메뉴 건너뛰기




Volumn 13, Issue 5, 2000, Pages 356-362

Identification of novel small molecule ligands that bind to tetanus toxin

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN; DOXORUBICIN; LIGAND; LIPOSOME; TETANUS TOXIN;

EID: 0034074081     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000009e     Document Type: Article
Times cited : (31)

References (48)
  • 1
    • 0002375630 scopus 로고
    • Clostridial neurotoxins. The molecular pathogenesis of tetanus and botulism
    • Springer-Verlag, Berlin
    • Montecucco, C. (1995) Clostridial Neurotoxins. The Molecular Pathogenesis of Tetanus and Botulism. In Current Topics in Microbiology and Immunology, Vol. 195, Springer-Verlag, Berlin.
    • (1995) Current Topics in Microbiology and Immunology , vol.195
    • Montecucco, C.1
  • 3
    • 0026497466 scopus 로고
    • Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
    • Schiavo, G., Benfenati, F., Poulain, B., Rossetto, O., Laureto, P. P. d., DasGupta, B. R., and Montecucco, C. (1992) Tetanus and Botulinum-B Neurotoxins Block Neurotransmitter Release by Proteolytic Cleavage of Synaptobrevin. Nature 359, 832-835.
    • (1992) Nature , vol.359 , pp. 832-835
    • Schiavo, G.1    Benfenati, F.2    Poulain, B.3    Rossetto, O.4    Laureto, P.P.D.5    DasGupta, B.R.6    Montecucco, C.7
  • 4
    • 0019450641 scopus 로고
    • High affinity binding of tetanus toxin to mammalian brain membranes
    • Rogers, T. B., and Snyder, S. H. (1981) High Affinity Binding of Tetanus Toxin to Mammalian Brain Membranes. J. Biol. Chem. 236, 2402-2407.
    • (1981) J. Biol. Chem. , vol.236 , pp. 2402-2407
    • Rogers, T.B.1    Snyder, S.H.2
  • 5
    • 0019305421 scopus 로고
    • Interaction of fragments B and C of tetanus toxin with neural and thyroid membranes and with gangliosides
    • Morris, N. P., Consiglio, E., Kohn, L. D., Habig, W. H., Hardegree, M. C., and Helting, T. B. (1980) Interaction of Fragments B and C of Tetanus Toxin with Neural and Thyroid Membranes and with Gangliosides. J. Biol. Chem. 255, 6071-6076.
    • (1980) J. Biol. Chem. , vol.255 , pp. 6071-6076
    • Morris, N.P.1    Consiglio, E.2    Kohn, L.D.3    Habig, W.H.4    Hardegree, M.C.5    Helting, T.B.6
  • 6
    • 0019310208 scopus 로고
    • Polystyrene-adsorbed gangliosides for investigation of the structure of the tetanus-toxin receptor
    • Holmgren, J., Elwing, H., Fredman, P., and Svennerholm, L. (1980) Polystyrene-Adsorbed Gangliosides for Investigation of the Structure of the Tetanus-Toxin Receptor. Eur. J. Biochem. 106, 371-379.
    • (1980) Eur. J. Biochem. , vol.106 , pp. 371-379
    • Holmgren, J.1    Elwing, H.2    Fredman, P.3    Svennerholm, L.4
  • 7
    • 0030591462 scopus 로고    scopus 로고
    • Gangliosides in phospholipid-bilayer membranes: Interaction with tetanus toxin
    • Winter, A., Ulrich, W. P., Wetterich, F., Weller, U., and Galla, H. J. (1996) Gangliosides in Phospholipid-Bilayer Membranes: Interaction with Tetanus Toxin. Chem. Phys. Lipids 81, 21-34.
