-
1
-
-
0002375630
-
Clostridial neurotoxins. The molecular pathogenesis of tetanus and botulism
-
Springer-Verlag, Berlin
-
Montecucco, C. (1995) Clostridial Neurotoxins. The Molecular Pathogenesis of Tetanus and Botulism. In Current Topics in Microbiology and Immunology, Vol. 195, Springer-Verlag, Berlin.
-
(1995)
Current Topics in Microbiology and Immunology
, vol.195
-
-
Montecucco, C.1
-
2
-
-
0027219725
-
Botulinum neurotoxin-A selectively cleaves the synaptic protein SNAP-25
-
Blasi, J., Chapman, E. R., Link, E. P., Binz, T., Yamasaki, S., DeCamill, P., Sudhof, T. C., Niemann, H., and Jahn, R. (1993) Botulinum Neurotoxin-A Selectively Cleaves the Synaptic Protein SNAP-25. Nature 365, 160-163.
-
(1993)
Nature
, vol.365
, pp. 160-163
-
-
Blasi, J.1
Chapman, E.R.2
Link, E.P.3
Binz, T.4
Yamasaki, S.5
DeCamill, P.6
Sudhof, T.C.7
Niemann, H.8
Jahn, R.9
-
3
-
-
0026497466
-
Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
-
Schiavo, G., Benfenati, F., Poulain, B., Rossetto, O., Laureto, P. P. d., DasGupta, B. R., and Montecucco, C. (1992) Tetanus and Botulinum-B Neurotoxins Block Neurotransmitter Release by Proteolytic Cleavage of Synaptobrevin. Nature 359, 832-835.
-
(1992)
Nature
, vol.359
, pp. 832-835
-
-
Schiavo, G.1
Benfenati, F.2
Poulain, B.3
Rossetto, O.4
Laureto, P.P.D.5
DasGupta, B.R.6
Montecucco, C.7
-
4
-
-
0019450641
-
High affinity binding of tetanus toxin to mammalian brain membranes
-
Rogers, T. B., and Snyder, S. H. (1981) High Affinity Binding of Tetanus Toxin to Mammalian Brain Membranes. J. Biol. Chem. 236, 2402-2407.
-
(1981)
J. Biol. Chem.
, vol.236
, pp. 2402-2407
-
-
Rogers, T.B.1
Snyder, S.H.2
-
5
-
-
0019305421
-
Interaction of fragments B and C of tetanus toxin with neural and thyroid membranes and with gangliosides
-
Morris, N. P., Consiglio, E., Kohn, L. D., Habig, W. H., Hardegree, M. C., and Helting, T. B. (1980) Interaction of Fragments B and C of Tetanus Toxin with Neural and Thyroid Membranes and with Gangliosides. J. Biol. Chem. 255, 6071-6076.
-
(1980)
J. Biol. Chem.
, vol.255
, pp. 6071-6076
-
-
Morris, N.P.1
Consiglio, E.2
Kohn, L.D.3
Habig, W.H.4
Hardegree, M.C.5
Helting, T.B.6
-
6
-
-
0019310208
-
Polystyrene-adsorbed gangliosides for investigation of the structure of the tetanus-toxin receptor
-
Holmgren, J., Elwing, H., Fredman, P., and Svennerholm, L. (1980) Polystyrene-Adsorbed Gangliosides for Investigation of the Structure of the Tetanus-Toxin Receptor. Eur. J. Biochem. 106, 371-379.
-
(1980)
Eur. J. Biochem.
, vol.106
, pp. 371-379
-
-
Holmgren, J.1
Elwing, H.2
Fredman, P.3
Svennerholm, L.4
-
7
-
-
0030591462
-
Gangliosides in phospholipid-bilayer membranes: Interaction with tetanus toxin
-
Winter, A., Ulrich, W. P., Wetterich, F., Weller, U., and Galla, H. J. (1996) Gangliosides in Phospholipid-Bilayer Membranes: Interaction with Tetanus Toxin. Chem. Phys. Lipids 81, 21-34.
