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Volumn 107, Issue 7, 2003, Pages 954-959

Protease-activated receptor 2-mediated vasodilatation in humans in vivo: Role of nitric oxide and prostanoids

Author keywords

Nitric oxide; Prostaglandins; Receptors; Vasodilation

Indexed keywords

NITRIC OXIDE; PROSTANOID; PROTEINASE ACTIVATED RECEPTOR 2; SERINE PROTEINASE;

EID: 0037465357     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000050620.37260.75     Document Type: Article
Times cited : (54)

References (36)
  • 2
    • 0030066317 scopus 로고    scopus 로고
    • Thrombin receptor activating mutations: Alteration of an extracellular agonist recognition domain causes constitutive signaling
    • Nanevicz T, Wang L, Chen M, et al. Thrombin receptor activating mutations: alteration of an extracellular agonist recognition domain causes constitutive signaling. J Biol Chem. 1996;271:702-706.
    • (1996) J Biol Chem , vol.271 , pp. 702-706
    • Nanevicz, T.1    Wang, L.2    Chen, M.3
  • 3
    • 0031919771 scopus 로고    scopus 로고
    • Receptor-activating peptides distinguish thrombin receptor (PAR-1) and protease activated receptor 2 (PAR-2) mediated hemodynamic responses in vivo
    • Cheung WM, Andrade-Gordon P, Derian CK, et al. Receptor-activating peptides distinguish thrombin receptor (PAR-1) and protease activated receptor 2 (PAR-2) mediated hemodynamic responses in vivo. Can J Physiol Pharmacol. 1998;76:16-25.
    • (1998) Can J Physiol Pharmacol , vol.76 , pp. 16-25
    • Cheung, W.M.1    Andrade-Gordon, P.2    Derian, C.K.3
  • 4
    • 0034648757 scopus 로고    scopus 로고
    • Thrombin signalling and protease-activated receptors
    • Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 2000;407:258-264.
    • (2000) Nature , vol.407 , pp. 258-264
    • Coughlin, S.R.1
  • 5
    • 0029929603 scopus 로고    scopus 로고
    • Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2
    • Bohm SK, Kong W, Bromme D, et al. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J. 1996;314(pt 3):1009-1016.
    • (1996) Biochem J , vol.314 , Issue.PART 3 , pp. 1009-1016
    • Bohm, S.K.1    Kong, W.2    Bromme, D.3
  • 6
    • 0025014627 scopus 로고
    • A new peptide coupling reagent devoid of toxic by-product
    • Coste J, Le-Nguyen D, Castro B, et al. A new peptide coupling reagent devoid of toxic by-product. Tetrahedron Lett. 1990;31:205-208.
    • (1990) Tetrahedron Lett , vol.31 , pp. 205-208
    • Coste, J.1    Le-Nguyen, D.2    Castro, B.3
  • 7
    • 0028851551 scopus 로고
    • Vasodilatation to arachidonic acid in humans: An insight into endogenous prostanoids and effects of aspirin
    • Bhagat K, Collier J, Vallance P. Vasodilatation to arachidonic acid in humans: an insight into endogenous prostanoids and effects of aspirin. Circulation. 1995;92:2113-2118.
    • (1995) Circulation , vol.92 , pp. 2113-2118
    • Bhagat, K.1    Collier, J.2    Vallance, P.3
  • 8
    • 0029030732 scopus 로고
    • Measuring forearm blood flow and interpreting the responses to drugs and mediators
    • Benjamin N, Calver A, Collier J, et al. Measuring forearm blood flow and interpreting the responses to drugs and mediators. Hypertension. 1995;25:918-923.
    • (1995) Hypertension , vol.25 , pp. 918-923
    • Benjamin, N.1    Calver, A.2    Collier, J.3
  • 9
    • 0034119983 scopus 로고    scopus 로고
    • Bradykinin-induced vasodilation of human forearm resistance vessels is primarily mediated by endothelium-dependent hyperpolarization
    • Honing ML, Smits P, Morrison PJ, et al. Bradykinin-induced vasodilation of human forearm resistance vessels is primarily mediated by endothelium-dependent hyperpolarization. Hypertension. 2000;35:1314-1318.
