메뉴 건너뛰기




Volumn 36, Issue 4, 1998, Pages 571-588

Recovery from the lethal effects of saxitoxin: A therapeutic window for 4-aminopyridine (4-AP)

Author keywords

4 Aminopyridine; 4 AP; Artificial ventilation; Cardiorespiratory collapse; Diaphragmatic electromyogram; Electrocardiogram; Electrocorticogram; Guinea pigs; Saxitoxin; Sodium bicarbonate; STX; Therapeutic window

Indexed keywords

SAXITOXIN;

EID: 0032496099     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(97)00158-X     Document Type: Article
Times cited : (15)

References (21)
  • 1
    • 0010428225 scopus 로고
    • 4-Aminopyridine antagonizes the lethal effects of saxitoxin (STX) and tetrodotoxin (TTX)
    • International Society of Toxicology Frederick, MD. July/August 1995
    • Benton, B. J., Spriggs, D. L., Capacio, B. R., Chang, F.-C. T. (1995) 4-Aminopyridine antagonizes the lethal effects of saxitoxin (STX) and tetrodotoxin (TTX). International Society of Toxicology, 5th Pan American Symposium on Animal, Plant and Microbial Toxins, p. 217. Frederick, MD. July/August 1995.
    • (1995) 5Th Pan American Symposium on Animal, Plant and Microbial Toxins , pp. 217
    • Benton, B.J.1    Spriggs, D.L.2    Capacio, B.R.3    Chang, F.-C.T.4
  • 3
    • 0024633233 scopus 로고
    • A procedure for chronic recording of diaphragmatic electromyographic activity
    • Chang F.-C. T., Harper R. M. A procedure for chronic recording of diaphragmatic electromyographic activity. Brain Res. Bull. 22:1989;561-563.
    • (1989) Brain Res. Bull , vol.22 , pp. 561-563
    • Chang, F.-C.T.1    Harper, R.M.2
  • 4
    • 0027161551 scopus 로고
    • Central and peripheral cardio-respiratory effects of saxitoxin (STX) in urethane-anesthetized guinea-pigs
    • Chang F.-C. T., Benton B. J., Lenz R. A., Capacio B. R. Central and peripheral cardio-respiratory effects of saxitoxin (STX) in urethane-anesthetized guinea-pigs. Toxicon. 31:1993;645-664.
    • (1993) Toxicon. , vol.31 , pp. 645-664
    • Chang, F.-C.T.1    Benton, B.J.2    Lenz, R.A.3    Capacio, B.R.4
  • 5
    • 0030175764 scopus 로고    scopus 로고
    • 4-Aminopyridine antagonizes saxitoxin (STX) and tetrodotoxin (TTX) induced cardiorespiratory depression
    • Chang F.-C. T., Bauer R. M., Benton B. J., Keller S. A., Capacio B. R. 4-Aminopyridine antagonizes saxitoxin (STX) and tetrodotoxin (TTX) induced cardiorespiratory depression. Toxicon. 34:1996;671-690.
    • (1996) Toxicon. , vol.34 , pp. 671-690
    • Chang, F.-C.T.1    Bauer, R.M.2    Benton, B.J.3    Keller, S.A.4    Capacio, B.R.5
  • 8
    • 0018405918 scopus 로고
    • Stimulation of phrenic nerve activity by an acetylcholine releasing drug: 4-aminopyridine
    • Folgering H., Rutten J., Agoston S. Stimulation of phrenic nerve activity by an acetylcholine releasing drug: 4-aminopyridine. Pflügers Arch. 379:1979;181-185.
    • (1979) Pflügers Arch. , vol.379 , pp. 181-185
    • Folgering, H.1    Rutten, J.2    Agoston, S.3
  • 9
    • 0019463154 scopus 로고
    • Cholinergic effect of 4-aminopyridine and adrenergic effect of 4-methyl-2-aminopyridine in cardiac muscles
    • Glover W. E. Cholinergic effect of 4-aminopyridine and adrenergic effect of 4-methyl-2-aminopyridine in cardiac muscles. Europ. J. Pharmac. 71:1981;21-31.
