion toxin acting on apamin-sensitive SK channel. J. Pept. Res. 54: 369-376.
155. Legrand AM. 1998. Ciguatera toxins: origin, transfer, through the food chain and toxicity to humans. In Proceedings of the 8th International Conference on Harmful Algae, Vigo, Spain, 25-29 June 1997, Ruguera J, Blanco ML, Fernandez ML, Wyatt T (eds). Xunta de Galicia and The Intergovernmental Oceanographic Commission (IOC): Spain; 39-43.
156. Lemichez E, Bomsel M, Devilliers G, Vanderspek J, Murphy JR, Lukianov EV, Olsnes S, Boquet P. 1997. Membrane translocation of diphtheria toxin fragment-a exploits early to late endosome trafficking machinery. Mol. Microbiol. 23: 445-457.
157. Lemley PV, Thalley BS, Stafford DC. 1995. Prophylactic and therapeutic efficacy of an avian antitoxin in ricin intoxication. Ther. Immunol. 2: 59-66.
158. Levine L, Fujiki H, Gjika HB, Van Vunakis H. 1987. Production of antibodies to palytoxin: neutralization of several biological properties of palytoxin. Toxicon 25: 1273-1282.
159. Lewis PJ, Babiuk LA. 1999. DNA vaccines: a review. Adv. Virus Res. 54: 129-188.
160. Li G, Shinozuka J, Uetsuka K, Nakayama H, Doi K. 1997. T-2 toxin-induced apoptosis in intestinal crypt epithelial cells of mice. Exp. Toxicol. Pathol. 49: 447-450.
161. Li H, Llera A, Tsuchiya D, Leder L, Ysern X, Schlievert PM, Karjalainen K, Mariuzza RA. 1998. Three-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B. Immunity 9: 807-816.
162. Li L, Holian A. 1998. Acrolein: a respiratory toxin that suppresses pulmonary host defense. Rev. Environ. Health 13: 99-108.
163. Li L, Singh BR. 1998. Isolation of synaptotagmin as a receptor for types A and E botulinum neurotoxin and analysis of their comparative binding using a new microtiter plate assay. J. Nat. Toxins 7: 215-226.
164. Li Y, Foran P, Fairweather NF, de Paiva A, Weller U, Dougan G, Dolly JO. 1994. A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain. Biochemistry 33: 7014-7020.
165. Lightstone FC, Prieto MC, Singh AK, Piqueras MC, Whittal RM, Knapp MS, Balhorn R, Roe DC. 2000. Identification of novel small molecule ligands that bind to tetanus toxin. Chem. Res. Toxicol. 13: 356-362.
166. Lindsay CD. 1996. Assessment of aspects of the toxicity of Clostridium perfringens epsilon-toxin using the MDCK cell line. Hum. Exp. Toxicol. 15: 904-908.
167. Ling H, Boodhoo A, Hazes B, Cummings MD, Armstrong GD, Brunton JLR. 1998. Structure of the Shiga-like toxin I B-pentamer complexed with an analogue of its receptor Gb3. Biochemistry 37: 1777-1788.
168. + channel. Biophys. J. 66: 1-13.
169. Lipps BV. 2000. Isolation of subunits, alpha, beta and gamma of the complex taipoxin from the venom of Australian taipan snake (Oxyuranus s. scutellatus): characterization of beta taipoxin as a potent mitogen. Toxicon 38: 1845-1854.
170. Liu BH, Yu FY, Chan MH, Yang YL. 2002. The effects of mycotoxins, fumonisin B1 and aflatoxin B1, on primary swine alveolar macrophages. Toxicol. Appl. Pharmacol. 180: 197-204.
171. Llewellyn LE, Moczydlowski EG. 1994. Characterization of saxitoxin binding to saxiphilin, a relative of the transferrin family that displays pH-dependent ligand binding. Biochemistry 33: 12312-12322.
172. Lloyd DR, Nicholson GM, Spence I, Connor M, Tyler MI, Howden ME. 1991. Frequency-dependent neuromuscular blockade by textilotoxin in vivo. Toxicon 29: 1266-1269.
173. Lombardo D, Dennis EA. 1985. Cobra venom phospholipase A2 inhibition by manoalide. A novel type of phospholipase inhibitor. J. Biol. Chem. 260: 7234-7240.
