Intratracheal administration of microcystin-LR, and its distribution

Toxicon

Volumn 39, Issue 2-3, 2001, Pages 265-271

  Ito, Emiko ^a   Kondo, Fumio ^b   Harada, Ken Ichi ^c  

^a CHIBA UNIVERSITY   (Japan)

^b AICHI PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^c MEIJO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOGINOSIN LR;

ABSORPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; BLEEDING; CAUSE OF DEATH; CECUM; CLEARANCE; CONFERENCE PAPER; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; EPITHELIUM CELL; GASTROINTESTINAL MUCOSA; IMMUNOHISTOCHEMISTRY; INTRATRACHEAL DRUG ADMINISTRATION; KIDNEY; LARGE INTESTINE; LETHALITY; LIVER; LUNG; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE; TISSUE DISTRIBUTION; TRACHEA;

EID: 0034598658     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(00)00124-0     Document Type: Conference Paper

References (19)

1. Adams W.H., Stone J.P., Sylvester B., Stoner R.D., Slatkin D.N., Tempel N.R., Sieferman H. Pathophysiology of cyanoginosin-LR: in vivo and in vitro studies, Toxicol. Appl. Pharmacol. 96:1988;248-257.
2. Dunn J. Algae kills dialysis patients in Brazil. BMJ. 312:1996;1183-1184.
3. Fitzgeorge R.B., Clark S.A., Keevil C.W. Route of intoxication. Codd G.A., Jefferies T.M., Keevil C.W., Potter E. Detection Methods for Cyanobacterial Toxins. 1994;69-74 The Royal Society of Chemistry, Cambridge.
4. Graham R.C., Lundholm U., Karnovsky M.J. Cytochemical demonstration of peroxidase activity with 3-amino-9-ethylcarbazole. J. Histochem. Cytochem. 13:1965;150-152.
5. Harada K.I., Suzuki M., Dahlem A.M., Beasley V.R., Carmichael W.W., Rinehart K.L. Improved method for purification of toxic peptide produced by cyanobacteria. Toxicon. 26:1988;433-439.
6. Honda A., Kamei K., Unnno H., Hiroshima K., Kuriyama T., Miyaji M. A murine model of zygomycosis by Cunninghamella bertholletiae. Mycopathol. 144:1999;141-146.
7. Hooser S.B., Beasley V.R., Lovell R.A., Carmichael W.W., Hascheck W.M. Toxicity of microcystin LR, a cyclic heptapeptide hepatotoxin from Microcystis aeruginosa to rats and mice. Vet. Pathol. 26:1989;246-252.
8. Ito E., Kondo F., Harada K.-I. Hepatic necrosis in aged mice by oral administration of microcystin-LR. Toxicon. 35:1997;231-239.
9. Ito E., Kondo F., Terao K., Harada K.-I. Neoplastic nodular formation in mouse liver induced by repeated intraperitoneal injection of microcystin-LR. Toxicon. 35:1997;1453-1457.
10. Ito E., Kondo F., Harada K.-I. First report on the distribution of orally administered microcystin-LR in mouse tissue using an immunostaining method. Toxicon. 38:2000;37-48.
11. Jochimsen E.M., Carmichael W.W., JiSi An, Cardo D.M., Cookson S.T., Holmes C.E.M., Antunes M.B.C., Filo D.A.M., Lyra T.M., Rarreto V.S.T., Azevedo S.M.F.O., Jarvis W.R. Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil. New Engl. J. Med. 338:1998;873-878.
12. Kuiper-Goodman T., Falconer I., Fitzgerald J. Human health aspects. Chorus I., Bartram J. Toxic Cyanobacteria in Water. 12:1976;114-153 E&FN Spon, London.
13. Nagata S., Soutome H., Tsutsumi T., Hasegawa A., Sekijima M., Sugamata M., Harada K.-I., Suganuma M., Ueno Y. Novel monoclonal antibodies against microcystin and their protective activity for hepatotoxicity. Natl. Tox. 3:1995;78-86.
14. Nishiwaki R., Ohta T., Sueoka E., Suganuma M., Harada K.I., Watanabe M.F., Fujiki H. Two significant aspects of microcystin-LR: specific binding and liver specificity. Cancer Lett. 83:1994;283-289.
15. Pouria S.P., de Andrade, A., Barbosa J., Cavalcanti R.L., Barreto V.T.S., Ward C.J., Preiser W., Poon G.K., Neild G.H., Codd G.A. Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil. Lancet. 352:1998;21-26.
16. Robinson N.A., Pace J.G., Matson C.F., Miura G.A., Lawrence W.B. Tissue distribution, excretion and hepatic biotrans formation of microcystin-LR in mice. J. Pharmac. Exp. Therap. 256:1991;17-182.
17. Ueno Y., Makita Y., Nagata S., Tsutsumi T., Yoshida F., Tamura S., Sakijima M., Tashiro F., Harada T., Yoshida T. No chronic oral toxicity of a low dose of microcystin-LR, a cyanobacterial hepatotoxin, in female BALB/c mice. Environ. Toxicol. 14:1999;45-55.
18. Yoshida T., Makita Y., Nagata S., Tsutsumi T., Yoshida F., Sekijima M., Tamura S., Ueno Y. Acute oral toxicity of microcystin-LR, a cyanobacterial hepatotoxin, in mice. Natl. Tox. 5:1997;91-95.
19. Yoshida T., Makita Y., Tsutsumi T., Nagata S., Tashiro F., Yoshida F., Sekijima M., Tamura S., Harada T., Maita K., Ueno Y. Immunohistochemical localization of microcystin-LR in the liver of mice: a study on the pathogenesis of microcystin-LR-induced hepatotoxicity. Toxicol. Pathol. 26:1998;411-418.