    • (1996) Chem. Phys. Lipids , vol.81 , pp. 21-34
    • Winter, A.1    Ulrich, W.P.2    Wetterich, F.3    Weller, U.4    Galla, H.J.5
  • 8
    • 0027265079 scopus 로고
    • Characterization of the receptor-binding domain of tetanus toxin
    • Halpern, J. L., and Loftus, A. (1993) Characterization of the Receptor-Binding Domain of Tetanus Toxin. J. Biol. Chem. 268, 11188-11192.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11188-11192
    • Halpern, J.L.1    Loftus, A.2
  • 9
    • 0030785294 scopus 로고    scopus 로고
    • Identification of a ganglioside recognition domain of tetanus toxin using a novel ganglioside photoaffinity ligand
    • Shapiro, R. E., Specht, C. D., Collins, B. E., Woods, A. S., Cotter, R. J., and Schnaar, R. L. (1997) Identification of a Ganglioside Recognition Domain of Tetanus Toxin Using a Novel Ganglioside Photoaffinity Ligand. J. Biol. Chem. 272, 30380-30386.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30380-30386
    • Shapiro, R.E.1    Specht, C.D.2    Collins, B.E.3    Woods, A.S.4    Cotter, R.J.5    Schnaar, R.L.6
  • 10
    • 0033023671 scopus 로고    scopus 로고
    • Structure, activity, and immune (T and B cell) recognition of botulinum neurotoxins
    • Atassi, M. Z., and Oshima, M. (1999) Structure, Activity, and Immune (T and B Cell) Recognition of Botulinum Neurotoxins. Crit. Rev. Immunol. 19, 219-260.
    • (1999) Crit. Rev. Immunol. , vol.19 , pp. 219-260
    • Atassi, M.Z.1    Oshima, M.2
  • 11
    • 0033605364 scopus 로고    scopus 로고
    • The looming threat of bioterrorism
    • Henderson, D. A. (1999) The Looming Threat of Bioterrorism. Science 283, 1279-1282.
    • (1999) Science , vol.283 , pp. 1279-1282
    • Henderson, D.A.1
  • 13
    • 0031712779 scopus 로고    scopus 로고
    • Crystal structure of botulinum neurotoxin type a and implications for toxicity
    • Lacy, D. B., Tepp, W., Cohen, A. C., DasGupta, B. R., and Stevens, R. C. (1998) Crystal Structure of Botulinum Neurotoxin Type A and Implications for Toxicity. Nat. Struct. Biol. 5, 898-902.
    • (1998) Nat. Struct. Biol. , vol.5 , pp. 898-902
    • Lacy, D.B.1    Tepp, W.2    Cohen, A.C.3    DasGupta, B.R.4    Stevens, R.C.5
  • 14
    • 0001975415 scopus 로고    scopus 로고
    • The 1.61 angstrom structure of the tetanus toxin ganglioside binding region: Solved by MAD and mir phase combination
    • Knapp, M., Segelke, B., and Rupp, B. (1998) The 1.61 Angstrom Structure of the Tetanus Toxin Ganglioside Binding Region: Solved by MAD and Mir Phase Combination. Am. Crystallogr. Assoc. 25, 90.
    • (1998) Am. Crystallogr. Assoc. , vol.25 , pp. 90
    • Knapp, M.1    Segelke, B.2    Rupp, B.3
  • 16
    • 6244283606 scopus 로고    scopus 로고
    • Critical evaluation of search algorithms for automated molecular docking and database screening
    • Ewing, T. J. A., and Kuntz, I. D. (1997) Critical Evaluation of Search Algorithms for Automated Molecular Docking and Database Screening. J. Comput. Chem. 18, 1175-1189.
    • (1997) J. Comput. Chem. , vol.18 , pp. 1175-1189
    • Ewing, T.J.A.1    Kuntz, I.D.2
  • 17
    • 0023936327 scopus 로고
    • Using shape complementarity as an initial screen in designing ligands for a receptor binding site of known three-dimensional structure
    • DesJarlais, R. L., Sheridan, R. P., Seibel, G. L., Dixon, J. S., Kuntz, I. D., and Venkataraghavan, R. (1988) Using Shape Complementarity as an Initial Screen in Designing Ligands for a Receptor Binding Site of Known Three-Dimensional Structure. J. Med. Chem. 31, 722-729.