-
(1996)
Chem. Phys. Lipids
, vol.81
, pp. 21-34
-
-
Winter, A.1
Ulrich, W.P.2
Wetterich, F.3
Weller, U.4
Galla, H.J.5
-
8
-
-
0027265079
-
Characterization of the receptor-binding domain of tetanus toxin
-
Halpern, J. L., and Loftus, A. (1993) Characterization of the Receptor-Binding Domain of Tetanus Toxin. J. Biol. Chem. 268, 11188-11192.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 11188-11192
-
-
Halpern, J.L.1
Loftus, A.2
-
9
-
-
0030785294
-
Identification of a ganglioside recognition domain of tetanus toxin using a novel ganglioside photoaffinity ligand
-
Shapiro, R. E., Specht, C. D., Collins, B. E., Woods, A. S., Cotter, R. J., and Schnaar, R. L. (1997) Identification of a Ganglioside Recognition Domain of Tetanus Toxin Using a Novel Ganglioside Photoaffinity Ligand. J. Biol. Chem. 272, 30380-30386.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30380-30386
-
-
Shapiro, R.E.1
Specht, C.D.2
Collins, B.E.3
Woods, A.S.4
Cotter, R.J.5
Schnaar, R.L.6
-
10
-
-
0033023671
-
Structure, activity, and immune (T and B cell) recognition of botulinum neurotoxins
-
Atassi, M. Z., and Oshima, M. (1999) Structure, Activity, and Immune (T and B Cell) Recognition of Botulinum Neurotoxins. Crit. Rev. Immunol. 19, 219-260.
-
(1999)
Crit. Rev. Immunol.
, vol.19
, pp. 219-260
-
-
Atassi, M.Z.1
Oshima, M.2
-
11
-
-
0033605364
-
The looming threat of bioterrorism
-
Henderson, D. A. (1999) The Looming Threat of Bioterrorism. Science 283, 1279-1282.
-
(1999)
Science
, vol.283
, pp. 1279-1282
-
-
Henderson, D.A.1
-
12
-
-
0011068111
-
The threat of deliberate disease in the 21st century
-
Report 24, Henry L. Stimson Center, Washington, DC
-
Pearson, G. S. (1998) The Threat of Deliberate Disease in the 21st Century. In Biological Weapons Proliferation: Reasons for Concern, Courses of Action, Report 24, Henry L. Stimson Center, Washington, DC.
-
(1998)
Biological Weapons Proliferation: Reasons for Concern, Courses of Action
-
-
Pearson, G.S.1
-
13
-
-
0031712779
-
Crystal structure of botulinum neurotoxin type a and implications for toxicity
-
Lacy, D. B., Tepp, W., Cohen, A. C., DasGupta, B. R., and Stevens, R. C. (1998) Crystal Structure of Botulinum Neurotoxin Type A and Implications for Toxicity. Nat. Struct. Biol. 5, 898-902.
-
(1998)
Nat. Struct. Biol.
, vol.5
, pp. 898-902
-
-
Lacy, D.B.1
Tepp, W.2
Cohen, A.C.3
DasGupta, B.R.4
Stevens, R.C.5
-
14
-
-
0001975415
-
The 1.61 angstrom structure of the tetanus toxin ganglioside binding region: Solved by MAD and mir phase combination
-
Knapp, M., Segelke, B., and Rupp, B. (1998) The 1.61 Angstrom Structure of the Tetanus Toxin Ganglioside Binding Region: Solved by MAD and Mir Phase Combination. Am. Crystallogr. Assoc. 25, 90.
-
(1998)
Am. Crystallogr. Assoc.
, vol.25
, pp. 90
-
-
Knapp, M.1
Segelke, B.2
Rupp, B.3
-
16
-
-
6244283606
-
Critical evaluation of search algorithms for automated molecular docking and database screening
-
Ewing, T. J. A., and Kuntz, I. D. (1997) Critical Evaluation of Search Algorithms for Automated Molecular Docking and Database Screening. J. Comput. Chem. 18, 1175-1189.