174. + channel. FEBS Lett. 219: 355-359.
175. London E. 1992. Diphtheria toxin: membrane interaction and membrane translocation. Biochim. Biophys. Acta 1113: 25-51.
176. Lord JM, Roberts LM, Robertus JD. 1994. Ricin: structure, mode of action, and some current applications. FASEB J. 8: 201-208.
177. Mackenzie CF, Smalley AJ, Barnas GM, Park SG. 1996. Tetrodotoxin infusion: nonventilatory effects and role in toxicity models. Acad. Emerg. Med. 3: 1106-1112.
178. MacLean JA, Xia W, Pinto CE, Zhao L, Liu HW, Kradin RL. 1996. Sequestration of inhaled particulate antigens by lung phagocytes. A mechanism for the effective inhibition of pulmonary cell-mediated immunity. Am. J. Pathol. 148: 657-666.
179. Manger RL, Leja LS, Lee SY, Hungerford JM, Welkell MM. 1993. Tetrazolium-based cell bioassay for neurotoxins active on voltage-sensitive sodium channels: semiautomated assay for saxitoxins, brevetoxins, and ciguatoxins. Anal. Biochem. 214: 190-194.
180. Marrs TC, Edginton JA, Price PN, Upshall DG. 1986. Acute toxicity of T2 mycotoxin to the guinea-pig by inhalation and subcutaneous routes. Br. J. Exp. Pathol. 67: 259-268.
181. Marshall IG, Harvey AL. 1990. Selective neuromuscular blocking properties of alpha-conotoxins in vivo. Toxicon 28: 231-234.
182. Matsumura K. 1995. In vivo neutralization of tetrodotoxin by a monoclonal antibody. Toxicon 33: 1239-1241.
183. Matsunaga S, Moore RE, Niemczura WP. 1989. Anatoxin-a(s), a potent anticholinesterase from Anabaena flos-aquae. J. Am. Chem. Soc. 111: 8021-8023.
184. Medaglini D, Ciabattini A, Spinosa MR, Maggi T, Marcotte H, Oggioni MR, Pozzi G. 2001. Immunization with recombinant Streptococcus gordonii expressing tetanus toxin fragment C confers protection from lethal challenge in mice. Vaccine 19: 1931-1939.
185. Merck. 1989a. Merck Index (11th edn). Merck: Rahway, NJ; 18-19.
186. Merck. 1989b. Merck Index (11th edn). Merck: Rahway, NJ; 30.
187. Mereish KA, Bunner DL, Ragland DR, Creasia DA. 1991. Protection against microcystin-LR-induced hepatotoxicity by Silymarin: biochemistry, histopathology, and lethality. Pharm. Res. 8: 273-277.
188. Mitchell JP, Roberts KD, Langley J, Koentgen F, Lambert JN. 1999. A direct method for the formation of peptide and carbohydrate dendrimers. Bioorg. Med. Chem. Lett. 9: 2785-2788.
189. Miura GA, Robinson NA, Geisbert TW, Bostian KA, White JD, Pace JG. 1989. Comparison of in vivo and in vitro toxic effects of microcystin-LR in fasted rats. Toxicon 27: 1229-1240.
190. Miyamoto O, Minami J, Toyoshima T, Nakamura T, Masada T, Nagao S, Negi T, Itano T, Okabe A. 1998. Neurotoxicity of Clostridium perfringens epsilon-toxin for the rat hippocampus via the glutamatergic system. Infect. Immun. 66: 2501-2508.
191. Miyamoto O, Sumitani K, Nakamura T, Yamagami S, Miyata S, Itano T, Negi T, Okabe A. 2000. Clostridium perfringens epsilon toxin causes excessive release of glutamate in the mouse hippocampus. FEMS Microbiol. Lett. 189: 109-113.
192. Montecucco C, Schiavo G. 1993. Tetanus and botulism neurotoxins: a new group of zinc proteases. Trends Biochem. Sci. 18: 324-327.
193. Montecucco C, Schiavo G. 1994. Mechanism of action of tetanus and botulinum neurotoxins. Mol. Microbiol. 13: 1-8.
194. Montecucco C, Schiavo G. 1995. Structure and function of tetanus and botulinum neurotoxins. Q. Rev. Biophys. 28: 423-472.