    • (1988) J. Med. Chem. , vol.31 , pp. 722-729
    • DesJarlais, R.L.1    Sheridan, R.P.2    Seibel, G.L.3    Dixon, J.S.4    Kuntz, I.D.5    Venkataraghavan, R.6
  • 19
    • 84986432941 scopus 로고
    • Automated docking with grid-based energy evaluation
    • Meng, E. C., Shoichet, B. K., and Kuntz, I. D. (1992) Automated Docking with Grid-Based Energy Evaluation. J. Comput. Chem. 13, 505-524.
    • (1992) J. Comput. Chem. , vol.13 , pp. 505-524
    • Meng, E.C.1    Shoichet, B.K.2    Kuntz, I.D.3
  • 21
    • 0000125764 scopus 로고
    • A new model for calculating atomic charges in molecules
    • Gasteiger, J., and Marsili, M. (1978) A New Model For Calculating Atomic Charges In Molecules. Tetrahedron Lett. 34, 3181-3184.
    • (1978) Tetrahedron Lett. , vol.34 , pp. 3181-3184
    • Gasteiger, J.1    Marsili, M.2
  • 22
    • 49149147973 scopus 로고
    • Iterative partial equalization of orbital electronegativity: A rapid access to atomic charges
    • Gasteiger, J., and Marsili, M. (1980) Iterative Partial Equalization of Orbital Electronegativity: A Rapid Access to Atomic Charges. Tetrahedron 36, 3219-3288.
    • (1980) Tetrahedron , vol.36 , pp. 3219-3288
    • Gasteiger, J.1    Marsili, M.2
  • 23
    • 84986870156 scopus 로고
    • Prediction of proton magnetic resonance shifts: The dependence on hydrogen charges obtained by iterative partial equalization of orbital electronegativity
    • Gasteiger, J., and Marsili, M. (1981) Prediction of Proton Magnetic Resonance Shifts: The Dependence on Hydrogen Charges Obtained by Iterative Partial Equalization of Orbital Electronegativity. Org. Magn. Reson. 15, 353-360.
    • (1981) Org. Magn. Reson. , vol.15 , pp. 353-360
    • Gasteiger, J.1    Marsili, M.2
  • 24
    • 0343581818 scopus 로고    scopus 로고
    • Tripos, Inc., St. Louis, MO
    • Sybyl (1997) Tripos, Inc., St. Louis, MO.
    • (1997) Sybyl
  • 25
    • 0343581819 scopus 로고
    • Ph.D. Thesis, School of Pharmacy, University of California, Berkeley, CA
    • Meng, E. C. (1993) Ph.D. Thesis, School of Pharmacy, University of California, Berkeley, CA.
    • (1993)
    • Meng, E.C.1
  • 28
    • 0000876636 scopus 로고
    • Measurement of macromolecular binding using electrospray mass spectrometry. Determination of dissociation constants for oligonucleotide-serum albumin complexes
    • Greig, M. J., Gaus, H., Cummins, L. L., Sasmor, H., and Griffey, R. H. (1995) Measurement of Macromolecular Binding Using Electrospray Mass Spectrometry. Determination of Dissociation Constants for Oligonucleotide-Serum Albumin Complexes. J. Am. Chem. Soc. 117, 10765-10766.
    • (1995) J. Am. Chem. Soc. , vol.117 , pp. 10765-10766
    • Greig, M.J.1    Gaus, H.2    Cummins, L.L.3    Sasmor, H.4    Griffey, R.H.5
  • 29
    • 0023047980 scopus 로고
    • Vesicles of variable sizes produced by a rapid extrusion procedure
    • Mayer, L. D., Hope, M. J., and Cullis, P. R. (1986) Vesicles of Variable Sizes Produced by a Rapid Extrusion Procedure. Biochim. Biophys. Acta 858, 161-168.