-
(1997)
J. Comput. Chem.
, vol.18
, pp. 1175-1189
-
-
Ewing, T.J.A.1
Kuntz, I.D.2
-
17
-
-
0023936327
-
Using shape complementarity as an initial screen in designing ligands for a receptor binding site of known three-dimensional structure
-
DesJarlais, R. L., Sheridan, R. P., Seibel, G. L., Dixon, J. S., Kuntz, I. D., and Venkataraghavan, R. (1988) Using Shape Complementarity as an Initial Screen in Designing Ligands for a Receptor Binding Site of Known Three-Dimensional Structure. J. Med. Chem. 31, 722-729.
-
(1988)
J. Med. Chem.
, vol.31
, pp. 722-729
-
-
DesJarlais, R.L.1
Sheridan, R.P.2
Seibel, G.L.3
Dixon, J.S.4
Kuntz, I.D.5
Venkataraghavan, R.6
-
18
-
-
0020491251
-
A geometric approach to macromolecule-ligand interactions
-
Kuntz, I. D., Blaney, J. M., Oatley, S. J., Langridge, R., and Ferrin, T. E. (1982) A Geometric Approach to Macromolecule-Ligand Interactions. J. Mol. Biol. 161, 269-288.
-
(1982)
J. Mol. Biol.
, vol.161
, pp. 269-288
-
-
Kuntz, I.D.1
Blaney, J.M.2
Oatley, S.J.3
Langridge, R.4
Ferrin, T.E.5
-
19
-
-
84986432941
-
Automated docking with grid-based energy evaluation
-
Meng, E. C., Shoichet, B. K., and Kuntz, I. D. (1992) Automated Docking with Grid-Based Energy Evaluation. J. Comput. Chem. 13, 505-524.
-
(1992)
J. Comput. Chem.
, vol.13
, pp. 505-524
-
-
Meng, E.C.1
Shoichet, B.K.2
Kuntz, I.D.3
-
21
-
-
0000125764
-
A new model for calculating atomic charges in molecules
-
Gasteiger, J., and Marsili, M. (1978) A New Model For Calculating Atomic Charges In Molecules. Tetrahedron Lett. 34, 3181-3184.
-
(1978)
Tetrahedron Lett.
, vol.34
, pp. 3181-3184
-
-
Gasteiger, J.1
Marsili, M.2
-
22
-
-
49149147973
-
Iterative partial equalization of orbital electronegativity: A rapid access to atomic charges
-
Gasteiger, J., and Marsili, M. (1980) Iterative Partial Equalization of Orbital Electronegativity: A Rapid Access to Atomic Charges. Tetrahedron 36, 3219-3288.
-
(1980)
Tetrahedron
, vol.36
, pp. 3219-3288
-
-
Gasteiger, J.1
Marsili, M.2
-
23
-
-
84986870156
-
Prediction of proton magnetic resonance shifts: The dependence on hydrogen charges obtained by iterative partial equalization of orbital electronegativity
-
Gasteiger, J., and Marsili, M. (1981) Prediction of Proton Magnetic Resonance Shifts: The Dependence on Hydrogen Charges Obtained by Iterative Partial Equalization of Orbital Electronegativity. Org. Magn. Reson. 15, 353-360.
-
(1981)
Org. Magn. Reson.
, vol.15
, pp. 353-360
-
-
Gasteiger, J.1
Marsili, M.2
-
24
-
-
0343581818
-
-
Tripos, Inc., St. Louis, MO
-
Sybyl (1997) Tripos, Inc., St. Louis, MO.
-
(1997)
Sybyl
-
-
-
25
-
-
0343581819
-
-
Ph.D. Thesis, School of Pharmacy, University of California, Berkeley, CA
-
Meng, E. C. (1993) Ph.D. Thesis, School of Pharmacy, University of California, Berkeley, CA.
-
(1993)
-
-
Meng, E.C.1
-
26
-
-
0021757436
-
A new force-field for molecular mechanical simulation of nucleic-acids and proteins
-
Weiner, S. J., Kollman, P. A., Case, D. A., Singh, U. C., Ohio, C., Alagona, G., Profeta, S., and Weiner, P. (1984) A New Force-Field For Molecular Mechanical Simulation of Nucleic-Acids and Proteins. J. Am. Chem. Soc. 106, 765-784.