195. Montecucco C, Schiavo G, Tugnoli V, de Grandis D. 1996. Botulinum neurotoxins: mechanism of action and therapeutic applications. Mol. Med. Today 2: 418-424.
196. Moore RE, Bartolini G. 1981. Structure of Palytoxin. J. Am. Chem. Soc. 103: 2491-2494.
197. Moreira-Ferreira AM, Kalapothakis E, Diniz CR, Chavez-Olortegui C. 1998. In vivo protection against Tityus serrulatus scorpion toxins by immunization of mice with a non-toxic protein. Toxicon 36: 333-339.
198. Murata M, Naoki H, Matsunaga S, Satake M, Yasumoto T. 1994. Structure and partial stereochemical assignments for maitotoxin, the most toxic and largest natural non-biopolymer. J. Am. Chem. Soc. 116: 7098-7107.
199. Myers CW, Daly JW, Malkin B. 1978. A dangerously toxic new frog (Phyllobates) used by Emberá Indians of Western Columbia, with discussion of blowgun fabrication and dart poisoning. Bull Am. Muse. Nat. Hist. 161: 311-365.
200. Nagahama M, Sakurai J. 1992. High-affinity binding of Clostridium perfringens epsilon-toxin to rat brain. Infect. Immun. 60: 1237-1240.
201. Nagahama M, Sakurai J. 1993. Effect of drugs acting on the central nervous system on the lethality in mice of Clostridium perfringens epsilon toxin. Toxicon 31: 427-435.
202. Nambiar MP, Wu HC. 1995. Ilimaquinone inhibits the cytotoxicities of ricin, diphtheria toxin, and other protein toxins in Vero cells. Exp. Cell Res. 219: 671-678.
203. Namikoshi M, Sivonen K, Evans WR, Carmichael WW, Sun F, Rouhiainen L, Luukkainen R, Rinehart KL. 1992. Two new L-serine variants of microcystins-LR and -RR from Anabaena SP. strains 202 A1 and 202 A2. Toxicon 30: 1457-1464.
204. Naseem SM, Pace JG. 1993. Effect of anti-inflammatory agents on ricin-induced macrophage toxicity. J. Biochem. Toxicol. 8: 145-153.
205. Naseem SM, Creasia DA. 1994. Oxidation of saxitoxin: detection and biological activity of its reaction products. Biochem. Mol. Biol. Int. 33: 177-186.
206. Naseem SM, Creasia DA. 1997. Comparative binding and toxicity of saxitoxin and saxitoxinol in mice and in cultured cells. Biochem. Mol. Biol. Int. 41: 377-388.
207. Naseem SM, Hines HB, Creasia DA. 1989. Effect of toxins on arachidonic acid metabolism in rat cultured pulmonary alveolar macrophages. Biochem. Int. 19: 583-592.
208. Neumann B, Engelhardt B, Wagner H, Holzmann B. 1997. Induction of acute inflammatory lung injury by staphylococcal enterotoxin B. J. Immunol. 158: 1862-1871.
209. Nicod LP. 1999. Pulmonary defence mechanisms. Respiration 66: 2-11.
210. Nishikawa K, Matsuoka K, Kita E, Okabe N, Mitzuguchi M, Hino K, Miyazawa S, Yamasaki C, Aoki J, Takashima S, Yamakawa Y, Nishijima M, Terunuma D, Kuzahara H, Natori Y. 2002. A therapeutic agent with oriented carbohydrates for treatment of infections by Shiga toxin-producing Escherichia coli O157: H7. Proc. Natl. Acad. Sci. USA 99: 7669-7674.
211. Nishiki T, Kamata Y, Nemoto Y, Omori A, Ito T, Takahashi M, Kozaki S. 1994. Identification of protein receptor for Clostridium botulinum type B neurotoxin in rat brain synaptosomes. J. Biol. Chem. 269: 10498-10503.
212. Oda T, Wu HC. 1993. Cerulenin inhibits the cytotoxicity of ricin, modeccin, Pseudomonas toxin, and diphtheria toxin in brefeldin A-resistant cell lines. J. Biol. Chem. 268: 12596-12602.