    • (2000) Hypertension , vol.35 , pp. 1314-1318
    • Honing, M.L.1    Smits, P.2    Morrison, P.J.3
  • 10
    • 0032577955 scopus 로고    scopus 로고
    • Atypical protease-activated receptor mediates endothelium-dependent relaxation of human coronary arteries
    • Hamilton JR, Nguyen PB, Cocks TM. Atypical protease-activated receptor mediates endothelium-dependent relaxation of human coronary arteries. Circ Res. 1998;82:1306-1311.
    • (1998) Circ Res , vol.82 , pp. 1306-1311
    • Hamilton, J.R.1    Nguyen, P.B.2    Cocks, T.M.3
  • 11
    • 0034936715 scopus 로고    scopus 로고
    • Protease-activated receptor (PAR) 1 but not PAR2 or PAR4 mediates endothelium-dependent relaxation to thrombin and trypsin in human pulmonary arteries
    • Hamilton JR, Moffatt JD, Frauman AG, et al. Protease-activated receptor (PAR) 1 but not PAR2 or PAR4 mediates endothelium-dependent relaxation to thrombin and trypsin in human pulmonary arteries. J Cardiovasc Pharmacol. 2001:38:108-119.
    • (2001) J Cardiovasc Pharmacol , vol.38 , pp. 108-119
    • Hamilton, J.R.1    Moffatt, J.D.2    Frauman, A.G.3
  • 12
    • 0032988474 scopus 로고    scopus 로고
    • Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1
    • Damiano BP, Cheung WM, Santulli RJ, et al. Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. J Pharmacol Exp Ther. 1999;288:671-678.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 671-678
    • Damiano, B.P.1    Cheung, W.M.2    Santulli, R.J.3
  • 13
    • 0030879202 scopus 로고    scopus 로고
    • Vascular effects of proteinaseactivated receptor 2 agonist peptide
    • Emilsson K, Wahlestedt C, Sun MK, et al. Vascular effects of proteinaseactivated receptor 2 agonist peptide. J Vasc Res. 1997:34:267-272.
    • (1997) J Vasc Res , vol.34 , pp. 267-272
    • Emilsson, K.1    Wahlestedt, C.2    Sun, M.K.3
  • 14
    • 0035816730 scopus 로고    scopus 로고
    • Increased expression of proteaseactivated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists
    • Hamilton JR, Frauman AG, Cocks TM. Increased expression of proteaseactivated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists. Circ Res. 2001;89:92-98.
    • (2001) Circ Res , vol.89 , pp. 92-98
    • Hamilton, J.R.1    Frauman, A.G.2    Cocks, T.M.3
  • 15
    • 0034671716 scopus 로고    scopus 로고
    • A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists
    • Compton SJ, Cairns JA, Palmer KJ, et al. A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists. J Biol Chem. 2000;275:39207-39212.
    • (2000) J Biol Chem , vol.275 , pp. 39207-39212
    • Compton, S.J.1    Cairns, J.A.2    Palmer, K.J.3
  • 16
    • 0024428094 scopus 로고
    • Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man
    • Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 1989;2:997-1000.
    • (1989) Lancet , vol.2 , pp. 997-1000
    • Vallance, P.1    Collier, J.2    Moncada, S.3
  • 17
    • 0033062214 scopus 로고    scopus 로고
    • Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS
    • Bhagat K, Hingorani AD, Palacios M, et al. Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS. Cardiovasc Res. 1999;41:754-764.
    • (1999) Cardiovasc Res , vol.41 , pp. 754-764
    • Bhagat, K.1    Hingorani, A.D.2    Palacios, M.3
  • 18
    • 0024409095 scopus 로고
    • Local inhibition of converting enzyme and vascular responses to angiotensin and bradykinin in the human forearm
    • Benjamin N, Cockcroft JR, Collier JG, et al. Local inhibition of converting enzyme and vascular responses to angiotensin and bradykinin in the human forearm. J Physiol. 1989;412:543-555.
    • (1989) J Physiol , vol.412 , pp. 543-555
    • Benjamin, N.1    Cockcroft, J.R.2    Collier, J.G.3
  • 19