-
(1984)
J. Am. Chem. Soc.
, vol.106
, pp. 765-784
-
-
Weiner, S.J.1
Kollman, P.A.2
Case, D.A.3
Singh, U.C.4
Ohio, C.5
Alagona, G.6
Profeta, S.7
Weiner, P.8
-
27
-
-
0022993246
-
Docking flexible ligands to macromolecular receptors by molecular shape
-
DesJarlais, R. L., Sheridan, R. P., Dixon, S., Kuntz, I. D., and Venkataraghavan, R. (1986) Docking Flexible Ligands to Macromolecular Receptors by Molecular Shape. J. Med. Chem. 29, 2149-2153.
-
(1986)
J. Med. Chem.
, vol.29
, pp. 2149-2153
-
-
DesJarlais, R.L.1
Sheridan, R.P.2
Dixon, S.3
Kuntz, I.D.4
Venkataraghavan, R.5
-
28
-
-
0000876636
-
Measurement of macromolecular binding using electrospray mass spectrometry. Determination of dissociation constants for oligonucleotide-serum albumin complexes
-
Greig, M. J., Gaus, H., Cummins, L. L., Sasmor, H., and Griffey, R. H. (1995) Measurement of Macromolecular Binding Using Electrospray Mass Spectrometry. Determination of Dissociation Constants for Oligonucleotide-Serum Albumin Complexes. J. Am. Chem. Soc. 117, 10765-10766.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 10765-10766
-
-
Greig, M.J.1
Gaus, H.2
Cummins, L.L.3
Sasmor, H.4
Griffey, R.H.5
-
29
-
-
0023047980
-
Vesicles of variable sizes produced by a rapid extrusion procedure
-
Mayer, L. D., Hope, M. J., and Cullis, P. R. (1986) Vesicles of Variable Sizes Produced by a Rapid Extrusion Procedure. Biochim. Biophys. Acta 858, 161-168.
-
(1986)
Biochim. Biophys. Acta
, vol.858
, pp. 161-168
-
-
Mayer, L.D.1
Hope, M.J.2
Cullis, P.R.3
-
30
-
-
0020176708
-
CONTIN: A general purpose constrained regularization program for inverting noisy linear algebraic or integral equations
-
Provencher, S. W. (1982) CONTIN: A General Purpose Constrained Regularization Program for Inverting Noisy Linear Algebraic or Integral Equations. Comput. Phys. Commun. 27, 229-242.
-
(1982)
Comput. Phys. Commun.
, vol.27
, pp. 229-242
-
-
Provencher, S.W.1
-
31
-
-
0030088496
-
Application of antibody and fluorophore-derivatized liposomes to heterogeneous immunoassays for D-dimer
-
Singh, A. K., Kilpatrick, P. K., and Carbonell, R. G. (1996) Application of Antibody and Fluorophore-Derivatized Liposomes to Heterogeneous Immunoassays for D-dimer. Biotechnol. Prog. 12, 272-280.
-
(1996)
Biotechnol. Prog.
, vol.12
, pp. 272-280
-
-
Singh, A.K.1
Kilpatrick, P.K.2
Carbonell, R.G.3
-
32
-
-
0027185772
-
Structure of a non-peptide inhibitor complexed with HIV-1 protease
-
Rutenber, E., Fauman, E. B., Keenan, R. J., Fong, S., Furth, P. S., Montellano, P. R. O. d., Meng, E., Kuntz, I. D., DeCamp, D. L., Salto, R., Rosé, J. R., Craik, C. S., and Stroud, R. M. (1993) Structure of a Non-peptide Inhibitor Complexed with HIV-1 Protease. J. Biol. Chem. 268, 15343-15346.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 15343-15346
-
-
Rutenber, E.1
Fauman, E.B.2
Keenan, R.J.3
Fong, S.4
Furth, P.S.5
Montellano, P.R.O.D.6
Meng, E.7
Kuntz, I.D.8
DeCamp, D.L.9
Salto, R.10
Rosé, J.R.11
Craik, C.S.12
Stroud, R.M.13
-
33
-
-
0025054246
-
Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease
-
Desjarlais, R. L., Seibel, G. L., Kuntz, I. D., Furth, P. S., Alvarez, J. C., Montellano, P. R. O. d., DeCamp, D. L., Babé, L. M., and Craik, C. S. (1990) Structure-Based Design of Nonpeptide Inhibitors Specific for the Human Immunodeficiency Virus 1 Protease. Proc. Natl. Acad. Sci. U.S.A. 87, 6644-6648.
