Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction

Journal of Clinical Investigation

Volumn 102, Issue 6, 1998, Pages 1152-1160

  Arbibe, Laurence ^a   Koumanov, Kamen ^c   Vial, Daniel ^a   Rougeot, Catherine ^b   Faure, Grazyna ^b   Havet, Nathalie ^a   Longacre, Shirley ^b   Vargaftig, B Boris ^a   Béréziat, Gilbert ^c   Voelker, Dennis R ^d   Wolf, Claude ^c   Touqui, Lhousseine ^a  

^a INSERM   (France)

^b INSTITUT PASTEUR   (France)

^c CNRS   (France)

^d NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Acute Respiratory Distress Syndrome; Lyso phospholipids; Phospholipase A2; Surfactant; Surfactant protein A

Indexed keywords

FATTY ACID; LUNG SURFACTANT; LYSOPHOSPHATIDYLCHOLINE; LYSOPHOSPHOLIPID; PALMITIC ACID; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PROTEIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RELEASE; GAS CHROMATOGRAPHY; GUINEA PIG; LUNG INJURY; LUNG LAVAGE; MALE; MASS SPECTROMETRY; NONHUMAN; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; RESPIRATORY DISTRESS SYNDROME;

EID: 0032530764     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3236     Document Type: Article

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