213. Okumura K, Masui K, Inoue S, Ikeda K, Hayashi K. 1999. Purification, characterization and cDNA cloning of a phospholipase A2 inhibitor from the serum of the non-venomous snake Elaphe quadrivirgata. Biochem. J. 341: 165-171.
214. Olsnes S, Pihl A. 1982. Toxic lectins and related proteins. In Molecular Action of Toxins and Viruses, Cohen P, van Heyningen S (eds). Elsevier Biomedical Press: Amsterdam, The Netherlands; 51-105.
215. Olson MA, Cuff L. 1999. Free energy determinants of binding the rRNA substrate and small ligands to ricin A-chain. Biophys. J. 76: 28-39.
216. Oyston PC, Payne DW, Havard HL, Williamson ED, Titball RW. 1998. Production of a non-toxic site-directed mutant of Clostridium perfringens epsilon-toxin which induces protective immunity in mice. Microbiology 144: 333-341.
217. Page D, Roy R. 1997. Synthesis and biological properties of mannosylated starburst poly(amidoamine) dendrimers. Bioconjug. Chem. 8: 714-723.
218. Pearson JA, Tyler MI, Retson KV, Howden ME. 1993. Studies on the subunit structure of textilotoxin, a potent presynaptic neurotoxin from the venom of the Australian common brown snake (Pseudonaja textilis). 3. The complete aminoacid sequences of all the subunits. Biochim. Biophys. Acta 1161: 223-229.
219. Peraica M, Radiç B, Luciç A, Pavloviç M. 1999. Toxic effects of mycotoxins in humans. Bull. World Health Organ. 77: 754-766.
220. Pierce RH. 1986. Red tide (Ptychodiscus brevis) toxin aerosols: a review. Toxicon 24: 955-965.
221. Pitzurra L, Marconi P, Bistoni F, Blasi E. 1989. Selective inhibition of cytokine-induced lysozyme activity by tetanus toxin in the GG2EE macrophage cell line. Infect. Immun. 57: 2452-2456.
222. Poli MA, Rivera VR, Pitt ML, Vogel P. 1996. Aerosolized specific antibody protects mice from lung injury associated with aerosolized ricin exposure. Toxicon 34: 1037-1044.
223. Potts BC, Faulkner DJ, Jacobs RS. 1992. Phospholipase A2 inhibitors from marine organisms. J. Nat. Prod. 55: 1701-1717.
224. Rao S, Sikdar SK. 2000. Modification of alpha subunit of RIIA sodium channels by aconitine. Pflugers Arch. 439: 349-355.
225. 2+: uptake in isolated ventricle strips. Res. Commun. Chem. Pathol. Pharmacol. 11: 55-64.
226. Rennard SI, West WW, Robbins RA. 1997. Epithelial cells in host defense. In Pulmonary Defences, Stockley RA (ed.). John Wiley: Chichester; 163-178.
227. Reynolds HY. 1997. Integrated host defense against infections. In The Lung: Scientific Foundations (2nd edn), Crystal RG, West JB, Weibel ER, Barnes PJ (eds). Lippincott-Raven: Philadelphia; 2353-2365.
228. Rizzo AF, Atroshi F, Ahotupa M, Sankari S, Elovaara E. 1994. Protective effect of antioxidants against free radical-mediated lipid peroxidation induced by DON or T-2 toxin. Zentralbl. Veterinarmed. [A] 41: 81-90.
229. Robbins A, Rennard SI. 1997. Biology of airway epithelial cells. In The Lung: Scientific Foundations (2nd edn), Crystal RG, West JB, Weibel ER, Barnes PJ (eds). Lippincott-Raven: Philadelphia; 445-457.
230. Robinson CP, Franz DR, Bondura ME. 1990. Lack of an effect of saxitonin on the contractility of isolated guinea-pig trachea, lung parenchyma and aorta. Toxicol. Lett. 51: 29-34.
231. Robinson NA, Miura GA, Matson CF, Dinterman RE, Pace JG. 1989. Characterization of chemically tritiated microcystin-LR and its distribution in mice. Toxicon 27: 1035-1042.