-
(1990)
Proc. Natl. Acad. Sci. U.S.A.
, vol.87
, pp. 6644-6648
-
-
Desjarlais, R.L.1
Seibel, G.L.2
Kuntz, I.D.3
Furth, P.S.4
Alvarez, J.C.5
Montellano, P.R.O.D.6
DeCamp, D.L.7
Babé, L.M.8
Craik, C.S.9
-
34
-
-
0032544145
-
Structure-based design of N-[2-(1-piperidinylethyl)]-N′-[2-(5-bromopyridyl)]thiourea and N-[2-(1-piperazinylethyl)]-N′-[2-(5-bromopyridyl)]thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase
-
Mao, C., Vig, R., Venkatachalam, T. K, Sudbeck, E. A., and Uckun, F. M. (1998) Structure-Based Design of N-[2-(1-piperidinylethyl)]-N′-[2-(5-bromopyridyl)]thiourea and N-[2-(1-piperazinylethyl)]-N′-[2-(5-bromopyridyl)]thiourea as Potent Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase. Bioorg. Med. Chem. Lett. 8, 2213-2218.
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 2213-2218
-
-
Mao, C.1
Vig, R.2
Venkatachalam, T.K.3
Sudbeck, E.A.4
Uckun, F.M.5
-
35
-
-
0031600220
-
Automated docking and the search for HIV protease inhibitors
-
Olson, A. J., and Goodsell, D. S. (1998) Automated Docking and the Search for HIV Protease Inhibitors. SAR QSAR Environ. Res. 8, 273-285.
-
(1998)
SAR QSAR Environ. Res.
, vol.8
, pp. 273-285
-
-
Olson, A.J.1
Goodsell, D.S.2
-
36
-
-
0030742486
-
Interaction between botulinum neurotoxin type A and ganglioside: Ganglioside inactivates the neurotoxin and quenches its fluorescence
-
Kamata, Y., Yoshimoto, M., and Kozaki, S. (1997) Interaction Between Botulinum Neurotoxin Type A and Ganglioside: Ganglioside Inactivates the Neurotoxin and Quenches Its Fluorescence. Toxicon 35, 1337-1340.
-
(1997)
Toxicon
, vol.35
, pp. 1337-1340
-
-
Kamata, Y.1
Yoshimoto, M.2
Kozaki, S.3
-
37
-
-
0033520494
-
Sequence homolgy and structural analysis of the clostridial neurotoxins
-
Lacy, D. B., and Stevens, R. C. (1999) Sequence Homolgy and Structural Analysis of the Clostridial Neurotoxins. J. Mol. Biol. 291, 1091-1104.
-
(1999)
J. Mol. Biol.
, vol.291
, pp. 1091-1104
-
-
Lacy, D.B.1
Stevens, R.C.2
-
38
-
-
0024438708
-
Electrospray ionization for mass spectrometry of large biomolecules
-
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., and Whitehouse, C. M. (1989) Electrospray Ionization For Mass Spectrometry of Large Biomolecules. Science 246, 64-71.
-
(1989)
Science
, vol.246
, pp. 64-71
-
-
Fenn, J.B.1
Mann, M.2
Meng, C.K.3
Wong, S.F.4
Whitehouse, C.M.5
-
39
-
-
26844503278
-
Molecular beams of macroions
-
Dole, M., Mack, L. L., Hines, R. L., Mobley, R. C., Ferguson, L. D., and Alice, M. B. (1968) Molecular Beams of Macroions. J. Chem. Phys. 49, 2240-2249.