    • (1986) Biochim. Biophys. Acta , vol.858 , pp. 161-168
    • Mayer, L.D.1    Hope, M.J.2    Cullis, P.R.3
  • 30
    • 0020176708 scopus 로고
    • CONTIN: A general purpose constrained regularization program for inverting noisy linear algebraic or integral equations
    • Provencher, S. W. (1982) CONTIN: A General Purpose Constrained Regularization Program for Inverting Noisy Linear Algebraic or Integral Equations. Comput. Phys. Commun. 27, 229-242.
    • (1982) Comput. Phys. Commun. , vol.27 , pp. 229-242
    • Provencher, S.W.1
  • 31
    • 0030088496 scopus 로고    scopus 로고
    • Application of antibody and fluorophore-derivatized liposomes to heterogeneous immunoassays for D-dimer
    • Singh, A. K., Kilpatrick, P. K., and Carbonell, R. G. (1996) Application of Antibody and Fluorophore-Derivatized Liposomes to Heterogeneous Immunoassays for D-dimer. Biotechnol. Prog. 12, 272-280.
    • (1996) Biotechnol. Prog. , vol.12 , pp. 272-280
    • Singh, A.K.1    Kilpatrick, P.K.2    Carbonell, R.G.3
  • 34
    • 0032544145 scopus 로고    scopus 로고
    • Structure-based design of N-[2-(1-piperidinylethyl)]-N′-[2-(5-bromopyridyl)]thiourea and N-[2-(1-piperazinylethyl)]-N′-[2-(5-bromopyridyl)]thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase
    • Mao, C., Vig, R., Venkatachalam, T. K, Sudbeck, E. A., and Uckun, F. M. (1998) Structure-Based Design of N-[2-(1-piperidinylethyl)]-N′-[2-(5-bromopyridyl)]thiourea and N-[2-(1-piperazinylethyl)]-N′-[2-(5-bromopyridyl)]thiourea as Potent Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase. Bioorg. Med. Chem. Lett. 8, 2213-2218.
    • (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 2213-2218
    • Mao, C.1    Vig, R.2    Venkatachalam, T.K.3    Sudbeck, E.A.4    Uckun, F.M.5
  • 35
    • 0031600220 scopus 로고    scopus 로고
    • Automated docking and the search for HIV protease inhibitors
    • Olson, A. J., and Goodsell, D. S. (1998) Automated Docking and the Search for HIV Protease Inhibitors. SAR QSAR Environ. Res. 8, 273-285.
    • (1998) SAR QSAR Environ. Res. , vol.8 , pp. 273-285
    • Olson, A.J.1    Goodsell, D.S.2
  • 36
    • 0030742486 scopus 로고    scopus 로고
    • Interaction between botulinum neurotoxin type A and ganglioside: Ganglioside inactivates the neurotoxin and quenches its fluorescence
    • Kamata, Y., Yoshimoto, M., and Kozaki, S. (1997) Interaction Between Botulinum Neurotoxin Type A and Ganglioside: Ganglioside Inactivates the Neurotoxin and Quenches Its Fluorescence. Toxicon 35, 1337-1340.
    • (1997) Toxicon , vol.35 , pp. 1337-1340
    • Kamata, Y.1    Yoshimoto, M.2    Kozaki, S.3
  • 37
    • 0033520494 scopus 로고    scopus 로고
    • Sequence homolgy and structural analysis of the clostridial neurotoxins
    • Lacy, D. B., and Stevens, R. C. (1999) Sequence Homolgy and Structural Analysis of the Clostridial Neurotoxins. J. Mol. Biol. 291, 1091-1104.
    • (1999) J. Mol. Biol. , vol.291 , pp. 1091-1104
    • Lacy, D.B.1    Stevens, R.C.2
  • 38
    • 0024438708 scopus 로고
    • Electrospray ionization for mass spectrometry of large biomolecules
    • Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., and Whitehouse, C. M. (1989) Electrospray Ionization For Mass Spectrometry of Large Biomolecules. Science 246, 64-71.