    • 0036152709 scopus 로고    scopus 로고
    • Protease activated receptor 2 and the cardiovascular system
    • Cicala C. Protease activated receptor 2 and the cardiovascular system. Br J Pharmacol. 2002;135:14-20.
    • (2002) Br J Pharmacol , vol.135 , pp. 14-20
    • Cicala, C.1
  • 20
    • 0033580606 scopus 로고    scopus 로고
    • Protease-activated receptor-2 involvement in hypotension in normal and endotoxemic rats in vivo
    • Cicala C, Pinto A, Bucci M. et al. Protease-activated receptor-2 involvement in hypotension in normal and endotoxemic rats in vivo. Circulation. 1999;99:2590-2597.
    • (1999) Circulation , vol.99 , pp. 2590-2597
    • Cicala, C.1    Pinto, A.2    Bucci, M.3
  • 21
    • 0036152776 scopus 로고    scopus 로고
    • Multiple mechanisms of vascular smooth muscle relaxation by the activation of proteinase-activated receptor 2 in mouse mesenteric arterioles
    • McGuire JJ, Hollenberg MD, Andrade-Gordon P, et al. Multiple mechanisms of vascular smooth muscle relaxation by the activation of proteinase-activated receptor 2 in mouse mesenteric arterioles. Br J Pharmacol. 2002;135:155-169.
    • (2002) Br J Pharmacol , vol.135 , pp. 155-169
    • McGuire, J.J.1    Hollenberg, M.D.2    Andrade-Gordon, P.3
  • 22
    • 0035378213 scopus 로고    scopus 로고
    • Pharmacological dissection of vascular effects caused by activation of protease-activated receptors 1 and 2 in anesthetized rats
    • Cicala C, Morello S, Santagada V, et al. Pharmacological dissection of vascular effects caused by activation of protease-activated receptors 1 and 2 in anesthetized rats. FASEB J. 2001;15:1433-1435.
    • (2001) FASEB J , vol.15 , pp. 1433-1435
    • Cicala, C.1    Morello, S.2    Santagada, V.3
  • 23
    • 0037040862 scopus 로고    scopus 로고
    • Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: Selective preservation in ischemia/reperfusion injury: Involvement of lipoxygenase products, VR1 receptors, and C-fibers
    • McLean PG, Aston D, Sarkar D, et al. Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia/reperfusion injury: involvement of lipoxygenase products, VR1 receptors, and C-fibers. Circ Res. 2002;90:465-472.
    • (2002) Circ Res , vol.90 , pp. 465-472
    • McLean, P.G.1    Aston, D.2    Sarkar, D.3
  • 24
    • 0036083719 scopus 로고    scopus 로고
    • PAR-2 elicits afferent arteriolar vasodilation by NO-dependent and NO-independent actions
    • Trottier G, Hollenberg M, Wang X, et al. PAR-2 elicits afferent arteriolar vasodilation by NO-dependent and NO-independent actions. Am J Physiol Renal Physiol. 2002;282:F891-F897.
    • (2002) Am J Physiol Renal Physiol , vol.282
    • Trottier, G.1    Hollenberg, M.2    Wang, X.3
  • 25
    • 0029113121 scopus 로고
    • Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2
    • Nystedt S, Emilsson K, Larsson AK, et al. Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. Eur J Biochem. 1995;232:84-89.
    • (1995) Eur J Biochem , vol.232 , pp. 84-89
    • Nystedt, S.1    Emilsson, K.2    Larsson, A.K.3
  • 26
    • 0034682915 scopus 로고    scopus 로고
    • Extrapancreatic trypsin-2 cleaves proteinase-activated receptor-2
    • Alm AK, Gagnemo-Persson R, Sorsa T, et al. Extrapancreatic trypsin-2 cleaves proteinase-activated receptor-2. Biochem Biophys Res Commun. 2000;275:77-83.
    • (2000) Biochem Biophys Res Commun , vol.275 , pp. 77-83
    • Alm, A.K.1    Gagnemo-Persson, R.2    Sorsa, T.3
  • 27
    • 15444346942 scopus 로고    scopus 로고
    • Interactions of mast cell tryptase with thrombin receptors and PAR-2
    • Molino M, Bamathan ES, Numerof R, et al. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem. 1997;272:4043-4049.
    • (1997) J Biol Chem , vol.272 , pp. 4043-4049
