The Crystal Structure of Tetanus Toxin Hc Fragment Complexed with a Synthetic GT1b Analogue Suggests Cross-linking between Ganglioside Receptors and the Toxin

Journal of Biological Chemistry

Volumn 276, Issue 34, 2001, Pages 32274-32281

  Fotinou, Constantina ^a   Emsley, Paul ^a   Black, Isobel ^a   Ando, Hiromune ^b   Ishida, Hideharu ^b   Kiso, Makoto ^b   Sinha, Katharine A ^c   Fairweather, Neil F ^c   Isaacs, Neil W ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b GIFU UNIVERSITY   (Japan)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPLEXATION; CRYSTAL STRUCTURE; DRUG PRODUCTS; TOXIC MATERIALS;

THERAPEUTIC AGENTS;

BIOCHEMISTRY;

GANGLIOSIDE; GANGLIOSIDE RECEPTOR; IMMUNOGLOBULIN HEAVY CHAIN; RECEPTOR; TETANUS TOXIN; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; GANGLIOSIDE, GT1;

ARTICLE; BINDING SITE; BOTULISM; CARBOXY TERMINAL SEQUENCE; CLOSTRIDIUM; CROSS LINKING; CRYSTAL STRUCTURE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; TETANUS; TOXIN STRUCTURE; CARBOHYDRATE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; MOLECULAR GENETICS; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM; POSIBACTERIA;

BINDING SITES; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; CRYSTALLOGRAPHY, X-RAY; GANGLIOSIDES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTORS, CELL SURFACE; TETANUS TOXIN;

EID: 0035943672     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103285200     Document Type: Article

References (54)