    • (1989) Science , vol.246 , pp. 64-71
    • Fenn, J.B.1    Mann, M.2    Meng, C.K.3    Wong, S.F.4    Whitehouse, C.M.5
  • 40
    • 0001413545 scopus 로고
    • Detection of noncovalent receptor-ligand complexes by mass spectrometry
    • Ganem, B., Li, Y.-T., and Henion, J. D. (1991) Detection of Noncovalent Receptor-Ligand Complexes by Mass Spectrometry. J. Am. Chem. Soc. 113, 6294-6296.
    • (1991) J. Am. Chem. Soc. , vol.113 , pp. 6294-6296
    • Ganem, B.1    Li, Y.-T.2    Henion, J.D.3
  • 41
    • 0001401150 scopus 로고
    • Observation of the heme-globin complex in native myoglobin by electrospray-ionization mass spectrometry
    • Katta, V., and Chait, B. T. (1991) Observation of the Heme-Globin Complex in Native Myoglobin by Electrospray-Ionization Mass Spectrometry. J. Am. Chem. Soc. 113, 8534-8535.
    • (1991) J. Am. Chem. Soc. , vol.113 , pp. 8534-8535
    • Katta, V.1    Chait, B.T.2
  • 42
    • 0030621966 scopus 로고    scopus 로고
    • Studying noncovalent protein complexes by electrospray ionization mass spectrometry
    • Loo, J. A. (1997) Studying Noncovalent Protein Complexes by Electrospray Ionization Mass Spectrometry. Mass Spectrom. Rev. 16, 1-23.
    • (1997) Mass Spectrom. Rev. , vol.16 , pp. 1-23
    • Loo, J.A.1
  • 43
    • 33846278908 scopus 로고    scopus 로고
    • New mass spectrometric methods for the study of noncovalent associations of biopolymers
    • Smith, R. D., Bruce, J. E., Wu, Q., and Lei, Q. P. (1997) New mass spectrometric methods for the study of noncovalent associations of biopolymers. Chem. Soc. Rev. 26, 191-202.
    • (1997) Chem. Soc. Rev. , vol.26 , pp. 191-202
    • Smith, R.D.1    Bruce, J.E.2    Wu, Q.3    Lei, Q.P.4
  • 44
    • 0019882891 scopus 로고
    • Tandem mass spectrometry
    • McLafferty, F. W. (1981) Tandem Mass Spectrometry. Science 214, 280-287.
    • (1981) Science , vol.214 , pp. 280-287
    • McLafferty, F.W.1
  • 45
    • 0030822741 scopus 로고    scopus 로고
    • Electrospray: Principles and practice
    • Gaskell, S. J. (1997) Electrospray: Principles and Practice. J. Mass Spectrom. 32, 677-688.
    • (1997) J. Mass Spectrom. , vol.32 , pp. 677-688
    • Gaskell, S.J.1
  • 46
    • 0342711776 scopus 로고
    • What is struture-based drug design?
    • Roe, D. C., and Kuntz, I. D. (1995) What is Struture-Based Drug Design? Pharm. News 2, 13-15.
    • (1995) Pharm. News , vol.2 , pp. 13-15
    • Roe, D.C.1    Kuntz, I.D.2
  • 47
    • 0027373925 scopus 로고
    • Calibration and assay development using the four-parameter logistic model
    • O'Connell, M. A., Belanger, B. A., and Haaland, P. D. (1993) Calibration and Assay Development Using the Four-Parameter Logistic Model. Chemom. Intell. Lab. Syst. 20, 97-114.
    • (1993) Chemom. Intell. Lab. Syst. , vol.20 , pp. 97-114
    • O'Connell, M.A.1    Belanger, B.A.2    Haaland, P.D.3
  • 48
    • 0342711775 scopus 로고    scopus 로고
    • Beilstein Information Systems, Inc., San Leandro, CA
    • Beilstein (1999) Beilstein Information Systems, Inc., San Leandro, CA.
    • (1999)
    • Beilstein1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.