232. Rogowski RS, Krueger BK, Blaustein MP. 1992. Purification and structural characterization of a potent potassium channel blocker from scorpion Tityus serrulatus venom. Biophys. J. 61: A250.
233. + channels blocked by alpha-dendrotoxin in synaptosomes. Proc. Natl. Acad. Sci. USA 91: 1475-1479.
234. Roitt I, Brostoff J, Male D. 1993a. Immunology (3rd end). Gower Medical Publishing: London; 4.6.
235. Roitt I, Brostoff J, Male D. 1993b. Immunology (3rd edn). Gower Medical Publishing: London; 11.2-11.3.
236. Rose F, Kurth-Landwehr C, Sibelius U, Reuner KH, Aktories K, Seeger W, Grimminger F. 1999. Role of actin depolymerization in the surfactant secretory response of alveolar epithelial type II cells. Am. J. Respir. Crit. Care Med. 159: 206-212.
237. Rosenstein Y, Lafarge-Frayssinet C. 1983. Inhibitory effect of Fusarium T2-toxin on lymphoid DNA and protein synthesis. Toxicol. Appl. Pharmacol. 70: 283-288.
238. Runnegar MT, Andrews J, Gerdes RG, Falconer IR. 1987. Injury to hepatocytes induced by a peptide toxin from the cyanobacterium Microcystis aeruginosa. Toxicon 25: 1235-1239.
239. Saint-Joanis B, Garnier T, Cole ST. 1989. Gene cloning shows the alpha-toxin of Clostridium perfringens to contain both sphingomyelinase and lecithinase activities. Mol. Gen. Genet. 219: 453-460.
240. Sakurai J. 1995. Toxins of Clostridium perfringens. Rev. Med. Microbiol. 6: 175-185.
241. Salamon FT, Fayen JD, Leonard ML, Finegan CK, Rich EA. 1992. Accessory function of human mononuclear phagocytes for lymphocyte responses to the superantigen staphylococcal enterotoxin B. Cell Immunol. 141: 466-484.
242. Sallusto F, Lanzavecchia A. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179: 1109-1118.
243. Saloga J, Leung DY, Reardon C, Giorno RC, Born W, Gelfand EW. 1996. Cutaneous exposure to the superantigen staphylococcal enterotoxin B elicits a T-cell-dependent inflammatory response. J. Invest. Dermatol. 106: 982-988.
244. Sandvig K, Olsnes S. 1982. Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. I. Requirement for calcium. J. Biol. Chem. 257: 7495-7503.
245. Sandvig K, van Deurs B. 1996. Endocytosis, intracellular transport, and cytotoxic action of Shiga toxin and ricin. Physiol. Rev. 76: 949-966.
246. Sandvig K, Olsnes S, Pihl A. 1978. Binding, uptake and degradation of the toxic proteins abrin and ricin by toxin-resistant cell variants. Eur. J. Biochem. 82: 13-23.
247. Schantz EJ. 1986. Chemistry and biology of saxitoxin and related toxins. Ann. NY Acad. Sci. 479: 15-23.
248. Schengrund CL, Das Gupta BR, Thompson JP, Ringler NJ. 1997. Inhibition of the adherence of botulinum toxin serotype A to immobilized GT1b by multivalent oligosaccharide GT1b-derivatized dendrimers. J. Neurochem. 69: S17A.
249. Schlesinger RB. 1995. Deposition and clearance of inhaled particles. In Concepts in Inhalation Toxicology (2nd edn), McClellan RO, Henderson RF (eds). Taylor & Francis: Washington; 191-224.
250. Schnitzer JE, Liu J, Oh P. 1995. Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases. J. Biol. Chem. 270: 14399-14404.
251. Schraufstatter IU, Cochrane CG. 1997. Oxidants: Types, sources, and mechanisms. In The Lung: Scientific Foundations (2nd edn), Crystal RG, West JB, Weibel ER, Barnes PJ (eds). Lippincott-Raven: Philadelphia; 2251-2258.
252. Sekino T, Kiyokawa N, Taguchi T, Ohmi K, Nakajima H, Suzuki T, Furukawa S, Nakao H, Takeda T, Fujimoto J. 2002. Inhibition of shiga toxin cytotoxicity in human renal cortical epithelial cells by nitrobenzylthioinosine. J. Infect. Dis. 185: 785-796.