-
(1968)
J. Chem. Phys.
, vol.49
, pp. 2240-2249
-
-
Dole, M.1
Mack, L.L.2
Hines, R.L.3
Mobley, R.C.4
Ferguson, L.D.5
Alice, M.B.6
-
40
-
-
0001413545
-
Detection of noncovalent receptor-ligand complexes by mass spectrometry
-
Ganem, B., Li, Y.-T., and Henion, J. D. (1991) Detection of Noncovalent Receptor-Ligand Complexes by Mass Spectrometry. J. Am. Chem. Soc. 113, 6294-6296.
-
(1991)
J. Am. Chem. Soc.
, vol.113
, pp. 6294-6296
-
-
Ganem, B.1
Li, Y.-T.2
Henion, J.D.3
-
41
-
-
0001401150
-
Observation of the heme-globin complex in native myoglobin by electrospray-ionization mass spectrometry
-
Katta, V., and Chait, B. T. (1991) Observation of the Heme-Globin Complex in Native Myoglobin by Electrospray-Ionization Mass Spectrometry. J. Am. Chem. Soc. 113, 8534-8535.
-
(1991)
J. Am. Chem. Soc.
, vol.113
, pp. 8534-8535
-
-
Katta, V.1
Chait, B.T.2
-
42
-
-
0030621966
-
Studying noncovalent protein complexes by electrospray ionization mass spectrometry
-
Loo, J. A. (1997) Studying Noncovalent Protein Complexes by Electrospray Ionization Mass Spectrometry. Mass Spectrom. Rev. 16, 1-23.
-
(1997)
Mass Spectrom. Rev.
, vol.16
, pp. 1-23
-
-
Loo, J.A.1
-
43
-
-
33846278908
-
New mass spectrometric methods for the study of noncovalent associations of biopolymers
-
Smith, R. D., Bruce, J. E., Wu, Q., and Lei, Q. P. (1997) New mass spectrometric methods for the study of noncovalent associations of biopolymers. Chem. Soc. Rev. 26, 191-202.
-
(1997)
Chem. Soc. Rev.
, vol.26
, pp. 191-202
-
-
Smith, R.D.1
Bruce, J.E.2
Wu, Q.3
Lei, Q.P.4
-
44
-
-
0019882891
-
Tandem mass spectrometry
-
McLafferty, F. W. (1981) Tandem Mass Spectrometry. Science 214, 280-287.
-
(1981)
Science
, vol.214
, pp. 280-287
-
-
McLafferty, F.W.1
-
45
-
-
0030822741
-
Electrospray: Principles and practice
-
Gaskell, S. J. (1997) Electrospray: Principles and Practice. J. Mass Spectrom. 32, 677-688.
-
(1997)
J. Mass Spectrom.
, vol.32
, pp. 677-688
-
-
Gaskell, S.J.1
-
46
-
-
0342711776
-
What is struture-based drug design?
-
Roe, D. C., and Kuntz, I. D. (1995) What is Struture-Based Drug Design? Pharm. News 2, 13-15.
-
(1995)
Pharm. News
, vol.2
, pp. 13-15
-
-
Roe, D.C.1
Kuntz, I.D.2
-
47
-
-
0027373925
-
Calibration and assay development using the four-parameter logistic model
-
O'Connell, M. A., Belanger, B. A., and Haaland, P. D. (1993) Calibration and Assay Development Using the Four-Parameter Logistic Model. Chemom. Intell. Lab. Syst. 20, 97-114.
-
(1993)
Chemom. Intell. Lab. Syst.
, vol.20
, pp. 97-114
-
-
O'Connell, M.A.1
Belanger, B.A.2
Haaland, P.D.3
-
48
-
-
0342711775
-
-
Beilstein Information Systems, Inc., San Leandro, CA
-
Beilstein (1999) Beilstein Information Systems, Inc., San Leandro, CA.
-
(1999)
-
-
Beilstein1
|