    • (1981) Europ. J. Pharmac. , vol.71 , pp. 21-31
    • Glover, W.E.1
  • 10
    • 0015334809 scopus 로고
    • Pharmacology of tetrodotoxin and saxitoxin
    • Kao C. Y. Pharmacology of tetrodotoxin and saxitoxin. Fed. Proc. 31:1972;1117-1123.
    • (1972) Fed. Proc. , vol.31 , pp. 1117-1123
    • Kao, C.Y.1
  • 11
    • 0017568555 scopus 로고
    • 4-Aminopyridine, a new drug tested in the treatment of Eaton-Lambert syndrome
    • Lundh H., Nilsson O., Rosen I. 4-Aminopyridine, a new drug tested in the treatment of Eaton-Lambert syndrome. J. Neurol. Neurosurg. Psychiatry. 40:1977;1109-1112.
    • (1977) J. Neurol. Neurosurg. Psychiatry , vol.40 , pp. 1109-1112
    • Lundh, H.1    Nilsson, O.2    Rosen, I.3
  • 13
    • 0019476136 scopus 로고
    • Treatment with oral 4-aminopyridine in disorders of neuromuscular transmission
    • Murray N. M. F., Newsom-Davis J. Treatment with oral 4-aminopyridine in disorders of neuromuscular transmission. Neurology. 31:1981;264-277.
    • (1981) Neurology , vol.31 , pp. 264-277
    • Murray, N.M.F.1    Newsom-Davis, J.2
  • 14
    • 0000870338 scopus 로고
    • Pharmacological study of poisons from shellfish and puffer fish
    • Murtha E. F. Pharmacological study of poisons from shellfish and puffer fish. Ann. N.Y. Acad. Sci. 90:1960;820-836.
    • (1960) Ann. N.Y. Acad. Sci. , vol.90 , pp. 820-836
    • Murtha, E.F.1
  • 15
    • 0015335198 scopus 로고
    • Mechanism of action of tetrodotoxin and saxitoxin on excitable membranes
    • Narahashi T. Mechanism of action of tetrodotoxin and saxitoxin on excitable membranes. Fed. Proced. 31:1972;1124-1132.
    • (1972) Fed. Proced. , vol.31 , pp. 1124-1132
    • Narahashi, T.1
  • 16
    • 0023276799 scopus 로고
    • 4-Aminopyridine produces epileptiform activity in hippocampus and enhances synaptic excitation and inhibition
    • Rutecki P. A., Lebeda F. J., Johnston D. 4-Aminopyridine produces epileptiform activity in hippocampus and enhances synaptic excitation and inhibition. J. Neurophysiol. 57:1987;1911-1924.
    • (1987) J. Neurophysiol. , vol.57 , pp. 1911-1924
    • Rutecki, P.A.1    Lebeda, F.J.2    Johnston, D.3
  • 18
    • 0019310355 scopus 로고
    • Aminopyridines and synaptic transmission
    • Thesleff S. Aminopyridines and synaptic transmission. Neuroscience. 5:1980;1413-1419.
    • (1980) Neuroscience , vol.5 , pp. 1413-1419
    • Thesleff, S.1
  • 20
    • 0018728507 scopus 로고
    • Positive inotropic effect of 4-aminopyridine on dog ventricular muscle
    • Yanagisawa T., Taira N. Positive inotropic effect of 4-aminopyridine on dog ventricular muscle. Naunyn-Schmiedeberg's Arch. Pharmacol. 307:1979;207-212.
    • (1979) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.307 , pp. 207-212
    • Yanagisawa, T.1    Taira, N.2
  • 21
    • 0017238608 scopus 로고
    • Interactions of aminopyridines with potassium channels of squid axon membranes
    • Yeh J. Z., Oxford G. S., Wu C. H., Narahashi T. Interactions of aminopyridines with potassium channels of squid axon membranes. Biophys. J. 16:1976;77-81.
    • (1976) Biophys. J. , vol.16 , pp. 77-81
    • Yeh, J.Z.1    Oxford, G.S.2    Wu, C.H.3    Narahashi, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.