253. Shaw DM, Gaerthe B, Leer RJ, Van Der Stap JG, Smittenaar C, Heijne Den Bak-Glashouwer M, Thole JE, Tielen FJ, Pouwels PH, Havenith CE. 2000. Engineering the microflora to vaccinate the mucosa: serum immunoglobulin G responses and activated draining cervical lymph nodes following mucosal application of tetanus toxin fragment C-expressing lactobacilli. Immunology 100: 510-518.
254. Shinozuka J, Li G, Kiatipattanasakul W, Uetsuka K, Nakayama H, Doi K. 1997. T-2 toxin-induced apoptosis in lymphoid organs of mice. Exp. Toxicol. Pathol. 49: 387-392.
255. Shortt SJ, Titball RW, Lindsay CD. 2000. An assessment of the in vitro toxicology of Clostridium perfringens type D epsilon-toxin in human and animal cells. Hum. Exp. Toxicol. 19: 108-116.
256. Sibille Y, Reynolds HY. 1990. Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am. Rev. Respir. Dis. 141: 471-501.
257. Silva AM, Novaes G, Heneine IF. 1994. The effect of dithiothreitol on the activity of tityustoxin from the scorpion Tityus serrulatus venom. Toxicol. Lett. 71: 97-101.
258. Simpson LL, Lautenslager GT, Kaiser II, Middlebrook JL. 1993. Identification of the site at which phospholipase A2 neurotoxins localize to produce their neuromuscular blocking effects. Toxicon 31: 13-26.
259. Simpson LL, Coffield JA, Bakry N. 1994. Inhibition of vacuolar adenosine triphosphatase antagonizes the effects of clostridial neurotoxins but not phospholipase A2 neurotoxins. J. Pharm. Exp. Ther. 269: 256-269.
260. Smith CG, Music SI. 1998. Pfiesteria in North Carolina. The medical inquiry continues. N. C. Med. J. 59: 216-220.
261. Stedman's Medical Dictionary. (26th edn). 2000. Williams and Wilkins: Baltimore; 897.
262. Stockley RA (ed). 1997. Pulmonary Defences. John Wiley: Chichester.
263. Stricklett PK, Hughes AK, Ergonul Z, Kohan DE. 2002. Molecular basis for upregulation by inflammatory cytokines of shiga toxin 1 cytotoxicity and globotriaosylceramide expression. J. Infect. Dis. 186: 976-982.
264. Su MJ, Coulter AR, Sutherland SK, Chang CC. 1983. The presynaptic neuromuscular blocking effect and phospholipase A2 activity of textilotoxin, a potent toxin isolated from the venom of the Australian brown snake, Pseudonaja textilis. Toxicon 21: 143-151.
265. Takx-Kohlen BCMJ. 1992. Immunomodulators. Future prospects. Pharmaceutisch. Weekblad. Sci. Ed. 14: 245-252.
266. Tanaka KS, Chen XY, Ichikawa Y, Tyler PC, Furneaux RH, Schramm VL. 2001. Biochemistry 40: 6845-6851.
267. Tesh VL, Samuel JE, Perera LP, Sharefkin JB, O'Brien AD. 1991. Evaluation of the role of Shiga and Shiga-like toxins in mediating direct damage to human vascular endothelial cells. J. Infect. Dis. 164: 344-352.
268. Tesh VL, Ramegowda B, Samuel JE. 1994. Purified Shiga-like toxins induce expression of proinflammatory cytokines from murine peritoneal macrophages. Infect. Immun. 62: 5085-5094.
269. Thompson JP, Schengrund CL. 1998. Inhibition of the adherence of cholera toxin and the heat-labile enterotoxin of Escherichia coli to cell-surface GM1 by oligosaccharide-derivatized dendrimers. Biochem. Pharmacol. 56: 591-597.
270. Thompson WL, Pace JG. 1992. Substances that protect cultured hepatocytes from the toxic effects of microcystin-LR. Toxicol. in Vitro 6: 579-587.
271. Titball RW. 1993. Bacterial phospholipases C. Microbiol. Rev. 57: 347-366.
272. Todar KU. 2002. Todar's Online Textbook of Bacteriology [Internet]. Department of Bacteriology, University of Wisconsin-Madison. Available from: http://www.textbookofbacteriology.net [Accessed July 2002].
