An assessment of the in vitro toxicology of Clostridium perfringens type D ε-toxin in human and animal cells

Human and Experimental Toxicology

Volumn 19, Issue 2, 2000, Pages 108-116

  Shortt, S J ^a   Titball, R W ^a   Lindsay, C D ^a  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

Clostridium perfringens; G 402; MDCK; MTS; toxin

Indexed keywords

BINDING PROTEIN; CLOSTRIDIUM TOXIN; GLYCOSYLATED PROTEIN; SIALIC ACID;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELL STRUCTURE; CELL VIABILITY; CLOSTRIDIUM PERFRINGENS; CONTROLLED STUDY; HUMAN; HUMAN CELL; MICROPHOTOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; TOXICOLOGY;

ANIMALIA; CLOSTRIDIUM; CLOSTRIDIUM PERFRINGENS;

EID: 0034032834     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/096032700678815710     Document Type: Article

References (29)

1. McDonel JL. Toxins of Clostridium perfringens types A, B, C, D and E. In: Pharmacology of bacterial toxins. Pergamon Press: Oxford, 1986; pp. 477-506.
2. Hatheway CL. Toxigenic clostridia. Clinical Microbiological Reviews 1990; 3: 66-98.
3. Brookes ME, Sterne M, Warrack GH. A reassessment of the criteria used for type differentiation of Clostridium perfringens. Journal of Pathology and Bacteriology 1957; 74: 185-195.
4. Payne DW, Oysten P. The Clostridium perfringens ε-toxin. In: The Clostridia: Molecular biology and pathogenesis. Academic Press Limited: London, 1997; pp, 439-447.
5. Habeeb AFSA, Lee CL, Atassi MZ. Conformational studies on modified proteins and peptides VII Conformation of ε-prototoxin and ε-toxin from Clostridium perfringens. Conformational changes associated with toxicity. Biochemica et Biophysica Ada 1973; 322: 245-250.
6. Shown AS, Habeeb AFSA. Structural studies on ε-toxin of Clostridium perfringens type D. Localisation of the site of tryptic scission necessary for activation of ε-toxin. Biochemical and Biophysical Research Communications 1977; 73: 889-896.
7. Payne DW et al. Evaluation of a new cytotoxicity assay for Clostridium perfringens type D epsilon toxin. FEMS Microbiology Letters 1994; 116: 161-168.
8. Morgan KT, Kelly BG, Buxton D. Vascular leakage produced in the brains of mice by Clostridium welchii type D toxin. Journal of Comparative Pathology 1975; 85: 461-466.
9. Buxton D, Morgan KT. Studies of lesions produced in the brains of colostrum deprived lambs by Clostridium welchii (Cl. Perfringens) type D toxin. Journal of Comparative Pathology 1976; 86: 435-447.
10. Buxton D. In vitro effects of Clostridium perfringens epsilon toxin on guinea-pig, mouse, rabbit and sheep cells. Journal of Medical Microbiology 1978b; 11: 299-302.
11. Morgan KT, Kelly BG. Ultrastructural study of brain lesions produced in mice by the administration of Clostridium welchii Type D toxin. Journal of Comparative; Pathology 1974; 84: 181-191.
12. Nagahama M, Sakurai J. Distribution of labeled Clostridium perfringens epsilon toxin in mice. Toxicology 1991; 29: 211-217.
13. Nagahama M, Sakurai J. High-affinity binding of Clostridium perfringens epsilon toxin to rat brain. Infection & Immunity 1992; 60: 1237-1240.
14. Bullen JJ. Role of toxins in host-parasite relationships. In: Ajl S, Kadis S and Montie TC, eds. Microbial Toxins. Academic Press: Vol 1. New York, 1970; pp. 233-276.
15. Bullen JJ, Scarisbrick R. Enterotoxaemia of sheep: experimental reproduction of the disease. Journal of Pathology and Bacteriology 1957; 73: 494-509.
16. Buxton A, Fraser G. Animal microbiology. Vol 1. Blackwell Scientific Publications Limited: Oxford, 1977; pp, 205-228.
17. Songer JG. Clostridial diseases of animals. In: Rood JI, McClane BA, Songer TG, Titball RW, eds. The Clostridia: molecular biology and pathogenesis. Academic Press Limited: London, 1997; pp. 153-182.
18. Havard HL, Hunter SE, Titball RW. Comparison of the nucleotide sequence and development of a PCR test for the epsilon toxin of Clostridium perfringens type B and type D. FEMS Microbiology Letters 1992; 76; 77-81.
19. Kaufman PB, Wu W, Kim D, Cseke LJ. Handbook of Molecular and Cellular Methods in Biology and Medicine. CRC Press, Incorporated: London, 1995: pp. 41-63.
20. Gill DM. Bacterial toxins: a table of lethal amounts. Microbiological Reviews 1982; 46: 86-94.
21. Lindsay CD, Hambrook JL, Upshall DG. Examination of the toxicity of Clostridium perfringens ε-toxin in the MDCK cell line. Toxicology in Vitro 1995; 9: 213-218.
22. Payne DW, Williamson ED, Titball RW. The Clostridium perfringens epsilon-toxin. Reviews in Medical Microbiology 1997; 8 (Suppl 1): S28-S30.
23. Hambrook JL, et al. Morphological, cytoskeletal and electrophysiological changes induced in MDCK cells by exposure to Clostridium perfringens β-toxin. Human and Experimental Toxicology 1996; 15: 150.
24. Donelli G et al. Evidence for the involvement of actin cytoskeleton in the in vitro response to Clostridium perfringens epsilon toxin [abstract]. Abstracts of the Second International Conference on the Molecular Biology and pathogenesis of the Clostridia. Paris : Société Française de Microbiologie, 1997.
25. Buxton D. Use of horseradish peroxidase to study the antagonism of Clostridium welchii (Cl. Perfringens) type D epsilon toxin in mice by the formalized epsilon prototoxin. Journal of Comparative Pathology 1976; 86: 435-447.
26. Lindsay CD. Assessment of aspects of the toxicity of Clostridium perfringens ε-toxin using the MDCK cell line. Human & Experimental Toxicology 1996; 15: 904-908.
27. Petit L ef al. Clostridium perfringens Epsilon-Toxin Acts on MDCK Cells by Forming a Large Membrane Complex. Journal of Bacteriology 1997; 179: 6480-6487.
28. Nagahama M, Ochi S, Sakurai J. Assembly of Clostridium perfringens epsilon-toxin on MDCK cell membrane. Journal of Natural Toxins 1998; 7: 291-302.
29. Griffiths GD, Lindsay CD, Upshall DG. Examination of the toxicity of several protein toxins of plant origin using bovine pulmonary endothelial cells. Toxicology 1994; 90: 11-27.