    • Molino, M.1    Bamathan, E.S.2    Numerof, R.3
  • 28
    • 0034624973 scopus 로고    scopus 로고
    • Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
    • Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA. 2000;97:5255-5260.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 5255-5260
    • Camerer, E.1    Huang, W.2    Coughlin, S.R.3
  • 29
    • 0034806035 scopus 로고    scopus 로고
    • Factor Xa-evoked relaxation in rat aorta: Involvement of PAR-2
    • Kawabata A, Kuroda R, Nakaya Y, et al. Factor Xa-evoked relaxation in rat aorta: involvement of PAR-2. Biochem Biophys Res Commun. 2001;282:432-435.
    • (2001) Biochem Biophys Res Commun , vol.282 , pp. 432-435
    • Kawabata, A.1    Kuroda, R.2    Nakaya, Y.3
  • 30
    • 0032508557 scopus 로고    scopus 로고
    • Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis
    • Lourbakos A, Chinni C, Thompson P, et al. Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis. FEBS Lett. 1998;435:45-48.
    • (1998) FEBS Lett , vol.435 , pp. 45-48
    • Lourbakos, A.1    Chinni, C.2    Thompson, P.3
  • 31
    • 0031690091 scopus 로고    scopus 로고
    • Increased vascular permeability by a specific agonist of protease-activated receptor-2 in rat hindpaw
    • Kawabata A, Kuroda R, Minami T, et al. Increased vascular permeability by a specific agonist of protease-activated receptor-2 in rat hindpaw. Br J Pharmacol. 1998;125:419-422.
    • (1998) Br J Pharmacol , vol.125 , pp. 419-422
    • Kawabata, A.1    Kuroda, R.2    Minami, T.3
  • 32
    • 15844401726 scopus 로고    scopus 로고
    • The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells: Comparison with the thrombin receptor
    • Nystedt S, Ramakrishnan V, Sundelin J. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells: comparison with the thrombin receptor. J Biol Chem. 1996;271:14910-14915.
    • (1996) J Biol Chem , vol.271 , pp. 14910-14915
    • Nystedt, S.1    Ramakrishnan, V.2    Sundelin, J.3
  • 33
    • 0019959445 scopus 로고
    • Disturbances of selected plasma proteins in hyperdynamic septic shock
    • Witte J, Jochum M, Scherer R, et al. Disturbances of selected plasma proteins in hyperdynamic septic shock. Intensive Care Med. 1982;8:215-222.
    • (1982) Intensive Care Med , vol.8 , pp. 215-222
    • Witte, J.1    Jochum, M.2    Scherer, R.3
  • 34
    • 0021346407 scopus 로고
    • Immunoreactive trypsin in the adult respiratory distress syndrome
    • Deby-Dupont G, Haas M, Pincemail J, et al. Immunoreactive trypsin in the adult respiratory distress syndrome. Intensive Care Med. 1984;10:7-12.
    • (1984) Intensive Care Med , vol.10 , pp. 7-12
    • Deby-Dupont, G.1    Haas, M.2    Pincemail, J.3
  • 35
    • 0029833729 scopus 로고    scopus 로고
    • Serum complex of trypsin 2 and alpha 1 antitrypsin as diagnostic and prognostic marker of acute pancreatitis: Clinical study in consecutive patients
    • Hedstrom J, Sainio V, Kemppainen E, et al. Serum complex of trypsin 2 and alpha 1 antitrypsin as diagnostic and prognostic marker of acute pancreatitis: clinical study in consecutive patients. BMJ. 1996;313:333-337.
    • (1996) BMJ , vol.313 , pp. 333-337
    • Hedstrom, J.1    Sainio, V.2    Kemppainen, E.3
  • 36
    • 0032712334 scopus 로고    scopus 로고
    • Trypsin and activation of circulating trypsinogen contribute to pancreatitis-associated lung injury
    • Hartwig W, Werner J, Jimenez RE, et al. Trypsin and activation of circulating trypsinogen contribute to pancreatitis-associated lung injury. Am J Physiol. 1999;277(pt 1):GI008-GI016.
    • (1999) Am J Physiol , vol.277 , Issue.PART 1
    • Hartwig, W.1    Werner, J.2    Jimenez, R.E.3


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