Serum complex of trypsin 2 and (alpha)(sub 1) antitrypsin as diagnostic and prognostic marker of acute pancreatitis: Clinical study in consecutive patients

BMJ

Volumn 313, Issue 7053, 1996, Pages 333-337

  Hedstrom, Johan ^a   Leinonen, Jari ^a   Stenman, Ulf Hakan ^a   Sainio, Vesa ^a   Kemppainen, Esko ^a   Haapiainen, Reijo ^a   Kivilaakso, Eero ^a   Schroder, Tom ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; AMYLASE; C REACTIVE PROTEIN; MARKER; TRYPSIN; TRYPSINOGEN;

ACUTE ABDOMEN; ACUTE PANCREATITIS; ADULT; ARTICLE; BLOOD LEVEL; CLINICAL TRIAL; COMPARATIVE STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC;

ABDOMINAL PAIN; ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; ALPHA 1-ANTITRYPSIN; AMYLASES; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; FEMALE; HUMANS; MALE; MIDDLE AGED; PANCREATITIS; PROGNOSIS; SENSITIVITY AND SPECIFICITY; TRYPSIN;

EID: 0029833729     PISSN: 09598138     EISSN: 14685833     Source Type: Journal    
DOI: 10.1136/bmj.313.7053.333     Document Type: Article

References (22)

1. Williamson RC. Early assessment of severity in acute pancreatitis. Gut 1984; 25: 1331–9.
2. Ranson JHC, Spencer FC. The role of peritoneal ravage in severe acute pancreatitis. Ann Surg 1978; 187: 565–575.
3. Levitt RG, Geisse GS, Sagel SS. Stanley RJ, Evens RG, Koehler RE et al. Complementary use of ultrasound and tomography in studies of the pancreas and kidney. Radiology 1978; 126: 149–152.
4. Dammann HG, Grabbe E, Runge M. Computed tomography and acute pancreatitis. Lancet 1980; 2: 860.
5. Block S, Maier W, Bittner M, Buhler M, Malfertheiner H, Beger HG. Identification of pancreas necrosis in severe acute pancreatitis: imaging procedures versus clinical staging. Gut 1986; 27: 1035–42.
6. Kivisaari L, Somer K, Standertskjold-Nordenstam C-G, Schroder T, Kivilaakso E, Lempinen M. A new method for the diagnosis of acute hemorrhagic-necrotizing pancreatitis using contrast-enhanced CT. Gastrointest Radiol 1984; 9: 27–30.
7. Steinberg WM, Goldstein SS, Davis ND, Shamma'a J, Anderson K. Diagnostic assays in acute pancreatitis. A study of sensitivity and specificity. Ann Intern Med 1985; 102: 576–580.
8. Salt WB, Schenker S. Amylase—its clinical significance: a review of the literature. Medicine 1976; 55: 269–289.
9. Mayer AD, McMahon MJ, Corfield AP, Cooper MJ, Dickson AP, Shearer MG et al. Controlled clinical trial of peritoneal ravage for the treatment of severe acute pancreatitis. N Engl J Med 1985; 312: 399–404.
10. Imrie CW, Benjamin IS, Ferguson JC, McKay AJ, Mackenzie I, O'Neill J et al. A single-centre double-blind trial of Trasylol therapy in primary acute pancreatitis. Br J Surg 1978; 65: 337–341.
11. Corfield AP, Cooper MJC, Williamson RCN. Acute pancreatitis: a lethal disease of increasing incidence. Gut 1985; 26: 724–729.
12. Ohlsson K, Eddeland A. Release of proteolytic enzymes in bile induced pancreatitis in dogs. Gastroenterology 1975; 69: 668–675.
13. Lasson A, Ohisson K. Protease inhibitors in acute human pancreatitis. Correlation between biochemical changes and clinical course. Scand J Gastroenterol 1984; 19: 779–786.
14. Ohisson K. Acute pancreatitis Biochemical, pathophysiological and therapeutics aspects. Acta Gastroenterol Belg 1988; 51: 3–12.
15. Itkonen O, Kolvonen E, Hurme M, Alfthan H, Schroder T, Stenman U.-H. Time-resolved immunofluorometric assays for trypsinogen-1 and 2 in serum reveal preferential elevation of trypsinogen-2 in pancreatitis. J Lab Clin Med 1990; 115: 712–718.
16. Durie PR, Gaskin KJ, Geokas MC, O'Rourke M, Largman C. Plasma immunoreactive anionic pancreatic trypsin in cystic fibrosis. J Pediatr Gastroenterol Nutr 1982; 1: 337–343.
17. Borgstrom A, Ohlsson K. Studies on the turnover of endogenous cathodal trypsinogen in man. Eur J Clin Invest 1978; 8: 379–382.
18. Hedstrom J, Leinonen J, Sainio V, Stenman U.-H. Time-resolved immunofluorometric assay of trypsin-2 complexed with alpha 1-antitrypsin in serum. Clin Chem 1994; 40: 1761–5.
19. Gudgeon AM, Heath DI, Hurley P, Jehanli A, Patel G, Wilson C et al. Trypsinogen activation peptides assay in the early prediction of severity of acute pancreatitis. Lancet 1990; 335: 4–8.
20. Fischer CL, Gill C, Forrester MG, Nakamura R. Quantitation of acute phase proteins postoperatively. Value in detection and monitoring of complications. Am J Clin Pathol 1976; 66: 840–846.
21. Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 1993; 39: 561–577.
22. Koivunen E, ltkonen O, Halila H, Stenman U-H. Cyst fluid of ovarian cancer patients contains high concentrations of trypsinogen-2. Cancer Res 1990; 50: 2375–8.