273. Toews GB. 1993. Pulmonary defense mechanisms. Semin. Respir. Infect. 8: 160-167.
274. Tokuyama T, Daly J, Witkop B. 1969. The structure of batrachotoxin, a steroidal alkaloid from the Colombian arrow poison frog, Phyllobates aurotaenia, and partial synthesis of batrachotoxin and its analogs and homologs. J. Am. Chem. Soc. 91: 3931-3938.
275. Tosteson MT, Halperin JA, Kishi Y, Tosteson DC. 1991. Palytoxin induces an increase in the cation conductance of red cells. J. Gen. Physiol. 98: 969-985.
276. Tuerk C, Gold L. 1990. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249: 505-510.
277. Uemura D, Ueda K, Hirata Y, Naoki H, Iwashita T. 1981. Further studies on palytoxin. II. Structure of palytoxin. Tetrahedron Lett. 22: 2781-2784.
278. Ueno Y. 1984. Toxicological features of T-2 toxin and related trichothecenes. Fundam. Appl. Toxicol. 4: S124-S132.
279. Ueno Y, Nakajima M, Sakai K, Ishii K, Sato N. 1973. Comparative toxicology of trichothec mycotoxins: inhibition of protein synthesis in animal cells. J. Biochem. (Tokyo) 74: 285-296.
280. Ulrich RG, Sidell S, Taylor TG, Wilhelmson CL, Franz DR. 1997. Staphylococcal enterotoxin B and related pyrogenic toxins. In Textbook of Military Medicine. Part 1. Medical Aspects of Chemical and Biological Warfare, Zajtchuk R, Bellamy RF (eds). Office of the Surgeon General Department of the Army: USA; 621-630.
281. Usami M, Satake M, Ishida S, Inoue A, Kan Y, Yasumoto T. 1995. Palytoxin analogs from the dinoflagellate Ostreopsis siamensis. J. Am. Chem. Soc. 117: 5389-5390.
282. USAMRIID. 1998. Comparative lethality of selected toxins and chemical agents in laboratory mice. In Medical Management of Biological Casualties. Handbook (3rd end), Eitzen E, Pavlin J, Cieslak T, Christopher G, Culpepper R (eds). U.S. Army Medical Research Institute of Infectious Diseases: Frederick, MD; Appendix C.
283. Van Renterghem C, Frelin C. 1993. 3,4-Dichlorobenzamil-sensitive monovalent cation channel induced by palytoxin in cultured aortic myocytes. Br. J. Pharmacol. 109: 859-865.
284. Van Ness BG, Howard JB, Bodley JW, 1980a. ADP-ribosylation of elongation factor 2 by diphtheria toxin. Isolation and properties of the novel ribosyl-amino acid and its hydrolysis products. J. Biol. Chem. 255: 10717-10720.
285. Van Ness BG, Howard JB, Bodley JW. 1980b. ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products. J. Biol. Chem. 255: 10710-10716.
286. Van Vleet TR, Klein PJ, Coulombe RA. 2002. Metabolism and cytotoxicity of aflatoxin bl in cytochrome P-450 expressing human lung cells. J. Toxicol. Environ. Health A 65: 853-867.
287. Venant A, Dazy AC, Diogene G, Metezeau P, Marano F. 1994. Effects of maitotoxin on calcium entry and phosphoinositide breakdown in the rabbit ciliated tracheal epithelium. Biol. Cell 82: 195-202.
288. Venant A, Dazy AC, Diogene G, Marano F. 1995. Differential effects of maitotoxin on calcium entry and ciliary beating in the rabbit ciliated tracheal epithelium. Biol. Cell 85: 197-205.
289. Vieytes MR, Louzao MC, Bujan MJ, Alfonso A, Cabado A, de la Cruz LF, Botana LM. 1991. Lack of specific saxitoxin binding to rat mast cells. Agents Actions 33: 92-93.
290. Vogtle F, Gestermann S, Hesse R, Schwierz B, Windisch B. 2000. Functional dendrimers. Prog. Polym. Sci. 25: 987-1041.