1. Montecucco, C., and Schiavo, G. (1994) Mol. Microbiol. 13, 1-8
2. Herreros, J., Lalli, G., Montecucco, C., and Schiavo, G. (1999) in The Comprehensive Sourcebook of Bacterial Protein Toxins (Alouf, J. E., and Freer, J. H., eds) pp. 202-228, Academic Press
3. Schiavo, G., Benfenati, F., Poulain, B., Rossetto, O., de Laureto, P. P., DasGupta, B. R., and Montecucco, C. (1992) Nature 359, 832-839
4. Lalli, G., Herreros, J., Osborne, S. L., Montecucco, C., Rossetto, O., and Schiavo, G. (1999) J. Cell Sci. 112, 2715-2724
5. Montecucco, C. (1986) Trends Biochem. Sci. 11, 314-317
6. Halpern, J. L., and Loftus, A. (1993) J. Biol. Chem. 268, 11188-11192
7. Halpern, J. L., and Neale, E. A. (1995) Curr. Top. Microbiol. Immunol. 195, 221-241
8. Sollner, T., Whitehart, S. W., Brunner, M., Erdjument-Bromage, H., Geromanos, S., Tempst, P., and Rothman, J. E. (1993) Nature 362, 318-324
9. Herreros, J., Lalli, G., Montecucco, C., and Schiavo, G. (2000) J. Neurochem. 74, 1941-1950
10. Herreros, J., Lalli, G., and Schiavo, G. (2000) Biochem. J. 347, 199-204
11. Janshoff, A., Steinem, C., Sieber, M., elBaya, A., Schmidt, M. A., and Galla, H. J. (1997) Eur. Biophys. J. 26, 261-270
12. Johnson, E. A. (1999) Annu. Rev. Microbiol. 53, 551-575
13. Pierce, E. J., Davison, M. D., Parton, R. G., Habig, W. H., and Critchley, D. R. (1986) Biochem. J. 236, 845-852
14. Bakry, N., Kamata, Y., Sorensen, R., and Simpson, L. L. (1991) J. Pharmacol. Exp. Ther. 258, 613-619
15. Nishiki, T., Kamata, Y., Nemoto, Y., Omori, A., Ito, T., Takahashi, M., and Kozaki, S. (1994) J. Biol. Chem. 269, 10498-10503
16. Li, L., and Singh, B. R. (1998) J. Nat. Toxins 7, 215-226
17. Kozaki, S., Kamata, Y., Watarai, S., Nishiki, T., and Mochida, S. (1998) Microb. Pathog. 25, 91-99
18. Karlsson, K. A. (1998) Acta Biochim. Pol. 45, 429-438
19. Van Heyningen, W. E., and Miller, P. (1961) J. Gen. Microbiol. 24, 107-119
20. Simpson, L. L., and Rapport, M. M. (1971) J. Neurochem. 18, 1341-1343
21. Van Heyningen, W. E. (1974) Nature 249, 415-417
22. Holmgren, J., Elwing, H., Fredman, P., and Svennerholm, L. (1980) Eur. J. Biochem. 106, 371-379
23. Angstrom, J., Teneberg, S., and Karlsson, K. A. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 11859-11863
24. Fishman, P. H. (1982) J. Membr. Biol. 69, 85-97
25. Williamson, L. C., Bateman, K. E., Clifford, J. C. M., and Neale, E. A. (1999) J. Biol. Chem. 274, 25173-25180
26. Kitamura, M., Takamiya, K., Aizawa, S., Furukawa, K., and Furukawa, K. (1999) Biochim. Biophys. Acta 1441, 1-3
27. Umland, T. C., Wingert, L. M., Swaminathan, S., Furey, W. F., Schmidt, J. J., and Sax, M. (1997) Nat. Struct. Biol. 4, 788-792
28. Emsley, P., Fotinou, C., Black, I., Fairweather, N. F., Charles, I. G., Watts, C., Hewitt, E., and Isaacs, N. W. (2000) J. Biol. Chem. 275, 8889-8894
29. Lacy, D. B., Tepp, W., Cohen, A. C., DasGupta, B. R., and Stevens, R. C. (1998) Nat. Struct. Biol. 5, 898-902
30. Figueiredo, D., Turcotte, C., Frankel, G., Li, Y., Dolly, O., Wilkin, G., Marriott, D., Fairweather, N., and Dougan, G. (1995) Infect. Immun. 63, 3218-3221
31. Shapiro, R. E., Specht, C. D., Collins, B. E., Woods, A. S., Cotter, R. J., and Schnaar, R. L. (1997) J. Biol. Chem. 272, 30380-30386
32. Ishida, H.-K., Ishida, H., Kiso, M., and Hasegawa, A. (1994) Tetrahedron Asymmetry 5, 2493-2512
33. Sinha, K., Box, M., Lalli, G., Schiavo, G., Schneider, H., Groves, M., Siligardi, G., and Fairweather, N. (2000) Mol. Microbiol. 37, 1041-1051
34. Navaza, J. (1994) Acta Cryst. Sec. A 50, 157-163
35. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Cryst. Sec. D 53, 240-255
36. Merritt, E. A., Sarfaty, S., van den Akker, F., L'Hoir, C., Martial, J. A., and Hol, W. G. J. (1994) Protein Sci. 3, 166-175
37. Lamzin, V. S., and Wilson, K. S. (1993) Acta Cryst. Sec. D 49, 129-147
38. Laskowski, R. A., Macarthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Cryst. 26, 283-291
39. Nicholls, A., Sharp, K. A., and Honig, B. (1991) Proteins 11, 281-296
40. Bohne, A., Lang, E., and von der Lieth, C. W. (1998) J. Mol. Model. 4, 33-43
41. Collaborative Computational Project Number 4 (1994) Acta Cryst. Sec. D 50, 760-763
42. Evans, S. V. (1993) J. Mol. Graph. 11, 134-138
43. Rini, J. M. (1995) Annu. Rev. Biophys. Biomol. Struct. 24, 551-577
44. Weis, W. I., and Drickamer, K. (1996) Annu. Rev. Biochem. 65, 441-473
45. Stehle, T., and Harrison, S. C. (1997) The EMBO J. 16, 5139-5148
46. Acquotti, D., Fronza, G., Ragg, E., and Sonnino, S. (1991) Chem. Phys. Lipids 59, 107-125
47. Veluraja, K., and Rao, V. S. R. (1984) Carbohydr. Polymers 4, 357-375
48. Kamata, Y., Yoshimoto, M., and Kozaki, S. (1997) Toxicon 35, 1337-1340
49. Lacy, D. B., and Stevens, R. C. (1999) J. Mol. Biol. 291, 1091-1104
50. Kubota, T., Watanabe, T., Yokosawa, N., Tsuzuki, K., Indoh, T., Moriishi, K., Sanda, K., Maki, Y., Inoue, K., and Fujii, N. (1997) Appl. Envirom. Microbiol. 63, 1214-1218
51. Swaminathan, S., and Eswaramoorthy, S. (2000) Nat. Struct. Biol. 7, 693-699
52. Sutton, J. M., Chow-Worn, O., Spaven, L., Silman, N. J., Hallis, B., and Shone, C. C. (2001) FEBS Lett. 493, 45-49
53. Leslie, A. G. W. (1992) in Joint CCP4 and ESF-EACMD Newsletter on Protein Crystallography, Daresbury Laboratory, Warrington, UK
54. Evans, P. R. (1993) in Proceedings of the CCP4 Study Weekend (Sawyer, L., Isaacs, N. W., and Bailey, S., ed) pp. 114-122, SERC Daresbury Laboratory, Warrington, UK