291. + channels resistant to batrachotoxin. Proc. Natl. Acad. Sci. USA 95: 2653-2658.
292. Ward PA. 1996. Role of complement, chemokines, and regulatory cytokines in acute lung injury. Ann. NY Acad. Sci. 796: 104-112.
293. Warren JR, Spero L, Metzger JF. 1974. Stabilization of native structure by the closed disulfide loop of staphylococcal enterotoxin B. Biochim. Biophys. Acta 359: 351-363.
294. Weibel ER. 1997. Design and morphometry of the pulmonary gas exchanger. In The Lung: Scientific Foundations (2nd edn), Crystal RG, West JB, Weibel ER, Barnes PJ (eds). Lippincott-Raven: Philadelphia; 1147-1157.
295. + current in cultured human retinal pigment epithelial cells. J. Physiol. (London) 476: 187-196.
296. + channel. Mol. Pharmacol. 44: 430-436.
297. Wewers MD, Gadek JE, Marsh CB. 1997. Pro-inflammatory cytokines. In The Lung: Scientific Foundations (2nd edn), Crystal RG, West JB, Weibel ER, Barnes PJ (eds). Lippincott-Raven: Philadelphia; 117-132.
298. White CW, Das KC. 1997. Role of cytokines in acute lung injury. In The Lung: Scientific Foundations (2nd edn), Crystal RG, West JB, Weibel ER, Barnes PJ (eds). Lippincott-Raven: Philadelphia; 2451-2464.
299. WHO. 1970. Bases of quantitative estimates. In Health Aspects of Chemical and Biological Weapons. WHO: Geneva; 84-100.
300. Wiberg GS, Stephenson NR. 1960. Toxicologic studies on paralytic shellfish poison. Toxicol. Appl. Pharmacol. 2: 607-615.
301. Wilhelmsen CL, Pitt ML. 1996. Lesions of acute inhaled lethal ricin intoxication in rhesus monkeys. Vet. Pathol. 33: 296-302.
302. Williamson LC, Neale EA. 1994. Bafilomycin A1 inhibits the action of tetanus toxin in spinal cord neurons in cell culture. J. Neurochem. 63: 2342-2345.
303. Woodward RB. 1964. Structure of tetrodotoxin. Pure Appl. Chem. 9: 49-74.
304. Wu AM, Wu JH, Herp A, Chow LP, Lin JY. 2001. Carbohydrate specificity of a toxic lectin, abrin A, from the seeds of Abrus precatorius (jequirity bean). Life Sci. 69: 2027-2038.
305. Yan X, Day P, Hollis T, Monzingo AF, Schelp E, Robertus JD, Milne GW, Wang S. 1998. Recognition and interaction of small rings with the ricin A-chain binding site. Proteins 31: 33-41.
306. Yasumoto T, Satake M. 1996. Chemistry, etiology and determination methods of ciguatera toxins. J. Toxicol. - Toxin Rev. 15: 91-107.
307. Yazdanpanah H, Roshanzamir F, Shafaghi B, Faizi M, Elhami M, Rasekh HR. 1997. Assessment of possible protective roles of selenium, zinc, and cis-stilbene oxide against acute T-2 toxin poisoning: a preliminary report. Nat. Toxins 5: 133-135.
308. Yeih DF, Chiang FT, Huang SK. 2000. Successful treatment of aconitine induced life threatening ventricular tachyarrhythmia with amiodarone. Heart 84: E8-E8.
309. Yuhas Y, Kaminsky E, Mor M, Ashkenazi S. 1996. Induction of nitric oxide production in mouse macrophages by Shiga toxin. J. Med. Microbiol. 45: 97-102.
310. Yutsudo T, Honda T, Miwatani T, Takeda Y. 1986. Characterization of purified Shiga toxin from Shigella dysenteriae 1. Microbiol. Immunol. 30: 1115-1127.
311. + pump of the gill of carp (Cyprinus carpio Linneo). Toxicon 34: 451-458.
312. Zhao X, Pike BR, Newcomb JK, Wang KK, Posmantur RM, Hayes RL. 1999. Maitotoxin induces calpain but not caspase-3 activation and necrotic cell death in primary septohippocampal cultures. Neurochem. Res. 24: 371-382.